#discoverbrighamElzerie de Jager, MBBS(Hons) Research Fellow, Center for Surgery and Public Health – Brigham and Women’s Hospital, Harvard Medical School and the Harvard T. H

#discoverbrigham

DISCOVERBRIGHAM

2018

12:00 PM

2:30-3:30 PM

5:00-6:00 PM

1:10-1:40 PM

1:50-2:20 PM

3:40-4:10 PM

4:20-4:50 PM

1:10-1:40 PM

1:50-2:20 PM

3:40-4:10 PM

4:20-4:50 PM

2018 AgendaZINNER BREAKOUT ROOM

ACROSS THE HOSPITAL

1:10-1:40 PM

1:50-2:20 PM

3:40-4:10 PM

4:20-4:50 PM

Trauma and Violence

Human Models to Study Human Diseases

Long Live the Lung

Experts Weigh in; Pathways to Weight Loss

Lunch and Demos

Poster Session

Awards Ceremony

ZINNER BOARDROOM

All of Us

Cancer in the Crosshairs

Boning Up on the Connection Between Muscle and Bone

Women are not Men

HALE CONFERENCE ROOM

Successful Innovation

Sleep Well, Live Well

Research Open Mic

No Wrong Door

Welcome to Discover Brigham!

Thank you for attending Discover Brigham 2018. We hope you that enjoy your

day of discovery and dive into the amazing research that takes place every

day at Brigham and Women’s Hospital. There are activities throughout the

hospital for you to visit where you’ll find out how we’re building a healthier

world through scientific discovery.

The day would not be possible without the efforts of those in countless

departments across the hospital or our wonderful Discover Brigham

volunteers. THANK YOU!

