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How is the cell cycle regulated?Sections 8.8 and 8.9
+Factors that affect Cell Division
Anchorage Dependence Cells must be in contact
with solid surface in order to divide
Density-Dependent Inhibition Once cells come in
contact with other cells they stop dividing
+Factors that affect Cell Division
Growth Factors Proteins secreted by
certain body cells that stimulate other cells to divide
+Control of the Cell Cycle
Built in stop signals in the cell cycle must be triggered by proteins for the cycle to progress
Three major checkpoints: G1
Most important; Check size; DNA replicated
G2 DNA properly replicated
M Chromosomes attached
to spindle fiber
+Cell Cycle Control
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How do cancer cells differ from other cells?Section 8.10
+Cancer
Uncontrolled cell division
Cells are not subject to normal cell cycle control
Cells divide continuously
+Benign Tumor vs. Malignant Tumor
Benign Tumor Not cancerous Remains at the site of
origin
Malignant Tumor Cancerous Abnormal mass that
can/will spread to other parts of the body
+Metastasis
The spread of cancer cells beyond their original site
Cancers are named for their site or origin Carcinoma – originate in
body covering (inner and outer lining)
Sarcoma – originate in supportive tissues
Leukemia – originate in blood forming tissues
Lymphoma – originate in lymphatic system
+Cancer Prevention & Treatment
