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1
SURVEY OF BIOCHEMISTRYCourse Review
2
PRS-1
• Catalytic efficiency is given by what expression?
1. kcat
2. kcat/KM
3. Vmax/KM
4. [E]T x kcat
3
PRS-1
• Catalytic efficiency is given by what expression?
1. kcat
2. kcat/KM
3. Vmax/KM
4. [E]T x kcat
4
PRS-2
• Which amino acid is an alpha-helix breaker?
1. Y2. W3. V4. P
5
PRS-2
• Which amino acid is an alpha-helix breaker?
1. Y2. W3. V4. P
6
PRS-3
• Amino acids are linked by what types of bonds in proteins?
1. Disulfide bonds2. Peptide bonds3. Both #1 and #24. None of the above
7
PRS-3
• Amino acids are linked by what types of bonds in proteins?
1. Disulfide bonds2. Peptide bonds3. Both #1 and #24. None of the above
8
PRS-4
• Which cofactors are required for the aldolase reaction?
1. NAD+
2. CoA3. FAD4. None
9
PRS-4
• Which cofactors are required for the aldolase reaction?
1. NAD+
2. CoA3. FAD4. None
10
PRS-5
• Which of the following is NOT an example of a cofactor?
1. Glucose2. Thiamine Pyrophosphate3. Pyridoxal Phosphate4. Coenzyme A
11
PRS-5
• Which of the following is NOT an example of a cofactor?
1. Glucose2. Thiamine Pyrophosphate3. Pyridoxal Phosphate4. Coenzyme A
12
PRS-6
• What function does glucagon exhibit?
1. Increasing glycogen breakdown2. Binding to receptors on liver cells3. Triggering increased levels of cAMP
production4. All of the above
13
PRS-6
• What function does glucagon exhibit?
1. Increasing glycogen breakdown2. Binding to receptors on liver cells3. Triggering increased levels of cAMP
production4. All of the above
14
PRS-7
• Pyruvate carboxylase converts ___ to _____.
1. Acetyl CoA to pyruvate 2. Pyruvate to acetyl Coa3. Pyruvate to Oxaloacetate4. Pyruvate to Phosphoenolpyruate
15
PRS-7
• Pyruvate carboxylase converts ___ to _____.
1. Acetyl CoA to pyruvate 2. Pyruvate to acetyl Coa3. Pyruvate to Oxaloacetate4. Pyruvate to Phosphoenolpyruate
16
PRS-8
• A point mutation in which a purine is replaced by a pyrimidine is called:
1. Transversion2. Transition3. Insertion4. Deletion
17
PRS-8
• A point mutation in which a purine is replaced by a pyrimidine is called:
1. Transversion2. Transition3. Insertion4. Deletion
See Section 25-4
From Reading - not mentioned in
lecture…
18
PRS-9
• Which statement is true?1. Hemoglobin binding of CO2 stabilizes the T
form
2. The sickle cell form of hemoglobin contains a point mutation (E->V)
3. 2,3-Bisphosphoglycerate decreases hemoglobin’s affinity for O2
4. All of the above
19
PRS-9
• Which statement is true?1. Hemoglobin binding of CO2 stabilizes the T
form
2. The sickle cell form of hemoglobin contains a point mutation (E->V)
3. 2,3-Bisphosphoglycerate decreases hemoglobin’s affinity for O2
4. All of the above
20
PRS-10
• Which of the following is a unit of O2 pressure?
1. mm Hg2. mol/L3. %4. nm
21
PRS-10
• Which of the following is a unit of O2 pressure?
1. mm Hg2. mol/L3. %4. nm
22
PRS-11
• See Figure 1. The shift from blue to red indicates:
1. An increase in pH
2. A decrease in pH
3. An increase in hemoglobin concentration
4. A decrease in hemoglobin concentration
23
PRS-11
• See Figure 1. The shift from blue to red indicates:
1. An increase in pH
2. A decrease in pH
3. An increase in hemoglobin concentration
4. A decrease in hemoglobin concentration
24
PRS-12
• Which are 5-C monosaccharides?
