1

1 2004-2005First Year Review(only Principles drugs have been updated; doesn’t include Derm)

2 AbciximabAntiplateletAnti-GPIIb/IIIa receptor antibody

3 AcetaminophenAnalgesic, Antipyretic

4 AdalimumabTNF inhibitorAnti-TNF antibodyUsed in rheumatoid arthritis

5 Adrenocorticotropin(ACTH)Anterior pituitary hormoneAnticonvulsantStimulates synthesisand release of cortisol

6 AlemtuzumabAntineoplasticAnti-CD52 antibody

7 AlfentanilOpioidGeneral anaestheticIntravenous anaesthetic

8 AllopurinolAntigoutAntineoplastic (supporting agent)Folic acid analogueXanthine oxidase inhibitor

9 AmantadineAntiviralAntiparkinsonTreatment of Influenza AInhibits replication

at the stage of uncoatingInhibits dopamine release

2

10 AmikacinAminoglycoside antibioticBactericidal protein synthesis inhibitor30S ribosomeFreezes initiation

11 Aminocaproic acid (EACA)ProcoagulantInhibitor of plasminogen activation(decreases fibrinolysis)

12 AminoglutethimideAntineoplasticImmunosuppressiveGlucocorticoid antagonistAromatase inhibitor(decreases steroid synthesis)

13 AminoglycosidesAntibioticsBactericidal protein synthesis inhibitors30S ribosomeFreeze initiation

14 AmitriptylineTricyclic antidepressant (TCA)

15 AmoxicillinPenicillin antibioticCell wall synthesis inhibitorAntiulcerAmino penicillinInhibits peptidoglycan cross-linking

16 AmphetamineIndirect sympathomimeticDrug of abuseADD treatmentStimulant

17 AmpicillinPenicillin antibioticCell wall synthesis inhibitorAmino penicillinInhibits peptidoglycan cross-linking

18 Amsacrine

3

AntineoplasticMiscellaneous

19 AngiostatinAntineoplasticAngiogenesis inhibitor

20 AnistreplaseThrombolyticStreptokinase + plasminogen

21 Anti-thymocyte globulinImmunosuppressiveAnti-T cell antibody

22 AprotininProcoagulantFibrinolytic inhibitorSerine protease inhibitor (“serpin”)Streptokinase inhibitor

23 ArgatrobanAnticoagulantDirect thrombin inhibitor

24 L-asparaginaseAntineoplasticProtein synthesis inhibitor

25 Aspirin(Acetylsalicylic acid, ASA)NSAID (acetylsalicylate)Analgesic, Anti-inflammatoryAntipyretic, AntiplateletIrreversible cyclooxygenase inhibitor

26 AtropineAnticholinergicAntimuscarinicTreatment for bradycardia, diarrhea, cholinesterase poisoning

27 AzathioprineImmunosuppressiveAntineoplasticAntimetabolite(“pseudofeedback inhibition” of HGPRT and PRP)

4

28 AzithromycinMacrolide antibioticBacteriostatic protein synthesis inhibitor50S ribosome Inhibits translocation

29 AztreonamNew β lactam antibioticMonobactam

30 BaclofenSkeletal muscle relaxantAnxiolyticGABAB agonist

31 BacitracinAntibioticCell wall synthesis inhibitorTopical, not a β lactam,Inhibits dephosphorylation of bactoprenol

32 BasiliximabImmunosuppressiveAnti-CD25 (interleukin 2 receptor)Organ transplant (antirejection)

33 Benzathine penicillin GPenicillin antibioticCell wall synthesis inhibitorInhibits peptidoglycan cross-linking Repository preparation

