50
Cranial Nerves Cranial Nerves 1. 1. Cranial nerves Cranial nerves overview: overview: origin and peripheral distribution origin and peripheral distribution functional components and modality functional components and modality innervation zones innervation zones I. I. Olfactory nerves, Olfactory nerves, nn. olfactorii nn. olfactorii II. II. Optic nerve, Optic nerve, n. opticus n. opticus III. III. Oculomotor nerve, Oculomotor nerve, n. oculomotorius n. oculomotorius IV. IV. Trochlear nerve, Trochlear nerve, n. trochlearis n. trochlearis V. V. Trigeminal nerve, Trigeminal nerve, n. trigeminus n. trigeminus VI. VI. Abducent nerve, Abducent nerve, n. abducens n. abducens VII. VII. Facial nerve, Facial nerve, n. facialis n. facialis VIII. VIII. Vestibulocochlear nerve, Vestibulocochlear nerve, n. vestibulocochlearis n. vestibulocochlearis IX. IX. Glossopharyngeal nerve, Glossopharyngeal nerve, n. glossopharyngeus n. glossopharyngeus X. X. Vagus nerve, Vagus nerve, n. vagus n. vagus XI. XI. Accessory nerve, Accessory nerve, n. accessorius n. accessorius XII. XII. Hypoglossal nerve, Hypoglossal nerve, n. hypoglossus n. hypoglossus

1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

  • Upload
    haminh

  • View
    216

  • Download
    0

Embed Size (px)

Citation preview

Page 1: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Cranial NervesCranial Nerves1.1. Cranial nerves Cranial nerves –– overview:overview:

�� origin and peripheral distributionorigin and peripheral distribution�� functional components and modalityfunctional components and modality�� innervation zonesinnervation zones

I.I. Olfactory nerves, Olfactory nerves, nn. olfactoriinn. olfactoriiII.II. Optic nerve, Optic nerve, n. opticusn. opticusIII.III. Oculomotor nerve, Oculomotor nerve, n. oculomotoriusn. oculomotoriusIV.IV. Trochlear nerve, Trochlear nerve, n. trochlearisn. trochlearisV.V. Trigeminal nerve, Trigeminal nerve, n. trigeminusn. trigeminusVI.VI. Abducent nerve, Abducent nerve, n. abducensn. abducensVII.VII. Facial nerve, Facial nerve, n. facialisn. facialisVIII.VIII.Vestibulocochlear nerve, Vestibulocochlear nerve, n. vestibulocochlearisn. vestibulocochlearisIX.IX. Glossopharyngeal nerve, Glossopharyngeal nerve, n. glossopharyngeusn. glossopharyngeusX.X. Vagus nerve, Vagus nerve, n. vagusn. vagusXI.XI. Accessory nerve, Accessory nerve, n. accessoriusn. accessoriusXII.XII. Hypoglossal nerve, Hypoglossal nerve, n. hypoglossusn. hypoglossus

Page 2: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 2

I.I. N. olfactoriusN. olfactoriusII.II. N. opticusN. opticusIII.III. N. oculomotoriusN. oculomotoriusIV.IV. N. trochlearisN. trochlearisV.V. N. trigeminusN. trigeminusVI.VI. N. abducensN. abducensVII.VII. N. facialisN. facialisVIII.VIII. N. vestibulocochlearisN. vestibulocochlearisIX.IX. N. glossopharyngeusN. glossopharyngeusX.X. N. vagusN. vagusXI.XI. N. accessoriusN. accessoriusXII.XII. N. hypoglossusN. hypoglossus

Cranial nervesCranial nervesCranial nervesCranial nerves

Page 3: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 3

� purely sensorysensory (afferent):�� n. olfactoriusn. olfactorius�� n. opticusn. opticus�� n. vestibulocochlearisn. vestibulocochlearis

