Οδηγός για τους Γονείς Guide for Parents

4

-

Biohellenika

Biohellenika,

:

04 24 44

48

1034

50

22 64

40

: E BIOHELLENIKA H A

Biohellenika

Wharton

()

A A:

I Y

. I -

O . A ()

O A .

Biohellenika

IOHELLENIKA

BIOHELLENIKA BIOHELLENIKA

.

Biohe enika

:

04

, .

.

.

;

;

.

,

.

Biohellenika

.

,

, .

05

. - , ( -) . . - , , ' ,

0

(-196 C).

,

,

,

:

. A. -

,

.

-

.

-

,

.

- B.

,

. - ,

, , , ,

.

.

.

.

,

. 1 3

.

06

, ,

, .

'

.

.

.

1990

,

.

.

.

,

.

.

1990,

. .

,

. .

,

.

,

'

.

07

,

.

,

. , ,

( ) ,

, .

.

.

Biohellenika,

, ,

.

, .

,

,

.

, .

,

.

,

, . .

,

.

,

.

-

-

15

2007, -

2008 -

Transplantation

Proceedings 2007, 39 (10): 3380-4.

08

. ( . ()

Wharton)

.

.

6

( Wharton

, ) ,

.

.

,

. .

Biohellenika,

,

.

,

,

,

( .

).

, , ,

,

.

.

,

, ,

,

,

.

.

09

.

,

, ,

Notch. H

35 ,

Biohellenika, .

. ,

.

.

.

.

,

. '

,

.

.

10

. -

. ()

.

BIOHELLENIKA

11

.

5

.

. -

, -

70 ,

10.000 -

-

.

,

. - .

-

(.. ),

-

.

- ,

.

,

-

. -

20

1/2000, -

. 1/170 .

, - 1/3 -

65

, - .

, -

,

.. -

-.

-

12

-

. -

,

,

. , -

.

-

,

,

, , , , , , ,

, .

,

. -

- .

,

, -

,

Crohn. :

- ,

,

-

- -

-

.

.

.

.

()

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

1998

02/04/2001

13/04/2001

11/12/2001

12/4/2002

ug 2002

May 2003

April 2004

14/6/2004

02/09/2004

15/02/2005

12/04/2005

Aug 2005

Aug 2005

18/9/2005

21/12/2005

Jan 2006

Jan 2006

13/02/2006

21/03/2006

24/03/2006

April 2006

May 2006

A

Shwachman-

Diamond

1

Angelman's

1

1

1

Albert Einstein Hosp.,

Sao Paulo, Brazil

Via Cord, USA

Mt. Sinai Hospital,

Toronto, Canada

(now Insception

Biosciences)

Via Cord, USA

CBR, USA

Cryo-Cell, USA

California Cryobank,

USA (now Family CB

Services)

Eurocord-Slovakia,

Slovak Republic

Leukemia (ALL)

CBR, USA

CBR, USA

CBR, USA

Cryo-Cell, USA

Cryo-Cell, USA

CBR, USA

VITA34, Germany

Family Cord Blood

Services, USA

Cryo-Cell, USA

CBR, USA

Insception

Biosciences, Canada

Elie Kartz Umbilical

Cord, Blood Bank,

USA

Cryo-Cell, USA

Cryo-Cell, USA

Albert Einstein Hospital, Sao

Paulo, Brazil

Mount Sinai Medical Center, New

York City, USA

Hospital for Sick Children,

Toronto, USA

Texas Children's Hospital,

Houston USA

University of Minnesota,

Minneapolis, USA

Cedars-Sinai Medical Center Los

Angeles, USA

Children's Hospital, Denver, USA

University Children's Hospital,

Bratislavia, Slovakia

Corcell, USA (then owned by

VITA34, Germany)

Children's Hosp., Seattlel, USA

Duke University, Durham, USA


Shands Hospital, Univestiy of

Florida, Gainesville, USA



University of Hamburg,

Hamburg, Germany



Vanderbilt University Medical

Center Nashville, USA

City of Hope, Duarte, USA

Hospital for Sick

Children,Toronto, Canada






Ferreira et al. 1999

Fruchtman et al.2001

Fruchtman et al. 2004

Thornley et al. 2004

Falcon Krauss,

Gunter 2006

Thornley et. Al.2004

Jesse's story

Thornley et. Al.2004

Falcon, Krauss,

Gunter 2006

Harris, Mapother,

Brown 2003 Hough et

al.2003 Thornely et.

