11 May 2018 Gastroenterology Plenary Session 1 - Abstracts · Programme subject to change. Status as of February 2018 11 May 2018 08:45 –10:15 Gastroenterology Plenary Session 1

Programme subject to change. Status as of February 2018

11 May 2018

08:45 – 10:15

Gastroenterology

Plenary Session 1 - Abstracts

08:45 – 08:55STAT6 variants interact with CYP2C19*17 to predict clinical outcome of

proton pump inhibitor therapy in children with eosinophilic oesophagitisJames Franciosci (United States)

08:55 – 09:05

Transmural healing evaluated by magnetic resonance enterography in

paediatric Crohn’s disease patients under maintenance treatment with

biologics

Ben Kang (Republic of Korea)

09:05- 09:15Viral infections as triggers of coeliac disease in a longitudinal birth

cohortChristian R. Kahrs (Norway)

09:15 – 09:25Mucosal healing and histological remission in pediatric ulcerative colitis:

does the target change the outcomes?Giulia D‘Arcangelo (Italy)

09:25 – 09:35Cystic fibrosis dyslipidemia revisited: a prospective, cross-sectional

studyJan Krzysztof Nowak (Poland)

09:35 – 09:45Development of the Pediatric Inflammatory Crohn´s MRE Index

(PICMI)- results from the ImageKids StudyDan Turner (Israel)

09:45 – 09:55 Profoundly increased mortality in patients with CF related cirrhosis Frederik H. Pals (Netherands)

09:55 – 10:05Retrospective analysis of pharmacokinetic Infliximab data in young IBD

patients at the age of 9 or younger

Maria Myrthe Elisabeth Jongsma

(Netherlands)


11 May 2018

08:45 – 10:15

Nutrition

Plenary Session - Abstracts

08:45 – 08:45

Human milk oligosaccharides profiles from healthy European

mothers: New insights from Atlas of Human Milk Nutrients, a

multicenter observational cohort

Aristea Binia (Switzerland)

98:45 – 09:00

Utilization of human milk oligosaccharide 2’-fucosyllactose by various

probiotic strains and characterization of gene clusters involved in

HMO metabolism by Bifidobacterium longum ssp. infantis Bi-26

Johanna Hirvonen (Finland)

09:00 – 09:10

Iron fortification may reduce efficacy of oral antibiotics against

enteropathogens, whereas galacto-oligosaccharides (GOS) mitigate

the adverse effects of iron fortification on the gut microbiome in

Kenyan infants

Guus Kortman (Netherlands)

09:10 – 09:20Administration of iron as drops has significant effects on the gut

microflora of iron-sufficient infants: a randomized controlled studyTorbjörn Lind (Sweden)

09:20 – 09:30A single intake of a polysaccharides mix reduces postprandial

triglycerides, ghrelin and appetite in obese children: a clinical trialElena Fornari (Italy)

09:30 – 09:40 The Cow Milk Symptom Score (CoMiSSTM) in healthy infants Yvan Vandenplas (Belgium)

09:40 – 09:50Prolonged minimal enteral nutrition versus slowly advancing enteral

nutrition in very low birth weight infants: Randomized controlled trialOzlem Bozkurt (Turkey)

09:50 – 10:00Pre- and postnatal nutrient restriction has differential effects on

systemic immunity development in preterm pigletsOle Bæk (Denmark)


11 May 2018

08:45 – 10:15

Hepatology

Plenary Session - Abstracts

08:45 – 09:00The liver regenerates ESPGHAN (50 years of ESPGHAN:

Hepatology)Deirde Kelly (United Kingdom)

09:00 – 09:15

The role of N-acetylcysteine in preventing hepatic injury associated

with systemic oxidative stress after extracorporeal shock wave

treatment

Sebahat Cam (Turkey)

09:15 – 09:25Portal infiltrate in protocol liver biopsies is associated with

histological phenotypes and donor specific antibodiesVladimir L Cousin (Switzerland)

09:25 – 09:35

The natural course of FIC1 deficiency and BSEP deficiency: initial

results from the NAPPED-consortium (NAtural course

andprognosis of PFIC and effect of biliary diversion)

Daan van Wessel (Netherlands)

09:35 – 09:45Alginate encapsulated hepatocytes for treatment of paediatric

failure in children: first clinical experienceAnil Dhawan (United Kingdoms)

09:45 – 09:55

Development and validation of a new diagnostic scoring system for

paediatric autoimmune hepatitis based on the ESPGHAN and

NASPGHAN 2009 proposal

José Vicente Arcos-Machancoses

(Spain)

09:55 – 10:05Chronic rejection after paediatric liver transplantation: impact of the

vanishing bile duct syndrome on long term graft survivalValeria Casotti (Italy)

