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www.helicobacterkorea.org
The 28th Annual Meeting of the Korean College of Helicobacter and Upper Gastrointestinal Research & the 3rd Seoul International Symposium on Helicobacter and Upper Gastrointestinal Diseases
SI-HUG 2020
Korean College of Helicobacter and Upper Gastrointestinal Research
July 17-18, 2020 CONRAD SEOUL, Korea
The 28th Annual Meeting of the Korean College of Helicobacter and Upper Gastrointestinal Research & the 3rd Seoul International Symposium on Helicobacter and Upper Gastrointestinal Diseases
154
PD-001
Propolis ethanol extract activity as anti-Helicobacter pylori on clarithromycin and metronidazole resistant strains
Yudith Annisa Ayu Rezkitha1,2,8, I Ketut Adnyana4, Yobella Priskila5, Ariel Panjaitan5, Elin Yulinah5, Neneng Ratnasari6, Ali Khomsan7, Ricky Indra Alfaray8,9, Kartika Afrida Fauzia8,9, Yoshio Yamaoka9, Muhammad Miftahussurur3,8 1Doctoral Program of Medical Science, Faculty of Medicine Universitas Airlangga, Surabaya, Jawa Timur, Indonesia, 2Faculty of Medicine, University Muhammadiyah of Surabaya, Surabaya, Jawa Timur, Indonesia, 3Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine-dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia, 4School of Pharmacy, School of Pharmacy, Bandung Institute of Technology, Bandung, Jawa Barat, Indonesia, 5Department of Pharmaceutical Chemistry, School of Pharmacy, Bandung Institute of Technology, Bandung, Jawa Barat, Indonesia, 6Department of Internal Medicine, Faculty of Medicine, Gadjah Mada University-dr. Sardjito Hospital, Yogyakarta, Indonesia, 7Department of Community Nutrition, Bogor Agriculture University, Bogor, Indonesia, 8Institute of Tropical Disease, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia, 9Department of Environmental And Preventive Medicine, Oita University Faculty of Medicine, Yufu, Oita, Japan
Purpose : Eradication of Helicobacter pylori infection still
become issue in Indonesia because of antimicrobial re-
sistance is still high, especially for metronidazole and
clarithromycin that is commonly used in the national
regiment therapy. Propolis extract is well known sub-
stance which has antimicrobial effect against some gram-
negative bacteria, but the effect against Helicobacter pylo-
ri remain unknown. The aim of this study was to know
the antimicrobial effect of Propolis extract against
Helicobacter pylori in clarithromycin and netronidazole
resistant strains.
Methods : Raw propolis from bee Trigona spp. obtained
from South Sulawesi, Indonesia was extracted by reflux
method using 70% ethanol, filtered and concentrated.
Anti-Helicobacter pylori effect of ethanol propolis extract
was tested on 10 types of Helicobacter pylori strains iso-
lated from dyspeptic patients. Microdilution method
and scratch method based on the results of the micro-
dilution test was used in determining the minimum in-
hibitory concentration (MIC) and minimum bactericidal
concentration (MBC) value of propolis extract used.
Combination effects were determined using the paper
tape method.
Results : Ethanol propolis extracts showed inhibition ac-
tivity at concentrations of 5% and 10% on all strains
Helicobacter pylori. MIC and MBC values were in the
range of 1024 - 8192 μg/mL and 1024 - 16348 μg/mL,
respectively. Propolis extract concentration required to
obtain a bactericidal effect against Helicobacter pylori was
the same or eight-fold higher than the corresponding
value. The combination of propolis extract and metroni-
dazole or claritomycin showed an additive effect.
Conclusions : Propolis might be can become additional
treatment against Helicobacter pylori infection that resist-
ance for metronidazole and clarithromycin treatment.