Al. 2004

Cryo-Cell

Thornely et. Al.2004

Eurocord - Slovakia

Advocate Hope

Children's Hosp., Oak

Lawn, USA Hayani et

al. 2007 VITA34

Thornely et. Al.2004

CBR

CBR

Cryo-Cell

Cryo-Cell

CBR

VITA34

Family Cord Blood

Services

Cryo-Cell

CBR

Insception

Biosciences

Elie Katz Umbilical

Cord Blood Bank,

Parent Paper 6/1

/2008

Cryo-Cell

Cryo-Cell

/ o

13

24

25

26

27

28

29

30

31

32

33

34

35

36

37

38

39

40

41

42

43

44

45

46

47

48

49

50

51

52

53

54

31/07/2006

19/09/2006

Sep 2006

09/01/2007

09/01/2007

Jan 2007

22/02/2007

01/03/2007

20/03/2007

23/03/2007

29/03/2007

Mar 2007

03/04/2007

03/04/2007

15/05/2007

17/05/2007

11/06/2007

20/07/2007

24/07/2007

28/08/2007

08/09/2007

Sept 2007

13/10/2007

23/10/2007

23/10/2007

04/12/2007

10/12/2007

15/01/2008

22/01/2008

08/02/2008

13/02/2008

1

1

1

1

1

1

1

CBR, USA

CBR, USA

Cryo-Cell, USA

Insception

Biosciences, Canada

CBR, USA

Cryo-Cell, USA

Insception

Biosciences, Canada

CBR, USA

ViaCord, USA

ViaCord, USA

ViaCord, USA

LiverTransplant Cryo-

Cell, USA

Insception

Biosciences, Canada

CBR, USA

CBR, USA

CBR, USA

CorCell, USA (Cord

Blood America)

CBR, USA

CBR, USA

CBR, USA

CorCell, USA (Cord

Blood America)

