Cairo University

Faculty of PharmacyCurriculum Vitae

Education Academic DegreesPhD

Pharmaceutical Sciences/ Chemistry of Natural Products/Metabolism of natural Pigments by Human Intestinal Bacteria/1994/ University of Toyama (Previously: Toyama Medical and Pharmaceutical University)-Japan

Master

Pharmacognosy/Pharmacognostical Study of Anagallis arvensis L. growing in Egypt/1985/Faculty of Pharmacy-Cairo University-Egypt

Bachelor

Pharmaceutical Sciences/1979/Faculty of Pharmacy-Cairo University-Egypt

Research interestBiologically Active Natural Products/Functional Foods/Healthy Nutrition

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Name: Meselhy R. Meselhy (M.R. Meselhy)

Title: Professor Dr.

Department: Pharmacognosy

E-mail: meselhy.meselhy@pharma.cu.edu.eg, meselhyragab@yahoo.com

Website: https://scholar.google.com/citations?user=&user=AMavG1wAAAAJ

Mobile: +2 1026200260

Phone: +202 38246100

Cairo University

Faculty of PharmacyCurriculum Vitae

Teaching Course Title

Undergraduate Courses(General Program)

205 Phytochemistry I

206 Phytochemistry II

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Undergraduate Courses (Clinical Program)

PG 404 Phytochemisty-1

Choose an item.PG 505 Phytochemistry-2

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Courses

Advanced Phytochemistry

Career History and Professional ExperienceTitles Cultural Counsellor and Director of the Cultural Bureau, Embassy of Egypt in Tokyo (2009-

2012)

Cultural Attaché, Cultural Bureau, Embassy of Egypt in Tokyo (2002-2005)

Professor of Natural Products Chemistry (2004-Present)

Associate Professor (1999-2004)

Assistant Professor (1994-1999)

Assistant Lecturer (1985-1994)

Instructor (1980-1984)

Awards State Award in Medical and Biological Sciences from the Egyptian Academy of Sciences and

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Cairo University

Faculty of PharmacyCurriculum Vitae

Technology (2000)

Visiting Professor, Institute of Natural Medicine, University of Toyama, Japan ((2001-2002)

Incentive Award from the Medical and Pharmaceutical Society of WAKAN-YAKU, Japan (1999)

Research Promoting Scientist Award from the University of Toyama, Japan (1998-2000)

Visiting Researcher Award, Institute of Natural Medicines, University of Toyama, Japan (1997-1998)

Advanced Technology Researcher Award, New Energy and Development Organization (NEDO), Tokyo, Japan (1996-1997)

Projects 1)- Role of human intestinal bacteria in the development of new medicine (NEDO, Japan 1996-1998); head of a research team.

2)-Rice bran nutraceuticals (RDI, MED/2009/214-423, Co-PI).

3)-Biodiesel production from algae as a renewable energy source in Egypt (Eu-Egypt-innovation fund-grant Scheme 1, 2014-2017, granted, member of a team from Egypt “ NRC, Cairo University, El-Sewedy Electric, ITM ”, and Holland “Wageningen University”).

4)- High value pharmaceutical raw material from food processing waste (STDF, ID # 7530, 2014-2016, granted, PI).

Publications and Presentations

Chapter in an edited book:

Meselhy, M. R. and Hattori, M. Recent studies on peony roots and a bioactive constituent, paeoniflorin in: Current Topics in Phytochemistry vol. 4, Research Trends, Trivandrum, India, 2000, p. 1-19, ISBN: 81-258-0069-7.

Publications:

58. Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii (2013). Sahar El-Mekkawy , Meselhy R. Meselhy , Nolitha Nkobole, Namrita Lall. Nat. Prod. Res., 27(2), 146-154.

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Please write down your books, book chapters, publications and conference presentations here as per “Bulletin of Faculty of Pharmacy, Cairo University” formats.