10:05 – 11:15

The thrombogenic risk induced by intraportal infusion of Adult

Derived Human Liver Stem/Mesenchymal Cells in Wistar rats can

be controlled with a combination of anticoagulant drugs, heparin

and bivalirudin

Louise Coppin (Belgium)


11 May 2018

10:15 – 10:45

Hepatology Keynote

Keynote Lecture (30 min)Chair: Henkjan Verkade

10:15 – 10:45 Low gamma-GT cholestasis Richard Thompson (United Kingdom)


11 May 2018

11:15 – 12:15

Nutrition

Parallel Session 2 - Abstracts

11:15 – 11:25Nutrient fortification improves postnatal growth without effects on

neurodevelopment in preterm pigsAgnethe May Ahnfeldt (Denmark)

11:25 – 11:35Presence of 6’SL during lactation promotes attention,

learning/memory and reduces impulsivity in the adult offspring in miceJonas Hauser (Switzerland)

11:35 – 11:45Effects of early feeding patterns on Nrg4 expression in adipose tissue

and relationship with NAFLDFan Yang (China)

11:45 – 11:55

Maternal choline supplementation during the third trimester of

pregnancy improves infant information processing speed: a

randomized, double-blind, controlled feeding study

Richard L. Canfield (United States)

11:55 – 12:05 The Prevention of Obesity in Toddlers (PROBIT) trial Anita Morandi (Italy)

12:05 – 12:15Resting energy expenditure in children with cerebral palsy: accuracy

of prediction formulae and elaboration of a population specific formulaFrancesca Penagini (Itay)


11 May 2018

11:15 – 12:15

Hepatology


11:15 – 11:25Next generation sequencing in the diagnostic approach to

neonatal/infantile cholestasisEmanuele Nicastro (Italy)

11:25 – 11:35MRI as a biomarker for Wilson’s disease in children: Early

observations from a larger trial into pediatric liver diseaseKamil Janowski (Poland)

11:35 – 11:45 Mutations in MYO5B in early onset cholestasis Iram Cockar (United Kingdom)

11:45 – 11:55

Capturing T-cell receptors. A potential new modality for targeting

hepatic tumours and Post-Transplantation Lymphoproliferative

Disease (PTLD)

Nicola Ruth (United Kingdoms)

11:55 – 12:05

Transient neonatal cholestasis of unknown cause is associated with

heterozygosity for pathogenic mutations in SERPINA1 or other

genes involved in cholestasis

A. Holvast (Netherlands)

12:05 – 12:15BMP-2 restoration rescues liver fibrosis injuries by attenuating TGF-

β1 signalingYing-Hsien Huang (Taiwan)


11 May 2018

11:15 – 12:15

Gastroenterology


11:15 – 11:25Evaluation of adalimumab effectiveness in paediatric patients with

ulcerative colitis in clinical practiceSteven Steiner (United States)

11:25 – 11:35Efficacy of Adalimumab as first-line “top-down” therapy in pediatric

Crohn’s Disease: 12 months of follow-upLetizia Zenzeri (Italy)

11:35 – 11:45Impact of changing treatment strategies on outcomes in paediatric

Ulcerative ColitisRishi Bolia (Australia)

11:45 – 11:55Manipulating the microbiome in pediatric Acute Severe Colitis with

antibiotics cocktail: a randomized controlled trialDan Turner (Israel)

11:55 – 12:05Cmorbidities in adolescents with inflammatory bowel disease: findings

from a population-based cohortAmit Assa (Israel)

12:05 – 12:15Improvements in medical treatment and surgical outcome of children

and adolescents with ulcerative colitis in the United KingdomMarcus KH Auth (United Kingdom)


11 May 2018

11:15 – 12:15

Gastroenterology


11:15 – 11:25The impact of genetic factors to familial predisposition of coeliac

disease in the TEDDY studyAnna Laitinen (Finland)

11:25 – 11:35Prevalence of type-1 diabetes autoimmunity in children at genetic risk

for coeliac diseaseKatharina Julia Werkstetter (Germany)

11:35 – 11:45Type 1 interferon pathway contributes to loss of tolerance to dietary

gluten in celiac diseaseValentina Discepolo (United States)

11:45 – 11:55

Exploring the gut-thyroid axis in paediatric cοeliac disease patients of

Hellenic origin reveals selected genomic variants in CTLA4, BACH2,

and IL23R genes that may account for overlapping susceptibility

between Graves’ disease and paediatric cοeliac disease

Theodora Katsila (Greece)

11:55 – 12:05Systemic antibiotics in the first year of life is associated with an

increased risk of diagnosed coeliac diseaseStine Dydensborg (Denmark)

12:05 – 12:15The large majority of coeliac children, adolescents and adults have a

high degree of perceived dietary competenceThomas Olsen Kipp (Denmark)


