00 Uap Course Outline Spring 07 01

The University of Asia PacificPharmacy Department

COURSE OUTLINEFALL 2006

Course Teacher-1 AFM Nazmus Sadat Course Teacher-2 AFM Shahidud Daula (RONI)

Phone: 9015281 Phone:

Mobile: 0187580453 Mobile: 01710783919

E-mail: [email protected] E-mail: [email protected]

Pharm 105 Introduction to Pharmacy LECT. NO.

Credit 2

CT-1 1. The History and Evolution of Pharmacy: The Drug-Taking Animal, Prehistoric Pharmacy, Antiquity, The Middle Ages, The Renaissance And Early Modern Europe, The Era Of Count And Pour, The Emergence Of Clinical Pharmacy, A Chronology For Pharmacists 8

CT-1 2. Complementary and Alternative Medicine, such as, Ayurvedic, Unani, Homoeopathic and other systems of medicines. 6

CT-2 3. Definition of drugs, Sources and classification of drugs, Official, nonofficial and unofficial drugs. Basic introduction on different types of dosage forms, Routes of drug administration, fate of drug after administration. 6

CT-1 4. An introduction to pharmacy and pharmacy education. Definition of Pharmacy, subjects taught in pharmacy etc. 1

CT-2 5. Pharmacy Profession and Ethics. Scope of pharmacy profession in different areas, such as, community, industry, government, etc. Ethics of pharmacy. 5

CT-2 6. Information resources for pharmaceutical science. Sources of drug information, the pharmacopoeias, codex etc. Internet resources on pharmaceutical and drug information. 3

Recommended Books:

1. Remington's Pharmaceutical Sciences.

Evaluation: Students will be evaluated through- Special Instructions:

Events Grading Scheme

Midterm 30% (To be announced, Class hour)

Final Term 50% (To be announced centrally)

Assessment 20%

Total: 100%

Signature & DateCourse Teacher 1.


Signature & DateHead, Pharmacy



Course Teacher-1 Masuda Khatun Course Teacher-2: Mesbahuddin Talukder

Phone: Phone:

Mobile: 0152383933 Mobile: 01712143717

E-mail: masuda [email protected] E-mail: [email protected]

Pharm 111 Inorganic Pharmacy-I LECT. NO.

Credit 2

CT-2 1. Structure of atoms: An elementary treatment of theories of atomic structure, quantum numbers, Pauli’s exclusion principle, origin of spectral lines. 5

CT-1 2. Chemical bonds: Electronic concept of valence, different types of chemical bond e.g. ionic, covalent, co-ordinate covalent, metallic, dipole, hydrogen bond etc., theories of covalent bonding and hybridization. 5

CT-2 3. Classification of elements: Modern periodic table and periodic law, variation of properties within periods and groups, usefulness and limitations of periodic table. 4

CT-2 4. Chemistry of alkali and alkaline earth metals: General characteristics of alkali and alkaline earth metals, chemistry of group IA & II elements and their compounds, comparison of alkaline earth metals with alkali metals, physiological importance and pharmaceutical applications of alkali and alkaline earth metals.

6

CT-1 5. Chemistry of co-ordination compounds: Ligands or coordinating groups, monodentate or unidentate ligands, polydentate ligands, co-ordination number, co-ordination sphere, chelation, factors affecting the stability of metal complexes, application of chelate formation, isomerism of co-ordination compounds, Warner's co-ordination theory, Sidgwick’s electronic concept of co-ordinate bond in co-ordination compounds, valence bond theory, pharmaceutical importance of chelation.

7

CT-1 6. Chemical Impurities: The occurrence of impurities in medicinal chemicals and substances used in pharmaceuticals. 3

Recommended books:1. Modern Inorganic Chemistry - S. Z. Haider2. Modern Inorganic Chemistry - Madan3. Inorganic Chemistry - Lee4. Bentley and Driver’s Textbook of Pharmaceutical Chemistry5. Modern Inorganic Pharmaceutical Chemistry - Discher6. Textbook of Inorganic Pharmaceutical Chemistry – Rogers7. Inorganic Medicinal & Pharmaceutical Chemistry- Block & Wilson





Assessment 20%

Total: 100%




Course Teacher-1 Md. Ziaur Rahman Khan Course Teacher-2: Mesbahuddin Talukder



Phone: Phone:

Mobile: 0186431648 Mobile: 01712143717


Pharm 113

Organic Pharmacy

LECT. NO.

Credit 3

CT-2 1. Introduction: History of organic chemistry, classification of organic compounds, systematic naming of organic compounds, electro negativity, polarity of bonds, polarity of molecules, structures and physical properties, intermolecular forces, carbonium ions, carbanion ions, electrophiles, nucleophiles, free radicals, hydrogen bonding, melting point, boiling point, solubility etc.

5

CT-2 2. Chemistry of aliphatic compounds 15

CT-2 (a) Alkanes, alkenes and alkynes: (b) Aldehydes and ketones: (c) Alcohols, ethers and epoxides: (d) Carboxylic acids: (e) Amines:

CT-2 3. Chemistry of aromatic compounds: Aromaticity, general chemistry of aromatic compounds, with special reference to biological and pharmaceutical importance. 10

a) Simple aromatic compoundsb) Aromatic halogen compoundsc) Aromatic nitro compoundsd) Aromatic amino compoundse) Diazonium salts and their related compoundsf) Sulphonic acidsg) Phenolsh) Alcohols, aldehydes, ktones and quininesi) Aromatic acids

Recommended Books:1. Organic Chemistry - Morrison and Boyd2. Textbook of Organic Chemistry - Bahl and Bahl3. Organic Chemistry, Vo1. I & II-Finar4. Organic Chemistry - Feiser and Feiser5. An Introduction to Organic Chemistry - Bahl and Bahl6. Introduction to organic laboratory techniques- Pavia and Lampman





Assessment 20%

Total: 100%






Course Teacher-1 Dr. Abdur Rashid Course Teacher-2: Mohammad Rashedul Islam

Phone: Phone:

Mobile: Mobile: 01715028898

E-mail: E-mail: [email protected]

Pharm 131 Pharmacognosy-I LECT. NO.

Credit 3CT-1 1. Definition and scope of Pharmacognosy, its historical development. 1

CT-1 2. Structures of the plant cell as a unit, its function and form; Introduction to the general structure of the morphological parts of the plants. 1

CT-2 3. Crude drugs: A general view of their origin, distribution, cultivation, collection, drying and storage, commerce and quality control.; Classification of drugs; Preparation of drugs for commercial market; Evaluation of crude drugs; Drug adulteration. 6

CT-2 4. Plant analysis: Extraction, separation, chromatography; types of plant constituents, comparative phytochemistry and chemotoxicity. 5

CT-1 5. Phytochemistry and pharmaceutical uses of the following plant constituents along with consideration of some important drugs of each group:(A). Lipids: Castor oil, Linseed oil, Coconut oil, Olive oil, Peanut oil, Chaulmoogra oil and beeswax. (B). Carbohydrate and related compounds: Sugars and sugar containing drugs- sucrose, dextrose, glucose, fructose etc. (C). Polysaccharide containing drugs- starches, dextrins etc. (D). Gums and mucilages- tragacanth, acacia, sterculia, sodium alginate, agar cellulose.

CT-2 6. Plants in complimentary and traditional systems of medicine: Introduction, different types of alternative systems of treatments (eg. Ayurvedic, Unani, Homeopathic medicine.), contribution of traditional drugs to modern medicines. Details of some common indigenous traditional drugs: Punarnava, Vashaka, Anantamul, Arjuna, Chirata, Picrorhiga, Kalomegh, Amla, Asoka, Bahera, Haritaki, Tulsi,Neem, Betel nut, Joan,Karela, Shajna, Carrot, Bael, Garlic, Jam and Madar. 4

CT-2 7. Vitamins and vitamin containing few selected animal drugs: Cod liver oil, Shark liver oil, Hilsha fish/liver oil etc. 4

Recommended Books:

1. Pharmacognosy - Tyler and Brady.2. Pharmacognosy - Trease and Evans.3. Pharmacognosy - Clause and Tyler.4. Study of some medicinal plant of Bangladesh- BCSIR, Chittagong.





Assessment 20%

Total: 100%






Course Teacher-1 Mr.Mesbah Uddin Talukdar Course Teacher-2: Md. Saiful Islam

Phone: Phone: 88-02-7540933

Mobile: Mobile: 0152455915

E-mail: E-mail:[email protected]

Pharm 115 Physical Pharmacy-I LECT. NO.

