100820

Safety Data SheetAccording to EC Directive 91/155/EEC

Date of issue: 21.05.2004Supersedes edition of 11.08.2003

1. Identification of the substance/preparation and of the company/undertakingIdentification of the productCatalogue No.: 100820Product name: Methenamine silver plating kit acc. to Gomori for microscopy

Periodic acid solution

Use of the substance/preparationIn Vitro Diagnostic Medical DeviceReagent for analysis

Company/undertaking identificationCompany: Merck KGaA * 64271 Darmstadt * Germany * Phone: +49 6151 72-0Emergency telephone No.: Please contact the regional Merck representation

in your country.

2. Composition/information on ingredientsAcid aqueous solution.

Hazardous ingredients:

Name according to EC Directives:CAS-No. EC No. EC-Index-No. Classification Content:Periodic acid10450-60-9 233-937-0 O; R8

C; R34 1 - < 5 %

(Full text of R-Phrases in heading 16)

3. Hazards identificationNo hazardous product as specified in Directive 67/548/EEC.

4. First aid measuresAfter inhalation: fresh air. After skin contact: wash off with plenty of water. Remove contaminated clothing. After eye contact: rinse out with plenty of water with the eyelid held wide open. Call inophtalmologist if necessary. After swallowing: make victim drink plenty of water. Consult doctor if feeling unwell.

The Safety Data Sheets for catalog items are also available at www.chemdat.info Page 1 of 5

Merck Safety Data SheetAccording to EC Directive 91/155/EEC

Catalogue No.: 100820Product name: Methenamine silver plating kit acc. to Gomori for microscopy


5. Fire-fighting measures

Suitable extinguishing media:In adaption to materials stored in the immediate neighbourhood.

Special risks:Non-combustible.

Special protective equipment for fire fighting:Do not stay in dangerous zone without self-contained breathing apparatus.

6. Accidental release measuresPerson-related precautionary measures: Avoid substance contact. Do not inhale vapours/aerosols.

Procedures for cleaning / absorption: Take up with liquid-absorbent material (e.g. Chemizorb ). Forward for disposal. Clean up affectedarea.

7. Handling and storage

Handling:

No further requirements.

Storage:Tightly closed and away from sources of ignition and heat. At +15C to +25C.

The data apply to the entire pack.

8. Exposure controls/personal protection

Personal protective equipment:Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of theprotective clothing to chemicals should be ascertained with the respective supplier.Respiratory protection: required when vapours/aerosols are generated.Eye protection: required





Hand protection: In full contact:Glove material: nitrile rubberLayer thickness: 0.11 mmBreakthrough time: > 480 Min.

In splash contact:Glove material: nitrile rubberLayer thickness: 0.11 mmBreakthrough time: > 480 Min.

The protective gloves to be used must comply with the specificationsof EC directive 89/686/EEC and the resultant standard EN374, forexample KCL 740 Dermatril (full contact), 740 Dermatril (splashcontact). The breakthrough times stated above were determined byKCL in laboratory tests acc. to EN374 with samples of the recommendedglove types. This recommendation applies only to the product stated in the safetydata sheet and supplied by us as well as to the purpose specified byus. When dissolving in or mixing with other substances and underconditions deviating from those stated in EN374 please contact thesupplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,Internet: www.kcl.de).

Industrial hygiene:Change contaminated clothing. Application of skin- protective barrier cream recommended. Wash handsafter working with substance.

9. Physical and chemical properties

Form: liquidColour: colourlessOdour: odourlesspH value ~ 1.6Melting point not availableBoiling point not availableIgnition temperature not availableFlash point not applicableExplosion limits lower not applicable

upper not applicableDensity (20 C) 1.005 g/cm3Solubility in Water not available





10. Stability and reactivity

Conditions to be avoidedHeating.

Substances to be avoidedsulfoxides, organic combustible substances, nonmetals (i.a. phosphorus), oxidizable substances. The generally known reaction partners of water.