� purely motormotor (efferent):�� n. oculomotoriusn. oculomotorius�� n. trochlearisn. trochlearis�� n. abducensn. abducens�� n. accessoriusn. accessorius�� n. hypoglossusn. hypoglossus

�� mixedmixed ((sensory&motorsensory&motor):):�� n. trigeminusn. trigeminus�� n. facialisn. facialis�� n. glossopharyngeusn. glossopharyngeus�� n. vagusn. vagus

�� autonomicautonomic ((parasympathetic):):�� n. oculomotoriusn. oculomotorius�� n. facialisn. facialis�� n. glossopharyngeusn. glossopharyngeus�� n. vagusn. vagus

Functional classificationFunctional classificationCranial nervesCranial nerves

Page 4: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 4

� Location within the brainstem:� ventrally:

�� n. olfactoriusn. olfactorius

�� n. opticusn. opticus

�� n. oculomotoriusn. oculomotorius

�� n. abducensn. abducens

�� n. hypoglossusn. hypoglossus

� laterally:�� n. trigeminusn. trigeminus

�� n. facialisn. facialis

�� n. vestibulocochlearis n. vestibulocochlearis

�� n. glossopharyngeusn. glossopharyngeus

�� n. vagusn. vagus

�� n. accessoriusn. accessorius

�� dorsallydorsally::�� n. trochlearisn. trochlearis

Cranial nervesCranial nerves

Anatomic relationshipsAnatomic relationships

Page 5: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 5

� Location within the brainstem:�� sensory column sensory column –– dorsolaterally

in the brainstem tegmentum:�� trigeminal sensory nuclear complextrigeminal sensory nuclear complex�� solitary tract nucleussolitary tract nucleus�� cochlear nucleicochlear nuclei�� vestibular nucleivestibular nuclei

�� motor columnmotor column – paramedian plan:�� oculomotor nerve nucleioculomotor nerve nuclei�� trochlear nerve nucleustrochlear nerve nucleus�� abducent nucleus abducent nucleus �� facial nucleusfacial nucleus�� nucleus ambiguus nucleus ambiguus �� hypoglossal nucleushypoglossal nucleus

�� autonomic nuclei autonomic nuclei – medially:�� autonomic nuclei of oculomotor nerveautonomic nuclei of oculomotor nerve�� dorsal nucleus of vagusdorsal nucleus of vagus

Cranial nervesCranial nerves

Distribution of cranial nerve nucleiDistribution of cranial nerve nuclei

Page 6: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 6

Simplified diagram of the sensory ganglia of the V, IX and X cranial nerves

Cranial nervesCranial nerves

Cranial gangliaCranial ganglia

Page 7: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 7

Cranial nervesCranial nerves

Terminal nerve, Terminal nerve, n. terminalisn. terminalis� the neglected cranial nerve: cranial nerve zero – C0� first description – Gustav Fritsch (1878) in the brains of sharks

“überzähliger Nerv” = supernumerary nerve� terminal nerve – Locy (1905) – closely connected with the lamina terminalis

� accessory olfactory nerve

� first description in humans – 1913� very distinct in human fetuses and infants� rudimentary (vestigial) in adult human brains

� non-myelinated axons� arise from autonomic as well as sensory neurons� pass through the cribriform plate

medial to those of the olfactory nerve fila� peripherally end in the nasal mucosa� centrally end in:

� lateral and medial septal nuclei� preoptic area and rostral perforate substance

� functions - uncertain:� related to the sensing of pheromones transmitting

sexual signals from the vomeronasal organ� play a role in reproductive (sexual) behavior

Page 8: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 8

� specific sense of smell (olfaction)

� the shortest cranial nerve –cribriform plate (lamina cribrosa)

