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Protecting ourglobal potential

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The industrysmost comprehensive

portfolio oftarget-specificbiorational solutions

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Active Ingredient

Bacillus thuringiensis subsp. israelensis Strain AM65-52 & SA3A

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Active Ingredient Bacillus sphaericus 2362Strain ABTS-1743

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Active Ingredient Bti, Strain AM65-52 +Bs 2362, Strain ABTS-1743

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FORMULATION KEY FEATURES HABITATS

Aqueous Suspension/SuspensionConcentrate (AS/SC)

Economical,ready-to-spray,liquid formulation

Open habitats withminimal vegetation

Water DispersibleGranule (WG/WDG)

Storage stabilityof a dry product;easy to mix;excellentsuspension;

WHOPES; can beapplied directly intocontainers

Open habitats withminimal vegetation;artificial and naturalcontainers

Granule(G/GS/GR/CG)

Penetratesvegetation

Vegetated or openhabitats

Water Soluble Pouch(WSP)

Easy-to-useformulation fordirect application

Catch basins,storm drains

Direct TabletsEasy-to-useformulation fordirect application

Artificial and naturalcontainers

Pellet (PT)Sinks directly tofeeding zone of midges

Lakes, pondsand other aquatichabitats wherenon-biting midgesare found

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The Gap

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The Solution

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MetaLarv S-PT

Valent BioSciences 10

S-PT = Spherical Pellet

Coin added for sizecomparison

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MetaLarv S-PT


1

2

3

The first release provides an initialflash of (S)-methoprene for immediatecontrol of mosquitoes; rate of releasenot dependent on water temperature

The second release takes place when the floodwaters rise, providing sustainedcontrol throughout the duration of the flood

MetaLarv S-PT remains effective after thewaters recede, ready to release (S)-methopreneduring the next flooding cycle (third release)

Triple Release Technology

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The Spherical AdvantageMetaLarv S-PT

Up to 42 days residualin floodwater habitats

Up to 28 dayspre-flood efficacy

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A promise for

global health

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The scienceof specificity

Naturally occurring soil bacteria

Bacillus thuringiensis subspecies israelensis (Bti) strain AM65-52 and strain SA3A

Bacillus sphaericus 2362 (Bs)strain ABTS-1743

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Active Ingredient Bti, Strain AM65-52

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The ProcessCUSTOMER-CENTRIC

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MetaLarv S-PT


What is MetaLarv S-PT?

VBCs first biological pre -flood insecticide for

floodwater areas Features the active ingredient (S)-methoprene

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Mode of Action

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Provides up to 42 days residual control (length of control dependent on

local conditions)

Can be applied up to 28 days prior to flood

Remains effective after flood/dry-down/re-flood event

Improved coverage at low rates

Greater aerial swaths in test conducted

Less respirable and particulate dust

Greater application flexibility

Low risk to non-target organisms

Advantages

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Field Efficacy Direct Applications

Demonstrated effective emergence inhibition: Applied at 2.5, 5, 10 lbs/acre Water up to 24" deep Mosquito species

Aedes aegypti Aedes taeniorhynchus Culex quinquefasciatus

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Field Efficacy Pre-flood Applications

Tested under a variety of conditions: Single flood and flood/dry-down/re-flood events

Applied 14, 17, 20, or 41 days prior to flooding Mosquito species

Aedes vexans Ochlerotatus dorsalis

Effective inhibition at flood onset and throughoutflood cycles At 10 pounds per acre, nearly 100% emergence inhibition

was achieved through three flood cycles over 42 days

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Improved coverageat low rates

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Particle Count

MetaLarv S-PT: 18 times more pellets per gram

MetaLarv

S-PT 125 - 150 per gram

Standard (S)-methoprene Pellet 5 - 10 per gram

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Coverage: Standard (S)-methoprene Pellet

Square = 1 square meterRate: 2.5 lbs/acre

1 m

1 m

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Coverage: MetaLarv S-PT

Square = 1 square meterRate: 2.5 lbs/acre

1 m

1 m

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Manufacturingconsistency

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Uniformity

MetaLarv

S-PT Standard (S)-methoprene Pellet

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Standard Size

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Payload

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Clean formulation

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Dust Pour

(S)-methoprene XRG(S)-methoprene Pellet MetaLarv S-PT

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Clean formulation

Shape improves:1. flow; minimize swath

skips at low rates AND2. attrition

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Protect Your Rotor Blades

MetaLarv

S-PT

Sand-based product (S-methoprene XRG)

0 sec 15 sec 30 sec 45 sec 60 sec

0 sec 15 sec 30 sec 45 sec 60 sec

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30-42 days residualin floodwater habitats




Clean formulation



Shape improves:Aerodynamics; allows

for greater aerial swaths

in tests conducted

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Helicopter Application (Isolair)

Swath characterizations conducted with MMCD in2009, 2010 and 2011

Peter DeChant estimates an effective swath of 80 ft.with a coefficient of variation of < 30.MetaLarv S- PT produces the best swath Ive seen at80+ ft via rotary wing Isolair applications

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Even though the flying conditionswere not perfect, we are pleasedwith the results of our evaluation.The swath pattern of the combinedruns is an improvement over our

current pellet formulation. MMCD, 2009


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Clean formulation



Shape improves:Aerodynamics; allows

for greater aerial swaths

in tests conducted

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How may we help you?

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Appendix

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Field EfficacyDirect Applications

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Field Efficacy: Direct Applications

EI of Aedes taeniorhynchus after direct application(5 and 10 lbs/acre) to microcosms in California

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EI of Aedes aegypti after direct application(2.5 lbs/acre) to containers in Malaysia

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EI of Culex quinquefasciatus after direct application(10 lbs/acre) to large plastic barrels in California

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Field EfficacyPre-floodApplications

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Field Efficacy: Pre-Flood Applications

EI of Aedes vexans after pre-flood backpack application(4 lbs/acre) to floodplains in Minnesota

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EI of Aedes vexans after 17-day pre-flood application(2.5 and 5 lbs/acre) to flood/dry-down/re-floodmicrocosms in Oregon

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EI of Aedes vexans after 20 and 41 days pre-floodapplication (5 lbs/acre) to flood/dry-down/re-floodmicrocosms in Washington

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EI of Ochlerotatus dorsalis after 14-day pre-floodapplication (10 lbs/acre) to flood/dry-down/re-floodmicrocosms in Washington

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Worker Exposure

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Dust Index

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Backpack Pellet Distribution

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Backpack Pellet Distribution

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Backpack Distribution: Variation

Documents

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