11 May 2018

11:15 – 13:15

Gastroenterology

Clinical Practice in Gastroenterology

Chairs: Erasmo Miele, Ilse

Broeckhart

11:15 – 11:35 Proton Pump Inhibitors: use and misuse Rok Orel (Slovenia)

11:35 – 11:55 Dealing with Potential Coeliacs: to do or not to do? Renata Auricchio (Italy)

11:55 – 12:15 Managing massive acute GI bleeding Mike Thomson (United Kingdom)

12:15 – 12:35 Rumination Maartje Singendonk (The Netherlands)

12:35 – 12:55 Eosinophilic Esophagitis: the latest Jorge Amil Dias (Portugal)

12:55 – 13:15Gastro-oesophageal reflux disease in infants: should we test? should

we treat?Silvia Salvatore (Italy)


11 May 2018

12:30 – 13:30

Gastroenterology


12:30 – 12:40

Long-term outcomes of pediatric patients admitted with acute severe

colitis - a multi-center study from the pediatric IBD Porto group of

ESPGHAN

Dror Shouval (Israel)

12:40 – 12:50Looking the truth in the eye - benchmarking care and outcomes against

the world’s largest paediatric IBD registryKai O. Hensel (United Kingdom)

12:50 – 13:00Predicting relapse in new-onset Crohn disease - results of the

prospective GROWTH CD StudySéamus Hussey (Ireland)

13:00 – 13:10Investigating CD8+ T-cell gene expression signatures as potential

prognostic biomarkers in paediatric inflammatory bowel diseaseMarco Gasparetto (United Kingdom)

13:10 – 13:20A treat-to target strategy guided by Pan-enteric valuation in paediatric

Crohn’s disease improves outcomes at 2 yearsSalvatore Oliva (Italy)

13:20 – 13:30

Incidence and characteristics of rare and severe complications in

children with paediatric-onset IBD; the international PIBD SETQuality

Safety Registry by PIBDnet

Martine Aardoom (Netherlands)


11 May 2018

12:30 – 13:30

Nutrition


12:30 – 12:40Dairy lipids incorporation in the diet increased Omega-3 status in

post-weaning rats.Gaetan Drouin (France)

12:40 – 12:50Maternal high-fat diet exposure leads to persistent inflammation and

altered metabolism of liver of male offspringSuchaorn Saengnipanthkul (Thailand)

12:50 – 13:00Glucocorticoids overexposure induced by neonatal overfeeding

enhanced hepatic LlipogenesisFan Yang (China)

13:00 – 13:10Newly developed infant gut simulator model for human milk

oligosaccharide fermentationKrista Salli (Finland)

13:10 – 13:20

Dietary treatment with extensively hydrolyzed casein formula with the

probiotic L.rhamnosus GG prevents the occurrence of functional

gastrointestinal disorders in children with cow’s milk allergy

Roberto Berni Canani (Italy)

13:20 – 13:30

Milk fat globule membrane alone and in combination with a prebiotic

moderates the impact of maternal separation on behavior and gut

microbiota

Sarmauli Manurung (Netherlands)


11 May 2018

12:30 – 13:30

Hepatology


12:30 – 12:40

MicroRNA-29a mitigation of endoplasmic reticulum and autophagy

aberrance counteracts in obstructive jaundice-induced fibrosis in

mice

Ying-Hsien Huang (Taiwan)

12:40 - 12:50Prospective evaluation of sclerosing cholangitis in children with

autoimmune liver diseaseNagendra Kumar (India)

12:50 – 13:00Validation of diagnostic scores including the new proposed

ESPGHAN score in Pediatric Autoimmune Liver diseaseVikrant Soot (India)

13:00 – 13:10

Sustained biochemical response to oral antibiotics in pediatric PSC

and ASC is correlated to changes in gut microbiota and serum bile

acids during therapy

Pauline Sambon (Belgium)

13:10 – 13:20The role of 2-Dimensional Ultrasound Shear Wave Elastography in

neonatal/infantile cholestatic jaundiceParaskevi Galina (Greece)

13:20 – 13:30Anticholestatic drugs as potential treatment for neonatal

hyperbilirubinemiaLori W.E. van der Schoor (Netherlands)


11 May 2018

12:30 – 13:30

Gastroenterology

Plenary Session 6 – Abstracts

12:30 – 12:40

Sensitisation to common food allergens and aeroallergens in relation to

functional gastrointestinal disorders in adolescents: results from the

GINIplus and LISA birth cohorts

Carla Harris (Germany)

12:40 – 12:50Long-term treatment with proton-pump inhibitors is effective in children

with eosinophilic esophagitisCarolina Gutiérrez-Junquera (Spain)

