54
1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701, USA E-mail: [email protected] Presentation in the Recovery Conference: Vision to Outcomes Hartford, CT, May 16-17, 2006 This presentation was supported by funds from the Connecticut Department of Mental Health and Addiction Services and data from NIDA grant no. R37-DA11323, and R01 DA15523 and SAMHSA/CSAT contract no. 270-2003-00006 . The opinions are those of the author do not reflect official positions of the government. Please address comments or questions to the author at [email protected] or 309-820-3805. A copy of these slides will be posted at www.chestnut.org/li/posters

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Page 1: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

1

Managing Substance Use Disorders (SUDS) as a Chronic Condition

Michael L. Dennis, Ph.D. Chestnut Health Systems

720 W. Chestnut, Bloomington, IL 61701, USA E-mail: [email protected]

Presentation in the Recovery Conference: Vision to Outcomes

Hartford, CT, May 16-17, 2006

This presentation was supported by funds from the Connecticut Department of Mental Health and Addiction Services and data from NIDA grant no. R37-DA11323, and R01 DA15523 and SAMHSA/CSAT contract no. 270-2003-00006 . The opinions are those of the author do not reflect official positions of the government . Please address comments or questions to the author at [email protected] or 309-820-3805. A copy of

these slides will be posted at www.chestnut.org/li/posters

.

Page 2: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

2

Problem and Purpose

• Over the past several decades there has been a growing recognition that a subset of substance users suffers from a chronic condition that requires multiple episodes of care over several years.

• This presentation will focus on 1. Describing the prevalence and characteristics of this subset of

people 2. the course of these disorders, and 3. the results of three experiments designed to improve the ways

in which this condition is managed across time and multiple episodes of care.

Page 3: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

3

Definition of Chronic SUD• While terms like substance use, abuse, dependence, and addiction are

frequently used interchangeably, state regulators, accreditation programs, clinical providers and more recently clinical researchers have become increasingly consistent in how they define chronic substance use disorders.

• The American Psychiatric Association (APA, 1994, 2000) and the World Health Organization (WHO, 1999) use the term “substance dependence” to indicate a pattern of chronic problems (e.g., withdrawal, inability to stop, giving up activities) that are likely to persist.

• They use the term “substance abuse” and “hazardous use”respectively to identify people not meeting the dependence criteria but having other moderate severity symptoms (e.g., hazardous use, legal problems) suggesting the need for treatment.

• These standards also recognize that the course of substance use disorders includes periods of relapse, treatment, incarceration, and remission (i.e., the absence of symptoms while in the community)

Page 4: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

4

Severity of Past Year Substance Use/Disorders (2002 U.S. Household Population age 12+= 235,143,246)

Dependence 5%

Abuse 4%

Regular AOD Use 8%

Any Infrequent Drug Use 4%

Light Alcohol Use Only 47%

No Alcohol or Drug Use

32%

Source: 2002 NSDUH and Dennis & Scott under review

Page 5: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

5

Problems Vary by Age

Source: 2002 NSDUH and Dennis & Scott under review

0

10

20

30

40

50

60

70

80

90

100

12-13

14-15

16-17

18-20

21-29

30-34

35-49

50-64

65+

No Alcohol or Drug Use

Light Alcohol Use Only

Any Infrequent Drug Use

Regular AOD Use

Abuse

Dependence

NSDUH Age Groups

Severity CategoryAdolescent

OnsetRemission

Increasing rate of non-

users

Page 6: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

6

Higher Severity is Associated with Higher Annual Cost to Society Per Person

Source: 2002 NSDUH and Dennis & Scott under review

$0$231 $231

$725$406

$0$0

$500

$1,000

$1,500

$2,000

$2,500

$3,000

$3,500

$4,000

No Alcohol orDrug Use

Light Alcohol

Use Only

AnyInfrequentDrug Use

Regular AODUse

Abuse Dependence

Median (50th percentile)

$948

$1,613

$1,078$1,309

$1,528

$3,058Mean (95% CI)