34 BenztropineAnticholinergicAntiparkinsonMuscarinic receptor antagonist

35 BetamethasoneAdrenocorticosteroidGlucocorticoidAnti-inflammatory steroidNot by inhalation

36 BethanecolCholinomimeticMuscarinic agonistInduces defecation and urination

5

Bronchoconstrictor

37 BleomycinAntineoplasticNatural productAntibiotic

38 BivalirudinAnticoagulantDirect thrombin inhibitor

39 BortezomibAntineoplasticProteosome inhibitor

40 BradykininInflammatory mediatorPlasma, hypotension, pain

41 BromocriptineAntiparkinsonDopamine (D2) agonistInhibits prolactin release

42 BrupropionSecond generation antidepressant

43 BuprenorphineOpioidPartial agonist

44 BuspironeSedative/hypnoticAnxiolytic

45 BusulfanAntineoplasticAlkylating agent

46 ButorphanolOpioidAnalgesicµ receptor partial agonistor antagonist

47 C3a, C5a

6

Inflammatory mediatorsAnaphylatoxinsLow molecular weight complement cleavage products

48 CarbamazepineAnticonvulsant

49 CarbenicillinPenicillin antibioticCell wall synthesis inhibitorAnti-pseudomonal penicillinInhibits peptidoglycan cross-linking

50 CarbidopaAntiparkinsonPeripheral dopa decarboxylase inhibitor

51 Carmustine (BCNU)AntineoplasticAlkylating AgentNitrosourea

52 CefaclorCephalosporin antibioticCell wall synthesis inhibitor2nd generationOral

53 CefadroxilCephalosporin antibioticCell wall synthesis inhibitor1st generationOral

54 CefepimeCephalosporin antibioticCell wall synthesis inhibitor4th generationCSF penetration

55 CefotaximeCephalosporin antibioticCell wall synthesis inhibitor3rd generationCSF penetration

56 Cefoxitin

7

Cephalosporin antibioticCell wall synthesis inhibitor2nd generation

57 CeftazidimeCephalosporin antibioticCell wall synthesis inhibitor3rd generation

58 CeftriaxoneCephalosporin antibioticCell wall synthesis inhibitor3rd generationCSF penetration

59 CefuroximeCephalosporin antibioticCell wall synthesis inhibitor2nd generationCSF penetration

60 CelecoxibNSAIDAnti-inflammatoryCyclooxygenase 2 (COX-2) inhibitor

61 CephalexinCephalosporin antibioticCell wall synthesis inhibitor1st generationOral

62 CephalosporinsAntibioticsβ lactamCell wall synthesis inhibitorsInhibit cross-linking of peptidoglycan

63 CephalothinCephalosporin antibioticCell wall synthesis inhibitor1st generationOral

64 CetirizineAntihistamineH1 antagonist

8

Non-sedating

65 Chloral hydrateSedative/HypnoticGeneral anaestheticActs on GABAA receptor complexSimilar to barbiturates

66 ChloramphenicolAntibioticBacteriostatic protein synthesis inhibitor50S ribosomeInhibits peptide bond formation

67 ChlordiazepoxideSedative/hypnoticAnxiolyticBenodiazepineActs on GABAA receptor complex

68 ChlorpheniramineClassical antihistamineH1 antagonist

69 ChlorpromazineAntipsychoticPhenothiazine

70 CiprofloxacinFluoroquinolone antibioticDNA replication inhibitorInhibits bacterial DNA gyrase

71 CisplatinAntineoplasticMiscellaneousCross-linking agent

72 ClarithromycinMacrolide antibioticBacteriostatic protein synthesis inhibitorAntiulcer50S ribosomeInhibits translocation

73 Clavulanic acidβ-lactamase inhibitor

9

Combined with antibacterials

74 ClindamycinAntibioticBacteriostatic protein synthesis inhibitor50S ribosomeAnaerobic infections

75 ClopidogrelAntiplateletADP receptor antagonist

76 CloxacillinPenicillin antibioticCell wall synthesis inhibitorPenicillinase resistant penicillinInhibits peptidoglycan cross-linking