ATM

Food

Gift Shop

Information Desk

Restroom

Elevator

Emergency

Pharmacy

Valet Parking

Parking Garage

Lunch

Registration

Poster Session

Sessions

Headshots

DISCOVER Key

Demos

MAP Key

Food

Gift Shop

Information Desk

Restroom

Elevator

Pharmacy

Valet Parking

Parking Garage

Lunch

Poster Session

Sessions

Headshots

RRReReRe igigigi ttststraara ititittitionooonon

DISCOVERDISCOVER KKeeyy

Demos

AAATTTAAAAA MMM

Food

EEEEEmmmmeeeeeerrrrrggggggeenenenenncccyyy

MAPMAPM KKeeyy

80 Francis St

60 Fenwood Rd

45 Francis St 15 Francis St

Binn

ey S

tree

t

Huntin

gton

Ave

nue

Shattuck Street

75 Francis StShuttle

Brigham Circle

ShapiroCardiovascularCenter

80Francis St Garage Vi

ning

Str

eet

Vining Street

45 Lobby

E Line

TH

E P

IKE

THE PIKE

2nd-Floor Bridgeto Children’s Hospital

3rd-Floor Bridgeto Dana-Farber

to Harvard

Medical School

To BrooklineAvenue

To LongwoodAvenue

THE PIKE

Hale Building forTransformative MedicineNeurosciencesCenter

NNNNNNNNNN

J

Valet

15 Lobby

PedestrianEntrance

2nd Floor

23

4

5

6

7

8

9

10

ATM

Food

Gift Shop

Information Desk

Restroom

Elevator

Emergency

Pharmacy

Valet Parking

Parking Garage

Lunch

Registration

Poster Session

Sessions

Headshots

DISCOVER Key

Demos

MAP Key

Food

Gift Shop

Information Desk

Restroom

Elevator

Pharmacy

Valet Parking

Parking Garage

Lunch

Poster Session

Sessions

Headshots



Demos

AAATTTAAAAA MMM

Food


MAPMAPM KKeeyy

80 Francis St

60 Fenwood Rd


Binn

ey S

tree

t

Huntin

gton

Ave

nue

Shattuck Street


Brigham Circle



ning

Str

eet

Vining Street

45 Lobby

E Line

TH

E P

IKE

THE PIKE



to Harvard

Medical School

To BrooklineAvenue

To LongwoodAvenue

THE PIKE


NNNNNNNNNN

J

Valet

15 Lobby

PedestrianEntrance

2nd Floor

ATM

Food

Gift Shop

Information Desk

Restroom

Elevator

Emergency

Pharmacy

Valet Parking

Parking Garage

Lunch

Registration

Poster Session

Sessions

Headshots

DISCOVER Key

Demos

MAP Key

Food

Gift Shop

Information Desk

Restroom

Elevator

Pharmacy

Valet Parking

Parking Garage

Lunch

Poster Session

Sessions

Headshots



Demos

AAATTTAAAAA MMM

Food


MAPMAPM KKeeyy

80 Francis St

60 Fenwood Rd


Binn

ey S

tree

t

Huntin

gton

Ave

nue

Shattuck Street


Brigham Circle



ning

Str

eet

Vining Street

45 Lobby

E Line

TH

E P

IKE

THE PIKE



to Harvard

Medical School

To BrooklineAvenue

To LongwoodAvenue

THE PIKE


NNNNNNNNNN

J

Valet

15 Lobby

PedestrianEntrance

2nd Floor

2nd floor3rd floor

1st floor

1

131211

14 15

KeyLactation Support ServicesGas Man® Inhalation Anesthesia SimulatorOrthopedic Discharge Nurse NavigatorYoga: Understanding the Underlying ScienceBrigham Education InstituterecoupERASMAE: Medication Access EngineIdentifying & Treating Nonmelanoma Skin CancerStop the BleedIndications-based CPOE PrototypeCystectomy PrehabilitationED Patient NavigatorDICOM VRMechanical Circulatory Support UnitZebrafish

DISCOVER BRIGHAM 2018Demo Map

1.2.3.4.5.6.7.8.9.

10.11.12.13.14.15.

ATM

Food

Gift Shop

Information Desk

Restroom

Elevator

Emergency

Pharmacy

Valet Parking

Parking Garage

Lunch

Registration

Poster Session

Sessions

Headshots

DISCOVER Key

Demos

MAP Key

Food

Gift Shop

Information Desk

Restroom

Elevator

Pharmacy

Valet Parking

Parking Garage

Lunch

Poster Session

Sessions

Headshots



Demos

AAATTTAAAAA MMM

Food


MAPMAPM KKeeyy

80 Francis St

60 Fenwood Rd


Binn

ey S

tree

t

Huntin

gton

Ave

nue

Shattuck Street


Brigham Circle



ning

Str

eet

Vining Street

45 Lobby

E Line

TH

E P

IKE

THE PIKE



to Harvard

Medical School

To BrooklineAvenue

To LongwoodAvenue

THE PIKE


NNNNNNNNNN

J

Valet

15 Lobby

PedestrianEntrance

2nd Floor

Lower Pike

1

DISCOVERDEMOSAt Discover Brigham, you’ll find a variety of interactive demonstrations and

displays from some of our researchers. We’ve created a map for you to use as

you make your way throughout the demos. The demos will be available from

12PM - 1PM today.

DISCOVERDEMOSLACTATION SUPPORT SERVICESThe Mamava suite, a freestanding, prefabricated lactation space, was a solution to help to fulfill this need. The Mamava provides a serene, private, and clean space for mothers to pump or to breastfeed their infants while visiting our hospital and creates a flexible space for staff to find additional areas in which to pump milk for their infants while at work.

GAS MAN® INHALATION ANESTHESIA SIMULATORGas Man® is a computer simulation which pictorially and graphically shows the path and progress of anesthetic gases moving from the vaporizer to the patient’s brain. Science students, medical students, residents, nurses, physicians, and practicing anesthesiologists can learn about drug movement around the body.

ORTHOPEDIC DISCHARGE NURSE NAVIGATORThe discharge nurse navigator (DNN) is a nurse-driven position that has helped improve workflow of the discharge process for the orthopedic patient population. This demo will take participants through the various responsibilities of the DNN and the resulting outcomes.

YOGA: UNDERSTANDING THE UNDERLYING SCIENCEIn easy-to-understand language, we will review some of the basic science underlying the psychophysiology of yoga practices and briefly describe ongoing cutting edge biomedical research. We will also do a brief chair-based practice of a few simple techniques.

BRIGHAM EDUCATION INSTITUTEThe Brigham Education Institute is dedicated to supporting our medical educators by offering access to a variety of resources including technological platforms such as providing you the opportunity to creating concept videos in our Ed Tech studio. Additionally, we offer BWH Medical Library services for all your research needs.

RECOUPERASrecoupERAS is a fully mobile app designed to complement the BWH Enhanced Recovery After Surgery (ERAS®) pathway. The recoupERAS app helps patients prepare for surgery, guides them through the hospital stay, and helps patients recover faster, safer, and more easily from surgery.