This includes people who are in recovery, elderly, or do not use

because of health problems Higher Costs

Page 7: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

7

Age of First Use Predicts Symptoms of Dependence an Average of 22 years Later

Source: Dennis, Babor, Roebuck & Donaldson (2002) and 1998 NHSDA

3945

63

71

3734

51

62

30

23

41

48

0

10

20

30

40

50

60

70

80

90

100

Tobacco, OR=1.3*,Pop.=151,442,082

Alcohol, OR=1.9*,Pop.=176,188,916

Marijuana, OR=1.5*,Pop.=71,704,012

Other, OR=1.5*, Pop.=38,997,916

% w

ith

1+ P

ast Y

ear

Sym

ptom

s

Under Age 15

Aged 15-17

Aged 18 or older

Tobacco: Pop.=151,442,082

OR=1.49*

Alcohol: Pop.=176,188,916

OR=2.74*

* p<.05

Marijuana:Pop.=71,704,012

OR=2.45*

Other Drugs:Pop.=38,997,916

OR=2.65*

Page 8: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

8

Study 2. Pathways to Recovery (Scott & Dennis)

Recruitment: 1995 to 1997

Sample: 1,326 participants from sequential admissions to a stratified sample of 22 treatment units in 12 facilities, administered by 10 agencies on Chicago's west side.

Levels of Care: Adult OP, IOP, MTP, HH, STR, LTR

Instrument: Augmented version of the Addiction SeverityIndex (A-ASI)

Follow-up: Of those alive and due, follow-up interviews werecompleted with 94 to 98% in annual interviews out

to 8 years (going to 10 years); over 80% completed within +/- 1 week of target date.

Funding: CSAT grant # T100664, contract # 270-97-7011NIDA grant 1R01 DA15523

Page 9: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

9

Intake Characteristics

• Participants were mostly African-American (88%), female (59%), and in their 30s (48%); At intake, 32% were homeless and 25% were involved in the criminal justice system.

• The most common substances used weekly were: cocaine (33%), heroin (31%), alcohol (27%), and marijuana (7%).

• Many met criteria for Major Depression (36%) or Generalized Anxiety Disorder (36%).

• 54% have been in treatment before (27% 2+ times)• The participants were initially referred to outpatient (19%),

methadone (19%), intensive outpatient (18%), halfway house (10%), short term residential (20%), long term residential (13%).

Page 10: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

10

Survival Analysis

• Time frames related to age of use, treatment, and death were measured across all sources and waves of information (taking the earliest first use, treatment episode, and 12 month period of abstinence or death).

• Age at last use was defined as the age when a person first completed a period of 12 month abstinence or had died (35 or 2.6% of the people died in 3 years).

• Durations were estimated with Cox Proportional Hazards Regression– censoring people who were in treatment or still using, – censoring years past which we had less than 100 people to make the estimate, and– creating a 30 year window of observation on the trajectory of substance use

disorders starting at the time of first use

Page 11: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

11

Age Distributions

0

20

40

60

80

100

120

140

160

180

0 10 20 30 40 50 60

Age

Age at first Use (0% censored)

Age at First Tx (0% cesored)

Age at Study Intake (0% censored)

Age at recovery or death (53% censored)

Page 12: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

12

Substance Use Careers Last for Decades P

erce

nt

in R

ecov

ery

Years from first use to 1+ years abstinence

302520151050

100%

90%

80%

70%

60%

50%

40%

30%

20%

10%

0%

Median duration of

27 years(IQR: 18 to

30+)

Source: Dennis et al 2005 (n=1,271)

Page 13: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

13

Substance Use Careers are Longer, the Younger the Age of First Use

Per

cen

t in

Rec

over

y

Years from first use to 1+ years abstinence

302520151050

100%

90%

80%

70%

60%

50%

40%

30%

20%

10%

0%

Source: Dennis et al 2005 (n=1,271)

under 15*

21+

15-20*

Age

of

1st U

se G

rou

ps

* p<.05 (different from 21+)

Page 14: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

14

Substance Use Careers are Shorter the Sooner People get to Treatment

Per

cen

t in

Rec

over

y

Years from first use to 1+ years abstinence

302520151050

100%

90%

80%

70%

60%

50%

40%

30%

20%

10%

0%

Source: Dennis et al 2005 (n=1,271)