77 ClozapineAntipsychotic

78 Cobalamin(cyanocobalamin, hydroxocobalamin)

VitaminTreatment forvitamin B12 deficiency

79 CocaineIndirect sympathomimeticDrug of abuseTopical anaestheticStimulantLocal anaesthetic

80 CodeineOpioidAnalgesicWeak agonist

81 Cortisol (Hydrocortisone)AdrenocorticosteroidGlucocorticoidAnti-inflammatory steroid

82 Cyclophosphamide

10

AntineoplasticAlkylating AgentNitrogen mustard

83 CycloserineAntibioticCell wall synthesis inhibitorSecondary TB drugInhibits formation of Park nucleotide

84 CyclosporineImmunosuppressiveAntineoplasticBinds cyclophilinInhibits calcineurin

85 Cytarabine (AraC)AntineoplasticAntimetabolite

86 DacarbazineAntineoplasticAlkylating Agent

87 DaclizumabImmunosuppressiveAnti-CD25 (interleukin 2 receptor) antibodyOrgan transplant (anti-rejection)

88 DactinomycinAntineoplasticNatural productAntibiotic

89 DalteparinAnticoagulantLMW HeparinATIII activator

90 DantroleneSkeletal muscle relaxantRyanodine receptor antagonistTreatment for malignant hyperthermia

91 DapsoneSulfone antibioticNucleic acid and

11

protein synthesis inhibitorInhibits dihydropteroate synthetaseLeprosy

92 DaunorubicinAntineoplasticAnthracycline antibioticNatural product

93 Deprenyl/selegilineAntiparkinsonMonoamine oxidase B inhibitor(MAO-I)Potentiates effects of L-Dopa

94 DesipramineTricyclic antidepressant (TCA)

95 Desmopressin acetateSynthetic analogue ofarginine vasopressinUsed in treatment of bleeding disorders

96 DexamethasoneAdrenocorticosteroidGlucocorticoidAntineoplasticAntiemeticAnti-inflammatory steroidNot by inhalation

97 DextromethorphanOpioidAntitussive

98 DiazepamSedative/hypnoticAnxiolyticAnticonvulsantBenzodiazepineActs on GABAA receptor complex

99 DiflunisalNSAIDAnalgesic, Anti-inflammatory AntipyreticCyclooxygenase inhibitor

100 Diphenhydramine

12

Classical antihistamineAntiemeticH1 antagonist

101 Diphenoxylate docusateAntidiarrhealOpiate

102 DipyridamoleAntiplateletPhosphodiesterase inhibitor(increases cAMP)

103 DoxorubicinAntineoplasticAnthracycline antibioticNatural product

104 DoxycyclineTetracycline antibioticBacteriostatic protein synthesis inhibitor30S ribosomePrevents aminoacyl tRNA attachment

