10th Drug Abuse Research Symposium

August 7, 2015 8:30 am – 4:30 pmCharles Drew University of Medicine and Science

Keck Lecture Hall1731 E. 120th Street, Los Angeles, CA 90059

http://www.cdrewu.edu/research/DrugAddictionResearch

NIH R24DA017298 Diversity-promoting Institutions Drug Abuse Research

Development Program (DIDARP) at Charles R. Drew University of Medicine & Science

Program Theme: “Metabolic Effects of Nicotine: It Matters”; Training Theme: “Research Teams

of the Future”

Originally funded September 2004Competitive renewal funded April 2014-5

yearsProgram officer: Vishnudutt Purohit, Ph.D.

DIDARP Specific Aims

• To increase the number of high quality drug addiction research projects related to the metabolic effects of nicotine to allow CDU to develop expertise and acquire preliminary data to be able to compete for NIDA P01, P50 or R01 grants;

• To continue to foster interest in substance abuse research among under-represented students and other trainees by providing meaningful educational and research experiences; and

• To continue to enhance the research infrastructure at CDU to support substance abuse research.

DIDARP Theme

• The theme of the training and education program is “Metabolic Effects of Nicotine: It Matters ”

• Incorporates expertise at CDU in both the basic and clinical aspects of substance abuse.

• Lead to collaborations with UCLA, Western University, CSU-DH, CSU-SB, Cal-tech, UTEP

DIDARP Student Involvement

• Students rotating in basic science labs and on clinical projects

• CSUDH-undergraduate/Master’s students• CSUDH-Bridges Program • King-Drew Magnet High School• CDU medical students and MPH students

Research Day Goals• Highlight substance abuse research at CDU and its affiliates

• Exposure of student and trainee research on substance abuse

• Expose potential trainees to potential substance abuse mentors

• Bring together substance abuse researchers for future seminars and funding opportunities

• Exposure of research on substance abuse at CDU to research and teaching faculty, physicians from the surrounding community including MLK-Outpatient Center and MLK Community Hospital and health clinics, drug abuse counselors, medical students, allied health professionals, community based health organization leaders, and other health care professionals

Research Day: Special Highlights

• Live streaming to UTEP, ETSU • Website:

http://www.cdrewu.edu/research/DrugAddictionResearch

• Slides, biosketch and pictures, .mp4 talks available shortly

• CME credit for Dr. Fowler’s Talk

Research Day Highlights• CE process and evaluations

– Maria Castro

•  CME evaluations– Jeonathan Rodriguez

• 8:45 – 8:55 am University Welcome

• Angela L. Minniefield, MPA– Vice President of Advancement, Strategic Development &

External Affairs

KEYNOTE SPEAKER

• 8:55-9:55 am Imaging brain chemistry in diseases of addiction (CME event)

• Joanna Fowler, PhD

Research Day Morning TalksPOLICY RESEARCH SUBSTANCE ABUSE

• 9:55-10:05 amIncreasing the Legal Age to Access Tobacco Product to 21: An overview

• Melitta Johnson, MHA  • 10:05-10:30 am Increasing the Legal Age to Access Tobacco Product

to 21: A Legislator’s Viewpoint• Ed Hernandez, O.D.

• 10:30-10:40 am MORNING BREAK• 10:40-11:00 am Public Health Efforts to Decrease Smoking in

California • Tonya Gorham Gallow, MSW• Cynthia A.K. Song Mayeda, RN, PHN, BSN

Research Day Morning TalksSUBSTANCE ABUSE: CLINICAL STUDIES

• 11:00-11:20 am Screening and Brief Intervention and Referral for Treatment: An Evidence-Based Approach to Alcohol Problem Prevention

• Shahrzad Bazargan, PhD

• 11:20-11:40 am Losing Your License to Drink: A new approach to reducing problem alcohol use

• Greg Midgette, PhD

• 11:40-12:00 pm Genetic and environmental determinants of drug use

• Emily Hartwell

Research Day Morning TalksTOP STUDENT/TRAINEE ORAL

PRESENTATIONS

• 12:00-12:10 pm Effects of Alcohol on U.S. Adolescent Sleep Patterns: A Systematic Review

• Nancy Carballo MSIV

• 12:10-12:20 pm Nicotine stimulates muscle de novo lipogenesis in mice but when combined with a high-fat diet it also causes intramyocellular lipid accumulation and mitochondrial abnormalities