Credit 3

CT-1 1. Chemical equilibrium: Law of mass action, determination of equilibrium constant, heterogeneous equilibrium and homogeneous equilibrium, the Le Chartelier principle, Van’t Hoff equation. 5

CT-1 2. Chemical thermodynamics: Introduction, the first law of thermodynamics, work, energy and heat, work of expansion, internal energy, determination of internal energy, heat change at constant volume and constant pressure, thermodynamic reversibility, work of isothermal reversible expansion of gases, the maximum work under the isothermal expansion of a gas, heat capacities, difference between molar heats, Adiabatic processes, Joule- Thomson experiment. 5

Thermo chemistry and thermo chemical law: Second law of thermodynamics, Carnot’s cycle and efficiency of a perfect engine, the concept of entropy and entropy changes for an ideal gas expansion, entropy changes of materials under various conditions, free energy and work functions, Gibbs Helmholtz equation, free energy changes under equilibrium, the Clausius-Claperon equation. 5

CT-2 3. Phase Equilibria: Phase, components and degree of freedom, the phase rules and its thermodynamic deviation, the phase diagrams of water and sulphur systems, partially miscible liquid pairs: the phenol and water, nicotine water system; Completely miscible liquid pairs and their separation by fractional distillation; freeze drying (lyophilization). 3

CT-2 4. Solution: Types and properties of solution; units of concentration; ideal and real solution; Henry’s law; distribution of solids between two immiscible liquids; distribution law; partition coefficient; solvent extraction. 3

CT-2 5. Solution of Electrolytes: Concentration expressions, equivalent weights, Colligative properties of dilute solution, Osmotic pressure, measurement of osmotic pressure, Van’t Hoff and Morse equations for osmotic pressure, Coefficients for expressing Colligative properties. 3

CT-2 6. Ionic Equilibria: Modern theories of acids, bases and salts, acid-base Equilibria, Sorensen’s pH scale, Species concentration as s function of pH, calculation of pH, acidity constants, 3

CT-2 7. Buffer and Isotonic Solutions : Buffer equations, Buffer capacity, Buffer in Pharmaceutic and Biologic systems, Buffered isotonic solutions, methods of adjusting tonicity and pH. 3

Recommended Books:

1. Principle of Physical Chemistry- Haque & Nawab

2. Physical Pharmacy- Martin

3. Elements of Physical Chemistry- Lewis & Glasstone

4. Physical Chemistry- Atkins







Assessment 20%

Total: 100%






Course Teacher-1 Parvin Akter Course Teacher-2: Mohammad Rashedul Islam


Mobile: 0152404308 Mobile: 01715028898


Pharm 117 Inorganic Pharmacy-II LECT. NO.

Credit 2

CT-2 1. Inorganic Medicinal Agents:

Gastrointestinal Agents: Antacids (Al, Mg preparations with application) & adsorbents, saline cathartics, their preparations with applications. 5

Agents for bone and bone growth: Calcium preparations. 1

Haematinic Agents: Iron and iron preparations. 2

Dental Preparations: Fluorides and other anti-caries agents, 3

Topical Agents: Zinc oxide, Iodine preparations, and other Anti-microbial, Astringents & Protective. 3

CT-2 2. Major Intra & Extra-cellular Electrolytes: 4

Major Physiological Ions, Electrolytes used for replacement therapy, Electrolytes used in acid-base therapy, Electrolytes combination therapy etc.

CT-1 3. Essential trace elements for nutrition and growth and their functions: Copper, cadmium, zinc, molybdenum, selenium, silicone etc. and their preparations. 4

CT-1 4. Radioactivity and radiopharmaceuticals: Introduction, types of radiation and their properties, radioactive decay, half-life, average life, modes of radioactive decay, interaction of radiation with matter, measurement of radioactivity, radiation hazard and radiological safety, biological effects of radiation, control of radiation exposure, storage of radioactive materials, medical applications of radionuclides, official radioactive compounds and their importance, toxicity of radioactive isotopes. 8





Assessment 20%

Total: 100%






Course Teacher-1 Kohinur Begum Course Teacher-2:


Mobile: 01713080285 Mobile:

E-mail: [email protected] E-mail:

Pharm 119 Pharmaceutical Microbiology-I LECT. NO.

Credit 3

CT-1 1. Introduction to Microbiology: Microbiology as a field of biology, place of microbiology in the living field, prokaryotic and eucaryotic protests, group of microorganisms, areas of microbiology, application of microbiology. 3

CT-1 2. History and Evolution of microbiology: Spontaneous generation and biogenesis; germs theory of diseases; pure culture concept; immunization; widening horizons. 3

CT-1 3. Microscopic observations of microorganisms: Bright field, dark field, fluorescence and phase contrast microscopy, electronic microscopy, preparations of microscopic examinations, wet mount and hanging drop techniques, fixed and stained smears, microbiological stains: simple and differential staining methods. 5

CT-1 4. Bacteria: Nomenclature of bacteria, morphology and fine structures, nutritional requirements, bacteriological media, growth and reproduction, quantitative measurements of bacterial growth, maintenance and preservation of pure culture of bacteria.

5. Microorganisms other than bacteria (brief study):

CT-1 a) Yeasts –Types, morphology, reproduction and physiology, pathogenic yeasts. 2

CT-1 b) Rickettsiae – Introduction, characteristics of rickettsiae, pathogenic rickettsiae, laboratory diagnosis of rickettsial diseases. 2

CT-1 c) Viruses – History of viruses, classification of viruses, characteristics of viruses, reproduction and cultivation of viruses, virus inhibition, control of virus infections, bacterial virus or bacteriophages, morphology and composition, cultivation of bacterial viruses, reproduction of bacterial viruses. 4

Recommended books:

1. Microbiology - Pelczar, Kreig and Khan.

2. Microbiology : An Introduction- Tortora, Funkee and Case

3. Biology of Microorganisms-T.D. Brock

4. Industrial Microbiology - Prsecott and Dunn.

5. Pharmaceutical Microbiology - Harris.

6. Fundamental Principles of Bacteriology - Salle.

7. Dispensing for Pharmaceutical Students - Cooper and Gunn.

8. Microbiology-Whistrech

9. Modern Medical Microbiology- Maj. Gen. M.R. Chowdhury.







Assessment 20%

Total: 100%






Course Teacher-1 AFM Nazmus Sadat Course Teacher-2: Mohmmad Shahriar

Phone: 9015281 Phone: 8118845

Mobile: 0187580453 Mobile: 01199844259


Pharm 121 Physiology-I LECT. NO.

Credit 3

CT-1 1. General PhysiologyPhysiology and its scope in pharmacy. Structure of cell, its various organelles and functions, cell division, body fluid compartments and its composition, transport across cell membrane and membrane potentials, homeostasis. 5

CT-2 2. Blood systemComposition and functions of blood. Plasma and its components, plasma proteins and their functions. Blood coagulation, blood transfusion and blood groups, hemolysis, ESR. Blood forming cells- characteristics, functions, their formation and destruction. Hemoglobin- its structure, properties, function and hemoglobin derivatives. Anemia- definition and classification, causes and clinical features of various anemia. 7

CT-2 3. Cardiovascular systemHeart- Structure and blood circulation. Cardiac muscle, their properties, origin of heart beat and action potential. Cardiac cycle, Heart sounds, cardiac output, ECG, Regulation of cardiac function. Blood pressure- types, significance, measurement and regulation. Hypertension-types and causes. 7

CT-1 4. Digestive systemStructure of different parts of alimentary system, gastrointestinal motility and its control, swallowing and defecation. Secretion of digestive juices from saliva, gastric, pancreatic, intestinal glands and bile. Functions of digestive juices and their mechanism and regulation of secretions. Digestion and absorption of various foodstuffs. Liver- it’s function, formation of bile and its circulation. 5

CT-1 5. Respiratory system Organs of respiratory system and its structure. inspiration and expiration, mechanism of respiration, pulmonary ventilation, ventilation volumes. Gaseous exchange through lungs, carriage of O2 and CO2. Hypoxia- causes and classification. 6

Recommended Books:

1. Human Physiology Vol. I & II – C.C. Chatterjee

2. Textbook of Medical Physiology – Guyton

3. Review of Medical Physiology- W.F. Guangm





Assessment 20%

Total: 100%






Course Teacher-1 Hamidur Rahman Gazi Course Teacher-2:Parvin Akter

Phone: 8018784 Phone:0152404308

Mobile: 0189453442 Mobile:0152404308


Pharm 123 Basic Anatomy LECT. NO.

Credit 2

1. Tissue: Definition and classification of tissue. Definition, classification, characteristics, distribution, minute structures and functions of different tissue. Bone and cartilage. 1

2. Alimentary system-oral cavity, pharynx, esophagus , stomach, small intestine, caecum, appendix, colon, sigmoid, rectum, anal canal. 4

3. Cardiovascular system- Heart, ascending aorta, arch of the aorta, descending thoracic aorta, abdominal aorta. 3

4. Respiratory system-nose, pharynx, larynx, trachea, bronchus, lung. 3

5. Urinary system-kidney, ureter, urinary bladder, urethra 3

6. Reproductive system: Female-ovary, uterus with fallopian tube, cervix, vagina; Male- Testis, ductus diferens, seminal vesicle, prostate, urethra. External genitalia: male- scrotum, penis. female-Labium majora, L.minora, clitories vaginal orifice. 4

7. Nervous system- CNS: Brain & spinal cord; PNS: spinal nerve & autonomic nervous system (sympathetic & parasympathetic) 3

8. Endocrine gland - Pituitary gland, thyroid & parathyroid gland, pancreas, adrenal gland, ovary, testis. 3

9. Exocrine gland - Parotid gland, submandibular gland, pancreas. 2

10. Metabolic organ - Liver with gall bladder. 2

11. Reticulo endothelial system - spleen, thymus, tonsil, lymph node, bone marrow. 2





Assessment 20%

Total: 100%






Course Teacher-1 Mohmmad Kaisarul Islam Course Teacher-2:




MST 201 Basic Mathematics & Statistics LECT. NO.