MAE: MEDICATION ACCESS ENGINEMAE is an interactive and patient-friendly navigator that directs patients to appropriate medication access resources. The demo takes the participant through various medication access scenarios (ex. Medicare donut hole, high copayments, etc.)

IDENTIFYING & TREATING NONMELANOMA SKIN CANCERThis interactive demo shows how dermatologists identify basal and squamous cell carcinomas and perform Mohs surgery, during which thin layers of cancer-containing tissue are progressively removed and examined under the microscope until tissues are cancer-free. Viewers can then test their knowledge by identifying these cancers among several pictures of skin lesions.

STOP THE BLEEDThis demo will teach bleeding control skills via tourniquet application, wound packing, and pressure application.

INDICATIONS-BASED CPOE PROTOTYPEWe will demonstrate a working prototype of an indications-based electronic prescribing system. This prototype is the culmination of a three year AHRQ funded project focused on incorporating the indication into the prescriber workflow.

CYSTECTOMY PREHABILITATIONOur interactive demo will include a demonstration of grip strength via a handheld dynamometer which is one of the tests used in our initial evaluation and a timed 5 time sit to stand test which is another outcome measure used showing cystectomy supplies and video of surgery.

ED PATIENT NAVIGATORThe ED Patient Navigator program piloted out of BWH ED is an innovative way for BWH affiliates to promote their programs in a setting that captures a large patient pool. High risk, vulnerable and difficult to reach patient populations affected by multiple social determinants of health can be re-routed back to primary care and BWH programs via an ED Patient Navigator facilitating the connections.

DICOM VRThese researchers are building a system that enables clinicians to intuitively view and manipulate medical images in a 3D VR environment to improve the speed, safety, and precision of image-guided cancer treatments. In this demo, participants will have the opportunity to put on a VR headset and try a new way of looking at and interacting with 3D medical images.

MECHANICAL CIRCULATORY SUPPORTThis demo will showcase The Brigham and Women’s Hos-pital Mechanical Circulatory Support (MCS) unit. We deliv-er state-of-the-art care for patients with end-stage heart failure. These patients have a mechanical pump known as ventricular assist device (VAD) implanted to their hearts; the VAD allows them not only to survive very severe heart diseases but also to live a normal life.

ZEBRAFISHAt this Discover Brigham Demo, we are planning to show adult zebrafish and we’ll bring a microscope to look at several developmental stages of embryos and explain how investigators use them for their research here at Brigham and Women’s Hospital.

Check out these demos across the hospital from 12PM to 1PM today.

TRAUMA & VIOLENCEInforming Our Research AgendaZINNER BREAKOUT ROOM

1:10PM - 1:40PM

DISCOVERRESEARCHThis roundtable will focus on mental health and intimate partner violence; two socially informed topics that are significantly intertwined with the #MeToo campaigns stirring across the globe. What can we be doing better to address mental health issues related to trauma and violence? Where is the research heading? A collaboratory will follow in Shapiro Lounge.

FEATURING

Bharti Khurana, MDProgram Director, Emergency Radiology, Brigham and Women’s Hospital @KhuranaBharti

Annie Lewis-O’Connor, PhD, NP-BC, MPH, FAANSenior Nurse Scientist, Founder & Director of the C.A.R.E Clinic at Brigham and Women’s Hospital; Research Associate, Department of Women’s Health; Co-Chair, Partners Trauma-Informed Steering Committee and BWH TIC Initiative; Instructor, Harvard Medical School

Elzerie de Jager, MBBS(Hons)Research Fellow, Center for Surgery and Public Health – Brigham and Women’s Hospital, Harvard Medical School and the Harvard T. H. Chan School of Public Health. @ElzerieDJ

Alexander Lin, PhDDirector of the Center for Clinical Spectroscopy, Brigham and Women’s Hospital; Assistant Professor of Radiology, Harvard Medical School

Eve Rittenberg, MD, MAPrimary Care Physician at BWHAssistant Professor at Harvard Medical School, 2018 Robert Wood Johnson Clinical Scholar

The goal of the All of Us Research Program is to create a community of one million people or more who are willing to share their unique health data with researchers. As in any large-scale, long-term study involving humans, there are significant challenges, such as the concern for patient privacy in the digital age, decade-long study retention, broad and deep community engagement, and the appropriate and timely return of research results to participants. A collaboratory will follow in Shapiro Lounge.