Key words : Helicobacter pylori, Propolis, Clarithromycin;
Metronidazole
PD-002
Comparison of furazolidone versus clarithromycin for eradication of Helicobacter pylori infection: A randomized multicenter clinical trial
Pezhman Alavinejad1, Seyed Saeed Seiedian1, Kave Ebadi Borna2, Eskandar Hajiani1, Maryam Lajmirnia1, Saeed Hesam3 1Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Iran, Islamic Republic of, 2Gi Ward, Ahvaz Amir-almomenin Hospital, Ahvaz, Khuzestan, Iran, Islamic Republic of, 3Department of Biostatics And Epidemiology School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Iran, Islamic Republic of
Purpose : To evaluate efficacy of furazolidone versus clar-
ithromycin in quadruple therapy for eradication of
Helicobacter pylori (HP)
Methods : During a 6 months period, all of the cases of
HP infection in 3 referral tertiary centers included
and randomly allocate to receive either clarithromycin
or furazolidone base quadruple regimen. For all of the
participants pantoprazole continued for 4 more weeks,
They underwent urea breath test to prove eradication.
Results : Overall 390 patients included (165 male (42%),
average age 44.2y). They diagnosed as non-ulcer dys-
pepsia (311 cases), peptic ulcer disease (30 cases) and in-
testinal metaplasia (45 cases). The participants randomly
allocated to groups A & B to receive either clari-
thromycin or furazolidone. In groups A and B, 80.9% &
82.1% of participants achieved eradication respectively
(P = 0.819). During study, there was not any major com-
plication but 3.1% of participants in each group re-
E-poster
155
ported minor side effects. In sub group analysis, the
eradication rate of clarithromycin among patients with
non-ulcer dyspepsia, PUD and intestinal metaplasia
were 80%, 100% & 55.6% respectively. These figures in
group B (furazolidone) were 80.7%, 100% & 85.7% re-
spectively (P = 0.906, 0 and 0.162; table 2). Overall, there
was no significant difference in success rate between clar-
ithromycin and furazolidone but in cases with intestinal
metaplasia, the positive results with furazolidone was
more (85.7% vs. 55.6%).
Conclusions : In areas with high rate of resistance to clar-
ithromycin, furazolidone could be a potential substitute
in HP eradication regimen and in cases with intestinal
metaplasia; furazolidone could be even more efficient.
Key words : Furazolidone, Clarithromycin, Hp
Flow chart of study (ITT: intention to treat; PP: per pro-
tocol; PABC: pantoprazole, amoxicillin, bismuth, clari-
thromycin; PABF: pantoprazole, amoxicillin, bismuth,
furazolidone).
PD-003
Helicobacter pylori eradication affects platelet count recovery in immune thrombocytopenia
Ayoung Lee1, Hyunsoo Chung1, Junshik Hong2, Youngil Koh2, Soo-Jeong Cho1, Ja Min Byun2, Sang Gyun Kim1, Inho Kim2 1Department of Internal Medicine And Liver Research Institute,, Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of
Purpose : Helicobacter pylori (H. pylori) infection is on
the rise as a cause of ITP, and the results show that platelet
recovery can be achieved after successful eradication.
The aim of this study is to clarify the long-term effect of
H. pylori eradication monotherapy on the platelet count
recovery in patients with ITP.
Methods : This study evaluated the long-term effects of
H. pylori eradication monotherapy on platelet count re-
covery in patients with ITP. H. pylori eradication was an-
alyzed in 61 ITP patients. Patients who maintained a
complete response (CR) for more than six months were
classified as sustained responders (SR).
Results : The prevalence of H. pylori infection was 54.3%
(75/138) and the success rate of eradication with
first-line therapy was 71.4% (35/49). Among the 61 pa-
tients, patients who achieved a complete response (CR)
at 2 months maintained a higher platelet counts there-
after (Figure 1). At 1 year after eradication, platelet count
increased 2.78 times in the eradicated group, 1.36 times
in the sustained infection group and 1.33 times in the no
infection group compared with baseline (P = 0.016). The
patients in the eradicated group and reached CR at 2
months after eradication showed SR in 77.8% (vs 14.3%
in NR, P = 0.010, Table 1).
Conclusions : In ITP patients with H. pylori infection,
the duration of CR in the eradicated group was longer
than sustained infection group, and obtaining CR at 2
months was associated with a sustained response.