Please follow your publications with the doi to enable fast tracing of your publication. Examples: Reference to a journal publication: 1. Van der Geer J, Hanraads JAJ, Lupton RA. The art of writing a scientific article. J Sci Commun 2010;163:51–9, DOI: XXXX. Reference to a book: 2. Strunk Jr W, White EB. The elements of style. 4th ed. New York: Longman; 2000, DOI XXXXX, ISBN XXXX.Reference to a chapter in an edited book: 3. Mettam GR, Adams LB. How to prepare an electronic version of your article. In: Jones BS, Smith RZ, editors. Introduction to the electronic age, New York: E-Publishing Inc; 2009, p. 281–304, DOI XXXXX, ISBN XXXX.Journal abbreviations source Journal names should be abbreviated according to the List of Title Word Abbreviations: http://www.issn.org/services/online-services/access-to-the-ltwa/.

Cairo University

Faculty of PharmacyCurriculum Vitae

57. Nesrin M. Fayek, Azza R. Abdel Monem, Mohamed Y. Mossa, Meselhy R. Meselhy (2013). New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits. Pharmacognosy Res. 5(2), 55-59.

56. Nesrin M. Fayek, Azza R. Abdel Monem, Mohamed Y. Mossa, Meselhy R. Meselhy, Amani H. Shazly (2012) Chemical and biological study of Manilkara zapota (L.)Van Royen leaves (Sapotaceae) cultivated in Egypt. Pharmacognosy Res. 4(2), 85-91.

55. Katsuko Komatsu, Yorinobu Nagayama, Ken Tanaka, Yun Ling, Shao-Qing Cai, Takayuki Omote, Meselhy M. R. (2006). Comparative study of chemical constituents of rhubarb from different origins. Chem. Pharm. Bull., 54, 1491-1499.

54. Katsuko Komatsu, Yorinobu Nagayama, Ken Tanaka, Yun Ling, Purusotam Basnet, Meselhy M. R. (2006). Development of a high performance liquid chromatographic method for systematic quantitative analysis of chemical constituents in rhubarb Chem. Pharm. Bull., 54, 941-947.

53. Shu Zhu, S., Kun Zou, K., Shaoqing Cai, S., Meselhy, M. R, Komatsu, K. (2004). Simultaneous determination of triterpene saponins in Ginseng drugs by high-performance liquid chromatography Chem. Pharm. Bull. 52, 995-998.

52. Basu NK, Kubota S, Meselhy M. R, Ciotti M, Chowdhury B, Hattori M, Owens IS (2004). Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal antiinflammatory drugs, depends upon phosphorylation. J Biol Chem. 279(27), 28320-28329.

51. Tohda C., Matsumoto N., Zou K., Meselhy M. R., Komatsu K. (2004). A(25-35)-induced memory impairment, axonal atrophy and synaptic loss are ameliorated by M1, a metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology 29, 860-868.

50. Tazawa, T., Zhao, H., Li, Y., Meselhy, M. R., Nakamura, N., Akao, T., Hattori, M. (2003). A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma. Biol. Pharm. Bull. 26, 1289-1294.

49. El-Askary, H., Meselhy, M. R., Galal, A. M. (2003). Sesquiterpenes from Cymbopogon proximus. Molecules 8, 670-677.

48. Meselhy , M. R. (2003). Constituents from Moghat, the roots of Glossostemon bruguieri (Desf.). Molecules 8, 614-621.

47. Zou, K., Shu, Z., Meselhy, M. R., Tohda, C.,Cai, S., Komatsu, K. (2002). Dammarane-type saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. J. Nat. Prod. 65, 1288-1292.

46. Meselhy, M. R. (2002). Inhibition of LPS-induced NO by the oleogum resin of Commiphora wightii and its constituents. Phytochemistry 62, 213-218.

45. Tohda, C., Matsumoto, N., Zou, K., Meselhy, M. R., Komatsu, K. (2002). Axonal and dendritic extension by protopanaxadiol saponins of Ginseng roots in SK-N-SH cells. Jpn. J. Pharmacol. 90, 254-262.