1. Glucose and ribose
2. Ribose and fructose
3. Ribose and mannose
4. None of the combinations above
25
PRS-12
• Which are 5-C monosaccharides?
1. Glucose and ribose
2. Ribose and fructose
3. Ribose and mannose
4. None of the combinations above
26
PRS-13
• Which reaction is an example of an acid-base catalyzed reaction?
1. Hexokinase2. Pyruvate kinase3. Phosphoglucose isomerase4. Pyruvate dehydrogenase
27
PRS-13
• Which reaction is an example of an acid-base catalyzed reaction?
1. Hexokinase Nucleophilic attack2. Pyruvate kinase Nucleophilic attack3. Phosphoglucose isomerase4. Pyruvate dehydrogenase
5-step Reaction
28
PRS-14
• Which of the following is not a step in the pyruvate dehydrogenase mechanism?
1. Decarboxylation2. Reduction of FAD to FADH2
3. Oxidation of NADH to NAD+ 4. Production of acetyl-CoA
29
PRS-14
• Which of the following is not a step in the pyruvate dehydrogenase mechanism?
1. Decarboxylation2. Reduction of FAD to FADH2
3. Oxidation of NADH to NAD+ 4. Production of acetyl-CoA
30
Pyruvate Dehydrogenase Rxn
31
PRS-15
• Which of the following is not a disulfide reducing agent?
1. Cysteine2. Beta-mercaptoethanol3. Lipoic acid4. Linoleic acid
32
PRS-15
33
PRS-16
• cDNA _____.
1. Is DNA found in the cytosol of a cell.
2. Comes from reverse transcription of mRNA.
3. Stands for “capped” DNA.
4. Contains the DNA sequence from the entire genome.
34
PRS-16
• cDNA _____.
1. Is DNA found in the cytosol of a cell.
2. Comes from reverse transcription of mRNA.
3. Stands for “capped” DNA.
4. Contains the DNA sequence from the entire genome.
35
PRS-17
• Which are nonpolar amino acids?
1. Gly, Val, Lys
2. Arg, Leu, Met
3. Ile, Pro, Phe
4. Ala, Met, Ser
36
PRS-17
• Which are nonpolar amino acids?
1. Gly, Val, Lys
2. Arg, Leu, Met
3. Ile, Pro, Phe
4. Ala, Met, Ser
37
PRS-18
• Beta sheets can contain _____.
1. Antiparallel strands
2. Parallel strands
3. Interstrand H-bonds
4. All of the above.
38
PRS-18
• Beta sheets can contain _____.
1. Antiparallel strands
2. Parallel strands
3. Interstrand H-bonds
4. All of the above.
39
PRS-19
• The hydrophobic effect is driven by ______.
1. Enthalpy2. Entropy3. The concentration of water4. Temperature
40
PRS-19
• The hydrophobic effect is driven by ______.
1. Enthalpy2. Entropy3. The concentration of water4. Temperature
41
PRS-20
• Which is a major component of brain lipids?
1. Fatty acids2. Triglycerides3. Gangliosides4. Phospholipids
42
PRS-20
• Which is a major component of brain lipids?
1. Fatty acids2. Triglycerides3. Gangliosides4. Phospholipids
43
Reminders
• Final exam is closed-book.• Bring a calculator.• Study by:
– Reading the text– Reviewing suggested HW problems– Reviewing What You Should Know
summaries (no more added)– Reviewing past exams– Studying lecture notes
44
CETL Course Survey(s)
• Course-Instructor Opinion Survey (CIOS)– http://www.coursesurvey.gatech.edu– Also on T-Square Home Page
• Pilot Survey– Go to T-Square: Announcements for link to
survey– Focus groups to learn more about student
opinions – Deadline: August 3, 2008– IRB Approval requested: minimal risk