CordBank, New

Zealand

CBR, USA

CBR, USA

CBR, USA

Progenics Cord Blood

Cryobank, Canada

Progenics Cord Blood

Cryobank, Canada

CBR, USA

CBR, USA

CBR, USA

Insception

Biosciences, Canada

City of Hope, Duarte, USA






Shands Hospital, University of







Miami Children's Hospital,

Miami, USA

Medical College of Virginia

Richmond, USA


Children's Memorial Hospital,

Chicago, USA











University of Minnesota,

Minneapolis, USA

Starship Children's Hospital,

Auckland, New Zealand

Samitiveq Srinakarin Children's

Hospital, Bangkok, Thailand




Queen Mary Hospital, Hong Kong





Hospital of Sick Children,

Toronto, Canada

CBR

CBR

Cryo-cell

Insception

Biosciences

CBR

Cryo-cell

Insception

Biosciences

CBR

ViaCord

ViaCord

ViaCord

Cryo-cell

Insception

Biosciences

CBR

CBR

CBR

CorCell

CordBank

THAI StemLife

CBR

CBR

CBR

Progenics

CBR

CBR

CBR

Insception

Biosciences

CBR

CBR

CBR

Insception

Biosciences

o

/

14

55

56

57

58

59

60

61

62

63

64

65

66

67

68

69

70

71

72

73

74

75

76

77

78

79

80

81

82

83

84

85

86

87

88

89

90

91

92

26/02/2008

18/03/2008

18/03/2008

25/03/2008

08/04/2008

15/04/2008

06/05/2008

16/05/2008

23/05/2008

27/05/2008

27/05/2008

03/06/2008

04/06/2008

10/06/2008

19/06/2008

20/06/2008

26/06/2008

01/07/2008

08/07/2008

08/07/2008

15/07/2008

15/07/2008

29/07/2008

29/07/2008

05/08/2008

08/08/2008

19/08/2008

26/08/2008

26/08/2008

02/09/2008

09/09/2008

16/09/2008

16/09/2008

23/09/2008

30/09/2008

30/09/2008

14/10/2008

17/10/2008

1

1

1

-

1

-

1

CBR, USA

CBR, USA

LifebankUSA, USA

CBR, USA

CBR, USA

CBR, USA

CBR, USA

Insception

Biosciences, Canada

CBR, USA

CBR, USA

CBR, USA

CBR, USA

ViaCord, USA

CBR, USA

CBR, USA

CBR, USA

ViaCord, USA

ViaCord, USA

CBR, USA

CBR, USA

ViaCord, USA

CBR, USA

CBR, USA

CBR, USA

ViaCord, USA

ViaCord, USA

CBR, USA

CBR, USA

CordBank, New

Zealand

CBR, USA

CBR, USA

CBR, USA

ViaCord, USA

CBR, USA

CBR, USA

MAZE, USA

CBR, USA

CBR, USA















Miami Children's Hospital,

University of Florid, Gainesville,

USA





Santa Rosa
























CBR

CBR

LifebankUSA

CBR

CBR

CBR

CBR

Insception

Biosciences

CBR

CBR

CBR

CBR

ViaCord

CBR

CBR

CBR

ViaCord

ViaCord

CBR

CBR

ViaCord

ViaCord

CBR

CBR

ViaCord

ViaCord

CBR

CBR

CordBank, Maia's

story

CBR

CBR

CBR

ViaCord

CBR

CBR

MAZE, Baby John

case study

CBR

CBR

o

/

15

93

94

95

96

97

98

99

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

28/10/2008

04/11/2008

11/11/2008

11/11/2008

21/11/2008

02/12/2008

30/12/2008

30/12/2008

06/01/2009

06/01/2009

06/01/2009

13/01/2009

20/01/2009

20/01/2009

27/01/2009

27/01/2009

27/01/2009

03/02/2009

03/02/2009

17/02/2009

17/02/2009

24/02/2009

24/02/2009

24/02/2009

03/03/2009

10/03/2009

17/03/2009

17/03/2009

24/03/2009

24/03/2009

24/03/2009

26/03/2009

07/04/2009

07/04/2009

21/04/2009

21/04/2009

21/04/2009

26/05/2009

02/06/2009

16/07/2009

13/07/2009

16/01/2010

1

1

CBR, USA

ViaCord, USA

CBR, USA

CBR, USA

CBR, USA

ViaCord, USA

ViaCord, USA

ViaCord, USA

CBR, USA

ViaCord, USA

ViaCord, USA

CBR, USA

CBR, USA

CBR, USA

CBR, USA

ViaCord, USA

VITA34, Germany

ViaCord, USA

ViaCord, USA

CBR, USA

ViaCord, USA

CBR, USA

ViaCord, USA

ViaCord, USA

ViaCord, USA

CBR, USA

ViaCord, USA

ViaCord, USA

CBR, USA

CBR, USA

CBR, USA

VITA34,Germany

CBR, USA

ViaCord, USA

CBR, USA

ViaCord, USA

ViaCord, USA

ViaCord, USA

ViaCord, USA

VITA34,Germany

BIOHELLENIKA

BIOHELLENIKA


















Knappschaftskrankenhaus,

Bochum, Germany















Technical, Durham, USA








Ruhr-University, Bochum,

Germany



CBR

ViaCord

CBR

CBR

CBR

ViaCord

ViaCord

ViaCord

CBR

ViaCord

ViaCord

CBR

CBR

CBR

CBR

ViaCord

VITACord

ViaCord

ViaCord

CBR

ViaCord

CBR

ViaCord

ViaCord

ViaCord

CBR

ViaCord

ViaCord

CBR

CBR

CBR

VITA34

CBR

ViaCord

CBR

ViaCord

ViaCord

ViaCord

ViaCord

VITA34, Press

Release

BIOHELLENIKA

BIOHELLENIKA

o

/

16

. .