Credit 3

Section A: Mathematics:

1. Graphs and gradients: (a) Rectangular co-ordinates, curve fitting gusting first degree equation in both variables, determination of slope, intercept and points of intersection, equation of first degree in both x and y (circle), ellipse, rectangular hyperbola etc. (b) Exponential and logarithmic curves, graphical solution equation, graphical solution of simultaneous equation. (c) Arithmetic progression, geometric progression, permutation, combination, the binomial theorem and exponential theorem. 2

2. Calculus: (a) Rate of process, rules of differentiation, successive and partial differentiation, differentiation of a function of a function relation between the derivatives of inverse function. (b) Rules of integration- integration as a summation, area under a curve, integration by partial fraction, graphical integration. 3

3. Matrices: Addition, subtraction and multiplication of matrices, unit matrix, row transformation, determinants, inverse of a matrix, solution of equation by matrix. 1

Section B: Statistics:

1. Graphical and diagrammatic representation- Graphs and diagrams. 2

2. Measurement of central tendency – Arithmetic mean, geometric mean, harmonic mean, median and mode. 2

3. Measures of dispersion – Range of mean deviation, variance, coefficient of variance, standard deviation. 3

4. Moments, Skewness and kurtosis. 3

5. Probability distribution – The normal, binominal and Poisson distribution, derivation, means and variances. 2

6. The basic ideas of significance test – Simple significance tests based on the normal distribution, comparison with a known standard, comparison of means of two large samples. 2

The use of ‘t’ test for small samples, importance of small sample comparison of sample mean with a standard, comparison of means of two small sample (unknown variances- assumed equal, not assumed equal) confidence limits. 2

X2 –tests of goodness of fit and homogeneity introduction to general idea, testing the fit of a whole frequency distribution to data, tests of homogeneity, variance ratio test. 1

7. The correlation of measurement – General notion of correlation, calculation of correlation coefficient. 2

8. Regression analysis – Basic idea of regression, calculation of regression coefficient, standard error and significance test. Partial correlation and multiple regression with two and more than two independent variables. 2



9. Simple experimental design and the analysis of variances – Introduction, completely randomized design, randomized block design, testing the homogeneity of variances. 1

10. Introduction to factorial experiments – Principle basic ideas, notation in 2n factorial, scope of more advanced designs. 1

11. Random samples and random numbers- the need and use, representative samples. 1





Assessment 20%

Total: 100%






Course Teacher-1 Dr. Mehdi Masud Course Teacher-2: Ziaur Rahman Khan

Phone:- Phone: -

Mobile: 01199105163 Mobile: 0186431648

E-mail: E-mail: [email protected]

Pharm 215 Physical Pharmacy – II LECT. NO.

Credit 3

1. Kinetics:

(A) Physical degradation of Pharmaceutical products: loss of water, absorption of water, loss of volatile constituents, polymorphism, color change.

(B) Chemical degradation: hydrolysis, oxidation, isomerization, polymerization, Decarboxylation, factors affecting chemical degradation etc.

(C) Chemical kinetics: Definitions, rates and orders of reactions, methods for determination of orders of reactions, influence of temperature on rate of reactions, theories of reaction rates, decomposition of pharmaceutical products, accelerated test for physical, chemical and photochemical stability, stability aspects of formulations, marketed products and clinical supplies, shelf life determination.

2. Interfacial phenomena: Adsorption and Interface, Freundlich and Langmuir isotherm, BET equation, Electrical properties of interfaces, electrical double layer, Nernst and zeta potential, Gibbs equation, spreading, surface active agents, Emulsifiers, detergents and antifoaming agents, surfactants and drug activity, surfactants and pharmaceutical products.

3. Rheology and rheology of dispersed system: Newtonian liquids, Non-Newtonian materials, yield value, plastic & pseudo plastic flow, dilatant and thixotropic flow, viscosity of suspending agents.

4. Colloids: Classification, preparation, electrical and optical properties, sedimentation, Stoke’s law, stability of colloidal dispersion, protective colloid, sensitization, dialysis, donnan membrane equilibrium, application and uses of colloidal preparation in pharmacy.

5. Electrochemistry: Electrical units and their interrelation, Faradays laws of electrolysis and electrochemical equivalents, electrolytic conduction, equivalent conductance and the related facts, conductometric titrations, transference numbers and their determination.

6. Electrochemical cells: Electrode and cell potentials, energies involved in electrode processes, reference electrodes, buffer solutions and measurement of PH; Potentiometric titrations and oxidation- reduction systems, concentration cells.

7. Micromeritics: Importance of particle size determination, Different means of expressing particle size, Methods of particle size determination, optical and electron microscope studies, coulter counter methods, Laser beam technique, Sieve analysis, sedimentation methods, particle shape and surface area, Measurement of particle surface area.





Assessment 20%

Total: 100%






Course Teacher-2 AFM Shahidud Daula Course Teacher-2:

Phone: Phone:



Pharm 217 Biochemistry and cellular biology LECT. NO.

Credit 2

1. Introduction to cell: Differences between prokaryotic cells and eukaryotic cells, structure and functions of mitochondria and chloroplasts, cytoskeleton, cell development and differentiation. 4

2. Plasma membrane, cell walls and cell surface: Principle of semi-permeability, active transport, endocytosis, exocytosis, bacterial, fungal and plant cell walls. 3

3. Nuclear structure and function: Cell division and cell cycle, mitosis and meiosis, structure and function of chromosomes. 3

4. Proteins: Important bonds in protein, important functions of protein in biological system, importance of amino acid sequence in protein structure, different amino acids structures and functions, peptide bond, disulfide bridge in protein structure, peptide bond is rigid and planner, a helix, b sheet, hairpin turn, denaturation and renaturation of protein, proteins are rich in hydrogen-bonding potentiality, different structures of protein, conformational change of protein, gel electrophoresis, 2-D gel electrophoresis, purification of protein, synthesis of protein, protein sequencing, recombinant DNA technology for protein sequencing. 8

5. Nucleic acids: Importance of nucleic acid study, different bases of DNA/RNA, nucleotide, nucleoside, structures of DNA, DNA chain has polarity, AT/GC structure, melting point of DNA, physical states of DNA, Replication, discovery of DNA polymerase I and III, mRNA, hybridization studies of mRNA, synthesis of mRNA, recombinant DNA technology, restriction enzymes, promoter region of DNA, RNA synthesis termination, tRNA, role of tRNA in protein synthesis, codons, DNA sequencing. 6

6. Enzymes: Definition, activation energy and enzymes, specificity of enzyme, regulation of enzymes activity, enzymes and reaction equilibria, enzyme kinetics, enzyme inhibition, common features of enzymes, enzyme cofactors & coenzymes. 5

Recommended Books:

1. Concepts in Biochemistry: - Rodney Boyer. 2nd Edition

2. Principle of Biochemistry – Leninger

3. Microbiology: An Introduction: Tortora, Funkee and Chasei

4. Biochemistry: Harper





Assessment 20%

Total: 100%






Course Teacher-1 Dr Mahboob Hossain Course Teacher-2: Mohammad Shahriar

Phone: 8651017 Phone: 8118845

Mobile: 0152324230 Mobile: 01199844259


Pharm 219 Pharmaceutical Microbiology -II LECT. NO.

Credit 2

CT- 1. Infectious diseases and causative organisms. 1

CT- 2. Basic concepts of Immunology: Infection Pathogenicity, virulence immunity. 3

CT- 3. Immunological Products: Active antigenic products, attenuated, inactivated and extract, viral and bacterial. Passive products, gamma globulin. 2

CT- 4. Sterilization: (a) Sterilization by dry heat: principle, hot air oven, method of use, applications, advantages and disadvantages of sterilization by moist heat, factors affecting sterilization by moist heat, principle of sterilization by stem under pressure, (b) Sterilization by filtration; (c) Sterilization by radiation; (d) Sterilization by gas. 5

CT- 5. Sterility testing and LAL testing methods of pharmaceutical products 3

CT- 6. Microbiological assay of antibiotics: Introduction, reference standard and units of activity, agar diffusion assay, theory of zone formation, factors affecting diffusion assay, Dose response curve, large plate assay using Latin square design, statistical interpretation of microbiological assay methods. 2

CT- 7. Microbiological monitoring methods for pharmaceutical industry: Different methods of microbial monitoring systems for environment in pharmaceutical industry. 2

CT- 8. Disinfectants and Antiseptics. 1

1





Assessment 20%

Total: 100%






Course Teacher-1 Dr.Mahboob Hossain Course Teacher-2: Masuda Khatun

Phone: 8651017 Phone:0152383933

Mobile:0152324230 Mobile:0152383933

E-mail:[email protected] E-mail:[email protected]

Pharm 221 Physiology– II LECT. NO.

