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10 mV
100 ms
5 s
10 mV
5 s
Transient current injection to the cell can toggle its state
I
V
I
V
Climbing Fiber Parallel Fiber
Climbing fibers response and Ca changes
LTD: Long Term Depression
LTD time course
LTD: specificity
PSTH: Post Stimulus Time Histogram
LTD: Properties
Involvement of AMPA receptors in LTD induction.
Pairing PF-mediated EPSPs with depolarization of PCs
Pairing quisqualate application with depolarization of cultured PCs
Involvement of mGluR1 and PKC in LTD induction.
In the presence of antibodies inactivating mGluR1
control
The same in knockout mice lacking functional mGluR1
BAPTA
PKC (19¯36)
PKC(glu27) (19¯36)
Control
Mechanism of LTD
SS activity following vestibular stimulation
CS activity following optical stimulation
Mechanism of VOR gain change
L7-PKC transgene
Expression of PKC in L7-PKC mice
Glutamate+Depolarization
LTD in L7-PKC mice
VOR gain change in L7-PKC mice
Involvement of PKC activation in LTD induction .
BAPTA
PKC (19¯36)
PKC(glu27) (19¯36)Control
NOS inhibitor L-NMMA
Control