44. Aboutabl, E. A., Meselhy, M. R., Afifi, M. (2002). Iridoids from Phlomis aurea growing in Egypt. Pharmazie 57, 646-647.

43. Abdel-Sattar, E., Meselhy, M. R., Al-Yahya, M. A.-A. (2002). New oxypregnane glycosides from Caralluma penicillata. Planta Med. 68, 430-434.

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Cairo University

Faculty of PharmacyCurriculum Vitae

42. El-Mekkawy, S., Meselhy, M. R., Abdel-Hafez, A. A., Nakamura, N., Hattori, M., Kawahata, T., Otake, T. (2002). Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives. Chem. Pharm. Bull. 50, 523-529.

41. Wang, L.-Q., Meselhy, M. R., Li, Y., Nakamura, N., Min, B.-S., Qin, G.-W., Hattori, M. (2001). The heterocyclic ring fission and dehydroxylation of catechins and related compounds. Chem. Pharm. Bull. 49, 1640-1643.

40. Nawawi, A., Nakamura, N., Meselhy, M. R., Hattori, M., Kurokawa, M., Shiraki, K., Kashiwaba, N., Ono, M.. (2001). In vivo antiviral activity of Stephania cepharantha against herpes simplex virus type-1. Phytother. Res. 15, 497-500.

39. Gao, J. J., Min, B. S., Akao, T., Meselhy, M. R., Nakamura, N., Hattori, M. (2001). Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum. J. Trad. Med. 18, 154-160.

38. Meselhy, M. R., Nishimoto, E., Akao, T., Hattori, M. (2001). Human intestinal Bacteroides, RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats. J. Trad. Med. 18, 169-176.

37. Meselhy, M. R., Nishimoto, E., Akao, T., Hattori, M. (2001). Metabolism of shikonin by a cell-free extract of Eubacterium sp. A-44, a human intestinal bacterium. J. Trad. Med. 18, 58-63.

36. Abdel-Hafez, A. A., Meselhy, M. R., Nakamura, N., Hattori, M., El-Gendy, M. A., Mahfouz, N. M., Mohamed, T. A. (2001). New paeonilactone-A adducts formed by anaerobic incubation of paeoniflorin with Lactobacillus brevis in the presence of arylthiols. Chem. Pharm. Bull. 49, 918-920.

35. Meselhy, M. R. and Hattori, M. (2000). Recent studies on peony roots and a bioactive constituent, paeoniflorin. Current Topics in Phytochemistry vol. 4, research Trends, Trivandrum, India, 2000, pp. 1-19.

34. Min, B. S., Meselhy, M. R., Hattori, M., Kim, H. M., Kim, Y. H. (2000). Cytotoxicity of shikonin metabolites with biotransformation of human intestinal bacteria. J. Microbiol. Biotechnol. 10, 514-517.

33. Wang, L.-Q., Meselhy, M. R., Li, Y., Hattori, M. (2000). Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone.. Chem. Pharm. Bull. 48, 1606-1610.

32. Li, Y., Meselhy, M. R., Wang, L.-Q., Ma, C.-M., Nakamura, N., Hattori, M. (2000). Biotransformation of a C-glycosylflavone, Abrusin 2-O--D-apioside, by human intestinal bacteria. Chem. Pharm. Bull. 48, 1239-1241.

31. Wang, L.-Q., Nakamura, N., Meselhy, M. R., Hattori, M., Zhao,W.-M., Cheng, K.-F., Yang, R.-Z., Qin, G.-W. (2000). Four mono-tetrahydrofuran ring acetogenins, montanacins B-E, from Annona Montana. Chem. Pharm. Bull. 48, 1109-1113.

30. Bando, M., Shibahara, N., Shimada, Y., Meselhy, M. R., Akao, T., Itoh, T., Terasawa, K. 2000. Pharmacokinetic study of paeoniflorin, paeonimetabolin-I and glycyrrhetic acid in humans after oral administration of paeony root, Glycyrrhiza and Shakuyaku-kanzo-to (Shao-Yao-Gan-Tang) J. Trad. Med. 17, 26-33.