.

.

,

.

.

.

: .

, Crohn

. .

.

.

.

.

..

.

.

Parkinson.

.

.

.

.

17

Biohellenika Biohellenika -

- .

-

Duke

, . -

Biohellenika . , .

. -

,

,

Duke

. Biohellenika. -

.

97%. , - Biohellenika, ( Duke ) Georgia. . ,

Biohellenika

.

(,

)

,

.

-

,

Biohellenika

Biohellenika

, .18

. ,

. ,

.

.

-

. . -

, -

,

. .

, -

, Biohellenika

,

9

. -

- , .

Biohellenika

. , Pittsburgh.

, 10

- by-pass

, ,

, - -

, , .

. -

.

Biohellenika,

Biohellenika .

10

,

, .

19

20

-

. Biohellenika

, -Biohellenika, - , (). , - 1:26000 . . , 18 . . , 18 , . . , , - , (Hayani et al 2007 . P11991):e296-300 Pediatrics, Gorin et al 2008 -J Clin Oncol 26(19):3183-8. , -

. ,

,

. .

- ,

. Alzheimer

,

.

. -

,

- .

, -

.

6. ., ., ., Biohellenika

- ., ., ., ., .

In vitro

.

.

o

22 . 22 1. I. Koliakou, . sagias, V. Karagiannis

/ 2007.A rapid and efficient same-day procedure for

obtaining and cryopreserving Wharton's jelly 7. . , . -, . ,

mesenchymal cells . .

J Biological Research 2011.

2. Nikos Tsagias, Kokkona Kouzi-Koliakos, Iro ,

Koliakos, Vassilios Karagiannis, Kogimtzis

Aleksandros, George Koliakos. o

15 Addition of adipose derived stem cells in cord

, 6-8 2007. blood cultures, stimulates their pluripotent

differentiation.

8. Tsagias N., Kouzi-Koliakos K., Karagiannis V., Transplantation Proceedings 2009, 41(10)4340-4

Hamidi Alamdari, D. Koliakos G.

Time and temperature before processing 3. Kodonas K., Kouzi-Koliakou K., Karakitsos G.,

influence the recovery of umbilical cord blood Papadimitriou S., Gogos C., Tziafas D.

Cryopreserved dental pulpstem/progenitor cells hematopoietic progenitors.

from miniature pigs: a tool for regenerative Transfusion 47(8): 1550-52, 2007.

endodontics

9. Koliakos G., Alamdari D., Tsagias N., Kouzi- 2009

Koliakos K., Michaloudi E., Karagiannis V.

4. Antonitsis P., Ioannidou E., Kaidoglou E., A novel high yield volume reduction method for

Charokopos N., Kalogeridis A., Kouzi-Koliakou K., the cryopreservation of umbilical cord blood

Kyriakopoulou I., Klonizakis I., Papakostantinou units.

Ch. Cytotherapy 4: 1-6, 2007

Cardiomyogenic potential of human adult bone

10. Tsagias N., Kouzi-Koliakos K., Alamdari D., marrow mesenchymal stem cells in vitro

Kostidou E., Koliakos G. Thorac Cardiovasc Surg 2008, 56(2): 77-82

Cell recovery sufficient for adult transplantation

5. ., Hamidi Alamdari D., - by additional cord blood collection from

., . placenta.

Transplantation Proceedings, 2007, 39(10):3380-4.

.

. o

33 , 3-5

2007

21

Biohellenika,

,

. ,

Biohellenika,

.

22

IOHELLENIKA

23

Dr. ,

. , Dr. -,

,

-

. Biohellenika.

,

Biohellenika

,

.

.

Biohellenika

. 24 , 7

Biohellenika , 365

. .

H Biohellenika ,

. Biohellenika

.

Biohellenika

.

.

,

,

. .

Biohellenika,

,

.

, Biohellenika

,

Wharton.

, .

24

BIOHELLENIKA

25

. ,

5

. Biohellenika

.

(kit) Biohellenika,

.