Key words : Immune Thrombocytopenia, Helicobacter
pylori Eradication, Platelet Recovery
Figure 1. Trend of Platelet Counts during 5-Year Follow-Up
among Groups with H. pylori Infection Status
The 28th Annual Meeting of the Korean College of Helicobacter and Upper Gastrointestinal Research & the 3rd Seoul International Symposium on Helicobacter and Upper Gastrointestinal Diseases
156
Table 1. Baseline characteristics between sustained res-
ponder and non-sustained responder in eradicated
group
PD-004
Effect of Helicobacter pylori eradication after subtotal gastrectomy on the survival rate of patients with gastric cancer: Follow-up for up to 15 years
Nayoung Kim, Yonghoon Choi, Cheol Min Shin, Dong Ho Lee Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
Purpose : Helicobacter pylori (HP) is known to play an
important role in the development of gastric cancer
(GC). The aim of this study was to analyze the effect of
HP eradication on the survival rate and cancer re-
currence in patients who underwent subtotal gas-
trectomy for GC.
Methods : A total of 1,379 patients diagnosed with gas-
tric adenocarcinoma who received surgical treatment at
the Seoul National University Bundang Hospital from
2003 to 2017 and tested positive for HP infection were
retrospectively analyzed. The overall and GC-related
survival according to HP eradication were compared;
other risk factors for GC-specific death and cancer re-
currence were analyzed, and propensity score matching
was performed.
Results : Statistically significant benefits of overall and
GC-specific survival were observed in the eradicated
group (n=779) compared to the non-eradicated group
(n=600) (all p<0.001), and these significant benefits
were maintained after propensity score matching (each
group n=525, all p<0.001). In Cox proportional hazards
univariate and multivariate analyses, age ≥60 years, final
cancer stage, and HP positivity were found to be in-
dependent risk factors for GC-specific death (age ≥60
years, adjusted hazard ratio [aHR] 1.74, p=0.014; cancer
stage II, aHR 5.94, p<0.001; cancer stage above III, aHR
17.35, p<0.001; HP positivity, aHR 3.79, p<0.001). In
addition, final cancer stage and HP positivity were in-
dependent risk factors for cancer recurrence (cancer
stage above III, aHR 6.62, p=0.004; HP positivity, aHR
3.89; p<0.001).
Conclusions : Our results suggest that treatment for HP
should be conducted more intensively in patients who
are surgically treated for GC, regardless of cancer stage.
Key words : Helicobacter pylori, Subtotal Gastrectomy,
Eradication
Jae Gyu Kim, M.D., Ph.D.
PresidentKorean College of Helicobacter and Upper Gastrointestinal Research
This is to certify that
SI-HUG 2020 Distinguished Poster Award
Has been selected as the awardee ofthe SI-HUG Distinguished Poster Award,
at the 28th Annual Meeting of the Korean College ofHelicobacter and Upper Gastrointestinal Research &
the 3rd Seoul International Symposium onHelicobacter and Upper Gastrointestinal Diseases,
held in Seoul, Korea.
July 17-18, 2020
Faculty of Medicine Universitas Airlangga, Indonesia
Yudith Annisa Ayu Rezkitha
Taiwan Fellowship Kotak Masuk x
辦事處
Kam, 17 Okt 00.43
kepada saya, erin.ichilin
Dear Bu Arin,
Kami ucapkan selamat, penelitian Anda mengenai "Enhancing Gender Fair Culture in Taiwan:
Opportunities and Challenges in Accessibility to Business Capital for Indonesian Migrant
Women" telah terpilih dalam 2019 Taiwan Fellowship.
Penelitian ini akan dimulai dari Januari -Juni 2020 (6 bulan) dan Anda akan mendapatkan
allowance fee sebesar NTD $50,000/bulan.
Terlampir adalah Guidelines mengenai Taiwan Fellowship, mohon dibaca terlebih dahulu. Dan
mohon dikonfirmasi kembali persetujuan mengikuti Taiwan Fellowship ini melalui email paling
lambat hari Senin (21 Oktober 2019) sebelum jam 10:00 pagi.
Thanks & Regards
Nita