ISSN 0036-807514 AUGUST 1992VOLUME 257NUMBER 5072

AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE

IEWS & COMMENT _ _ PERSPECTIVES

Fetal Transplants Show PromiseThe Tissue Bank's Shaky Underpinnings

Chemistry Curricula Edge Towarda New World

NSF Holds Plan Close to Its Vest

Mitochondrial Eve: Wounded, But NotDead Yet

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Reading the Bones for Modem Human Origins

RESEARCH NEWS

Huge Impact Tied to Mass Extinction i 878

Getting Some "Backbone":

How lMHC Binds Peptides

Microgravity Materials Science Strives toStay in Orbit

Possible Evolutionary Role Explored for"Jumping Genes"

Science Innovation '92:The San Francisco Sequel

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Intermolecular InteractionsW. Klemperer

Splicing Takes a HollidayJ. A. Steitz

ARTICLESThe Nature of the Metal-Metal Bondin Bimetallic Surfaces

J. A. Rodriguez and D. W. Goodman

PATENT POLICYGenes, Patents, and Product 903DevelopmentR. S. Eisenberg

Genome Research: Fulfilling thePublic's Expectations for Knowledge andCommercializationR. G. Adler

Patents on Random ComplementaryDNA Fragments?T. D. Kiley

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DEPARTMENTSTHIS WEEK IN SCIENCE 857

EDITORIAL 859Science Is Great, But Scientists Are Still People:A. Komberg

LETTERS 860Drugs from Third World Plants: I. S. JohnsonoComputing in Science: J. Ross * Condom Use: F.L. Sonenstein * NSF and Duplicate Grant Submis-sions: D. Jaron * Combating Epidemic Cholera:R. A. Finkelstein * Nucleoside DiphosphateKinase: Conclusions Withdrawn: P. A. Randazzo,R. A. Kahn, J. K. Northrup

SCIENCESCOPE

RANDOM SAMPLESBush Administration Weighs in on AIDSSocieties Sound Alarm on Biodiversity, etc.

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BOOK REVIEWS 981The Code of Codes, reviewed by B. D. Davis *

Everyday Cognition in Adulhood and Late Life, T. A.

Salthouse * Andean Magrtism and Its TectonicSetting, B. S. Singer * Vignettes: Tales ofInvention* Books Received

PRODUCTS & MATERIALS 987

_AAAS Board of Directors -BoardIof Reviewing Editors_

Leon M. LedermanRetiring President,Chairman

F. Sherwood RowlandPresident

Eloise E. ClarkPresident-elect

Mary Ellen AveryFrancisco J. AyalaRobert A. Frosch

Florence P. HaseltineAlan SchriesheimJean'ne M. ShreeveChang-Lin TienWarren M. Washington

William T. GoldenTreasurer

Richard S. NicholsonExecutive Officer

John AbelsonFrederick W. AltDon L. AndersonStephen J. BenkovicDavid E. BloomFloyd E. BloomHenry R. BourneJames J. BullKathryn CalameC. Thomas CaskeyDennis W. Choi

John M. CoffinBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. FearonHarry A. FozzardVictor R. FuchsTheodore H. GeballeMargaret J. GellerJohn C. GerhartRoger 1. M. Glass

Stephen P. GoffCorey S. GoodmanStephen J. GouldIra HerskowitzEric F. JohnsonStephen M. KosslynMichael LaBarberaCharles S. Levings Ill

Harvey F. LodishRichard LosickAnthony R. Means

Mortimer MishkinRoger A. NicollWilliam H. Orme-Johnson Ill

Stuart L. PimmYeshayau PockerDennis A. PowersRalph S. QuatranoV. RamanathanErkki RuoslahtiRonald H. SchwartzTerrence J. Sejnowski

Thomas A. SteitzRichard F. ThompsonRobert T. N. TjianEmil R. UnanueGeerat J. VermeijBert VogelsteinHarold WeintraubZena WerbGeorge M. WhitesidesOwen N. WitteKeith Yamamoto

SCIENCE * VOL. 257 * 14 AUGUST 1992

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COVERComputer simulation of a molecular beam of the ben-zene-water dimer. The sizable penetration of the vander Waals surfaces, depicted by the dotted surfaces inthe bottom right corner (light blue for water and pink forbenzene), illustrates the hydrogen bond interaction of

water with the benzene t electron cloud. See page 942and the Perspective on page 887. [Computer graphics:Geoffrey A. Blake and Siddharth Dasgupta. Production:Mario Blanco and Carolynn Sherby, Molecular SimulationsInc.]