20+

0-9*

10-19*

Yea

rs t

o 1st

Tx

Gro

up

s

* p<.05 (different from 20+)

Page 15: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

15

It Takes Decades and Multiple Episodes of Treatment

Years from first Tx to 1+ years abstinence

2520151050

Median duration of 9 years

(IQR: 3 to 23) and 3 to 4

episodes of care

Per

cen

t in

Rec

over

y

100%

90%

80%

70%

60%

50%

40%

30%

20%

10%

0%

Source: Dennis et al 2005 (n=1,271)

Page 16: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

16

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Over 55% Continued to Changed Status Between Annual Follow-up Interviews (83% over 3 years)

In thecommunityIn Recovery

In TreatmentIncarcerated

In thecommunityusing

In the Community Using(57%)

Inc.(6%)

Recovery(26%)

In Tx.(12%)

Status at 24 months

Status at 36 months

Page 17: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

17

The Cyclical Course of Relapse, Incarceration, Treatment and Recovery

In the Community

Using (53% stable)

In Treatment (21% stable)

In Recovery (58% stable)

Incarcerated(37% stable)

6%

13%

28%

30%

8%

25%

31%

4%

44%7%

29%

7%

Treatment is the most likely path

to recovery

P not the same in both directions

Source: Scott et al 2005

Page 18: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

18Source: Scott et al 2005

Predictors of Change Also Vary by Direction

In the Community

Using (53% stable)

In Recovery (58% stable)

13%

29%

Probability of Relapsing from Abstinence + times in treatment (1.21) - female (0.58) + homelessness (1.64) - number of arrests (1.12)

- ASI legal composite (0.84)- # of sober friend (0.82)- per 77 self help sessions (1.41)

Probability of Transitioning from Using to Abstinence - mental distress (0.88) + older at first use (1.12) -ASI legal composite (0.84) + homelessness (1.27)

+ # of sober friend (1.23)+ per 8 weeks in treatment (1.14)

Page 19: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

19

Post Script on the Pathways Study

• There is clearly a subset of people for whom substance use disorders are a chronic condition that last for many years

• Rather than a single transition, most people cycle through abstinence, relapse, incarceration and treatment 3 to 4 times before reaching a sustained recovery.

• It is possible to predict the likelihood risk of when people will transition

• Treatment predicts who transitions from use to recovery and self help group participation predicts who stays in recovery.

Page 20: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

20

Treatment Participation

• Only 1 in 5 people with dependence or abuse in the U.S. receive any kind of treatment, and about half of those access it through publicly-funded substance abuse treatment (Epstein, 2002)

• People presenting to publicly funded treatment with dependence (vs. others with abuse, intoxication, primarily other psychiatric diagnoses) are more likely to have been – in treatment before one or more times (57% vs. 39%, OR=1.46, p<.05), – in treatment 3 or more times (16% vs. 9%, OR=1.79, p<.05),– assigned to intensive outpatient (15% vs. 6%, OR=2.52, p<.05) – assigned to residential treatment (16% vs. 5%, OR=3.17, p<.05)

(OAS, 2002 on line data at http://webapp.icpsr.umich.edu/cocoon/ICPSR-SERIES/00056.xml)

• People with 3 or more diagnoses were significantly more likely than those with just 1 diagnosis to enter treatment (34% vs. 7%) (Kessler, et al., 1996).

Page 21: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

21

The Majority Stay in Tx Less than 90 days

Source: Data received through August 4, 2004 from 23 States (CA, CO, GA, HI, IA, IL, KS, MA, MD, ME, MI, MN, MO, MT, NE, NJ, OH, OK, RI, SC, TX, UT, WY) as reported in Office of Applied Studies (OAS; 2005). Treatment Episode Data Set (TEDS): 2002. Discharges from Substance Abuse Treatment Services, DASIS Series: S-25, DHHS Publication No. (SMA) 04-3967, Rockville, MD: Substance Abuse and Mental Health Services Administration. Retrieved from http://wwwdasis.samhsa.gov/teds02/2002_teds_rpt_d.pdf .

