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1
SURVEY OF BIOCHEMISTRYLipids & Biological Membranes
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CETL Course Survey(s)
• Course-Instructor Opinion Survey (CIOS)– http://www.coursesurvey.gatech.edu– Also on T-Square Home Page
• Pilot Survey– Go to T-Square: Announcements for link to
survey– Focus groups to learn more about student
opinions – Deadline: August 3, 2008– IRB Approval requested: minimal risk
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PRS Update
• Scores on T-Square this weekend
• Next week– Mon: Fatty Acid Oxidation– Wed and Fri: Course Review via PRS – Point Summary
• 75-100% of total points = 10 PRS POINTS• 50-74% of total points = 5 PRS POINTS• 1-49% of total points = 1 PRS POINT• 0% = 0 PRS POINTS
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Types of Lipids
• Fatty Acids • Triacylglycerols• Glycerophospholipids• Sphingolipids• Steroids• Isoprenoids• Eicosanoids
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Fatty Acids
Carboxylic acids with nonpolar hydrocarbon
chain
Fatty acids can be saturated with H’s or unsaturated with H’s
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Fatty Acids
Double bonds can be cis or trans - usually see cis form
Cis form causesmolecule to kink
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Common Fatty Acids
Know C12 - C20 names and structures!
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Triacylglycerols
• R1, R2 and R3 are fatty acid chains• Most abundant!• Energy reservoirs
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Glycerophospholipids
• R1 and R2 are fatty acid chains• X = functional group• Abundant in bio membranes
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Classes of Glycerophospholipids
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Phospholipases
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Sphingolipids
Sphingolipids are also found in membranes.
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SphingolipidsSphingomyelin
Compose 10-20% of plasma membrane
Head group couldalso be a
phosphoethanolamine group
-O3P-CH2CH2NH3+
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SphingolipidsCerebrosides
Sugar head group and no phosphate
From Avantilipids.com
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SphingolipdsGangliosides
• Most complex, found in brain tissue
Be familiar with
structure but do not memorize for Final
Exam
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Steroids:Structure of Cholesterol
Know this!
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Steroids
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Steroids
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Arachidonic Acid Breakdown
Involved in pain and fever,
blood pressure, blood
coagulation, reproduction
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Micelles
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Lipid Bilayer and Glycophorin A
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Biological Membranes