� 18-20 bundles, fila olfactoria –non-myelinated axons

� olfactory receptor neurons –

40 millions in olfactory epithelium

� Іst neuron of the olfactory pathway

Cranial nervesCranial nerves

Olfactory nerves, Olfactory nerves, nn. olfactoriinn. olfactorii

Page 9: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 9

� olfactory bulb – synaptic glomeruli

� nucleus of termination of cranial nerve I

� mitral, granule and periglomerular cells

� initial part of rhinencephalon

Cranial nervesCranial nerves

Olfactory bulb, Olfactory bulb, bulbus olfactoriusbulbus olfactorius

Page 10: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 10

� specific sense of sight (vision)� intraorbital part – 25 mm long

� canal part ~ 5 mm long

� intracranial part ~ 10 mm long

� 1 million axons of ganglion cells in the retina

� ІІІrd neuron of the visual pathway

Cranial nervesCranial nerves

Optic nerve,Optic nerve, n. opticusn. opticus~ 4 cm long

Page 11: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 11

� optic disc (optic nerve head)

� a. et v. centralis retinae

� optic canal

� through anulus tendineus communisanulus tendineus communis

� optic chiasm � optic tract:� partial (~ 53%) decussation

of the (medial) fibers

Cranial nervesCranial nerves

Optic nerve,Optic nerve, n. opticusn. opticus

Page 12: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 12

Cranial nervesCranial nerves

Optomotor groupOptomotor group�� oculomotor nerveoculomotor nerve, ,

n. oculomotoriusn. oculomotorius�� trochlear nervetrochlear nerve, ,

n. trochlearisn. trochlearis�� abducent nerveabducent nerve, ,

n. abducensn. abducens

Page 13: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 13

Oculomotor nerveOculomotor nerve , , n. oculomotoriusn. oculomotoriusCranial nervesCranial nerves

�� IIIIIIrdrd cranial nerve cranial nerve –– somatomotor and somatomotor and parasympatheticparasympathetic

�� nuclei at the level ofnuclei at the level of superior colliculussuperior colliculus::�� nucleus nervi oculomotoriinucleus nervi oculomotorii – motor�� nucleus oculomotorius accessorius nucleus oculomotorius accessorius

(of Edinger(of Edinger--Westphal) Westphal) – autonomic

�� sulcus medialis cruris cerebrisulcus medialis cruris cerebri�� fissura orbitalis superiorfissura orbitalis superior�� anulus tendineus communisanulus tendineus communis

Page 14: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 14

Oculomotor nerveOculomotor nerve , , n. oculomotoriusn. oculomotoriusCranial nervesCranial nerves

NB:NB: Modern Latin, from Modern Latin, from GreekGreek strabismosstrabismos; squint; squint--eyedeyed

�� ramus superior:ramus superior:�� m. rectus superiorm. rectus superior�� m. levator palpebrae superiorism. levator palpebrae superioris

�� ramus inferior ramus inferior – motor fibers::�� mm. rectus inferior et medialismm. rectus inferior et medialis�� m. obliquus inferiorm. obliquus inferior

�� radix oculomotoria parasympathica radix oculomotoria parasympathica (ramus ad ganglion ciliare) (ramus ad ganglion ciliare) –autonomic fibers from ramus inferior

�� ganglion ciliareganglion ciliare –– nn.ciliares brevesnn.ciliares breves�� m. ciliarism. ciliaris�� m. sphincter pupillaem. sphincter pupillae

in injuryin injury �� divergentdivergent strabismusstrabismus

Page 15: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 15

�� IVIVthth cranial nerve cranial nerve –– motormotor ((optomotoroptomotor) ) nervenerve

�� nucleusnucleus –– upperupper partpart ofof thethe inferiorinferior colliculuscolliculus::

�� nucleus nervi troclearisnucleus nervi troclearis

�� dorsal emergence dorsal emergence –– below the inferior colliculusbelow the inferior colliculus

�� trochlear decussationtrochlear decussation

Cranial nervesCranial nerves

Trochlear nerve, Trochlear nerve, n. trochlearisn. trochlearis

Page 16: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 16

�� fissura orbitalis superiorfissura orbitalis superior

� above anulus tendineus communisanulus tendineus communis (Zinn)(Zinn)