, .

.

.

Biohellenika,

, . -

,

Biohellenika ,

.

.

,

,

,

,

.

26

Biohellenika

,

.

15

.

2007,

2008

.

.

Biohellenika

.

Biohellenika,

, .

.

,

,

.

ransplantation Proceedings 2007,

39 (10): 3380-4,

27

.

,

, -

, .

. -

Biohellenika -

,

. -

.

.

- Biohellenika -

,

.

.

.

,

,

. ,

,

- .

-

.

-

.

Biohellenika -

-

Wharton

28

. ( )

,

,

-

.

.

2003

,

(N.I.H.)

,

.

Biohellenika

.

,

,

, -

.

,

.

,

5 .

,

.

()

29

1 2 3

24

()

0. , . (4 C).

,

. .

.

( 24 ).

.

.

; !

30

Biohellenika

.

Biohellenika,

,

.

, . ,

. .

,

.

,

-,

. ,

.

.

,

.

Biohellenika .

,

, .

.

1

2

3

Biohellenika

.

31

-

ISO 15189.

-

.

.

.

: ,

,

.

>35

. (.. )

, FISH (1 2 )

QF-PCR ( PCR).

:

Biohellenika

.

32

Down

,

. .

()

,

, ,

.

.

. 24

(HPV)

.

: Biohellenika

A. .

B.

,

. , ,

. (Real Time PCR).

C. .

(Real Time PCR). Biohellenika

, o

.

3 .

Real Time PCR

,

Biohellenika

,

.

,

,

.

(Real-Time PCR): .

. , ,

.

: .

: 100%

: 97,2-100%

.

:

. .

Biohellenika (

Gendia ).

2.000

55 .

,

.

Real-Time PCR.

33

I

34

35

.

Biohellenika

- 24

. . '

,

. -

- Biohellenika.

,

( ) ,

7 . Biohellenika - . . Biohellenika, . . - .

Biohellenika, -

. '

courier, - , -

. -

. - Biohellenika

-

- , ,

Biohellenika ZEDA

.

.

. .

. ,

.

. -

36

Biohellenika .

Biohellenika , , ISO , 9001:2008 Lloyd's Register Quality Assurance . 362306/2002 ISO 9001:2008 . , Biohellenika ( (American Association , of Blood Banks) ).

. Biohellenika

(SO)

(. 410/8-2-

Biohellenika 2008 . 618/2-10-2009)

,

. 3066/2002,

. ( ,

, (PCR)

).

CE Biohellenika

(CE/IVD).

ISO 13485

.

.

(ISO) -

.

.

37

.

,

ISO 14644-5

VDI 2083 BSR.

.

Biohellenika

,

24

. , .

.

.

.

.

,

,

, 20 . ,

AABB, JACIE Netcord, ISO 9001,

13485, 14644, 15189 27001.

CE, 24-

-

().

. Biohellenika -

, -

. (

-). Biohellenika

, AXP General

-Electric. -

, ,

. Biohellenika GMP, -

- ,

.

Biohellenika 8

-, 5 3

, ,

38

.

.

, -

. -

(), -

server back up mirror.

-

,

,

- -

,

, -

. -

- Biohellenika

. 95%

-. -

. -

- Cytotherapy 2007 9(7): 654-9.

, -Koliakos G, Alamdari D, Tsagias N, Kouzi-

Koliakos K, Michaloudi E, Karagiannis V. ''A

novel high-yield volume-reduction method for

. the cryopreservation of UC blood units'',

, -

Duke.

20

-

Biohellenika - -

.

Biohellenika - .

-

Biohellenika - .

.

39

,

. - Biohellenika

. .

,

,

,

50.000 ,

. ,

,

Biohellenika.

Biohellenika

Biohellenika -

(Voyager)

.

. Biohellenika .

: - . 2007

Biohellenika ,

.

, 2007 . Biohellenika

.

. 2008.

.

40

BIOHELLENIKA

41

1.

.

.

5. Biohellenika

. Biohellenika

.

(American Association of Blood Banks)

2.