105 Drotrecogin alfa(Activated Protein C)AnticoagulantMany actionsTreatment for septic shock

106 EdrecolomabAntineoplasticAnti-17-1A antibody

107 EnfluraneGeneral anaestheticInhaled anaesthetic

108 EnoxaparinAnticoagulantLMW HeparinATIII activator

109 EntacaponeAntiparkinsonPeripheral catechol-o-methyltransferase inhibitor

13

110 Ephedra(Ma Huang)Dietary supplementAmphetamine-like stimulant

111 EptifibatideAntiplateletGPIIb/IIIa antagonist

112 ErythromycinMacrolide antibioticBacteriostatic protein synthesis inhibitor50S ribosomeInhibits translocation

113 Erythropoietin (EPO)CytokinePrimary regulator of RBC synthesis

114 EtanerceptTNF inhibitorTumor necrosis factor receptor+ Fc portion of IgGUsed in rheumatoid arthritis

115 EthanolDrug of abuseSedative

116 EthosuximideAnticonvulsant

117 EtomidateGeneral anaestheticIntravenous anaesthetic

118 EtoposideAntineoplasticNatural productPlant alkaloid

119 FentanylOpioidAnalgesicµ receptor agonist

14

120 FexofenadineAntihistamineH1 antagonistNon-sedating

121 FlumazenilBenzodiazepine antagonistActs on GABAA receptor complex

122 5-FluorouracilAntineoplasticAntimetaboliteThymidylate synthase inhibitor

123 FluoxetineAntidepressantSelective serotonin reuptake inhibitor (SSRI)

124 FlurazepamSedative/HypnoticBenzodiazepineActs on GABAA receptor complex

125 Fluorinated Quinolonesciprofloxacin, norfloxacin

AntibioticsDNA replication inhibitorsInhibit bacterial DNA gyrase

126 Folic acidVitaminTreatment for folicacid deficiency

127 GefitinibAntineoplasticMiscellaneousTyrosine kinase inhibitor

128 GemcitabineAntineoplasticAntimetabolite

129 GemtuzumabAntineoplastic

15

Anti-CD33 antibody

130 GentamicinAminoglycoside antibioticBactericidal protein synthesis inhibitor30S ribosomeFreezes initiation

131 Ginko bilobaDietary supplementTreatment of Alzheimer symptoms

132 GlutethimideSedative/Hypnotic

133 HaloperidolAntipsychotic

134 HalothaneGeneral anaestheticInhaled anaesthetic

135 HeparinAnticoagulantATIII activator

136 HeroinDrug of abuseOpioid

137 HirudinAnticoagulantDirect thrombin inhibitor(DTI)

138 HistamineInflammatory mediatorStored in mast cells and basophils

139 HydrocortisoneAdrenocorticosteroidGlucocorticoidAnti-inflammatory steroid

140 4-HydroxycoumarinOral anticoagulant

16

Vitamin K synthesis inhibitor

141 HydroxyureaAntineoplasticMiscellaneousRibonucleotide reductase inhibitor

142 HydroxyzineClassical antihistamineH1 antagonist

143 IbritumomabAntineoplasticAnti-CD20 antibody

144 IbuprofenNSAIDAnalgesic, Anti-inflammatory AntipyreticReversible cyclooxygenase inhibitor

145 ImatinibAntineoplasticMiscellaneousTyrosine kinase inhibitor

146 Imipenem/CilastatinNew β lactam antibioticCilastatin inhibits akidney dipeptidase that inactivates imipenem

147 ImipramineIndirect sympathomimeticTricyclic antidepressant (TCA)Antimicturant

148 IndomethacinNSAIDAnalgesic, Anti-inflammatory, AntipyreticCyclooxygenase inhibitorTocolyticUterine relaxant

149 InfliximabTNF inhibitorAnti-TNF monoclonal antibodyTreatment of IBD

17

150 Interferon alphaAntiviral for hepatitisAntineoplasticCytokineAnti-angiogenesis

151 Interleukin 2Cytokine Antineoplastic

152 Interleukin 11Cytokine Antineoplastic (supporting agent)

153 Interleukin 12Cytokine Antineoplastic (supporting agent)

154 IrinotecanAntineoplasticNatural product

155 IsofluraneGeneral anaestheticInhaled anaesthetic

156 KallidinInflammatory mediatorPlasma, hypotension, pain

157 Kava kavaDietary supplementStress relief andtreatment of insomnia

158 KetamineGeneral anaestheticDrug of abuseSedative

159 KetoprofenNSAIDAnalgesic, Anti-inflammatory,AntipyreticCyclooxygenase inhibitor

18

160 LepirudinAnticoagulantDirect thrombin inhibitor (DTI)

161 LevodopaAntiparkinsonDopamine precursor

162 LeucovorinAntineoplastic (supporting agent)Folic acid analogue(used in methotrexate rescue)

163 Leukotriene B4 (LTB4)Inflammatory mediatorLipoxygenase productof arachidonate metabolismChemotactic

164 Leukotrienes C4, D4, E4(LTC4, LTD4, LTE4)Inflammatory mediatorsCysteinyl leukotrienesPeptidyl leukotrienesSRS-ALipoxygenase products ofarachidonate metabolism