Credit 3

CT-1 1. Nervous system

Neuron- properties, classification and functions. Neuroglial cells and their functions. Nerve fibers-Definition, types, properties of nerve fibers, origin and propagation of nerve impulses across nerve fibers, action potential. Synapse- classification, structure, properties and functions. Neurotransmitters- classifications and functions, never endings.

Different types of sensations- Mechanism and properties of sensations, Receptors- definition, classifications, properties and functions.

Reflex and reflex arc , their classifications, properties and components of reflex arc. Principal division of nervous system – CNS and PNS. Functions of different parts of CNS. Ascending and descending tracts of spinal cord. Differences between – somatic & autonomic, and sympathetic & parasympathetic nervous system. Cranial and spinal nerves & their functions. Regulation of autonomic nervous system. Muscle tone- definition & regulation. CSF- definition , composition and function.

CT-2 2. Endocrine System

Different endocrine glands & their structure & functions of pituitary, thyroid, parathyroid, adrenal & pancreatic glands. Functions & regulation of secretion of hormones. Abnormal hormone secretions.

CT-2 3. Excretory System

Structure of kidney, nephron & its different parts. Renal circulation- its regulation & measurements. Renal clearance & its importance. Urine- its composition & properties. Counter current mechanism. Role of kidney in acid-base balance of blood & in maintenance of plasma volume.

CT-2 4. Reproductive System

Testis & accessory reproductive systems & their functions. Male hormones and their functions. Spermatogenesis and its hormonal regulation.

Organs of female reproduction system and their functions. Menstruation cycle, different phases & its regulation. Ovogenesis & ovulation and its control. Female sex hormones & their functions, Pregnancy and lactation & their hormonal control.

CT-1 5. Regulation of body temperature

Heat production & heat dissipation. Role of hypothalamus & other nerve factors in body temperature regulation. Abnormalities in body temperature regulation.

Recommended Books:

1. Human physiology (vol. I & II) - C. C. Chatterjee.

2. Medical Physiology – Guyton.

3. Text book of Medical physiology – Ganon.

4. Practical physiology – C. L. Ghai.







Assessment 20%

Total: 100%






Course Teacher-1 Md. Sharifur Rahman Course Teacher-2:Parvin Akter

Phone: Phone:0152404308

Mobile: 01711807630 Mobile:0152404308

E-mail: E-mail:[email protected]

Pharm 231 Pharmacognosy- II LECT. NO.

Credit 2

1. Glycosides and glycoside containing drugs. Classifications, source and use of different types of glycosides.

1. Isothiocyanate: Mustard.

2. Cyanogenetic: Wild Cherry.

3. Antharaquinone glycosides: Cascara sagrada, aloe, senna, rhubarb.

4. Saponins: Sarsaparila, glycyrrhiza, dioscorea.

5. Cardiac: Digitalis, strophanthus, squill.

2. Alkaloids: Distribution, properties, tests, extraction, structure types and classification. The details of the following:

1. Pyridine, piperidine: Areca, conium

2. Tropane: Belladonna, Stramonium, hyoscyamus and coca.

3. Quinoline: Cinchona.

4. Isoquinoline: Ipecac, opium.

5. Indole: Rauwolfia, nux-vomica, ergot.

6. Imidazole: Pilocarpus.

7. Steroidal: Veretrum viride, aconite.

8. Purine bases: Coffee, tea.

9. Lupinane: Lupinus

3. Volatile oils and related terpenoids: Methods of obtaining volatile oils; Chemistry of the volatile oils and their medicinal and commercial uses.

4. Phenolic compounds and tannins: Chemical nature and test for tannins, some tannin containing drugs such as Nutgall and Catechu.

5. Resin and resin combinations (resin, oleoresin, oleo gum resin, balsam): Jalap, Cannabis, Capsicum, Ginger, Myrrh, Tolu Balsam, and Benzoin.

6. Herbs as health foods: Alfa alfa, Apricot pits, Arnica, garlic, onion, Ginseng, Spiriluna Fenugreek, Sassafras and Honey.

7. Poisonous plants ant natural pesticides: Datura, Poison Hemlock, Water Hemlock, Foxglove (Digitalis), Ipomoea, Tobacco, Poppy, Pyrethrum flower, Derris and Lanchocarpus, Red Squll, Strychnine etc.

Recommended Books:

1. Pharmacognosy – Tyler and brady.

2. Pharmacognosy – Trease and evans.

3. Pharmacognosy – Clause and Tyler.

4. Textbook of Pharmacognosy – Willis.



5. Practical Pharmacognosy – Zafar & Gandhi.





Assessment 20%

Total: 100%






Course Teacher-1 Jakir Ahmed Chowdhury Course Teacher-2:

Phone:7219747 Phone:



Pharm 241 Pharmaceutical Technology-I LECT. NO.

Credit 3

1. Liquid dosage forms: Solution and Elixirs, theory of solution, different factors affecting solution process, advantages and disadvantages, formulation consideration, manufacturing considerations, packaging of liquids, preservation and stability aspects, Quality control of liquids.

2. Dispersed system:

(a) Properties of dispersed systems: Theoretical aspects of suspension, emulsion and colloids, surface char and zeta potential, Inter- particle force, crystal growth, wetting, adsorption at solid-liquid interface, surface and interfacial tension, flocculation and coalescence.

(b) Suspension: Advantages and disadvantages, aggregated and dispersed system, formulation of suspension, Manufacturing of suspension, stability of suspension, Evaluation and quality analysis of suspension, Rheological consideration, illustrative examples.

(c) Emulsion: Definition and applications, advantages and disadvantages, theory of emulsion, formation of emulsion, Classification of emulsifying agents, HLB values of surface active agents, formulation of emulsion, manufacturing of emulsion, stability of emulsion, Evaluation and quality analysis of emulsion, Rheological considerations, illustrative examples.

3. Semisolids (Ointments, paste, gels): Structure of skin, percutaneous absorption of drugs, definition and classification of semisolid preparations, classification of bases, formulation, manufacturing, consideration, evaluation and quality analysis of semisolid preparations.

4. Suppositories: Drug absorption from colon, classification of suppositories, merits and demerits of suppository, suppository bases, formulation, manufacturing and testing of suppositories.

Recommended Books:

1. Dispensing for pharmaceutical students-Cooper & Gunn

2. American Pharmacy – Sprowl.

3. Remington’s Pharmaceutical Sciences.

4. Dispensing of medication- Husa & Martin.

5. Pharmaceutical Practice-Aulton

6. An introduction to Pharmaceutical Formulations- Fishburn

7. An introduction to Pharmaceutical Productions-Polderman

8. The Extra Pharmacopoeia- Martindale

9. Bentey’s Textbook of Pharmaceutics

10. Tutorial Pharmacy-Cooper & Gunn







Assessment 20%

Total: 100%






Course Teacher-1 Prof. Dr. Rebeca Banoo Course Teacher-2:

Phone: 9664877( R ) Phone:



Pharm 243 Pharmaceutical Analysis– I LECT. NO.

Credit 3

1. Aqueous Acid-Base Titration: Definition, distribution of acid-base species with PH of the medium, acid-base titrimetry for determination of weekly acidic and basic pharmaceuticals, Indicators (theories) and their selection, applications.

2. Oxidation-Reduction Titration: Principles and concepts, determination involving potassium permanganate, potassium dichromate, potassium bromate, Iodiometric and iodiometric determination, miscellaneous oxidation and reduction titration, indicators, applications.

3. Complexometric Titration: Introduction to complexometric titration, complexes and chelates, stability of complex ions, titration based on complex formation, types of complexometric titration, techniques employed in chelometric titration, methods of end point detection, titration selectivity and masking reagents.

4. Non aqueous Acid-Base Titration: Theoretical considerations and principles, Bronsted-Lowry theory of acids and bases, non aqueous solvents, titration of weak acids and weak bases, application and scope of non aqueous titration.

5. Potentiometric titration: Introduction, theory and principles, electrochemical cells and half-cells, electrodes, measurement of potential, application of potentiometric titration.

6. Amperometric titration: Introduction, theoretical considerations, instrumentation, general polarographic analysis, amperometric titration using one and two electrodes.

7. Aquametry: Principle and scope, Physical methods of water determination, chemical method of water determination, Karl-Fischer procedure –principle, chemistry, methodology, equipment, end point detection and limitation.

8. Testing of Pharmaceutical and potable waters: Test for waters according to BP and USP, Total Organic Carbon (TOC) equipment and methods, Biological Oxygen Demand (BOD) and Chemical Oxygen Demand (COD).