29. El-Mekkawy, S., Meselhy, M. R., Nakamura, N., Hattori, M., Kawahata, K., Otake, T. (2000). Anti-HIV-1 phorbol esters from the seeds of Croton tiglium Phytochemistry 54, 457-464.

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Cairo University

Faculty of PharmacyCurriculum Vitae

28. Meselhy M. R. (2000). Human intestinal bacteria responsible for the metabolism of saikosaponins J. Trad. Med. 17, 1-11 (2000).

27. Ahmed, A. S., Nakamura, N., Meselhy, M. R., Makhboul, M. A., El-Emary, N., Hattori, M. (2000). Phenolic constituents from Grevillea robusta.. Phytochemistry 53, 149-154.

26. El-Mekkawy, S., Meselhy, M. R., Nakamura, N., Hattori, M., kawahata, K., Otake, T. (1999). 12-O-Acetylphorbol-13-decanoate potently inhibits cytopathic effects of human immunodeficiency virus type 1 (HIV-1), without activation of protein kinase C. Chem. Pharm. Bull. 47, 1346-1347.

25. Kawata, Y., Ma, Ch-m., Meselhy, M. R., Nakamura, N, Wang, H., Hattori, M., Namba, T., Satoh, K., Kuraishi, Y. (1999). Conversion of aconitine to lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice. J. Trad. Med. 16, 15-23.

24. Abdel-Hafez, A. A., Meselhy, M. R., Nakamura, N., Hattori, M., Watanabe, H., Murakami, Y., El-Gendy, M. A., Mahfouz, N. M., Mohamed, T. (1999). Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis. Biol. Pharm. Bull. 22, 491-497.

23. Abdel-Hafez, A. A., Meselhy, M. R., Nakamura, N., Hattori, M., Murakami, Y., El-Gendy, M. A., Mahfouz, N. M., Mohamed, T. (1998). Effects of paeoniflorin derivatives on the scopolamine-induced amnesia using a passive avoidance task in mice; structure-activity relationship. Biol. Pharm. Bull. 21, 1174-1179.

22. Abdel-Hafez, A. A., Meselhy, M. R., Nakamura, N., Hattori, M., Watanabe, H., Mohamed, T., Mahfouz, N. M., El-Gendy, M. A. (1998). Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis. Chem. Pharm. Bull. 46, 1486-1487.

21. Galal, A. M., Abdel-Sattar, E., El-Feraly, F. S., Mossa, J. S., Meselhy, M. R., Kadota, S., Namba, T. (1998). Diterpene acids from Conyza incana. Phytochemistry 48, 159-163.

20. Kida, H., Akao, T., Meselhy, M. R., Hattori, M. (1998). Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and Eubacterium sp. A-44-infected rats. Biol. Pharm. Bull. 21, 588-593.

19. Meselhy, M. R., Heikal, O. A., Akao, T., Khojimatov, O., Hattori, M., Ono, H., Sadakane, C. (1998).Disposition of paeoniflorin and paeonimetabolin I in rats after oral administration of Toki-shakuyaku-san and Shakuyaku-kanzo-to. Natural Medicines 52, 265-268.

18. Hussein, G., Nakamura, N., Meselhy, M. R., Hattori, M. (1998). Phenolics from Mytenus sensgalensis Phytochemistry 50, 689-694.

17. El-Mekkawy, S., Meselhy, M. R., Nakamura, N., Tezuka, Y., Hattori, M., Kakiuchi, N., Shimotohno, K., Kawahata, T., Otake, T. (1998). Anti-HIV-1 and anti-HIV-1 protease substances from Ganoderma lucidum Phytochemistry 49, 1651-1657.