A COMMUNITY CONVERSATION ON EQUITY IN PRECISION MEDICINEMaking All of Us Work for All of UsZINNER BOARDROOM

1:10PM - 1:40PM

FEATURING

Elizabeth Karlson, MD, MMScProfessor of Medicine, Harvard Medical School; Principal Investigator, All of Us

Latrice Landry, PhD, MMScFellow, Brigham and Women’s Hospital, Dana Farber Cancer Institute and Harvard Medical School

Jonathan Jackson, PhDDirector, MGH Community Access Recruitment & Engagement (CARE) Research Center; All of Us New England Engagement Co-Investigator

SUCCESSFUL INNOVATIONAt An Academic Medical Center HALE CONFERENCE ROOM

1:10PM - 1:40PM

Panelists will highlight Brigham Health’s collaborative approach to innovation, showcasing what successful innovation at an academic medical center looks like, with representation from BCRISP, the Brigham Innovation Hub, as well as from frontline innovators and start-up partners. A collaboratory will follow in Brigham Digital innovation Hub.

FEATURING

Josie Elias, MBA, MPHProgram Manager, Digital Health Innovation @josieelias

Karl Laskowski, MD, MBAAssociate Medical Director, Brigham Care Redesign Incubator Startup Program (BCRISP)@LaskowskiKR

Brad Diephuis, MD, MBACo-Founder & CEO, Herald Health

Moderated byGideon GilManaging Editor, Enterprise and Partnerships, STAT

HUMAN MODELS TOSTUDY HUMAN DISEASESAt An Academic Medical Center ZINNER BREAKOUT ROOM

1:50PM - 2:20PM

The BRI Infectious & Immunologic Diseases Research Program has recently conferred a BRI NextGen Award to explore the possibility of creating a human disease challenges center at the hospital. This session will brainstorm the regulatory, ethical and biosafety considerations of setting up such a Center at BWH as well as the ability to fund and sustain it successfully in the long term.FEATURING

Yemi Talabi-Oates, MBAAdministrative Director, Center for Clinical Investigation

Gerald B. Pier, MA, PhDProfessor of Medicine, Brigham and Women’s Hospital

During this session, these risks will be discussed, and tools will be suggested for improving sleep patterns with various evidence-based interventions.

Participants will also be able to complete a personal sleep assessment that will indicate their risk-level for sleep disorders, as well as refer them to the sleep clinic if necessary. A collaboratory will follow in Hale Conference Room.

CANCER IN THE CROSSHAIRSInnovative Testing and TherapiesZINNER BOARDROOM

1:50PM - 2:20PM

Experts in the field will share their thoughts in this session about bringing tools, including the immune system and the latest imaging technologies, to bear on the diagnosis as well as treatment of cancer. Come discuss the diagnostic advances and innovations that are being applied right now in cancer as well as research methods being used to treat advanced cancers. A collaboratory will follow in Shapiro Lounge.

FEATURING

Elizabeth Henske, MDDirector, BWH Center for LAM Research and Clinical Care

Scott J. Rodig, MD, PhDAssociate Professor of Pathology, Harvard Medical School; Attending Physician, Hematopathology, Hematology Laboratory, and Molecular Diagnostic services; Director of the Tissue Biomarker Laboratory, Center for Immuno-Oncology

Jon C. Aster, MD, PhDProfessor of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Chief, Division of Hematopathology, Brigham and Women’s Hospital

Clare Tempany, MDFerenc Jolesz MD Professor of Radiology, Harvard Medical SchoolVice-Chair, Radiology Research, Brigham and Women’s Hospital;Director, National Center for Image Guided Therapy

David R. Walt, PhDHansjörg Wyss Professor of Biologically Inspired Engineering, Harvard Medical School, Professor of Pathology, Harvard Medical School, Department of Pathology, Harvard Medical School, Brigham and Women’s Hospital

SLEEP WELL, LIVE WELLWhy Sleep Matters to HealthHALE CONFERENCE ROOM

1:50PM - 2:20PM

FEATURING

Charles A. Czeisler, MD, PhDBaldino Professor of Sleep MedicineDirector of the Division of Sleep Medicine, Harvard Medical School, Chief of the Division of Sleep Medicine, Brigham and Women’s Hospital, Affiliate Faculty Member, Neuroscience Program, Harvard Medical School & the Health Science & Technology Program at HMS/MIT

LONG LIVE THE LUNGZINNER BREAKOUT ROOM

3:40PM - 4:10PM

The experts at the Lung Center are bringing the latest technological advances to Brigham and Women’s Hospital to expand options for lung transplant recipients, increase the number of organs available, and improve the viability of donor lungs. A collaboratory will follow in the Shapiro Lounge.

