01.11.10Lecture 1: An Introduction to Cell Biology

Professors

Cell Biology half:Steve Rogers

422 Fordham HallSrogers@bio.unc.edu

Office hours by appointment

Development half:Jason Reed

104 Coker HallJreed@email.unc.edu

Office hours: TBA

Teaching Assistants

Alli McMullenallison_mcmullen@med.unc.edu

Kyle Grodekylegrode@gmail.com

Office hours: TBA

Course format

• Lectures: MWF 11 to 11:50 AM

• Recitations begin January 19th and attendance is required. Students will turn in weekly problem set and TAs will go over the answers.

Class Website

• http://www.bio.unc.edu/Courses/2010Spring/Biol205-006/

• Lecture notes will be posted the day before the lecture (.PDFfile)

• Problem sets will be posted on Friday afternoon and will be due the following week in recitation

Required Textbooks

• Essential Cell Biology, 3rd edition, by Alberts et al. (first half of the course)

• Principles of Development, 2nd edition, by Wolpert (second half of the course)

Grading Policies

• 4 non-cumulative exams count towards 92% of the final grade. Weekly problem sets count towards 8% of final grade.

• Tests will cover information in lectures, recitations, and reading assignments

• Make-up exams will be given only for valid reasons (medical excuses)

• Regrade requests must be submitted prior to the next exam

Policies

• UNC-CH honor code. All exams are to be taken without books notes, or other people and you will be asked to sign a pledge to that effect.

• Please turn off your cell phones during class

Advising for Biology Majors

•

• Degree Programs • Biology General Education Requirements • Bachelor of Arts in Biology • Bachelor of Science in Biology • Minor in Biology

• Advising-How to find a Biology adviser• Undergraduate Advising • Abbey Fellow-Dr. Elaine Yeh yeh@email.unc.edu

• Resources• Biology Majors' Manual• Study Abroad • Registrar's Online Services •

• Research Opportunities • Undergraduate Research • Biology Honors Program Funding & Outreach • Office of Undergraduate Research •

Please go to the Biology Department websitehttp://www.bio.unc.edu/Undergraduate/ to find information about:

What is cell Biology?

What is cell Biology?

Divisions in the biological sciences are based on degrees of “complexity”

Biochemistry & Biophysics: study of the structures and behaviors of molecules

Microbiology: study of prokaryotic cells and viruses

Cell Biology: study of the structure and function of eukaryotic cells

Developmental Biology: study of how communities of cells form tissues, organs, and build an organism

Anatomy & Physiology: study of the structures and functions of tissues and organs

Zoology & Plant Biology: study of the organisms

Ecology: study of how organisms interact with each other and with their environments

Levels of Biological Complexity

1.Biochemistry & Biophysics2.Microbiology3.Cell Biology4.Developmental Biology5.Anatomy & Physiology6.Zoology & Plant Biology7.Ecology

Understanding cell biology is important to understand the basis for disease

• Hypercholesterolemia (defective uptake of lipoproteins)• Cystic fibrosis (misfolding of key protein)• Hypertension (defective cell-cell adhesion in the kidney)• Congenital heart defects (errors in cell migration during development)• Myscular dystrophy (defective attachment of the plasma membrane to the

cytoskeleton)• Lysosomal storage disease (defective intracellular transport of enzymes)• Food-borne illness (Salmonella, E. coli)• Cancer (errors in cell division, migration, cell polarity, growth, etc)• Ageing• All disease states are caused at the cellular level

Understanding cell biology is important to make informed decisions on social issues

• Genetic engineering of foods• Biotechnology• Organ growth in culture• Stem cell research• Forensic sciences• Archaeology