12:50 – 13:00A partly fermented infant milk formula with scGOS/lcFOS reduces

stress-induced gut permeability and gut hypersensitivity in ratsIngrid B. Renes (Netherlands)

13:00 – 13:10Predictive factors of histological complication in EA-TEF patients during

10 years’ prospective endoscopic follow-upLaetitia Marie Petit (Switzerland)

13:10 – 13:20 Automated detection of infant crying and fussing for clinical applications Thomas Ludwig (Singapore)

13:20 – 13:30Therapeutic efficacy of ginger on vomiting in children with acute

gastroenteritisRoberto Berni Canani (Italy)


11 May 2018

15:15 – 17:15

Liver transplantation

Parallel Symposium

Chairs: Jörg Jahnel, Wendy van der

Woerd

15:15 – 15:48Donor specific antibodies and liver transplantation - current

concepts and future Suzanne McDiarmid (USA)

15:48 - 15:58Abstract: Subclinical biliary strictures revealed by mild ductular

proliferation in grafts of paediatric liver transplant recipientsNaire Sansotta (Italy)

15:48 – 16:31 Pharmacokinetics and pharmacogenetics in liver transplantation Vanessa Guy (Belgium)

16:31 - 16:41

Abstract: Comparison of outcome in post-transplant

lymphoproliferative disorder after paediatric small bowel versus

isolated liver transplantation in a single tertiary transplant centre

Fang Kuan Chiou (United Kingdom)

16:41 – 17:14 Nutrition – before and after liver transplantation Girish Gupte (UK)


11 May 2018

15:15 – 17:15

Nutrition

Severe acute malnutrition (SAM); aetiology and management

Chairs: Christian Molgaard, André

Briend

15:15 – 15:40 The history of treatment of SAM: Where are we today? André Briend (Finland)

15:40 – 15:50

Abstract: Refeeding with lactose and milk minerals alters the gut

microbiota and expands plasma volume in a piglet model of moderate

malnutrition

Thomas Thymann (Denmark)

15:50 – 16:15Starved Guts: Morphologic and Functional Intestinal Changes in

MalnutritionPaul Kelly (United Kingdom)

16:15 – 16:25Abstract: Development of grip strength references in healthy children

and their usability in sick childrenSarah Williamson (United Kingdom)

16:25 – 16:50 Key nutrients in the treatment of acute malnutrition Robert Bandsma (Canada)

16:50 – 17:15 How should we treat SAM in practice? Tsinuel Girma (Ethiopia)


11 May 2018

15:15 – 17:15

Gastroenterology

Updates in paediatric IBDChairs: Paolo Lionetti, Dan Turner

15:15 – 15:3350 years of IBD in ESPGHAN Part 1:

History of IBD in ESPGHAN Ian Sanderson (United Kingdom)

15:33 – 15:56 Classification of IBD into subtypes - beyond CD vs UC Richard Russell (United Kingdom)

15:56 – 16:06Abstract: Phenotypic variation in pediatric IBD by age: A multi-centre

inception cohort study of the Canadian Children IBD NetworkJasbir Dhaliwal (Canada)

16:06 – 16:29 It is not always IBD: eosinophilic diseases of the intestine Noam Zevit (Israel)

16:29 – 16:52 Cannabis for IBD and in children - what is the current evidence Lissy de Ridder (Netherlands)

16:52 – 17:15Thromboembolic prophylaxis in paediatric IBD - time to learn from the

adults?David Wilson (United Kingdom)


11 May 2018

15:15 – 17:15

Gastroenterology

Pancreatitis in children: major challenges

Chairs: Michael Wilschanski,

Dominique Debray

15:15 – 15:23 50 years of the Pancreas in ESPGHAN John Dodge (United Kingdom)

15:23 -15:46Recurrent and chronic pancreatitis - what have we learned from

INSPPIRE?Aliye Uc (USA)

15:46 – 15:56Abstract: Butyrate has effects on intestinal smooth muscle adaptation

in rats with massive small bowel resectionLina Dai (China)

15:56 – 16:19 The genetics of recurrent pancreatitis: an update Heiko Witt (Germany)

16:19 – 16:29

Abstract: Primary experience in safety and efficacy with

duodenojejunal bypass liner in morbidly obese adolescents implanted

for one year

Matjaz Homan (Slovenia)

16:29 – 16:52 New aspects of imaging in paediatric pancreatitis Grzegorz Oracz (Poland)

16:52 – 17:15 Autoimmune Pancreatitis in Children – A distinct Entity Isabelle Scheers (Belgium)

Documents

11 May 2018 Gastroenterology Plenary Session 1 - Abstracts · Programme subject to change. Status as of February 2018 11 May 2018 08:45 –10:15 Gastroenterology Plenary Session 1