RESEARCH ARTICLES IEI

Crystal Structures of Two Viral Peptides F 919in Complex with Murine MHC Class I H-2KbD. H. Fremont, M. Matsumura, E. A. Stura,P. A. Peterson, I. A. Wilson

Emerging Principles for the Recognition F 927of Peptide Antigens by MHC Class I MoleculesM. Matsumura, D. H. Fremont, P. A. Peterson,I. A. Wilson

REPORTSA Lunar Occultation of the Dust-Scattering 935Halo Around GX 5-1 Observed with ROSATP. Predehl, J. H. M. M. Schmitt, S. L. Snowden,J. Trumper

High-Velocity Pulsars in the Galactic Halo 937D. Eichler and J. Silk

Benzene Forms Hydrogen Bonds r 942with WaterS. Suzuki, P. G. Green, R. E. Bumgamer,S. Dasgupta, W. A. Goddard III, G. A. Blake

Synthesis of Fluoropolymers in 945Supercritical Carbon Dioxide

J. M. DeSimone, Z. Guan, C. S. Elsbernd

Internal Stark Effect Measurement of the 947Electric Field at the Amino Terminus of an a HelixD. J. Lockhart and P. S. Kim

The Reversal and Splitting of Waves in an 951Excitable Medium Caused by an Electrical FieldH. Sevclfkova, M. Marek, S. C. Muller

Coeval 40ArM9Ar Ages of 65.0 Million ° 954Years Ago from Chicxulub Crater Melt Rockand Cretaceous-Tertiary Boundary TektitesC. C. Swisher III, J. M. Grajales-Nishimura,A. Montanari, S. V. Margolis, P. Claeys,W. Alvarez,P. Renne, E. Cedillo-Pardo, F. J-M. R. Maurrasse,G. H. Curtis, J. Smit, M. 0. McWilliams

Pseudo-Half-Knot Formation with RNA 95D. J. Ecker, T. A. Vickers, T. W. Bruice,S. M. Freier, R. D. Jenison, M. Manoharan,M. Zounes

Combining Experimental Information from 96Crystal and Solution Studies: Joint X-rayand NMR RefinementB. Shaanan, A. M. Gronenbom, G. H. Cohen,G. L. Gilliland, B. Veerapandian, D. R. Davies,G. M. Clore

A Critical Role for Conserved Residues Fin the Cleft of HLA-A2 in Presentationof a Nonapeptide to T CellsF. Latron, L. Pazmany, J. Morrison, R. Moots,M. A. Saper, A. McMichael, J. L. Strominger

Differential Display of EukaryoticMessenger RNA by Means of thePolymerase Chain ReactionP. Liang and A. B. Pardee

Biosynthesis of Human Papillomavirusfrom a Continuous Cell Line UponEpithelial DifferentiationC. Meyers, M. G. Frattini, J. B. Hudson,L. A. Laimins

Rapamycin-Induced Inhibition of the70-Kilodalton S6 Protein KinaseD. J. Price, J. R. Grove, V. Calvo, J. Avruch,B. E. Bierer

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A Point Mutation of the a2-Adrenoceptor 977That Blocks Coupling to Potassium But NotCalcium CurrentsA. Surprenant, D. A. Horstman, H. Akbarali,L. E. Limbird

PI Indicates accompanying feature

* SCIENCE (ISSN 0036-8075) Is published weekly on Friday, except the last week InDecember, by the American Association for the Advancement of Science, 1333 H Street,NW, Washington, DC 20005. Second-class postage (publication No. 484460) paid at Washington,DC, and additional mailing offices. Copyright @ 1992 by the American Association for the Advance-ment of Science. The title SCIENCE is a registered trademark of the AAAS. Domestic individualmembership and subscription (51 issues): $87 ($47 allocated to subscription). Domestic institutionalsubscription (51 issues): $195. Foreign postage extra: Mexico, Caribbean (surface mail) $50;other countries (air assist delivery) $95. First class, airmail, student and emeritus rates on

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Bulk rates on request. Authorization to photocopy material for internal or personal use undercircumstances not falling within the fair use provisions of the Copyright Act is granted by AAAS tclibraries and other users registered with the Copyright Clearance Center (CCC) TransactionalReporting Service, provided that the base fee of $1 per copy plus $0.10 per page is paid directlyto CCC, 27 Congress Street, Salem, MA 01970. The identification code for Science is 0036-8075/83$1 + .10. Science is indexed in the Reader's Guide to Periodical Literature and in severalspecialized indexes.* TheAmerican Association fortheAdvancementof Science wasfounded in 1848and incorporatedin 1874. Its objectives are to further the work of scientists, to facilitate cooperation among them, tofoster scientific freedom and responsibility, to improve the effectiveness of science in the promotionof human welfare, to advance education in science, and to increase public understanding and appre-ciation of the importance and promise of the methods of science in human progress.

SCIENCE * VOL. 257 * 14 AUGUST 1992

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