� innervation:

�� m. obliquus superiorm. obliquus superior

�� in injuryin injury �� torsional diplopiatorsional diplopia

Cranial nervesCranial nerves

Trochlear nerve, Trochlear nerve, n. trochlearisn. trochlearis

Page 17: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 17

Cranial nervesCranial nerves

Abducent nerve, Abducent nerve, n. abducensn. abducens�� VIVIthth cranial nerve cranial nerve ––

motormotor ((optomotoroptomotor) ) nervenerve

�� nucleusnucleus –– in pons (fossa rhomboidea) beneath the colliculus facialis::�� nucleus nervi abducentisnucleus nervi abducentis

� emergence between the pons and the medullar pyramid

Page 18: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 18

� through anulus anulus tendineus communistendineus communis

� innervation:�� m. rectus lateralism. rectus lateralis

�� in injuryin injury ��

convergentconvergent strabismusstrabismus

Cranial nervesCranial nerves

Abducent nerve, Abducent nerve, n. abducensn. abducens

Page 19: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 19

�� VVthth cranial nervecranial nerve –– the largest cranial nervethe largest cranial nerve

�� Mixed nerveMixed nerve::�� sensorysensory – sensory innervation

of orofacial region�� motormotor (n. mandibularis) –

supply of masticatory muscles

� Formation:� larger sensory root, sensory root, radix sensoria (major)radix sensoria (major)� smaller motor root,motor root, radix motoria (minor)radix motoria (minor)

� Emergence – at the level of the pons

Cranial nervesCranial nerves

Trigeminal nerve, Trigeminal nerve, n. trigeminusn. trigeminus

Page 20: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 20

�� Three sensory nucleiThree sensory nuclei – in the brainstem:

�� main (principal) sensory nucleus main (principal) sensory nucleus –– pontinepontine

�� spinal trigeminal nucleusspinal trigeminal nucleus

�� mesencephalic nucleusmesencephalic nucleus

�� Motor nucleus Motor nucleus – in the pons:

�� motor trigeminal nucleusmotor trigeminal nucleus

Cranial nervesCranial nerves

Trigeminal nuclear complexTrigeminal nuclear complex

Page 21: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 21

�� ganglion trigeminale, ganglion trigeminale,

(semilunare, Gasseri)(semilunare, Gasseri)

�� impressio trigeminalisimpressio trigeminalis

�� cavum trigeminale (Meckeli)cavum trigeminale (Meckeli)

� pseudounipolar neurons

Johann Lorentz Johann Lorentz GasserGasser

17231723--17651765

Cranial nervesCranial nerves

Trigeminal ganglion, Trigeminal ganglion, ganglion trigeminaleganglion trigeminale

Page 22: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 22

� Major branchesbranches::�� ophthalmic nerve ophthalmic nerve –– pure sensorypure sensory

n. ophthalmicusn. ophthalmicus

�� maxillary nerve maxillary nerve –– pure sensorypure sensory

n. maxillarisn. maxillaris

�� mandibular nerve mandibular nerve –– mixed, motor&sensorymixed, motor&sensory

n. mandibularisn. mandibularis

Cranial nervesCranial nerves

Trigeminal nerve, Trigeminal nerve, n. trigeminusn. trigeminus

Page 23: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 23

Ophthalmic nerveOphthalmic nerve ,, n. ophthalmicusn. ophthalmicusCranial nervesCranial nerves

�� BranchesBranches::�� n. frontalis:n. frontalis:

�� n. supraorbitalis n. supraorbitalis –– rr. medialis et lateralisrr. medialis et lateralis�� n. supratrochlearisn. supratrochlearis

�� n. nasociliaris:n. nasociliaris:�� ramus communicans cum ganglio ciliariramus communicans cum ganglio ciliari�� n. ethmoidalis anterior et posteriorn. ethmoidalis anterior et posterior�� n. infratrochlearisn. infratrochlearis