9. Short study of (I) Refractometry (II) Polarimetry (III) Nephlometry.(IV) Particle analysis methods, such as, coulter counter and laser beam particle analyzers.

Recommended Books:

1. A Textbook of Pharmaceutical Analysis- K.A. Connors

2. Quantitative Pharmaceutical Analysis- Chatten

3. Quantitative Inorganic Analysis vol. I & II- Vogel

4. United State Pharmacopoeia

5. British Pharmacopoeia.

6. Quality Control in Pharmaceutical Industry- M.S. Cooper







Assessment 20%

Total: 100%






Course Teacher-1 Irin Dewan Course Teacher-2

Phone: Phone:


E-mail: E-mail:

Pharm 251 Basic Pharmaceutics LECT. NO.

Credit 3

CT-1 1. Pre-formulation: Preliminary evaluation and molecular optimization, bulk characterization of the material and polymorphism, thermal properties, particle characterization, bulk density, powder flow properties, solubility analysis, Pka

determination, PH solubility profile, effect of temperature, solubilization, partition coefficient, dissolution, stability analysis, solution stability, solid state stability. 5

CT-1 2. Chemical and Physical incompatibility. 4

CT-1 3. Pharmaceutical excipients: Chemistry, Physical properties and uses of following excipients, acidifying agents, air displacement agents, alkalizing agent, antifoaming agents, antimicrobial preservatives, antioxidants, buffering agents, chelating agent, colors, complexing agents, emulsifying agents, flavoring agents and perfumes, Humectant, ointment bases, solvents, Stiffening agents, Wetting and solubilizing agent. 6

CT-1 4. Basic principles of compounding and Dispensing: Weight, measures and units calculation for compounding and dispensing, fundamental operation in compounding, good pharmaceutical practices in compounding and dispensing, containers and closures for dispensed products, responding to the prescription, Labelling of dispensed medications. 5

CT-1 5. Pharmaceutical Calculations:

Mathematical principles, common and decimal fractions, exponents and power and root, logarithmic calculations, reducing and enlarging formulas, ratio and proportions, percentage calculations, ratio strength, stock solution, parts per million, dilution and concentration, temperatures, dosage calculations. 6

CT-1 6. Polymer Science for pharmaceuticals

Pharmaceutical applications, physical, chemical and mechanical properties, molecular weight and distribution, polymer solution properties, plasticization and elastomers. 4

Recommended Books:

1. Dispensing for pharmaceutical students-Cooper & Gunn

2. American Pharmacy – Sprowl.







9. Bentey’s Textbook of Pharmaceutics

10. Tutorial Pharmacy-Cooper & Gunn







Assessment 20%

Total: 100%






Course Teacher-1Dr. Abul Hasnat Course Teacher-2:


Mobile:0152432671 Mobile:

E-mail:[email protected] E-mail:

Pharm 261 Pharmacology-I LECT. NO.

Credit 3

1. Definition of Pharmacology, drug, medicine, pro-drug, pharmacokinetics, pharmacodynamics, agonist, synergism,side effect, toxicity, teratogenicity, drug interaction, drug tolerance, drug dependence, drug abuse, idiosyncrasy, dose, dosage form, absorption, distribution, bioavailability, distribution, protein binding, metabolism & excretion, Routes of drug administration.

2. Basic concept of drug action: receptor, nature of receptor, drug antagonism, Relation between drug dose & clinical response.

3. Signalling mechanism and drug action, legand gated channels, G-proteins and second messengers.

4. Drugs for peptic ulcer: antacid, H2-receptor, proton pump inhibitors, PG analogues, mucosal-protective agent, Anti Helicobacter pylori agents.

5. Anticoagulant: Heparin, calcium complexing agents, Heparin, oral anticoagulants

6. Autacoids: Amine, lipid & peptide autacoids.

7. Haematinic drugs: Iron, vit B12 , folic acid erythropoietin

8. Sedative & hypnotic drugs: Benzodiazepine & Barbiturates.

9. CNS stimulant drugs: Strychnine, xanthine & methylxanthine, amphetamine, nicotine.

10. Chemotherapy of parasites: Drugs used in helminthiasis, malaria, leishmaniasis & trichomoniasis.

Recommended Books:

1. Pharmacological basis of therapeutics-Goodman & Gillman.

2. Medical Pharmacology-Katzung.

3. Medical Pharmacology-Meyer.

4. Medical Pharmacology-A. Goth.

5. Pharmacology & Pharmacotherapeutics-R.S. Satosker.





Assessment 20%

Total: 100%






Course Teacher-1 Mr.Saiful Islam Course Teacher-2:

Phone: 88-02-7540933 Phone:



Pharm 271 Pathology LECT. NO.

Credit 2

1. Definition and scope of pathology 1

2. General concept of disease

3. Cellular injury and adaptation 6

4. Inflammation 3

5. Pathological calcification 2

6. Body defense mechanisms 2

7. Nutritional diseases 3

8. Neoplasia 3

9. Thrombosis and other disorders of circulation 3

10. Infectious disease 2

11. Immunological disease. 2

12. Name, Definition and examination of all common pathological tests and the standard values. 2

Recommended Books:

1. Pathologic basis of disease- Robins.

2. Practical pathology and Microbiology- M.A. Khaleque.





Assessment 20%

Total: 100%






Course Teacher-1 Md. Giasuddin Course Teacher-2:

Phone: Phone:


E-mail: E-mail:

Pharm 333 Medicinal Chemistry-I (Pre-requisite-Biomolecular Pharmacy) LECT. NO.

3 Credits

1 Basic principles of medicinal chemistry

2 Receptors:

Definition, classification, chemistry, drug-receptor binding at the active site, drug-receptor interaction, G-proteins, calmodulin and different protein kinases.

3 Knowledge of the chemistry, synthesis and structure activity relationships of the following compounds of medicinal importance:

Alkaloids b) Glycosides

4 Stereo-chemistry:

Optical, geometric and bio-isosterism, optical activity, stereochemistry of drug molecule and biological action.

5 Characterization of organic reactions and reaction mechanism (substitution, elimination and addition reactions)

6 A detailed study of the important name reactions such as Wittig reactions, Grignard reactions, Friedel-Craft reactions, Reformatsky reactions etc.

7 Course Review

Recommended Books

1. A Textbook of Medicinal Chemistry-Wilson & Gisvold

2. Medicinal Chemistry-Burger

3. Organic Chemistry (Vol. 1& 2)-Finar

4. Organic Chemistry-Morrison & Boyd





Assessment 20%

Total: 100%




Course Teacher-1 Ms. Irin Dewan Course Teacher-2:



Phone: Phone:


E-mail: E-mail:

Pharm 305 Marketing LECT. NO.

3 Credits

1 Principle of Marketing

2 Strategic marketing planning

3 Consumer markets and buying behavior

4 Market segmentation and target market strategies

5 Product promotion

6 Advertising

7 Products: Planning and Development

8 Positioning and product life cycle

9 Branding

10 Pricing

Recommended Books:

Marketing management by Philip Kotler& Garry Armstrong

Basic principles of marketing by Jeorge R.Terry





Assessment 20%

Total: 100%






Course Teacher-1 Dr.Md. Selim Reza Course Teacher-2:




Pharm 341 Pharmaceutical Technology-II LECT. NO.

3 Credit

1 Formulation and manufacturing of tablets: Manufacturing of tablets by wet granulation, dry granulation and by direct compression. Granulation of powder for tableting, advantage and disadvantages of different process, Processing machineries used in tablet manufacturing.

2 Common tableting problems and evaluation of tablets: Hardness measurement, weight variation test, thickness and diameter,friability,disintegration time, dissolution time, mechanism of tablet disintegration and dissolution, In process quality control methods in tablet manufacturing, study of common tableting problems.

3 Tablet coating:

Definitions and classifications of coating methods, advantages and disadvantages of coating methods, different methods of coating, sugar coating, different stages of sugar coating, problems of sugar coating, theory of film coating, film formers, plasticizer, solvents, other excipients, problems of film coating, enteric coating polymers, formulations of enteric coating, dry coating (compression coating), comparison between sugar coating and film coating, conventional, perforated and fluidized coating machines

4 Hard gelatin capsules:

Definition, classification, advantages and limitations of capsule dosage form, gelatin and its manufacture, manufacture of hard capsule shells, properties and formulation of capsules, capsule filling machines, tooling and accessories, problems in capsule manufacturing, quality control methods of capsules, packaging of capsules

5 Soft gelatin capsules:

Definition, classification, advantages, limitations, properties and formulation of soft capsules, manufacturing of soft capsules, problems in soft capsule manufacturing, quality control methods of soft capsules, packaging of soft capsules

6 Microencapsulation technology: Purpose, method of preparation, evaluation, pharmaceutical and biological applications of microencapsulations process.