165 LidocaineClass I antiarrhythmicLocal anaestheticNa+ channel blocker(activated and inactivated channels)

166 LinezolidOxazolidinone antibioticProtein synthesis inhibitor50S ribosomal subunit

167 LithiumAntidepressantUsed to treatmanic/depressive disorder

168 Lomustine (CCNU)Antineoplastic

19

Alkylating AgentNitrosourea

169 LoperamideAntidiarrhealOpiate

170 LoratidineAntihistamineH1 antagonistNon-sedating

171 LorazepamAnxiolyticAnticonvulsantBenzodiazepineActs on GABAA receptor complex

172 Lysergic acid diethylamide(LSD)Drug of abuseHallucinogen

173 Macrolideserythromycin, azithromycin, clarithromycin

AntibioticsBacteriostatic protein synthesis inhibitors50S ribosome

174 MarijuanaDrug of abuseCannabinoid

175 MechlorethamineAntineoplasticAlkylating AgentNitrogen mustard

176 MeclofenamateNSAIDAnalgesic, Anti-inflammatory, AntipyreticCyclooxygenase inhibitor

177 MelphalanAntineoplasticAlkylating Agent

20

Nitrogen mustard

178 MeperidineOpioid analgesicµ receptor agonist

179 MepivacaineLocal anaesthetic

180 MeprobamateSedative/hypnoticAnxiolytic

181 6-MercaptopurineAntineoplasticAntimetabolite(“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)

182 MesnaAntineoplastic (supporting agent)Prevent hemorrhagic cystitisdue to cyclophosphamide

183 MethicillinPenicillin antibioticCell wall synthesis inhibitorPencillinase resistant penicillinInhibits peptidoglycan cross-linking

184 MethotrexateImmunosuppressiveAntineoplasticFolic acid antagonistDihydrofolate reductase inhibitor

185 MethylprednisoloneAdrenocorticosteroidGlucocorticoidAnti-inflammatory steroidNot by inhalation

186 MetronidazoleAntibioticAntiparasiticAntiulcerAnaerobesReduction leads to intermediates

21

that damage DNA

187 MinocyclineTetracycline antibioticBacteriostatic protein synthesis inhibitor30S ribosomePrevents aminoacyl tRNA attachment

188 Mitomycin CAntineoplasticNatural productAntibiotic

189 MetamphetamineDrug of abuseStimulant

190 MethadoneOpioidµ receptor agonist

191 MontelukastLeukotriene inhibitorLTR1 and LTD4 antagonistAsthma treatment

192 MorphineOpioidAnalgesicµ receptor agonist

193 Muromonab-CD3ImmunosuppressiveMouse monoclonal anti-CD3 antibodyOrgan transplant (anti-rejection)

194 MycophenolateImmunosuppressiveInhibits inosine monophosphate dehydrogenase activity

195 NalbuphineOpioid antagonistµ receptor antagonist

196 NalmefeneOpioid antagonist

22

197 NalorphineOpioid antagonist

198 NaloxoneOpioid antagonist

199 NaltrexoneOpioid antagonist

200 NaproxenNSAIDAnalgesic, Anti-inflammatory, AntipyreticCyclooxygenase inhibitor

201 NafcillinPenicillin antibioticCell wall synthesis inhibitorPenicillinase resistant penicillinInhibits peptidoglycan cross-linking

202 NeomycinAminoglycoside antibioticBactericidal protein synthesis inhibitor30S ribosomeFreezes initiationTopical

203 NeostigmineAnticholinesteraseVasodilatorTreatment for myaesthenia gravisPromotes defecation and urinationBronchoconstrictor

204 NetilmicinAminoglycoside antibioticBactericidal protein synthesis inhibitor30S ribosomeFreezes initiation

205 NicotineCholinomimeticDrug of abuseNicotinic receptor agonist(skeletal muscle contraction)

23

StimulantSmoking cessation medication

206 Nitrous oxideGeneral anaestheticInhaled anaesthetic

207 Non-steroidalAnti-inflammatory Drugs (NSAIDs)Analgesic, Anti-inflammatory, AntipyreticCyclooxygenase inhibitors

208 NorfloxacinFluoroquinolone antibioticDNA replication inhibitorInhibits bacterial DNA gyrase

209 NortriptylineTricyclic antidepressant (TCA)

210 OmalizumabAnti-asthmaAnti-IgE antibody

211 OxacillinPenicillin antibioticCell wall synthesis inhibitorPencillinase resistant penicillinInhibits peptidoglycan cross-linking

212 OxazepamSedative/hypnoticAnxiolyticBenzodiazepineActs on GABAA receptor complex

213 OxybutininAnticholinergicMuscarinic receptor antagonistPrevents urination

214 OxycodoneAnalgesicOpioid agonist

215 Oxytetracycline

24

Tetracycline antibioticBacteriostatic protein synthesis inhibitor30S ribosomePrevents aminoacyl tRNA attachment