52

42

20

33

0

30

60

90

Outpatient IntensiveOutpatient

Short TermResidential

Long TermResidential

Level of Care

Med

ian

Len

gth

of S

tay

in D

ays

Page 22: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

22

Less Than Half Are Positively Discharged

Source: Data received through August 4, 2004 from 23 States (CA, CO, GA, HI, IA, IL, KS, MA, MD, ME, MI, MN, MO, MT, NE, NJ, OH, OK, RI, SC, TX, UT, WY) as reported in Office of Applied Studies (OAS; 2005). Treatment Episode Data Set (TEDS): 2002. Discharges from Substance Abuse Treatment Services, DASIS Series: S-25, DHHS Publication No. (SMA) 04-3967, Rockville, MD: Substance Abuse and Mental Health Services Administration. Retrieved from http://wwwdasis.samhsa.gov/teds02/2002_teds_rpt_d.pdf .

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Outpatient IntensiveOutpatient

Short TermResidential

Long TermResidential

Level of Care

Dis

char

ge S

tatu

s

Other

Terminated

Dropped out

Completed

Transferred

Less than 10% are transferred

Page 23: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

23

Number of GAIN Sites

Adolescent and Adult Treatment Program GAIN Clinical Collaborators

30 to 6010 to 292 to 91

One or more state or county wide systems uses the GAIN

One or more state or county wide systems considering using the GAIN

07/05

Page 24: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

24

Multiple Co-occurring Problems Contribute to Chronicity

0% 20%

40%

60%

80%

100%

Health Distress

Internal Disorders

External Disorders

Crime/Violence

Criminal JusticeSystem

Involvement

Dependent (n=1221)

Other (n=385)

0% 20%

40%

60%

80%

100%

Dependent (n=3135)

Other (n=2617)

Adolescents Adults

Source: GAIN Coordinating Center Data Set

Exception

Page 25: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

25

Treatment Outcomes by Level of Care: Recovery*

* Recovery defined as no past month use, abuse, or dependence symptoms while living in the community. Percentages in parentheses are the treatment outcome (intake to 12 month change) and the stability of the outcomes (3months to 12 month change) Source: CSAT Adolescent Treatment Outcome Data Set (n-9,276)

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Pre-Intake Mon 1-3 Mon 4-6 Mon 7-9 Mon 10-12

Per

cent

in P

ast

Mon

th R

ecov

ery* Outpatient (+79%, -1%)

Residential(+143%, +17%)

Post Corr/Res (+220%, +18%)

OP & Resid

Similar

CC better

Page 26: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

26

Findings from the Assertive Continuing Care (ACC) Experiment

• 183 adolescents admitted to residential substance abuse treatment

• Treated for 30-90 days inpatient, then discharged to outpatient treatment

• Random assignment to usual continuing care (UCC) or “assertive continuing care” (ACC)

• Over 90% follow-up 3, 6, & 9 months post discharge

Source: Godley et al 2002, in press

Page 27: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

27

Time to Enter Continuing Care and Relapse after Residential Treatment (Age 12-17)

Source: Godley et al., 2004 for relapse and 2000 Statewide Illinois DARTS data for CC admissions

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

0 10 20 30 40 50 60 70 80 90

Days after Residential (capped at 90)

Per

cen

t of

Clie

nts

Cont.CareAdmis.

Relapse

Page 28: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

28

ACC Enhancements

• Continue to participate in UCC

• Home Visits

• Sessions for adolescent, parents, and together

• Sessions based on ACRA manual (Godley, Meyers et al., 2001)

• Case Management based on ACC manual (Godley et al, 2001) to assist with other issues (e.g., job finding, medication evaluation)

Page 29: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

29

Assertive Continuing Care (ACC)Hypotheses

Assertive Continuin

g Care

General Continuin

g Care Adherence

Relative to UCC, ACC will increase General Continuing Care Adherence (GCCA)

Early Abstinence

GCCA (whether due to UCC or ACC) will be associated with higher rates of early abstinence

Sustained Abstinence

Early abstinence will be associated with higher rates of long term abstinence.