16. Meselhy, M. R. (1998). Hopane-type saponins from Polycarpon succulentum-II. Phytochemmistry 48, 1415-1421).

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Cairo University

Faculty of PharmacyCurriculum Vitae

15. Kida, H., Akao, T., Meselhy, M. R., Hattori, M. (1997). Enzymes responsible for the metabolism of saikosaponins from Eubacterium sp. A-44, a human intestinal anaerobe. Biol. Pharm. Bull. 20, 1274-1278.

14. Kida, H., Nakamura, N., Meselhy, M. R., Akao, T., Hattori, M. (1997). Isolation and identification of human intestinal bacteria capable of hydrolyzing saikosaponins. J. Trad. Med. 14, 34-40.

13. Helal, A. M., Nakamura, N., Meselhy, M. R., El-Fishawy, A. M., Hattori, M., Mahran, G. H. (1997). Guaianolides from Centaurea scoparia, growing in Egypt. Phytochemistry 45, 551-554.

12. Meselhy, M. R., Nakamura, N., Hattori, M. (1997). Biotransformation of (-)-epicatechin 3-O-gallate by human intestinal bacteria. Chem. Pharm. Bull. 45, 888-893.

11. Nakamura, N., Shiho, K., Lim, Y. A., Meselhy, M. R., Hottori, M., Gupta, M. P., Correa, M. (1997). Dammarane-type triterpenes from Cordia spinescens. Phytochemistry 46, 1139-1141.

10. Meselhy, M. R., Aboutabl, E. A. (1997). Hopane-type saponins from Polycarpon succulentum, growing in Egypt. Phytochemistry 44, 925-929.

9. Meselhy, M. R., Momose, Y., Hatakeyama, N., Kadota, S., Hattori, M., Namba, T. (1995). Effect of tinctormine on contraction and Ca2+ currents in single cardiac myocytes from dog. Phytomedicine 4, 277-281.

8. El-Mekkawy, S., Meselhy, M. R., Kusumoto, I., Kadota, S., Hattori, M., Namba, T. (1995). Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. Chem. Pharm. Bull. 43, 641-648.

7. Meselhy, M. R., Kadota, S., Hattori, M., Namba, T. (1994). Biotransformation of shikonin by human intestinal bacteria. Tetrahedron 50, 3081-3098.

6. Meselhy, M. R., Aboutabl, E. A., Shoka, A. A. (1994). Preliminary phytochemical and pharmacological screening of Polycarpon succulentum, Polycarpea repens and Gymnocarpos decandrum (Caryophyllaceae). Bull. Fac. Pharm. Cairo Univ. 32, 399-405.

5. Meselhy, M. R., Kadota, S., Tsubuno, K., Kusai, A., Hattori, M., Namba, T. (1994). Shikometabolins A, B, C and D, novel dimeric naphthoquinone metabolites obtained from shikonin by human intestinal bacteria. Tetrahedron Lett. 35, 583-586.

4. El-Mekkawy, S., Meselhy, M. R., Kawata, Y., Kadota, S., Hattori, M., Namba, T. (1993). Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria. Planta Med. 59, 293.

3. Meselhy, M., R., Kadota, S., Kusai, A., Hattori, M., Namba, T. (1993). Two new quinochalcone yellow pigments from Carthamus tinctorius and Ca2+ antagonistic activity of tinctormine. Chem. Pharm. Bull. 41, 1796-1802.

2. Meselhy, M., R., Kadota, S., Hattori, M., Namba, T. (1993). Metabolism of safflor yellow B by human intestinal bacteria. J. Nat. Prod. 56, 39-45.

1. Meselhy, M., R., Kadota, S., Momose, Y., Hattori, M., Namba, T. (1992). Tinctormine, a novel Ca2+ antagonist N-containing quinochalcone C-glycoside from Carthamus tinctorius L. Chem. Pharm. Bull. 40, 3355-3357.

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Cairo University

Faculty of PharmacyCurriculum Vitae

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Cairo University

Faculty of PharmacyCurriculum Vitae

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