Hazardous decomposition productsno information available

11. Toxicological information

Acute toxicity

Quantitative data on the toxicity of this product are not available.Further toxicological informationProperty that must be anticipated on the basis of the components of the preparation: After inhalation of vapours/aerosols: Irritations of mucous membranes, coughing. After skin contact: Slight irritations. After eye contact: Slight irritations. After swallowing: irritations of mucous membranes in the mouth, pharynx, oesophagus andgastrointestinal tract.

Further dataThe product should be handled with the care usual when dealing with chemicals.

12. Ecological informationEcotoxic effects: Quantitative data on the ecological effect of this product are not available.

Further ecologic data: No ecological problems are to be expected when the product is handled and used with due care andattention.

13. Disposal considerations

Product:Chemicals must be disposed of in compliance with the respective national regulations. Under www.retrologistik.de you will find country- and substance-specific information as well as contact partners.

Packaging:Merck product packaging must be disposed of in compliance with the country-specific regulationsor must be passed to a packaging return system. Under www.retrologistik.de you will find specialinformation on the respective national conditions as well as contact partners.





14. Transport informationRoad & Rail ADR, RID

UN 3316 CHEMIE-TESTSATZ, 9, IIIInland waterway ADN, ADNR not testedSea IMDG-Code

UN 3316 CHEMICAL KIT, 9, IIIEms F-A S-P

Air CAO, PAXCHEMICAL KIT, 9, UN 3316, III

The transport regulations are cited according to international regulations and in the formapplicable in Germany . Possible national deviations in other countries are not considered. THESE TRANSPORT DATA APPLY TO THE ENTIRE PACK !

15. Regulatory information

Labelling according to EC DirectivesSymbol: ---R-phrases: ---S-phrases: ---

16. Other information

Text of any R phrases referred to under heading 2:

8 Contact with combustible material may cause fire.34 Causes burns.

Reason for alterationChapter 14: transport information.General update.

Regional representation:This information is given on the authorised Safety Data Sheet for your country.

The information contained herein is based on the present state of our knowledge. Itcharacterizes the product with regard to the appropriate safety precautions. It does notrepresent a guarantee of the properties of the product.





Silver nitrate solution



in your country.

2. Composition/information on ingredientsAqueous solution.


Name according to EC Directives:CAS-No. EC No. EC-Index-No. Classification Content:Silver nitrate7761-88-8 231-853-9 047-001-00-2 C; R34

N; R50/53 0.25 - < 1 %


3. Hazards identificationHarmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.








Special risks:Non-combustible. Ambient fire may liberate hazardous vapours.

Special protective equipment for fire fighting:Do not stay in dangerous zone without self-contained breathing apparatus.

Other information:Prevent fire-fighting water from entering surface water or groundwater.


Environmental-protection measures: Do not allow to enter sewerage system.



Handling:


Storage:Tightly closed and away from sources of ignition and heat. At +15C to +25C.Protected from light.



Personal protective equipment:Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of theprotective clothing to chemicals should be ascertained with the respective supplier.Respiratory protection: required when vapours/aerosols are generated.Eye protection: required





Hand protection: In full contact:Glove material: nitrile rubberLayer thickness: 0.11 mmBreakthrough time: > 480 Min.



Industrial hygiene:Change contaminated clothing. Wash hands after working with substance.


Form: liquidColour: colourlessOdour: odourlesspH value (20 C) ~ 5Melting point not applicableBoiling point not applicableIgnition temperature not applicableFlash point not applicableExplosion limits lower not applicable

upper not applicableDensity (20 C) 1.001 g/cm3Solubility in

not applicable






Conditions to be avoidedno information available

Substances to be avoidedThe generally known reaction partners of water.


Further informationlight-sensitive.


Acute toxicity

Quantitative data on the toxicity of this product are not available.Further toxicological informationHazardous properties cannot be excluded, but are relatively improbable due to the low concentration of the dissolved substance(s).

Other notes: The following applies to soluble silver compounds: only slightly absorbed via the gastrointestinaltract. Strong irritations after contact with eyes and skin. The following applies to nitrites/nitrates in general: methaemoglobinaemia after the uptake of largequantities.