Page 30: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

30

ACC Improved Adherence

Source: Godley et al 2002, forthcoming

0% 10%

20%

30%

40%

50%

60%

70%

80%

Weekly Tx Weekly 12 step meetings

Regular urine tests

Contact w/probation/school

Follow up on referrals*

ACC * p<.05

90%

100%

Relapse prevention*

Communication skills training*

Problem solving component*

Meet with parents 1-2x month*

Weekly telephone contact*

Referrals to other services*

Discuss probation/school compliance*

Adherence: Meets 7/12 criteria*

UCC

Page 31: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

31

GCCA Improved Early (0-3 mon.) Abstinence

Source: Godley et al 2002, forthcoming

24%

36% 38%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Any AOD (OR=2.16*) Alcohol (OR=1.94*) Marijuana (OR=1.98*)

Low (0-6/12) GCCA

43%

55% 55%

High (7-12/12) GCCA * p<.05

Page 32: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

32

Early (0-3 mon.) Abstinence Improved Sustained (4-9 mon.) Abstinence

Source: Godley et al 2002, forthcoming

19% 22% 22%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Any AOD (OR=11.16*) Alcohol (OR=5.47*) Marijuana (OR=11.15*)

Early(0-3 mon.) Relapse

69%

59%

73%

Early (0-3 mon.) Abstainer * p<.05

Page 33: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

33

Post script on ACC

• The ACC intervention improved adolescent adherence to the continuing care expectations of both residential and outpatient staff; doing so improved the rates of short term abstinence and, consequently, long term abstinence.

• Despite these gains, many adolescents in ACC (and more in UCC) did not adhere to continuing care plans.

• The ACC preliminary findings are published and the main findings are currently under review.

• Several CSAT grantees are also seeking to replicate ACC as part of the Adolescent Residential Treatment (ART) and Assertive Adolescent Family Therapy (AAFT) programs.

• A second ACC experiment is currently under way to evaluate whether providing contingency management will further improve outcomes.

• The ACC manual is being distributed via the website and the CD you have been provided.

Page 34: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

34

The Early Re-Intervention (ERI) Experiments

ERI 1 ERI 2Recruitment Recruited 448 from

Community Based Treatment in Chicago in 2000 (84% of eligible recruited)

Recruited 446 from Community Based Treatment in Chicago in 2004 (93% of eligible recruited)

Design Random assignment to Recovery Management Checkups (RMC) or control

Random assignment to Recovery Management Checkups (RMC) or control

Follow-Up Quarterly for 2 years (95-97% per wave)

Quarterly for 4 years (95 to 97% per wave)

Data Sources GAIN, CEST, Urine, Salvia

Staff logs

GAIN, CEST, CAI, Neo, CRI, Urine, Staff logs

Publication Dennis, Scott & Funk 2003; Scott, Dennis & Foss, 2005

Scott & Dennis, under review (12 month findings)

Funding Source NIDA grant R37-DA11323

Page 35: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

35

Sample Characteristics of ERI 1 & 2 Experiments

0% 20%

40%

60%

80%

100%

African American

Age 30-49

Female

Employed

Dependence

Prior Treatment

Residential Treatment

Other Mental Disorders

Homeless

Physical Health Problems

ERI 1 (n=448)

ERI 2 (n=446)

Page 36: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

36

Need For Treatment Re-Intervention

• Eligibility: Not already in treatment or incarcerated and living in the community

• Need: Yes to at least one of the following…(a) During the past 90 days, have you used alcohol,

marijuana, cocaine, or other drugs on 13 or more days?(b) During the past 90 days, have you gotten drunk or been

high for most of 1 or more days?(c) During the past 90 days, has your alcohol or drug use

caused you not to meet your responsibilities at work/school/home on 1 or more days?

(d) During the past week, had withdrawal symptoms when you tried to stop, cut down, or control your use?

(e) Do you feel that you need to return to treatment?(f) During the past month, has your substance use caused you

any problems?