( Wharton). Biohellenika

.

,

,

. ,

.3066/2002,

, ,

.

3. . , ' 410

8/2/2008 .

Biohellenika , 6. :

Biohellenika

ISO 9001:2008 Lloyd's Register

Quality Assurance

. ,

4. . (

Biohellenika ,

,

:

.

42

). 10. . Biohellenika

ISO 13485

. 100

7. .

(clean rooms):

11. :

GMP, Biohellenika

Qualification of the ,

clean rooms

BSR Ingenieur Buro, ISO 14644-5 ,

. .

8. : 12. : Biohellenika

GMP.

,

'

(20

(CE, IVD). ).

9. : Biohellenika

,

. Biohellenika

13. :

2589

31/12/2009.

43

.

.

.

14. : Biohellenika

50.000 ' .

, 18. : Biohellenika

.

.

. .

15. :

.

16. :

(

)

.

17. :

44

E H A

Biohellenika

45

-

- , -

. 90 - .

-

, -

. .

, .

,

. .

. - -

. -

- . -

-

. -

, - .

, ,

GMP

. . -

-

-

. .

- cryoflex

-

-196C '

. -

2000 2006. -

3,5% 9,6% , -

. (75%)

- .

2 , Khuu et al, Biohellenika o

Cytotheraphy 2002, 4 (6): 539-540.

Biohellenika

-().

Biohellenika

.

46

-

.

.

, Biohellenika Biohellenika AXP Autoexpress 2.500 , 800 Platfrom Thermogenesis USA, 90% . - - 80 , 90% . - , 80% Master Biohellenika o 15% . - . Dr. , . , ,

Dr. , , -

-,

() - - :

Biohellenika 1.

. .

H Biohellenika

, 90%.

: -2. -

-

,

, .

,

3. -

.

4.

. (

) . ,

-5. PCR

,

, .

-6.

25 .

Biohellenika

47

, - , ,

.

. 4

,

,

1 -196C, Biohellenika , - 20 . , -

'

5 . , -

Biohellenika , ,

, -

, -

. - (bar code).

2 . ( - - , - Biohellenika -, ) . , - - . 20 , . - . , - . .

18 . Biohellenika 3

20 ,

. .

18 -

..

Biohellenika

48

A A: Y

49

.

, .

6.

:

1.

, .

7. .

2. .

8. .

3.

( , .

,

9.

).

4. ,

(,

, ISO, )

. , .

10.

.

.

5. ,

. ;

Biohellenika

,

.

50

I O A O A

51

1988: -

-

, ' 5 63%, , ,

Fanconi ( ). - 23%.

1998:

-

. , 20 ,

, , , . .

1991: :

-

- , -

. -

- .

,

,

. ,

1992:

-

. -

. 2001:

1995: Lancet,

, ,

90%

., -

2003: -

3.000

-. , -

- ' .

2004: Gesine Koegler

,

. Journal of Experimental Medicine

- .

. 1997:

,

-

52

2007: .

2006:

,

.

, .

Transfusion, 2006: Biohellenika,

(). .

2007:

10%

24, 40% 80% 2003

24 , 3

. .

(2007) .

,

. .

Tsagias et al, 2007: Transfusion vol 472008:

,

.

2009: Biohellenika

.

2010: H Biohellenika

.

: Biohellenika

( ,

, -

)

,

.

53

4 7 2010 - .

To - (Word , -Cord Blood Congress) - - . - Biohellenika - . - Biohellenika , : - . ,

, - .

,

- San Francisco,

- .

. - - . - . , - . Biohellenika - - . - , Biohellenika, . .

. , , , - - , - - . - . - -

Word Cord Blood Congress

4-7 / 11 / 2010

54 55

. ,

. -

, -

.

Biohellenika, Kurtzberg. -

Biohellenika

,

.

-

, .

-

- .

.

- ,

.

., -

,

,

.

- .

-

, 16 .

.

o Biohellenika - Biohellenika 8

-

-

Duke . San Francisco 3-5/6/2010

- ,

- -. - Biohellenika - .