Biological effects: Harmfull effect on aquatic organisms. May cause long-term adverse effects in the aquatic environment.

Further ecologic data: The following applies to silver compounds in general: biological effects: silver ions toxic for aquatic organisms; bacteria: Ps. putida toxic as from 0.006 mg/l ; protozoa: U. parduczitoxic as from 0.1 mg/l ; arthropods: D. daphnia EC50: 0.004 mg/l; algae: M. aeruginosa toxic asfrom 0.0007 mg/l ; Sc. quadricauda toxic as from 0.009 mg/l . The following applies to nitrates in general: may contribute to the eutrophication of water supplies.Hazard for drinking water. Fish: LC50 > 500 mg/l.

Do not allow to enter waters, waste water, or soil!














Labelling according to EC DirectivesSymbol: ---R-phrases: 52/53 Harmful to aquatic organisms, may cause long-term

adverse effects in the aquatic environment.S-phrases: ---



34 Causes burns.50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the

aquatic environment.





Reduced labelling on the container due to small quantity.








Methenamine borate tablets



in your country.

2. Composition/information on ingredientsPreparation contains inorganic and organic compounds.


Name according to EC Directives:CAS-No. EC No. EC-Index-No. Classification Content:Hexamethylenetetramine100-97-0 202-905-8 612-101-00-2 F; R11

Xn; R42/43 50 %


3. Hazards identificationHighly flammable. May cause sensitization by inhalation and skin contact.

4. First aid measuresAfter inhalation: fresh air. Call in physician. After skin contact: wash off with plenty of water. Remove contaminated clothing. After eye contact: rinse out with plenty of water with the eyelid held wide open. Call inophtalmologist. After swallowing: immediately make victim drink plenty of water. Call in physician.






Suitable extinguishing media:powder, foam, water.

Special risks:Combustible. Development of hazardous combustion gases or vapours possible in the event of fire. Thefollowing may develop in event of fire: formaldehyde vapours, ammonia, nitrous gases.

Special protective equipment for fire fighting:Do not stay in dangerous zone without self-contained breathing apparatus. In order to avoid contact with skin, keep a safety distance and wear suitable protective clothing.

Other information:Contain escaping vapours with water. Prevent fire-fighting water from entering surface water orgroundwater.

6. Accidental release measuresPerson-related precautionary measures: Avoid substance contact. Avoid generation of dusts; do not inhale dusts. Ensure supply of fresh airin enclosed rooms.

Environmental-protection measures: Do not allow to enter sewerage system; risk of explosion!

Procedures for cleaning / absorption: Take up dry. Forward for disposal. Clean up affected area. Avoid generation of dusts.


Handling:

Notes for safe handling: Work under hood . Do not inhale substance.

Notes for prevention of fire and explosion:Keep away from sources of ignition. Take measures to prevent electrostatic charging.

Storage:Tightly closed and away from sources of ignition and heat. Dry. At +15C to +25C.



Specific control parameterEC

Name MethenamineSensitization Sah Danger of sensitization of the airways and the skin





Personal protective equipment:Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of theprotective clothing to chemicals should be ascertained with the respective supplier.Respiratory protection: required when dusts are generated.Eye protection: requiredHand protection: In full contact:

Glove material: nitrile rubberLayer thickness: 0.11 mmBreakthrough time: > 480 Min.



Industrial hygiene:Change contaminated clothing. Apply skin-protective barrier cream. Wash hands after working withsubstance.


Form: tabletsColour: whiteOdour: odourlesspH value

at 10.6 g/l H2O (25 C) ~ 9Melting point not availableBoiling point not applicableIgnition temperature not availableFlash point not availableExplosion limits lower not available

upper not availableDensity not availableSolubility in

water (25 C) 10.6 g/l






Conditions to be avoidedHeating (decomposition).Substances to be avoidedstrong oxidizing agents, peroxi compounds, hydrogen halides.

Hazardous decomposition productsin the event of fire: See chapter 5.