�� n. lacrimalisn. lacrimalis �� gl. lacrimalis, upper eyelid and conjunctiva�� ramus communicans cum nervo zygomaticoramus communicans cum nervo zygomatico

Page 24: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 24

Maxillary nerveMaxillary nerve ,, n. maxillarisn. maxillarisCranial nervesCranial nerves

�� BranchesBranches::�� n. zygomaticus n. zygomaticus – in fossa pterygopalatina:

� ramus zygomaticofacialis� ramus zygomaticotemporalis

�� n. infraorbitalis:n. infraorbitalis:� rr. palpebrales inferiores� rr. nasales externi et interni� rr. labiales superiores� nn. alveolares superiores,

postt., medius et inff. � plexus dentalis superior�� ganglion pterygopalatinumganglion pterygopalatinum

Page 25: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 25

Mandibular nerveMandibular nerve ,, n. mandibularisn. mandibularis�� foramen ovaleforamen ovale

�� fossa infratemporalisfossa infratemporalis

�� pars anterior et posteriorpars anterior et posterior

�� Motor branches Motor branches ––

muscles of masticationmuscles of mastication::

�� nn. temporales profundinn. temporales profundi

�� n. massetericusn. massetericus

�� n. pterygoideus lateralisn. pterygoideus lateralis

�� n. pterygoideus medialis:n. pterygoideus medialis:

�� n. musculi tensoris veli palatinin. musculi tensoris veli palatini

�� n. musculi tensoris tympanin. musculi tensoris tympani

Cranial nervesCranial nerves

Page 26: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 26

�� Sensory branchesSensory branches::�� n. buccalisn. buccalis�� n. auriculotemporalisn. auriculotemporalis�� n. lingualis n. lingualis �� chorda tympanichorda tympani

�� Mixed branchMixed branch::�� n. alveolaris inferiorn. alveolaris inferior

�� n. mylohyoideusn. mylohyoideus�� plexus dentalis inferiorplexus dentalis inferior�� n. mentalisn. mentalis

�� ganglion oticumganglion oticum �� n. auriculotemporalis n. auriculotemporalis �� gl. parotideagl. parotidea�� ganglion submandibulareganglion submandibulare �� gl. submandibularis et gl. sublingualisgl. submandibularis et gl. sublingualis

Cranial nervesCranial nerves

Mandibular nerveMandibular nerve ,, n. mandibularisn. mandibularis

Page 27: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 27

Trigeminal neuralgiaTrigeminal neuralgia�� "The Suicide Disease"The Suicide Disease““ or or tic douloureuxtic douloureux

(also known as prosopalgia)(also known as prosopalgia)� key trigger points� trigeminal nerve block

Cranial nervesCranial nerves

Page 28: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 28

�� mixed nervemixed nerve: motor root � facial (mimic) muscles,

sensory and parasympathetic root � glands

(nervus intermedius) � tongue and soft palate

�� motor nucleusmotor nucleus – in pons at the level of facial colliculus:

�� facial nucleusfacial nucleus

�� parasympathetic nucleusparasympathetic nucleus:

�� superior salivatory nucleussuperior salivatory nucleus, incl. nucl. lacrimalis

�� sensory nucleussensory nucleus – common nucleus with nn. IX and X:

�� solitary tract nucleussolitary tract nucleus

Facial nerveFacial nerve , , n. facialisn. facialisCranial nervesCranial nerves

Page 29: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 29

Facial nerveFacial nerve , , n. facialisn. facialisCranial nervesCranial nerves

�� emergenceemergence – between the olive andinferior cerebellar peduncle

� course into meatus acusticus internusmeatus acusticus internus� branch off n. intermediusn. intermedius (somatosensory)

�� geniculargenicular ganglionganglion (ganglion geniculatum)�� branches ibranches inside the internal acoustic meatusnside the internal acoustic meatus�� in the facialin the facial canalcanal:

� n. petrosus major � ganglion pterygopalatinum� n. stapedius � m. stapedius�� chorda tympanichorda tympani � n. lingualis � ganglion submandibulare

Page 30: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 30

Facial nerveFacial nerve , , n. facialisn. facialisCranial nervesCranial nerves

�� Parasympathetic innervation:Parasympathetic innervation:

� visceral efferents

�n. petrosus major� ganglion pterygopalatinum

�n. stapedius � m. stapedius

��chorda tympanichorda tympani � n. lingualis

� ganglion submandibulare

Page 31: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 31

� at exit of stylomastoid foramen:

�� n. auricularis posteriorn. auricularis posterior

�� r. digastricusr. digastricus �� r. communicansr. communicans

cum nervo glossopharyngeocum nervo glossopharyngeo

�� r. stylohyoideus r. stylohyoideus

� on the face – plexus intraparotideusplexus intraparotideus:� temporal branches, rr. temporalesrr. temporales

� zygomatic branches, rr. zygomaticirr. zygomatici

� buccal branches, rr. buccalesrr. buccales

� marginal mandibular, r. marginalis r. marginalis mandibulaemandibulae

� cervical, r. collir. colli

Nerve branches outside skullNerve branches outside skullCranial nervesCranial nerves

Page 32: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 32

�� motor innervationmotor innervation of the face�� sensory innervationsensory innervation of the anterior ⅔ of the tongue�� paralysis of cranial nerve VIIparalysis of cranial nerve VII resulting in inability to

control facial muscles on the affected side

Cranial nervesCranial nerves

Facial (BellFacial (Bell ’’s) palsys) palsy

Page 33: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 33

Cranial nervesCranial nerves

Vestibulocochlear nerveVestibulocochlear nerve� specific sense of sound and equilibrium (balance):

� vestibular nerve (upper root)

� cochlear nerve (lower root)

�� vestibular nerve:vestibular nerve:

�� ScarpaScarpa’’s ganglions ganglion (ganglion vestibulare) (ganglion vestibulare) – superior&inferior

� peripherally � receptor cells of the maculae and cristae

� centrally � vestibular nuclei in the brainstem

Page 34: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 34

Cranial nervesCranial nerves

Vestibulocochlear nerveVestibulocochlear nerve� specific sense of sound and equilibrium (balance):

� vestibular nerve (upper root)

� cochlear nerve (lower root)

�� cochlear nerve:cochlear nerve:

�� spiral ganglionspiral ganglion (ganglion cochleare) – bipolar neurons

� peripherally � hair cells of the organ of Corti

� centrally � cochlear nuclei in the brainstem

Page 35: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 35

�� Vestibular nuclear complexVestibular nuclear complex::�� superior vestibular nucleus (Bechterew)superior vestibular nucleus (Bechterew)

�� inferior vestibular nucleus (Roller)inferior vestibular nucleus (Roller)

�� medial vestibular nucleus (Schwalbe)medial vestibular nucleus (Schwalbe)

�� lateral vestibular nucleus (Deiters)lateral vestibular nucleus (Deiters)

Cranial nervesCranial nerves

Vestibular nucleiVestibular nuclei

Page 36: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 36

�� Cochlear nuclei:Cochlear nuclei:�� ventral cochlear nucleusventral cochlear nucleus

�� dorsal cochlear nucleusdorsal cochlear nucleus

Cranial nervesCranial nerves

Cochlear nucleiCochlear nuclei

Page 37: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 37

Cranial nervesCranial nerves

Glossopharyngeal nerveGlossopharyngeal nerve�� mixed branchiomeric nervemixed branchiomeric nerve – motor, somatosensory,

special visceral afferent and parasympathetic fibers

�� site of emergencesite of emergence – 3-4 rootlets in the groove betweenthe olive and inferior cerebellar peduncle

� leaves the cranial cavity through the jugular foramen

Page 38: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 38

Cranial nervesCranial nerves

Glossopharyngeal nerve nucleiGlossopharyngeal nerve nuclei�� nucleinuclei – in the medulla oblongata:

