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09_10 Sliding filament theory
Slide number: 1
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Tropomyosin
Troponin complex
Actin monomers
Actin filament
Myosin filament
ADP + P ADP + P
09_10 Sliding filament theory
Slide number: 2
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Tropomyosin
Troponin complex
Actin monomers
Actin filament
Myosin filament
Ca+2
Muscle contractionRelease of Ca+2 from sarcoplasmic reticulum exposes binding sites on thin filament:
Ca+2 binds to troponin complex
Tropomyosin pulled aside
Binding sites on actin filament exposed
1 Exposed binding sites on actin allow the muscle contraction cycle to occur
Ca+2 Ca+2 Ca+2
ADP + P ADP + P
ADP + P ADP + P
Ca+2 Ca+2 Ca+2
09_10 Sliding filament theory
Slide number: 3
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
2 Cross-bridge binds actin to myosin
ADP + P ADP + P
ADP + P ADP + P
Contraction cycle
P PADP ADP
09_10 Sliding filament theory
Slide number: 4
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
3 Cross-bridge pulls actin filament (power stroke), ADP and P released from myosin
ADP + P
ADP + P ADP + P
Contraction cycle
Contraction cycle
P PADP ADP
ATP ATP ATP
09_10 Sliding filament theory
Slide number: 5
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
ATP
4 New ATP binds to myosin, causing linkage to release
09_10 Sliding filament theory
Slide number: 6
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
ATP ATP ATP
5 ATP splits, whichprovides power to“cock” the myosincross-bridge
ADP + P ADP + P
Contraction cycle
Ca+2 Ca+2 Ca+2
09_10 Sliding filament theory
Slide number: 7
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
ADP + P ADP + P
ADP + P ADP + P
Contraction cycle
09_10 Sliding filament theory
Slide number: 8
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Ca+2 Ca+2 Ca+2
Ca+2
ATP
Active transport of Ca+2 into sarcoplasmic reticulum, which requires ATP, makes myosin binding sites unavailable.
Muscle relaxation
ADP + P ADP + P
ADP + P ADP + P
09_10 Sliding filament theory
Slide number: 9
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
1 Exposed binding sites on actin allow the muscle contraction cycle to occur
Ca+2 Ca+2 Ca+2
ADP + P ADP + P
Contraction cycle
2 Cross-bridge binds actin to myosin
ADP + P ADP + P
P PADP ADP
3
ADP + P
Cross-bridge pulls actin filament (power stroke), ADP and P released from myosin
ATP ATP ATP
ATP
4 New ATP binds to myosin, causing linkage to release
ADP + P ADP + P
5 ATP splits, whichprovides power to“cock” the myosincross-bridge
09_10 Sliding filament theory
Slide number: 10
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Tropomyosin
Troponin complex
Actin monomers
Actin filament
Myosin filament
ADP + P ADP + P
Ca+2
Muscle contractionRelease of Ca+2 from sarcoplasmic reticulum exposes binding sites on thin filament:
Ca+2 binds to troponin complex
Tropomyosin pulled aside
Binding sites on actin filament exposed
1
Ca+2 Ca+2 Ca+2
ADP + P ADP + P
Ca+2
ATP
Active transport of Ca+2 into sarcoplasmic reticulum, which requires ATP, makes myosin binding sites unavailable.
Muscle relaxation
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