Acute toxicity

Quantitative data on the toxicity of this product are not available.Further toxicological informationApplicable to the main component:

After inhalation: Irritations of the mucous membranes, coughing, and dyspnoea. Risk of airwayssensitization. After skin contact: Slight irritations. Risk of skin sensitization. After eye contact: Slight irritations. After swallowing of large amounts: gastrointestinal complaints, Nausea, vomiting, dyspnoea. Damageof: kidneys.

Further dataFurther hazardous properties cannot be excluded. The product should be handled with the care usual when dealing with chemicals.

12. Ecological informationThe following data refer to the toxicologically determinant component of the formulation:

Ecotoxic effects: Biological effects: Fish toxicity: P.promelas LC50: 49.8 g/l /96 h. Daphnia toxicity: Daphnia magna EC50: 36 g/l /48 h. Algeal toxicity: Selenastrum capricornutum IC0: 1500 mg/l /14 d. Bacterial toxicity: Pseudomonas fluorescens EC0: 5000 mg/l /16 h.

Further ecologic data: BOD 2.02 % from TOD /5 d; TOD: 2054 mg/g.

Do not allow to enter waters, waste water, or soil!














Labelling according to EC DirectivesSymbol: F Highly flammable

Xn HarmfulR-phrases: 42/43 May cause sensitization by inhalation and skin

contact.

S-phrases: 22-24-37-45 Do not breathe dust. Avoid contact with skin. Wearsuitable gloves. In case of accident or if you feelunwell, seek medical advice immediately (show thelabel where possible).



11 Highly flammable.42/43 May cause sensitization by inhalation and skin contact.Reduced labelling on the container due to small quantity.







Gold chloride solution



in your country.

2. Composition/information on ingredientsAqueous solution of inorganic compounds.













Handling:





Personal protective equipment:Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of theprotective clothing to chemicals should be ascertained with the respective supplier.Respiratory protection: required when vapours/aerosols are generated.Eye protection: requiredHand protection: In full contact:



The protective gloves to be used must comply with the specificationsof EC directive 89/686/EEC and the resultant standard EN374, forexample KCL 740 Dermatril (full contact), 740 Dermatril (splashcontact). This recommendation applies only to the product stated in the safetydata sheet and supplied by us as well as to the purpose specified byus. When dissolving in or mixing with other substances and underconditions deviating from those stated in EN374 please contact thesupplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,Internet: www.kcl.de).



Form: liquidColour: yellowOdour: odourlesspH value (20 C) ~ 2.5Melting point not availableBoiling point not availableIgnition temperature not available





Flash point not applicableExplosion limits lower not applicable







Acute toxicity

Quantitative data on the toxicity of this product are not available.Further toxicological informationHazardous properties cannot be excluded but are unlikely when the product is handledappropriately.











Sodium thiosulfate solution



in your country.

2. Composition/information on ingredientsAqueous solution of inorganic compounds.


4. First aid measuresAfter inhalation: fresh air. After skin contact: wash off with plenty of water. Remove contaminated clothing. After eye contact: rinse out with plenty of water with the eyelid held wide open. After swallowing: make victim drink plenty of water. Consult doctor if feeling unwell.




6. Accidental release measuresPerson-related precautionary measures: Do not inhale vapours/aerosols.







Handling:











Form: liquidColour: colourlessOdour: odourlesspH value (20 C) ~ 5Melting point not availableBoiling point not availableIgnition temperature not available





Flash point not applicableExplosion limits lower not applicable







Acute toxicity












Light green SF solution



in your country.

2. Composition/information on ingredientsAqueous solution of inorganic and organic compounds.






Other information:Prevent fire-fighting water from entering surface water or groundwater.





6. Accidental release measuresPerson-related precautionary measures: Do not inhale vapours/aerosols.

Environmental-protection measures: Do not allow to enter sewerage system.



Handling:















Form: liquidColour: dark greenOdour: acidicpH value (20 C) ~ 3Melting point not availableBoiling point not availableIgnition temperature not availableFlash point not applicableExplosion limits lower not applicable







Acute toxicity






Documents

100820