• Desean L. Lee

LUNCH BREAK AND MEET WITH DRS FOWLER AND FRANCES AND POSTER VIEWING

• 12:20-1:15 pm • No food or drinks in the auditorium• Give your ticket• Veggie sandwiches for those preferring • Audience will go to lunch in shifts with trainees first• Trainees and researchers can meet with Drs. Fowler

and Leslie outside to the right of the auditorium• Those who didn’t register in advance, can get

remaining tickets at morning break. If no tickets remain, can get food if still available

• 2 student posters available for viewing

PRESIDENTIALWELCOME

• 1:15- 1:20 pm  

• David M. Carlisle, MD, PhD President and CEO

STUDENT/TRAINEE ORAL PRESENTATIONS

• 1:20-1:30 pm Chronic nicotine exposure during adolescence alters the rewarding properties of the cannabinoid agonist CP 55,940 in young adult male rats.

• Andrea D Hardin

• 1:30-1:40 pm Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis in male mice by inhibiting AMP-activated protein kinase independent of fibroblast growth factor 21

• Mark Falz

Afternoon SessionCLINICAL STUDIES

• 1:40-1:55 pm Prescription Drug Abuse Research – DIDARP at ETSU (via videoconference)

• Robert Pack, PhD, MPH• 1:55 -2:10 pm Affect Regulation and Smoking in

Women• Raina Pang, Ph.D.

BASIC SCIENCE RESEARCH

• 2:10 -2:40 pm Drugs of abuse and brain development• Frances M. Leslie, PhD • 2:40-2:55 pm Neuroimmune regulation of the

mesolimbic dopamine system during morphine withdrawal• Anna Taylor, BSc, PhD • 2:55 -3:15 pm The role of alpha2-containing

nAChRs in learning, memory and addiction• Shahrdad Lotfipour, PhD• 3:15-3:25 pm AFTERNOON BREAK

BASIC SCIENCE RESEARCH

• 3:25-3:40 pm Nicotine and diabetes related genes/signaling molecules

• Arbi Nazarian, PhD

• 3:40-3:55 pm Nicotine Plus Coke, Sugar Coke and Diet coke on body weight, food intake and hepatic and muscle steatosis

• Carl Sims

• 3:55-4:10 pm Insight into how opioids affect brain cells

• Yulong Chen, PhD

• 4:10-4:25 pm Nociceptin receptor (NOP) as a potential target for the development of medications to treat drug addiction

• Kabirullah Lutfy, PhD (via Webex)

CLOSING REMARKS• 4:25-4:30 pm • PRESENTATION OF PRIZE FOR TOP STUDENT

PRESENTATION AND POST-CONFERENCE EVALUATIONS Theodore Friedman, MD, PhD

• 4:30 pm ADJOURN

Instructions to Speakers

• Please adhere to your time limits• We will give you 5 and 1 minute warnings• Please speak into the microphone• Allow time for questions• Repeat the question

Instructions to Audience

• Return promptly to your seat after breaks• Silence your cell phone• Keep your questions short• Remote listeners will be muted, I will

unmute during questions or you can use the chat function on webex.

Web and Podcasts

• Web streaming and podcast (MP4) should be available, check out the home page at http://www.cdrewu.edu/research/DrugAddictionResearch to download.

• Please make sure we have your email

Evaluations

Pacific Southwest Addiction Technology Transfer Center Survey– Pre-conference evaluations (green)

– Post-conference evaluations (blue)

– Turn in completed forms at registration table

CDU CME-turn in questions and evaluations at the registration table

Turning in the evaluations helps with planning next years event and helps with funding

• Joanna Fowler, PhD• Frances M. Leslie, PhD • Senator Ed Hernandez, OD• NIDA• DIDARP Advisory Committee• Darlene Parker-Kelly, Jabbar Hart, Dennis Curtis (AV)

• Jeonathan Rodriguez, Annika Gill, Ron Edelstein-CME team

• Student/Staff helpers-Petra Duran, Beverly Jackson, Jorge Espinoza, Kamrul Hasan, Ashley Gonzalez, Maria Diaz-Romero, Jennifer Tran, Jessica Rajavi, May Ong

• Beth Rutkowski, Maria Castro, Tom Freese, UCLA Integrated Substance Abuse Programs/ Pacific Southwest Addiction Technology Transfer Center

• AXIS -Accelerating Excellence in Translational Science-National Institute on Minority Health and Health Disparities- U54MD007598

• UCLA CTSI grant-UL1TR000124

• DIDARP grant R24DA017298

Substance Abuse Research at Charles Drew University

For more information about substance abuse research and student opportunities at CDU, contact Dr. Friedman at 310-668-5197 or

theodorefriedman@cdrewu.edu