Page 37: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

37

Recovery Management Checkups (RMC) in both ERI 1 & 2 included:

• Quarterly Screening to determining “Eligibility” and “Need”

• Linkage meeting/motivational interviewing to:– provide personalized feedback to participants about their

substance use and related problems, – help the participant recognize the problem and consider

returning to treatment, – address existing barriers to treatment, and – schedule an assessment.

• Linkage assistance– reminder calls and rescheduling– Transportation and being escorted as needed

Page 38: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

38

720630540450360270180900

1.0

.9

.8

.7

.6

.5

.4

.3

.2

.1

0.0

H1: RMC Clients will return to treatment sooner

Control (51% readmitted)

Days to Readmission

Percent to be R

eadmitted

OR: 1.34X2

(1)=6.8, p<.01

RMC(64% readmitted)

Median of 376 vs. 600 days,

Wald=5.2, p<.05

Median of 376 vs. 600 days,

Wald=5.2, p<.05

Page 39: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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H2: RMC clients will receive more treatment

Days % with 90+ Days

50

0

10

20

30

40

50

60

70

Control RMC

Mea

n D

ays

of S

ubse

quen

t Tre

atm

ent

(m

onth

s 4-

24)

t(390)=2.65, p<.05

17%

6225%

0%

5%

10%

15%

20%

25%

30%

Control RMC

% w

ith

90+

day

s of

Sub

sequ

ent

Tre

atm

ent (

mon

ths

4-24

)

OR 1.61, X2(1)=4.1, p<.05

Page 40: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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H3: RMC clients will be less likely to use at 24m

43%

56%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Control (n=244) RMC (n=224)

X2(1) = 7.7, p<.01

Page 41: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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However, 32% of individuals change status between the beginning and end of the quarter (82% over two years)

In thecommunityIn Recovery

In Treatment

IncarceratedIn thecommunityusing

In the Community Using(41%)

Inc.(5%)

Recovery(42%)

In Tx.(12%)

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100% End of Quarter

Beginning of Quarter(3,136 quarterly transition

Observations on 448 unique people)Status at beginning of Quarter

Status at the end of Quarter

Page 42: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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Source: ERI experiments (Scott, Dennis, & Foss, 2005)

Impact on Primary Pathways to Recovery(incarceration not shown)

In the Communityy

Using (71% stable)

In Treatment (35% stable)

In Recovery (76% stable)

27%

5%

8%

33%

18%

17%

Transition to Tx - Freq. of Use (0.7)

+ Prob. Orient. (1.4)+ Desire for Help (1.6)

+ RMC (3.22)

Again the Probability of

Entering Recovery is Higher from

Treatment

Transition to Recov. - Freq. of Use (0.7)

- Dep/Abs Prob (0.7)- Recovery Env. (0.8)- Access Barriers (0.8)+ Prob. Orient. (1.3)+ Self Efficacy (1.2)

+ Self Help Hist (1.2)+ per 10 wks Tx (1.2)

Page 43: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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Other Variables That Lost Significance in Multivariate Model

• Problem Recognition, External Pressure, Internal Motivation, Treatment Resistance

• Current Withdrawal, Number of Diagnosis, Emotional Problems, Illegal Activity, Homelessness

• Coming from a controlled environment• Involvement with the Criminal Justice System,

Mental Health, Health, or Training/School Systems

• Lifetime number of prior treatment, arrests• Gender, Race, Age, Employment

Page 44: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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Modifications to RMC for ERI -2 included:

• Switch to on-site urine monitoring with immediate feedback to improve detection

• Transportation assistance for everyone to improve the show rates for assessment and treatment

• Improved Quality Assurance/Adherence• Engagement assistance to improve the rates of staying at

least 14 days– Daily contact (mostly face to face)– Acting as an ombudsman– Agreement from provider not to administratively

discharge from treatment without contacting us first

Page 45: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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0%

20%

40%

60%

80%

100%F

ollo

w-u

p(9

6% a

vg)

Nee

ded

Tx

(45%

avg

)

Atte

nded

Lin

kage

(99%

avg

)