�� motormotor –– nucleusnucleus ambiguusambiguus (common with nn. X and XI)

�� parasympatheticparasympathetic –– inferior salivatory nucleus inferior salivatory nucleus

�� sensory:sensory:�� solitary tract nucleus solitary tract nucleus (common with nn. VII and X)

�� spinal trigeminal nucleusspinal trigeminal nucleus? – common sensation

� in foramen jugulare:foramen jugulare:�� superior ganglion (jugular ganglion)superior ganglion (jugular ganglion)�� inferior ganglion (petrosal ganglion)inferior ganglion (petrosal ganglion)

Page 39: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 39

Cranial nervesCranial nerves

Glossopharyngeal nerve branchesGlossopharyngeal nerve branches� muscular branchesbranches� stylopharyngealstylopharyngeal

�� sensory branches:sensory branches:�� tympanic nervetympanic nerve �� plexus tympanicusplexus tympanicus

�� carotid sinus nervecarotid sinus nerve

�� pharyngeal branchespharyngeal branches

�� tonsillar branchestonsillar branches

�� lingual branches lingual branches –– posterior posterior ⅓⅓(postsulcal) part of tongue (postsulcal) part of tongue

�� parasympathetic (secretomotor) branches:parasympathetic (secretomotor) branches:�� lesser petrosal nerve lesser petrosal nerve �� oticotic ganglion ganglion ��

auriculotemporal nerve auriculotemporal nerve �� parotid glandparotid gland

Page 40: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 40

�� mixed (mixed (pneumogastricpneumogastric) nervenerve – motor, somatosensory, special visceral afferent and parasympathetic fibers

�� emergenceemergence – below the n. IX; with 8-10 rootlets in posterolateral sulcus between the olive and inferior cerebellar peduncle

� leaves the cranial cavity through the jugular foramen

Cranial nervesCranial nerves

Vagus nerve, Vagus nerve, n. vagusn. vagus

NB:NB: Latin vagusvagus means literally "Wandering"means literally "Wandering"

Page 41: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 41

Cranial nervesCranial nerves

Nuclei and parts of the vagus nerveNuclei and parts of the vagus nerve

NB:NB: Latin vagusvagus means literally "Wandering"means literally "Wandering"

�� nucleinuclei – in the medulla oblongata:

�� motormotor –– nucleus ambiguus nucleus ambiguus (common with nn. IX and XI)

�� sensorysensory –– solitary tract nucleus solitary tract nucleus (common with VII and IX)

�� parasympatheticparasympathetic –– dorsal vagal nucleusdorsal vagal nucleus

� in foramen jugulare:foramen jugulare:�� superior (jugular) ganglionsuperior (jugular) ganglion

�� inferiorinferior (nodose)(nodose) ganglionganglion –– C2-C3

�� partsparts::

�� craniocranio--cervicalcervical

�� thoracicthoracic

�� abdominalabdominal

Page 42: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 42

Vagus nerve: cranioVagus nerve: cranio --cervical partcervical partCranial nervesCranial nerves

� branches in the jugular fossa:�� meningeal branchesmeningeal branches�� auricular branchauricular branch

�� branches in the neck:branches in the neck:�� pharyngeal branch pharyngeal branch �� branches to the carotid bodybranches to the carotid body�� superiorsuperior laryngeal nerve laryngeal nerve –– external and internalexternal and internal�� superior cardiac branchessuperior cardiac branches�� rami communicantes cum IX, XI, XIIrami communicantes cum IX, XI, XII

Page 43: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 43

� branches in the thorax:

�� recurrent laryngeal nerverecurrent laryngeal nerve �� inferior laryngeal nerveinferior laryngeal nerve