8 Course Review

Recommended books:

1. Dispensing for pharmaceutical students-Cooper & Gunn2. American Pharmacy - Sprowl.3. Remington’s Pharmaceutical Sciences.4. Dispensing of medication- Husa & Martin.5. Pharmaceutical Practice-Aulton6. An introduction to Pharmaceutical Formulations- Fishburn7. An introduction to Pharmaceutical Productions-Polderman8. The Extra Pharmacopoeia- Martindale9. Bentey’s Textbook of Pharmaceutics10. Tutorial Pharmacy-Cooper & Gunn11. Pharmaceutics-Aulton







Assessment 20%

Total: 100%






Course Teacher-1 Dr. Habibur Rahman Course Teacher-2:

Phone: Phone:


E-mail: E-mail:

Pharm 353 Biopharmaceutics & Pharmacokinetics-I LECT. NO.

3 Credits

1 Introduction:

Biopharmaceutics & clinical pharmacokinetics and their role in formulation development and clinical setting

2 Fate of drugs after administration, absorption of drugs through various routes, mechanism of absorption, apparent volume of distribution of drugs

3 Physical significance of drug concentration in blood, bio-availability, biological half-life, physiological significance, methods of modifying drug delivery dosage forms, controlled delivery of drug in sustained action medication

4 Effect of protein binding on drug disposition characteristics

5 Drug metabolism and elimination

6 Blood products and plasma substitutes

7 Immunological products

8 Course review

Recommended Books

1. Biopharmaceutics & Clinical pharmacokinetics-M. Gibaldi

2. Biopharmaceutics & Clinical pharmacokinetics-Notari

3. Biopharmaceutics & relevant pharmacokinetics- T.G. Wagner

4. Biopharmaceutics & Drug interactions-Cadwallader

5. Pharmacokinetics-M. Gibaldi & D. Perrier





Assessment 20%

Total: 100%




Course Teacher-1 Dr. Md. Mohibur Rahman Course Teacher-2:



Phone: Phone:


E-mail: E-mail:

Pharm 361 Pharmacology-II (Pre-requisite-Pharmacology-I) LECT. NO.

3 Credits

1 Pharmacology of drugs affecting cardio-vascular system:

General considerations pharmacological actions, mechanism of action, therapeutic uses, side effects and structure activity relationships of the following drugs-

i) Diuretics and anti-diuretics

ii) Drugs used in Angina and Myocardial infarction

iii) Anti-hypertensive drugs

iv) Drugs used in heart failure

2 Chemotherapy of microbial diseases:

i) General considerations.

ii) Penicillin, Cephalosporins and other b-lactum antibiotics.

iii) Aminoglycosides.

iv) Tetracycline, Chloramphenicol and Erythromycin.

v) Sulfonamides, Trimethoprim-sulfamethoxazole, Quinolones and agents used in Urinary Tract Infection.

vi) Anti-fungal drugs.

vii) Antiviral agents.

3 Drugs acting on blood and blood forming organs:

i) Haematinic drugs.

ii) Anticoagulants.

Recommended Books

1. Pharmacological Basis of Therapeutics – Goodman and Gillman.

2. Medical Pharmacology – Katzung.

3. Medical Pharmacology – Meyer.

4. Medical Pharmacology – A.Goth.

5. Pharmacology and Pharmacotherapeutics – R.S.Satosker.





Assessment 20%

Total: 100%






Course Teacher-1 Dr. Md. Khalid Hossain Course Teacher-2:

Phone: 9661920-79, Ex-8144 Phone:



Pharm 335 Medicinal Chemistry – II (Pre-requisite-Medicinal Chemistry-I & Organic Chemistry)

LECT. NO.

3 Credits

1 Principles of drug design: Theory, different traditional and mechanism based approaches to drug design, application of quantum mechanics, computer aided drug designing (CADD), molecular modeling, congeneric series and clinical evaluation.

6

2 Chemistry of drug metabolism and concept of pro-drug. 6

3 Knowledge of the chemistry, synthesis and structure activity relationship of the following groups of medicinal substances:

7

a) Hormones.

b) Antibiotics.

4 Synthesis of natural products and heterocyclic compounds. 5

5 Toxicity studies of drugs. 4

6 Course Review 2

Recommended Books

1. A Textbook of Medicinal Chemistry – Wilson and Gisvold.

2. Medicinal Chemistry – Burger.

3. Organic Chemistry (vol. 1 & 2) – Finar.

4. Organic Chemistry – Morrison and Boyd.





Assessment 20%

Total: 100%






Course Teacher-1 S.M . Ashraful Alam Course Teacher-2:


Mobile: 01715391854, 0152405335 Mobile:


Pharm 345 Pharmaceutical Technology-II (Pre-requisite-Pharmaceutical Technology – I)

LECT. NO.

3 Credits

1. Introduction 2

2. Powder and granules: 5

Reasons for granulation, properties of granules, size and shape, surface area, density, strength and friability, Pharmaceutical granulation machines: Wet & Dry granulation methods.

3. Tablet formulation: 5

Definitions and classifications, advantages and disadvantages, properties of tablets, tableting excipients, formulation of tablets, modern tabletting excipients, directly compressible vehicles, tablet compression machines, formulation of special tablets, effervescent tablets, compression coated tablets, chewable tablets, common tabletting problems.

4. Tablet tooling: 1

Types of tablet tooling, Steel selection, Maintenance and storage of tooling.

5. Evaluation of tablets: 2

Hardness measurement, weight variation tests, thickness and diameter, friability, disintegration time, dissolution time, mechanism of tablet disintegration and dissolution, in process quality control methods in tablet manufacture

6. Tablet coating: 5

Definitions and classifications of coating methods, advantages and disadvantages of coating methods, different methods of coating, sugar coating, different stages of sugar coating, problems of sugar coating, theory of film coating, film formers, plasticizer, solvents, other excipients, problems of film coating, enteric coating polymers, formulations of enteric coating, dry coating (compression coating), comparison between sugar coating and film coating, conventional, perforated and fluidized coating machines

7. Hard gelatin capsules: 7

Definition, classification, advantages and limitations of capsule dosage form, gelatin and its manufacture, manufacture of hard capsule shells, properties and formulation of capsules, capsule filling machines, tooling and accessories, problems in capsule manufacturing, quality control methods of capsules, packaging of capsules

8. Soft gelatin capsules: 3

Definition, classification, advantages, limitations, properties and formulation of soft capsules, manufacturing of soft capsules, problems in soft capsule manufacturing, quality control methods of soft capsules, packaging of soft capsules

9. Course review 1

Recommended Books



1. The Theory and practice - Lachman of Industrial Pharmacy.

2. American Pharmacy - Sprowl.

3. Pharmaceutics - Aulton.











Assessment 20%

Total: 100%






Course Teacher-1 Hamidur Rahman Gazi Course Teacher-2:




Pharm 347 Advanced Pharmaceutical Analysis-I (Pre-requisite-Pharmaceutical Analysis-I & II)

LECT. NO.

3 credits

1 Introduction 1

2 Polarography 5

3 Conductometry 4

4 Electrogravimetry 3

5 X-ray crystallography 4

6 Potentiometry 5

7 Amperometry 3

8 Bioassay of antibiotics with statistical evaluation 5

Recommended Books

1. A Textbook of Pharmaceutical Analysis- K.A. Connors

2. Quantitative Pharmaceutical Analysis- Chatten

3. Quantitative Inorganic Analysis vol. I & II- Vogel

4. United State Pharmacopoeia

5. British Pharmacopoeia.

6. Quality Control in Pharmaceutical Industry- M.S. Cooper





Assessment 20%

Total: 100%






Course Teacher-1 S. M. Ashraful Alam Course Teacher-2:


Mobile: 01715391854, 0152405335 Mobile:


Pharm 349 Pharmaceutical Engineering (Pre-requisite-Pharmaceutical Technology – I) LECT. NO.

3 Credits

1 Drying: 4

Theory and types of drying, Methods of drying of wet solids: Convective, Conductive and Radiation drying, Dryers for dilute solutions and suspensions, Freeze drying, Solute migration during drying.

2 Mixing: 6

Theory and types of mixing, Degree of mixing, The mixing of powdered materials and miscible liquids and suspensions, The mixing of semisolids, Factors affecting mixing process, Types of semisolid mixers.

3 Clarification and filtration: 3

Definition and theory of filtration, Factors affecting filtration rate, Mechanism of filtration, Industrial filters and filtration techniques.

4 Lay out plan of pharmaceutical manufacturing plant: 2

Guidelines for selecting new plant sites,

Pharmaceutical lay out plan and design, criteria for production facilities.

5 Water treatment plants in pharmaceutical industry: 4

Sources of raw water, Natural impurities in raw water and their removal, Purification methods of raw water, Definition and classification of pharmaceutical water, Manufacture and storage of pharmaceutical water, Distillation of water, Ion-exchange process, Reverse osmosis, Microbiological quality and analysis of pharmaceutical water.

6 Humidity control and air conditioning: 5

Importance of humidity control in pharmaceutical industry, Psychometry, Methods of humidity control.