Agr

eed

to T

xA

sses

smen

t(4

8% a

vg)

Sho

wed

to T

xA

sses

smen

t(4

2% a

vg)

Sho

wed

to T

x(3

5% a

vg)

Sta

yed

in T

x 14

+ d

ays

(60%

avg

)

ERI 1MaxAvgMin

Adherence to Recovery Management Checkup (RMC) Protocol in ERI 1 vs. 2

Source: ERI experiments (Dennis, Scott, & Funk 2003; Scott, Dennis, & Funk, 2005; Scott & Dennis, forthcoming)

Generally averaged as well or better

Quality assurance and transportation assistance reduced the variance

ImprovedScreening

ERI 2

Improved Retention

Page 46: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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% Readmitted (Months 4-12)

Relative to Control clients, RMC clients were more likely to return to treatment

Source: ERI experiments (Dennis, Scott, & Funk 2003; Scott, Dennis, & Funk, 2005; Scot & Dennis, forthcoming

30%38%

22%

36%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

ERI 1 (d=+.17)T ERI-2 (d=+.30)*

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

*p<.05ERI 1 RMC ERI 2 Control ERI 2 RMCERI 1 Control

Page 47: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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Mean Days of Treatment Received (months 4-12)

20

28

17

30

0

10

20

30

40

50

ERI 1 (d=+.16) ERI-2 (d=+.28)*

0

10

20

30

40

50

ERI 1 OM ERI 1 RMC ERI 2 OM ERI 2 RMC *p<.05

RMC clients received more Total Days of Treatment

Source: ERI experiments (Dennis, Scott, & Funk 2003; Scott, Dennis, & Funk, 2005; Scott & Dennis forthcoming)

ERI 1 RMC ERI 2 Control ERI 2 RMCERI 1 Control

Page 48: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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% with any successive quarters in need of treatment

42% 42%

63%

54%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

ERI 1 (d= -.00) ERI-2 (d= -.23)*

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

ERI 1 OM ERI 1 RMC ERI 2 OM ERI 2 RMC *p<.05

RMC clients were less likely to haveSuccessive Quarters in Need of Treatment

Source: ERI experiments (Dennis, Scott, & Funk 2003; Scott, Dennis, & Funk, 2005; Scott & Dennis forthcoming)

ERI 1 RMC ERI 2 Control ERI 2 RMCERI 1 Control

Page 49: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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In Need of Tx (using in community) at 12 months

52% 50%

60%

47%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

ERI 1 (d= -.07) ERI-2 (d= -.32)*

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

ERI 1 OM ERI 1 RMC ERI 2 OM ERI 2 RMC *p<.05

RMC clients were less likely to be in need of treatment at the end of 12 months

Source: ERI experiments (Dennis, Scott, & Funk 2003; Scott, Dennis, & Funk, 2005; Scott & Dennis forthcoming)

Every Quarter this difference has been growing; Hence our plans to go out 4 years

ERI 1 RMC ERI 2 Control ERI 2 RMCERI 1 Control

Page 50: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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Post Script on ERI experiments

• Again, severity was inversely related to returning to treatment on your own and treatment was the key predictor of transitioning to recovery

• The ERI experiments demonstrate that the cycle of relapse, treatment re-entry and recovery can be shortened through more proactive intervention

• Working to ensure engagement for at least 14 days upon readmission helped to improve outcomes

Page 51: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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Other Emerging Recovery Support Initiatives

• Interactive phone and web based monitoring and recovery support

• Self help groups

• Recovery homes

• Recovery High Schools & Colleges

• Well-briety movement in Indian Country

• Recovery advocacy movement

• Network for the Improvement of Addiction Treatment (NIATx; http://www.pathstorecovery.org/

• Washington Circle Group (http://www.washingtoncircle.org/) and other efforts to introduce performance monitoring

Page 52: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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Reprise

• These studies provide converging evidence demonstrating that substance use disorders commonly present with a wide range of co-occurring problems that are likely to interfere with recovery.