�� inferior cardiac branchesinferior cardiac branches

�� thoracic cardiac branchesthoracic cardiac branches

�� oesophageal branchesoesophageal branches

�� bronchial and tracheal branchesbronchial and tracheal branches

�� anterior&posterior pulmonary branchesanterior&posterior pulmonary branches

Cranial nervesCranial nerves

Vagus nerve: thoracic partVagus nerve: thoracic part

Page 44: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 44

� branches in the abdomen:

�� anterior vagal trunkanterior vagal trunk ��

plexus gastricus anterior:plexus gastricus anterior:

�� gastric branchesgastric branches

�� hepatic brancheshepatic branches

�� posterior vagal trunkposterior vagal trunk ��

plexus gastricus posterior:plexus gastricus posterior:

�� coeliac branchescoeliac branches

�� renal and suprarenal renal and suprarenal

branchesbranches

�� splenic branchessplenic branches

�� intestinalintestinal branchesbranches

Cranial nervesCranial nerves

Vagus nerve: abdominal partVagus nerve: abdominal part

Page 45: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 45

Accessory nerve, Accessory nerve, n. accessoriusn. accessorius� purely motormotor nervenerve – controls specific muscles of the neck

�� origin:origin:�� cranial root cranial root – smaller, part of the vagus nerve

(pars vagalis)(pars vagalis)�� spinal root spinal root –– pars spinalispars spinalis �� spinal accessory nervespinal accessory nerve

�� nucleinuclei – in the medulla and spinal cord:�� nucleus ambiguus nucleus ambiguus (common with nn. IX and X) �� spinal nucleus spinal nucleus –– in the upper in the upper spinal cordspinal cord (C1-C5)

Cranial nervesCranial nerves

Page 46: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 46

Accessory nerve, Accessory nerve, n. accessoriusn. accessorius�� two parts join in two parts join in foramen jugulareforamen jugulare

�� truncus nervi accessoriitruncus nervi accessorii

�� branches:branches:

�� internalinternal ramusramus �� n. vagus n. vagus �� n. laryngeus recurrensn. laryngeus recurrens

�� external ramus external ramus – motor supply:�� m. sternocleidomastoideusm. sternocleidomastoideus

�� m. trapeziusm. trapezius

Cranial nervesCranial nerves

Page 47: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 47

Lesions of the accessory nerveLesions of the accessory nerve�� paralysis of the trapezius muscleparalysis of the trapezius muscle

�� paralysis of the sternocleidomastoid muscleparalysis of the sternocleidomastoid muscle

Cranial nervesCranial nerves

Page 48: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 48

Hypoglossal nerveHypoglossal nerve , , n. hypoglossusn. hypoglossusCranial nervesCranial nerves

� purely motormotor nervenerve – motor nerve of the tongue�� emergenceemergence – with 10-15 rootlets in anterolateral sulcus�� nucleusnucleus – in hypoglossal triangle of the fourth ventricle:

�� hypoglossalhypoglossal nucleusnucleus – 2 cm long

� leaves cranium through canalis nervi hypoglossicanalis nervi hypoglossi

Page 49: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 49

Hypoglossal nerveHypoglossal nerve , , n. hypoglossusn. hypoglossusCranial nervesCranial nerves

�� branches:branches:�� meningeal branchmeningeal branch�� descending branch descending branch (radix superior ansae cervicalis)(radix superior ansae cervicalis)

�� muscular branches to thyrohyoid&geniohyoidmuscular branches to thyrohyoid&geniohyoid�� lingual branches to:lingual branches to:

�� styloglossusstyloglossus�� hyoglossus hyoglossus �� genioglossusgenioglossus

Page 50: 1. Cranial nerves – overview - nikolai.lazarov.pronikolai.lazarov.pro/lectures/2014-2015/medicine/neuroanatomy/11... · 1. Cranial nerves – overview: origin and peripheral distribution

Prof. Dr. Nikolai LazarovProf. Dr. Nikolai Lazarov 50

Thank youThank you……

Can have fun with aCan have fun with a--nana--toto--my!my!