7 Centrifugation: 1

Principles of centrifugation, Industrial centrifuges.

8 Evaporation & distillation:

Principles of evaporation, Factors affecting evaporation, Evaporation machines and uses. 1

9 Safety methods in pharmaceutical industry: 1

Fire protection, Handling of dangerous and toxic chemicals, Waste disposal, Animal handling in pharmaceutical industry.

10 Milling and size separation: 2

Theoretical aspects of milling, Influence of material properties on milling, Crack propagation and toughness, Surface hardness, Energy requirements, Influence of size reduction on size distribution, Factors affecting milling, Industrial size reduction methods, Selection of particle size reduction methods.





Assessment 20%



Total: 100%






Course Teacher-1 Dr.Habibur Rahman Course Teacher-2:

Phone: Phone:


E-mail: E-mail:

Pharm 355

Biopharmaceutics & Pharmacokinetics-II (Pre-requisite-Biopharmaceutics & Pharmacokinetics-II)

LECT. NO.

3 Credits

1 Introduction

2 Compartmental kinetics:

Compartmental models, determination of different pharmacokinetic parameters from plasma and urine after drug administration by IV and oral route

3 The concept of clearances:

Mechanism and factors affecting renal clearance, clearance ratio, determination of renal clearance, extraction ratio, hepatic clearance, biliary excretion etc.

4 Methods of determining residuals:

Back feathering technique

5 Multiple dosage regimen

6 Different methods of determining zero and first order absorption rate constant, the Plateau principle and the concept of steady state

7 Non-linear pharmacokinetics with special reference to one compartmental model after IV administration, detection of non-linearity (saturation principle)

8 Bio-availability and bio-equivalence study

9 Dose adjustment in patients with or without renal and hepatic failure

10 Course review

Recommended Books

1. Biopharmaceutics & Clinical pharmacokinetics-M. Gibaldi

2. Biopharmaceutics & Clinical pharmacokinetics-Notari

3. Biopharmaceutics & relevant pharmacokinetics- T.G. Wagner

4. Biopharmaceutics & Drug interactions-Cadwallader

5. Pharmacokinetics-M. Gibaldi & D. Perrier





Assessment 20%



Total: 100%






Course Teacher-1 Ms. Bilkis Begum Course Teacher-2:



E-mail: E-mail:

Pharm 363

Pharmacology-III (Pre-requisite-Pharmacology-I & II) LECT. NO.

3 Credits

1 Drugs acting on CNS:

i) CNS stimulating drugs

ii) Cholinergic and anti-cholinergic drugs

iii) Adrenergic and anti-adrenergic drugs

iv) Sedatives and hypnotics

v) Psychotropic and anti-depressant drugs

2 Anti-neoplastic drugs

3 Chemotherapeutic agents:

i) Anti-tubercular drugs

ii) Drugs in the treatment of leprosy

iii) Anti-epileptic drugs

4 Anti-diarrheal agents

Recommended Books

1. Pharmacological Basis of Therapeutics – Goodman and Gillman.

2. Medical Pharmacology – Katzung.

3. Medical Pharmacology – Meyer.

4. Medical Pharmacology – A.Goth.

5. Pharmacology and Pharmacotherapeutics – R.S.Satosker





Assessment 20%

Total: 100%






Course Teacher-1 Mr. Moshiur Rahman Course Teacher-2:

Phone: 9661774-6 (off) Phone:

Mobile: 01711810245, 01711869855 Mobile:

E-mail: E-mail:

ACT 401 Accounting LECT. NO.

2 Credits

1. Introduction to Accounting, Generally Accepted Accounting Principles (GAAP), Accounting Cycle, Accounting Information Processing, information user groups.

2. a) Principles of journal entries, ledger, trial balance, adjusting entries, rectifying entries, financial statement (income statement, cash flow statement, balance sheet)

b) Bank reconciliation statement, objectives and procedure.

3. Managerial and Cost Accounting

a) Introduction to cash concepts

b) Job order costing

c) Process costing (including contract costing)

d) Cost-volume-profit analysis

e) Costing for decision making and reporting

f) Flexible budget and standard costing

4. Capital budgeting

5. Analysis of financial statements

Reference books

1. Accounting Principles - Hermenson





Assessment 20%

Total: 100%






Course Teacher-1 Dr. Shaila Kabir Course Teacher-2:



E-mail: kabir [email protected] E-mail:

Pharm 435 Advanced Medicinal Chemistry (Pre-requisite-Medicinal Chemistry-I & II)

LECT. NO.

3Credits

1 Sedatives and hypnotics

2 Autocoids

3 Narcotic analgesics

4 Non-steroidal anti-inflammatory drugs

5 Tranquilizing agents

6 Anti-diarrheal agents

7 Anti-cancer agents

8 Membrane acting drugs: Drugs acting on Ca++, K+, Na+ channels

9 Anti-malarial agents

10 Vitamins

11 OTC drugs with their significance

12 Course review

Recommended Books

1. A Textbook of Medicinal Chemistry-Wilson & Gisvold

2. Medicinal Chemistry-Burger

3. Organic Chemistry (Vol. 1& 2)-Finar

4. Organic Chemistry-Morrison & Boyd





Assessment 20%

Total: 100%






Course Teacher-1 Md. Ziaur Rahman Khan Course Teacher-2:

Phone: Phone:



Pharm 437 Regulatory Affairs LECT. NO.

2 Credits

Drug Abuse:

1 Problems in drug abuse 1

2 Drugs of abuse 3

3 Legal Aspects 1

4 Treatment and Rehabilitation 1

Pharmacy Practice in Bangladesh:

1 Scope, opportunities in the government and the armed forces 2

2 Drug administration and Pharmacy Council of Bangladesh, their scope and functions 2

3 Regulations and laws governing the practices of pharmacy (The Pharmacy Ordinance 1976)

4

4 Policies, sales, regulation and laws concerning to the manufacture, possession, distribution, sale of drugs and poisons: The Drug Policy 1982, Essential Drug List, The Drug Act 1940, The Drug (control) ordinance 1982, The Narcotics (control) Act 1990, The Poisons Act 1919 and related amendments

10

5 control of Drug Advertisements and prices, patented and trade marked medicine, proprietary medicine, schedules of drugs and poisons, regulation of cosmetics and poison control

1

6 Professional characteristics and ethical norms, relationship of trust, ethical considerations during pharmacy practice, deficiencies of self-regulation, adherence of self-regulation

1

7 The Pharmacist’s code of ethics 2

8 Government Health Policy 2

Recommended Books

1. The Pharmacy Ordinance, 1976, Ministry of Law and Parliamentary affairs, Government of Bangladesh, Dhaka2. The Drugs (control) Ordinance, 1982, Ministry of Law and Land Reforms Government of Bangladesh, Dhaka.3. Drug Policy of Bangladesh, Ministry of Health and Population Control, Health Division, Dhaka.4. A Textbook of Forensic Pharmacy-B.M. Mithal5. Pharmacist’s Code of Ethics, Pharmacy Council of Bangladesh





Assessment 20%

Total: 100%






Course Teacher-1 Prof. Reza-ul Jalil Course Teacher-2:



E-mail: E-mail:

Pharm 441 Pharmaceutical Technology-III (Pre-requisite-Pharmaceutical Technology-I & II)

LECT. NO.

3 Credits

1 Introduction 1

2 Design and operation of clean room: 12

Sources of contamination, Air flow systems: Conventional, Unidirectional and Laminar air flow units, Air filtration mechanisms: Fibrous and HEPA filters, Temperature and humidity control, Building design, construction and use, Personnel, Protective clothing, Cleaning and disinfecting, Commissioning test of clean and aseptic rooms, Routine monitoring tests, The operation of clean aseptic room, Key factors in clean room operations.

MID TERM 1

3 Parenteral products: 9

Definition and classification, Formulation consideration: Vehicles and additives, Containers, Manufacturing consideration: Environment, Manufacturing techniques, Raw materials and machines, Quality control of parenteral products: Sterility tests, Pyrogen test, Clarity test, Leak test for ampoules, Packaging of parenteral products.

4 Opthalmic products: 3

Anatomy of eye and adnexa, Absorption of drugs in the eye, Classification of opthalmic products, Safety considerations, Formulation considerations: Vehicles additives, Manufacturing considerations: Environment, Manufacturing techniques, Raw materials and machines, Quality control of opthalmic products, Packaging of opthalmic products.

5 Packaging technology: 3

Purpose of packaging, properties of packaging materials, factors influencing choice of package, advantages and disadvantages of packaging materials, glass and glass containers, metal and metal containers, plastic and plastic containers, films, foils and laminates, rubber based materials, closures, tamper resistant packaging, testing and quality assurance of packaging materials, different packing machines and accessories, organization of packaging line, labeling.