• They show that the majority of people accessing publicly funded substance abuse treatment have been in treatment before, are likely to return, and may need several additional episodes of care before they reach a point of stable recovery.

• Yet over half do make it to recovery• The three experiments demonstrated that it is feasible to

alter the substance use trajectories and treatment careers.

Page 53: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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We need to..• Educate policy makers, staff and clients to have more realistic expectations• Redefine the continuum of care to include monitoring and other proactive

interventions between primary episodes of care. • Shift our focus from intake matching to on-going monitoring, matching over

time, and strategies that take the cycle into account• Identify other venues (e.g., jails, emergency rooms) where recovery

management can be initiated• Evaluate the costs and determine generalizability to other populations

through replication• Explore changes in funding, licensure and accreditation to accommodate and

encourage above

Page 54: 1 Managing Substance Use Disorders (SUDS) as a Chronic Condition Michael L. Dennis, Ph.D. Chestnut Health Systems 720 W. Chestnut, Bloomington, IL 61701,

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Sources and Related Work• American Psychiatric Association. (1994). American Psychiatric Association diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American

Psychiatric Association.• American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (DSM-IV-TR) (4th - text revision ed.). Washington, DC: American

Psychiatric Association. • Epstein, J. F. (2002). Substance dependence, abuse and treatment: Findings from the 2000 National Household Survey on Drug Abuse (NHSDA Series A-16, DHHS

Publication No. SMA 02-3642). Rockville, MD: Substance Abuse and Mental Health Services Administration, Office of Applied Studies. Retrieved from http://www.DrugAbuseStatistics.SAMHSA.gov.

• GAIN Coordinating Center Data Set (2005). Bloomington, IL: Chestnut Health Systems. See www.chestnut.org/li/gain .• Kessler, R. C., Nelson, G. B., McGonagle, K. A., Edlund, M. J., Frank, R. G., & Leaf, P. J. (1996). The epidemiology of co-occurring mental disorders and substance use

disorders in the national comorbidity survey: Implications for prevention and services utilization. Journal of Orthopsychiatry, 66, 17-31.• Dennis, M. L., Scott, C. K. (under review). Managing substance use disorders (SUD) as a chronic condition. NIDA Science and Perspectives.• Dennis, M. L., Scott, C. K., Funk, R., & Foss, M. A. (2005). The duration and correlates of addiction and treatment careers. Journal of Substance Abuse Treatment, 28, S51-

S62.• Dennis, M. L., Scott, C. K., & Funk, R. (2003). An experimental evaluation of recovery management checkups (RMC) for people with chronic substance use disorders.

Evaluation and Program Planning, 26(3), 339-352.• Godley, M. D., Godley, S. H., Dennis, M. L., Funk, R., & Passetti, L. (2002). Preliminary outcomes from the assertive continuing care experiment for adolescents discharged

from residential treatment. Journal of Substance Abuse Treatment, 23, 21-32.• Office Applied Studies (2002). Analysis of the 2002 National Survey on Drug Use and Health (NSDUH) on line at

http://webapp.icpsr.umich.edu/cocoon/ICPSR-SERIES/00064.xml . • Office Applied Studies (2002). Analysis of the 2002 Treatment Episode Data Set (TEDS) on line data at http://webapp.icpsr.umich.edu/cocoon/ICPSR-SERIES/00056.xml) • Scott, C. K., & Dennis, M. L. (forthcoming). A Replicable Model for Managing Addiction as a Chronic Condition using Quarterly Recovery Management Check-ups

(RMC). Manuscript under review.• Scott, C. K., Dennis, M. L., & Foss, M. A. (2005). Utilizing recovery management checkups to shorten the cycle of relapse, treatment re-entry, and recovery. Drug and

Alcohol Dependence, 78, 325-338.• Scott, C. K., Foss, M. A., & Dennis, M. L. (2005). Pathways in the relapse, treatment, and recovery cycle over three years. Journal of Substance Abuse Treatment, 28, S61-

S70.• World Health Organization (WHO). (1999). The International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10). Geneva,

Switzerland: World Health Organization. Retrieved from www.who.int/whosis/icd10/index.html.