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Ω Race

THE Ω RACE SYSTEM(Risk Analysis of Casual Effects)

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Ω Race is a computing system able to combine clinical data of the patient known to the Cardiologist together with the genetic data held by the Laboratory.Ω Race is and advanced computing system to estimate the alteration of the cardiovascular risk caused by interaction of the presence of specific polymorphisms and objective clinical circumstances.

What Ω Race System is?

Personal profile

Ω Race

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Ω RaceRequirements to use the Ω Race

System Have an Internet

Connection

Have an e-mail account

Available printer

LABORATORIES

CARDIOLOGISTS

Ω Race Intended audience

Ω Race

CARDIOLO-GIST

The cardiologist insert personal and anamnestic

data of the patient into the Ω-Race System and

prescribes the innovative genetic testing with

Cardio Kit. The patient is sent to a Laboratory

that performs Cardio Kit test.

The Laboratory performs the test and inserts

the genetic data into the Ω Race System.

From this moment the integrated genetic risk

evaluation system becomes active. The

integration of the genetic and clinical profiles

will generate an evaluation that will produce a

scoresheet issued by the Laboratory.

LABORATORY

CARDIOLOGIST

The cardiologist gets the laboratory’s scoresheet with the

calculation of the integrated genetic risk (Genetic factors

integrated with traditional risk factors) at 5, 10, 15 and 20

years. The Cardiologist on the basis of the scoresheet issues

a report, sets the therapy and creates its personal patient’s

archive.

Ω Race

The laboratory buys Cardio KitΩ RaceService combination: Cardio kit and Ω

Race

Strip activation Key-Code

The laboratory activates strips by digiting Cardio Kit Key Code in Ω Race System

Cardiologist/Laboratory: Web registration with the support of Distributor. (Distributor supported by Nuclear Laser Medicine)

Entering personal data of the patient

Entering anamnestic data of the patient

Entering polimorphisms detected on Cardio Kit strip

Laboratory calculates the genetic integrated risk with Ω Race System

The cardiologist releases a personalized diagnosis to the patient

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The activation of a workstation, and registration to the Ω Race System, is accessible to two different figures

Laboratories

Register the patient (general data)Entering anamnestic dataGenerate an accountMakes the follow-up

Information exchangePIN share Register the patient

Entering genetic dataIf authorized can enter the

personal and anamnestic data Generate a report

Ω Race

Doctors: cardioligists

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Ω Race PIN

Doctor (ex: Cardiologist) Laboratory

Ω RACE @ Nestor 2012-2014 – Customized risk factorFri, 26 Sep 2014 14:31:24

Laboratory of Analysis: LAB A

Patients Data:Surname: Van BeethovenName: LudwigAddress: Bonnstrasse 1, Bonn Personal Code: VBELDWXX1770XX

Authorization PIN: 8C6325

PIN code univocally identifies the patient

Ω Race

CARDIOLO-GIST

LABORATORIES

*The Insertion of the Patient’s e-mail address is necessary to send the report

Personal Data ofPatient

Anamnestic

Data of Patient

Weight and height

Hypertension

Arterial pressure

Hypercholesterolemia

Total Cholesterol

LDL - HDL

Drugs

Smoke

Diabetes

Cardiovascular

Name and Surname

Sex

Age

Address

Name of the Cardiologist

Cardiologist’s e-mail

address

*Patient’s e-mail address

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LABORATORIES

Ω Race

Inclusion of genetic polimorphysms and scoresheet generation

SCORESHEET

Example of how introduce data:

Locus : 9p21

SNP : RS 1333049

Possible combination to select: ● GG ●GC ●CCPersonal and anamnestic data of the patient, recorded into the patient’s chart,

can be displayed by Laboratory through the PIN code If they have previously been entered into the system by the Cardiologist

How to interpretate the integrated genetic risk?

❖ The risk factor is presented as a colored cells matrix. Colors indicate the risk level (Green: low risk, …, violet: high risk) of getting a Cardio Vascular Disease (CVD).

❖ The first column shows the integrated genetic risk to next 5 years. Further columns show the risk at ranges of 5 years each in the future up to a forecast of 20 years.

❖ As example “X” sign in column “Risk at 15 years” into a dark green cell means the probability of a Cardio Vascular Disease event in next 15 years goes with a probability between 5 and 10% (as indicated left side under “Key” column). Namely took 100 persons with same characteristics of the patient under examination, in between of 5 and 10 of them will get a CVD in next 15 years.

❖ Finally it is possible to compare the integrated genetic risk with the same risk calculated without the genetic profile.

Less than 5%

Risk at 5 years

5% - 10%

15% - 20%

20% - 30%

Over 30%

Risk at 10

years

Risk at 15

years

Risk at 20

years

10% - 15%

CVD Risk VI

CVD Risk V

CVD Risk IV

CVD Risk III

CVD Risk II

CVD Risk I

Key Integrated Genetic Risk

Compare to clinical risk

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LABORATORY

Ω Race

CARDIOLOGIST

Scoresheet transmission to Cardiologist and Patient

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Ω Race

Cardiologist evaluates the risk factor indicated in the scoresheet and generates a report

CARDIOLOGIST

REPORT

How to interpretate the integrated genetic risk?

❖ This case shows two matrices. Left one considers into evaluation genetic factors while the right one is an evaluation of the risk without taking into account genetic factors.

❖ Notice how for the patient under evaluation, despite having a very low risk factor, the risk of a Cardio Vascular Disease (CAD) increases from “Less than 5%” to “5% - 10%” at 15 years, if genetic factors are taken into consideration in addiction to traditional clinical risks.

Risk at 5 years

Risk at 10

years

Risk at 15

years

Risk at 20

years

Less than 5%

5% - 10%

15% - 20%

20% - 30%

Over 30%

10% - 15%

CVD Risk VI

CVD Risk V

CVD Risk IV

CVD Risk III

CVD Risk II

CVD Risk I

Risk at 5 years

Risk at 10

years

Risk at 15

years

Risk at 20

years

Risk at 5 years

Risk at 10

years

Risk at 15

years

Risk at 20

years

Key Integrated Genetic Risk Traditional Clinical Risk

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Ω Race PRIVACY The system is protected by:

1. User Name

3. PIN

2. Password

4. Security protocol HyperText Transfer Protocol over Secure Socket Layer (HTTPS)

5. The Ω Race System do not divulge sensitive information about patients like personal data

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Ω Race

Information for Cardio Kit may be found:- at www.nlm.it- by writing an e-mail at export@nlm.it - soon at www.cardiokit-nlm.com dedicated website to Cardio Kit currently under construction for english version.

SUPPORT TO THE SERVICE SYSTEM CARDIO KIT AND Ω RACE

Where & how?

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Ω Race

Thanks For Your Attention!