6 Good Manufacturing Practice: Good Manufacturing Practice, WHO guideline. 1

Recommended Books

1. Theory and practice of Industrial Pharmacy- Lachmann.2. American Pharmacy- Sprowl.3. Pharmaceutics- Aulton.4. Remington’s Pharmaceutical Sciences.5. Dispensing for Pharmaceutical Students- Cooper & Gunn.6. Dispensing of Medication-Husa & Martin.7. Bentley’s Textbook of Pharmaceutics.8. Tutorial Pharmacy- Aulton.9. An introduction to Pharmaceutical Formulations- Fishburn.







Assessment 20%

Total: 100%






Course Teacher-1Prof.Dr.Chowdhury Mahmood Hasan

Course Teacher-2:

Phone: Phone:


E-mail: E-mail:

Pharm 447 Advanced Pharmaceutical Analysis-II (Pre-requisite- Pharm Analysis-I & II & Adv Pharma Analysis-II)

LECT. NO.

3 Credits

1 Introduction 1

2 UV spectroscopy 2

3 IR spectroscopy 2

4 NMR spectroscopy 15

5 Mass spectroscopy 4

6 Radio-Chemical Methods of Analysis

Recommended Books

1. Methods of spectroscopy – Pavia

2. Spectroscopy – William Kemp

3. Spectroscopic Methods – Sharma

4. Textbook of Pharmaceutical Analysis – Connor.





Assessment 20%

Total: 100%






Course Teacher-1 Ms. Bilkis Begum Course Teacher-2:



E-mail: E-mail:

Pharm 461 Pharmacology-IV (Pre-requisite-Pharmacology-I, II & III) LECT. NO.

3 Credits

1 Hormone and hormone-related antagonists:

a) Adenohypophyseal hormone and their hypothalamic releasing factors.

b) Thyroid hormones and anti-thyroid drugs.

c) Estrogen and progestins.

d) Androgens.

e) Adrenocortical steroids and their synthetic analog.

f) Insulin and oral hypoglycemic drugs.

g) Agents using calcification and bone turn over.

2 Ophthalmology:

Overview of ocular physiology and biochemistry, ocular structure, delivery strategies, chemotherapy of microbial diseases of the eye, use of other agents for ophthalmic therapy.

3 Chemotherapy of parasitic infection:

Drugs used in malaria, helminthiasis, tripanosomiasis, leishmaniasis, amebiasis, giardiasis and trichinosis

4 Vitamins:

Water and fat soluble vitamins

5 Course Review

Recommended Books

1. Pharmacological basis of therapeutics- Goodman and Gillman.

2. Medical Pharmacology- Katzung.

3. Medical Pharmacology- Meyer.

4. Medical Pharmacology- A. Goth.

5. Pharmacology and Pharmacotherapeutics- R.S. Satosker.





Assessment 20%

Total: 100%






Course Teacher-1 Md. Moshiur Rahman Course Teacher-2:

Phone: 9661774-6 (off) Phone:

Mobile: 01711810245, 01711869855 Mobile:

E-mail: E-mail:

ECN 403 Business Economics LECT. NO.

2 Credits

This course explores the economic concepts and theories that are fundamental to decision making of economic agents such as business firms, consumers and government. It equips students with a better understanding of the larger economic environment. At the micro level, it examines the behavior of consumers and producers and price information under various forms of competition. At the macro level, it examines how macro aggregates such as national income; employment, general price level, inflation rate, interest rates and exchange rates are determined. Real cases, particularly those pertaining to current issues, will be examined to demonstrate the application of theory.

Recommended Books

1. Macroeconomic Analysis by Shappiro2. Microeconomics - Schaum’s outline series3. Macroeconomics - Schaum’s outline series4. Microeconomic Theory – K.K. Dewett5. Economics – Samuelson





Assessment 20%

Total: 100%






Course Teacher-1 Md. Elias Al-Mamun Course Teacher-2: Mr. Rashed

Phone: Phone:

Mobile: Mobile:

E-mail: E-mail:

MMT 405 Pharmaceutical Marketing & Management LECT. NO.

3 Credits 1 Introduction

2 Management & its nature and purpose, managerial function, roll and skill, social responsibility and ethics of pharmaceutical managers

3 Planning, organizing, staffing, leading & controlling

4 Managerial role of pharmacists, Pharmacists in different services of health and pharmaceutical industry, marketing & sales, regulatory affair research & development, hospital pharmacy, community pharmacy etc.

5 Concept of Marketing:

i) Introduction to the price, place, positioning and promotion

ii) Marketing strategies

iii) Market Targeting, product positioning, product life cycle, new product development

iv) Advertising

v) Sales management

6 Global trends in pharmaceutical industry

Recommended Books

1. Management: A global perspective by Weirich, Heinz & Koontz

2. Principles and Methods of Pharmacy Management by H.A. Smith

3. Marketing Management by Philip Kotler & Garry Armstrong

4. Basic Principles of Marketing by Jeorge R. Terry





Assessment 20%

Total: 100%






Course Teacher-1 Jakir Ahmed Chowdhury Course Teacher-2:




Pharm 445 Cosmetology LECT. NO.

3 Credits

1 Introduction

2 Physiology of teeth, hair and skin in relation to the cosmetics

3 Formulation, manufacturing and quality control of the following types of cosmetics:

a) Tooth, paste, tooth powder

b) Creams – cold & vanishing creams

c) Shampoo – transparent & egg shampoo

d) Shaving preparations – shaving cream, shaving foam, after shave lotion, pre-shave lotion

e) Hand & body lotion

f) Deodorants & anti-perspirant

g) Different types of face & body powders

h) Lipsticks & lip lacquers

i) Nail polishes

j) Perfumes

k) Bathing soaps





Assessment 20%

Total: 100%






Course Teacher-1 Mr. Kibria Course Teacher-2:

Phone: Phone:

Mobile: Mobile:

E-mail: E-mail:

Pharm 455 Clinical & Community Pharmacy LECT. NO.

3 credits

Clinical Pharmacy:

1 Introduction to clinical pharmacy

2 Basic concepts of pharmacotherapy:

a) Clinical pharmacokinetics and individualization of dosage regimen

b) Drug induced diseases

c) Adverse drug interaction

d) Clinical toxicology

3 Interpretation of common clinical laboratory tests

4 Pathophysiology & Therapeutics:

i) Fluid and electrolyte disorders and shock

ii) Infectious diseases

iii) Cardio-vascular diseases

iv) Kidney and urinary tract disorders

v) Nervous system disorders

vi) Endocrine and reproductive disorders

5 Drug information

6 Hospital pharmacy:

A comprehensive knowledge of hospital pharmacy, control of special classes of drugs, floor stock drug, hospital pharmacist in educational and training programs, health education and public health

Community Pharmacy:

1 Definition and scope of community pharmacy

2 Organization inventory control and management of retail pharmacy business

3 Communication, counseling for patient compliance

4 Role of pharmacist in community health care and education

Recommended Books

1. Clinical Pharmacy and Therapeutics by Herfindal, Gourly & Hort

2. Therapeutic basis of Clinical Pharmacy in the tropics by Aguwa

3. Hospital Pharmacy by William Hasan

4. Textbook of Hospital Pharmacy by Allwood







Assessment 20%

Total: 100%






Course Teacher-1 Dr. Md. Selim Reza Course Teacher-2:




Pharm 449 Pharmaceutical Technology-IV (Pre-requisite- Pharmaceutical Technology – I, II & III)

LECT. NO.

3 Credits

1 Introduction

2 Compaction and compression of powder:

Physics of tablet compression, mechanism of tablet formation, bonding in tablets, the effect of compressional force on tablet properties, effect of lubricants on tablet compression and binding, instrumented tablet machines and tooling, problems associated with large scale manufacturing of tablet

3 Sustained release drug delivery systems:

Principles, advantages, limitations and types of SR dosage forms, methods of obtaining SR effects of drugs, formulation and manufacturing of SR matrix tablets, drug release mechanisms from SR dosage forms, evaluation of SR dosage forms, excipients in SR dosage forms, dose calculation for SR dosage forms

4 Micro-encapsulation Technology:

Purpose, methods of preparation, evaluation

5 Aerosol science and technology :

Definition and classification of aerosols, Propellants for aerosol manufacturing, Components of aerosol formulation, Containers and valves for aerosols, Metered dose delivery of aerosols, Manufacturing of aerosols; Testing and quality assurance of aerosols.

6 Drug delivery to the lungs:

Drug administration to the respiratory tract, Mechanism and factors affecting deposition of drugs in the respiratory tract, Quality control systems in manufacturing Metered dose inhalers

7 Course Review

Recommended Books

1. Theory and practice of Industrial Pharmacy- Lachmann.2. American Pharmacy- Sprowl.3. Pharmaceutics- Aulton.4. Remington’s Pharmaceutical Sciences.5. Dispensing for Pharmaceutical Students- Cooper & Gunn.6. Dispensing of Medication-Husa & Martin.7. Bentley’s Textbook of Pharmaceutics.8. Tutorial Pharmacy- Aulton.





Assessment 20%

Total: 100%




Documents

00 Uap Course Outline Spring 07 01