-

- ,

- -

- ,

.

.

,

, 21

.

.

-

-

-, . -

. -

. -

- .

-

, -

,

- Duke

- .

8

San Francisco

3-5/6/2010

56 57

-

Duke , . J. Kurtzberg.

Biohellenika Biohellenika

,

.

.

-

-

-

.

. - iohellenika

31

, .

-

Biohellenika,

. ,

Voyager, 23 , .

.

.

- - , . Biohellenika . - . -

- -

28/7/2009.

- .

-

.

-

. Biohellenika

. ,

, 10 . -

- -

- .

. .

-

-

.

. Biohellenika,

-

,

, ,

,

. Biohellenika

-

-

.

.

-

Duke . -

97%, ,

. ,

. . -

-

58 59

BIOHELLENIKA DUKE

.

Duke

.

4

.

-

. O

, ,

, . .

,

. . -

97% -

.

.

. -

O - -

.

Georgia - .

- 20 -

-,

, -

8 .

Biohellenika

.

.

Biohellenika - .

Duke

. ,

Biohellenika,

( )

Biohellenika .

.

-

10

,

,

. .

.

-

, -

Biohellenika -

-

. - -

9 .

. -

-

. 9

-

.

, -

, -, ,

. ,

-

, -

-

-.

, , ,

. ,

.

.

60

KEEGAN & KELDAN

Keldan Wendy. DOHENEY, , -

.

.

:

.

Keegan -

.

, Keegan

Keldan. .

. , ,

. Wendy Doheney

.

Keegan .

Doheneys

. 3

. Keegan

,

Wendy.

.

Keegan

.

, .

Wendy

Keegan -

. :

Doheneys

Keegan.

, -

-

Keegan. -

61

. DALLAS HEXTELL

Dallas

:

: , -

, .

. Cynthia,

. -

Dallas

- .

Dallas

Cynthia Hextell,

Dallas, - Dallas.

Dr. David T. Harris,

. Hextells -

:

Dallas -

. . Dallas ,

, -

,

. - -

, ''.

. , Hextells

Hextells -

Dallas. Dallas,

, .

.

Dallas -

18 . ,

Hextells ,

. Hextells . Dallas, Polly

-Harlan,

: Dallas -

,

, .

.

62

-

1

.

-

,

.

.

100%

. 2

30% .

. Biohellenika -

-

.

.

50.000

.

Biohellenika

,

(AABB & ),

(ISO)

.

Biohellenika

, 100

.

.

-

.

( ).

3

1/100.000 .

,

( 25%

) 4,5

.

.

. 6

12.000 .

.

.

1. Gluckman E, et al: Outcome of cord-blood transplantationfrom 6. http://www.eae.gr/images/uploads/%20% 201354.pdf

related and unrelated donors. EurocordTransplant Group and the 7. drastriotita-el-mon-metamosx08.ppt,

European Blood AndMarrow Transplantation Group. N Engl J ,

Med1997;337:373381.8. Al Gratwohl 2010, JAMA, 303(16):1617-1623

2. 9. 19 2010 ( 13/3/2009

10. Smith RA et al 2009. Biol Blood Marrow & Transp 3. ioAcademy Bulletin-10/200715:1086-1093

4. Gluckman 201011. Krutzberg et al 2009: Curr Opin Pediatr 21(1):22-29

5. Lauber S et al. The Mannheim Cord Blood Bank: Experiences and 12. Joseph R. W. 2008. J Support Oncol,6:361-372Perspectives for the Future. Transfus Med Hemother. 2010

Apr;37(2):90-97. 13. Wiseman DH at all 2010), Biol Blood Marrow Transpl

!

BIOHELLENIKA

63

Biohellenika

2

.

70% 7

,

1/3 (10%) 8,9

.

, ,

,

.

-

,

-

,

.

-

.

-

.

2

.

30%

, -

-

.

1/3 (10%) 9

. 10

(10%) .

11

50% .

, .

,

12

.

-

.

5% -

-

13

.

,

Documents

Οδηγός για τους Γονείς Guide for Parents