216 PaclitaxelAntineoplasticNatural productPlant alkaloid (taxane)

217 PalivizumabAntiviralMonoclonal antibody againstthe surface ofrespiratory syncytial virus

218 Para-aminosalicylic acidAntibioticNucleic acid andprotein synthesis inhibitorInhibits dihydropteroate synthetaseSecondary TB drug

219 ParaldehydeSedative/Hypnotic

220 Penicillinsβ lactam antibioticsCell wall synthesis inhibitorsInhibit cross-linking of peptidoglycan

221 Penicillin GPenicillin antibioticCell wall synthesis inhibitorAcid labileInhibits peptidoglycan cross-linking

222 Penicillin VPenicillin antibioticCell wall synthesis inhibitorMore acid resistant than Penicillin GInhibits peptidoglycan cross-linking

223 PentazocineOpioid analgesicµ receptor partial agonist or antagonist

25

224 PentobarbitalSedative/HypnoticBarbiturate

225 PentostatinAntineoplasticMiscellaneousEnzyme inhibitor(blocks purine synthesis)

226 Phencyclidine (PCP)Drug of abuseHallucinogen

227 PhenobarbitalSedative/HypnoticAnticonvulsantBarbiturate

228 PhenytoinAnticonvulsantClass I antiarrhythmicNa+ channel blocker(inactivated channels)

229 PhytonadioneVitamin KWarfarin antagonist

230 PiperacillinPenicillin antibioticCell wall synthesis inhibitorAnti-pseudomonal penicillinInhibits peptidoglycan cross-linking

231 PiroxicamNSAIDAnalgesic, Anti-inflammatory, AntipyreticCyclooxygenase inhibitor

232 Platelet Activating Factor (PAF)Inflammatory mediatorLipidHypotensive

233 Polymyxin B

26

AntibioticDisrupts gram negative cell membraneBinds phosphatidylethanolamineBactericidal

234 PramipexoleAntiparkinsonDopamine agonist (non-ergot)

235 PrednisoneAdrenocorticosteroidGlucocorticoidAntineoplasticAnti-inflammatoryNot by inhalation

236 PrimidoneAnticonvulsant

237 ProbenecidUricosuricAdjunct in penicillin therapy

238 ProcaineLocal anaesthetic

239 Procaine Penicillin GPenicillin antibioticCell wall synthesis inhibitorRepository preparationInhibits peptidoglycan cross-linking

240 ProcarbazineAntineoplasticMiscellaneousProbably acts as alkylating agent

241 PromethazineClassical antihistamineAntipsychoticAntiemeticH1 antagonist

242 PropofolGeneral anaestheticIntravenous anaesthetic

27

243 Prostaglandin D2 (PGD2)BronchoconstrictorCyclooxygenase product of arachidonate metabolism

244 Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost)Oxytocic prostaglandinInflammatory mediatorCyclooxygenase product of arachidonate metabolismUterine stimulantCervical ripener

245 Prostaglandin F2 (PGF2)Inflammatory mediatorCyclooxygenase product of arachidonate metabolism

246 Prostaglandin I2 (PGI2)Inflammatory mediatorInhibits platelet aggregation Cyclooxygenase product of arachidonatemetabolism

247 Protamine SulfateHeparin antagonist

248 Quinopristin/DalfopristinStreptogramin antibioticProtein synthesis inhibitor50S ribosomal subunit

249 ResperidoneAntipsychotic

250 RifampinAntibioticNucleic acid synthesis inhibitorInhibits DNA dependent RNA polymeraseMajor drug for TB

251 RituxumabAntineoplasticAnti-CD20 antibody

252 RofecoxibNSAIDAnti-inflammatory

28

Cyclooxygenase 2 (COX-2) inhibitor

253 RopiniroleAntiparkinsonDopamine agonist (non-ergot)

254 Sargramostim(GM-CSF)Colony stimulating factorWBC (granulocyte and macrophage)stimulant

255 SertralineAntidepressantSelective serotonin reuptake inhibitor (SSRI)

256 SildenafilVasodilatorPromotes erection

257 Silver sulfadiazineSulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitorInhibits dihydropteroate synthetaseTopical

