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DefinitionsBiospecimen
Uses, Storage
Ethical, Legal, Social, Cultural
Issues
(Optional)InformedConsent
(Optional)Pharmaco-genetics
2
skin, hair, nails, cheek cells, blood, urine
saliva
3
What types of tissues are used as
biospecimens?
4
Mature cells do not have a
nucleus (thus no DNA)
5
What are mature red blood cells?
6
*****
Daily Double
*****
7
Contains the genetic code for
humans
8
What is DNA? What are the
chromosomes? What is the nucleus?
9
Also called "repository"
10
What is a "biobank"?
11
Specimens do not require informed
consent for use in studies
12
What is a biobank?
13
To find better treatments for
diseases
14
What is a purpose for
biospecimen research?
15
Minus 80 degree freezer
16
How / where are biospecimens
stored?
17
Does NOT require informed consent for future studies
18
What is a biobank / repository?
19
blood draw, biopsy, surgery
20
What are some sources for
biospecimens?
21
Handling during collection,
temperature fluctuations,
exposure to air
22
What can damage the
quality of biospecmens?
23
Havasupai Tribe
24
What is the name of the tribe that won a
lawsuit in 2010 about unethical genetic research study?
25
Arizona State University
26
What is the name of the research
institution involved with the 2010
Havasupai lawsuit?
27
Diabetes, obesity, cancer, heart
condition studies
28
In what types of study topics / diseases are
most tribes and urban Indian programs
interested?
29
Research specimens that are
used to create patents for drugs or
devices
30
What type of biospecimen research studies do most tribal
nations oppose?
31
The tribe thought the specimens were for 1
study only and researchers thought specimens were for repository / biobank
32
What was a key issue within the
Havasupai lawsuit against ASU?
33
Who owns the specimen? Where and how stored?
Who benefits from patents resulting
from the research?
34
What are examples of tribal issues with
biospecimen research?
35
For example: Your name,
address, tribal affiliations
36
What are examples of
"private" information?
37
Privacy, safety, confidentiality of
study participants
38
What is the role / purpose of the
IRB?
39
Requires questions / answers and
discussion between participant and
recruiter
40
What is the informed consent
PROCESS?
41
Only a signed form, a legal
contract, a binding document
42
What is NOT true about informed
consent?
43
Safer drugs, fewer side effects, tailor
treatments to tumor pathways
44
What are goals of pharmaco-genetics?
45
Science is close to its goals for only a
small portion of medications so far
46
What is tailoring drug
medications?
47
Included in codeine,
acetaminophen, diazapam,
Erythromycin
48
What is Cytochrome
P-450?
49
The enzyme required to metabolize
codeine into morphine
51
Balance results in the liver unable to convert codeine into morphine
52
What is likely if the body has more 3A4
than 2D6?