258 SirolimusImmunosuppressiveBinds FKBP, inhibits mTOR (mammalian kinase target of rapamycin) & cell cycle progression

259 SpectinomycinAntibioticBacteriostatic protein synthesis inhibitor30S ribosome

260 St. John’s WortDietary supplementAntidepressant

261 StreptokinaseThrombolytic

262 StreptomycinAminoglycoside antibiotic

29

Bactericidal protein synthesis inhibitor30S ribosomeFreezes initiation

263 SufentanilOpioidGeneral anaestheticIntravenous anaesthetic

264 SulfacetamideSulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitorInhibits dihydropteroate synthetaseTopical

265 SulfadoxineSulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitorDihydropteroate synthetase inhibitor

266 SulfamethoxazoleSulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitorInhibits dihydropteroate synthetase

267 SulfisoxazoleSulfonamide antibioticNucleic acid andprotein synthesis inhibitorInhibits dihydropteroate synthetase

268 SulfonamidesAntibioticsNucleic acid andprotein synthesis inhibitorsInhibit dihydropteroate synthetase

269 SulindacNSAIDAnalgesic, Anti-inflammatory, AntipyreticCyclooxygenase inhibitor

270 TacrolimusImmunosuppressive

30

AntineoplasticBinds FKBP (FK506 binding protein)Inhibits calcineurin

271 TemazepamSedative/HypnoticBenzodiazepineActs on GABAA receptor complex

272 TetracaineLocal anaesthetic

273 TetracyclineAntibioticBacteriostatic protein synthesis inhibitorAntiulcer30S ribosomePrevents aminoacyl tRNA attachment

274 ThalidomideAntineoplasticLeprosy treatmentAnti-angiogenicAnti-TNFα

275 6-ThioguanineAntineoplasticAntimetabolite(“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)

276 ThiopentalGeneral anaestheticUltra-short-acting barbiturate

277 ThioridazineAntipsychoticPhenothiazine

278 ThiotepaAntineoplasticAlkylating agent

279 ThiothixeneAntipsychotic

280 Thromboxane A2 (TXA2)

31

AutacoidPromotes platelet aggregationCyclooxygenase product of arachidonate metabolism

281 TiclopidineAntiplateletADP receptor antagonist

282 TicarcillinPenicillin antibioticCell wall synthesis inhibitorAnti-pseudomonal penicillinInhibits peptidoglycan cross-linking

283 Tissue plasminogen activatorsThrombolytics

284 TobramycinAminoglycoside antibioticBactericidal protein synthesis inhibitor30S ribosomeFreezes initiation

285 TolterodineAnticholinergicMuscarinic receptor antagonistPrevents urination

286 TositumomabAntineoplasticAnti-CD20 antibody

287 TranylcypromineAntidepressantMonoamine oxidase inhibitor (MAO-I)

288 TrastuzumabAntineoplasticAnti-HER2 antibody

289 TriazolamSedative/HypnoticBenzodiazepineActs on GABAA receptor complex

290 TrifluoperazineAntipsychotic

32

Phenothiazine

291 TrihexyphenidylAntiparkinsonAntimuscarinic

292 TrimethoprimAntibioticProtein and nucleic acidsynthesis inhibitorFolic acid antagonistInhibits bacterial dihydrofolate reductase

293 TripelennamineClassical antihistamineH1 antagonist

294 Tumor necrosis factor αCytokineAntineoplastic

295 UrokinaseThrombolytic

296 Valproic acidAnticonvulsant

297 VancomycinAntibioticInhibits cell wall synthesisNot a β lactam

298 VigabatrinAnticonvulsantIrreversible GABA aminotransferase inhibitor

299 VinblastineAntineoplasticVinca alkaloidNatural product

300 VincristineAntineoplasticVinca alkaloidNatural product

301 Warfarin

33

AnticoagulantVitamin K synthesis inhibitor

302 ZafirlukastLeukotriene inhibitorLTR1 and LTD4 antagonistAsthma treatment

303 ZileutonLeukotriene inhibitor5-lipoxygenase inhibitorUsed in asthma

304 ZolpidemSedative/HypnoticNon-benzodiazepine