FEATURING

Bruce Levy, MDParker B. Francis Professor of Medicine, Harvard Medical SchoolChief, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital

Steven P. Keller, MD, PhDInstructor of Medicine; Medical Director of ECMO, Brigham and Women’s Hospital

Patient GuestJason Crowell

Antonio Coppolino, III, MD, MScDirector of Ex Vivo Lung Perfusion, Brigham and Women’s HospitalInstructor, Harvard Medical School

Hari Mallidi, MD, FRCSCExecutive Director, for ECMO, Heart & Vascular Center; Co-Director, Lung Transplant, ECMO and Lung Assist Devices, The Lung Center

BONING UP ON THE CONNECTION BETWEENMuscle and BoneZINNER BOARDROOM

3:40PM - 4:10PM

Leaders in this field hope to bring communities together within this muscle-bone interface, in order to discuss and generate innovative research given the critical importance of muscles with regard to bone healing. Through a collaborative approach from clinical and basic scientists, the role of muscle in bone healing will be discussed. A collaboratory will follow in the Shapiro Lounge.

FEATURING

Ronald Neppl, PhDInstructor, Orthopaedic Surgery

Indranil Sinha, MDAssociate Director, BWH Trauma and Burn Center; Assistant Professor of Plastic Surgery, HMS; Plastic Surgery, Trauma, Burn and Surgical Critical Care, Restorative Surgery

Julia Charles, MD, PhDAssociate Physician, Brigham and Women’s Hospital, Assistant Professor, Harvard Medical Schoool, Orthopaedic Surgery & Medicine

Michael Weaver, MDChief, Orthopaedic Trauma, Associate Professor, Harvard Medical School, Orthopaedic Surgery

Paul Yu, MD, PhDAssociate Physician, Brigham and Women’s Hospital, Associate Professor of Medicine, Harvard Medical School @bmprii

RESEARCH OPEN MICPostdocs Present their ResearchBORNSTEIN AMPHITHEATRE

3:40PM - 4:10PM

Four postdocs will have less than five minutes to captivate the audience through their enthusiasm, clarity of content, and the compelling nature of their work. The champion will win a $1,000 prize!

FEATURING

ParticipantsChristopher Benway, PhDResearch Fellow in Medicine

Sarah Boukezzi, PhDResearch Fellow in Women’s Health

Krinio Giannikou, PhDResearch Fellow in Medicine

Yupeng Tu, PhDResearch Fellow in Radiology

Emcee/ChairDeepak Bhere, PhDResearch Fellow in NeurosurgeryVP of Communication, BWH Postdoctoral Association

WOMEN ARE NOT MENWhy Sex MattersZINNER BOARDROOM

4:20PM - 4:50PM

Those who attend this panel will not only gain a better understanding of the diseases women are at risk for across the life-span, but also the many resources available that are tailored specifically to women. It will be an informative and empowering dialogue, validating the need to study and treat disease through sex-gender informed research and medicine. A collaboratory will follow in the Shapiro Lounge.FEATURING

Hadine Joffe, MD, MScExecutive Director, Mary Horrigan Connors Center for Women’s Health and Gender Biology; Paula A. Johnson Associate Professor of Psychiatry in the Field of Women’s Health, Harvard Medical SchoolVice Chair for Psychiatry Research, Department of Psychiatry

Ursula Kaiser, MDChief, Division of Endocrinology, Diabetes and HypertensionProfessor, HMS; Endocrinology, Diabetes and HypertensionCo-Director of the Brigham Research Institute

Kathy Rexrode, MDChief, Division of Women’s Health, Department of Medicine, BWHFaculty Director, Office for Women’s Careers, Center for Diversity and Inclusion, BWH; Associate Professor of Medicine, HMS; Associate Physician, Division of General medicine, Department of Medicine, BWH; Associate Physician, Division of Preventive Medicine, Department of Medicine, BWH

NO WRONG DOORCutting-Edge Opioid Use Disorder Treatment at Brigham HealthBORNSTEIN AMPHITHEATRE

4:20PM - 4:50PM

The Department of Psychiatry at Brigham and Women’s Hospital opened the Brigham Health Bridge Clinic, connecting patients who have substance abuse disorders with the long-term care they will need following discharge. Please join our panel of experts who will discuss the treatment programs and specialized approaches they take in confronting opioid addiction.

FEATURING

Joji Suzuki, MDAssociate Psychiatrist, Brigham and Women’s HospitalAssistant Professor of Psychiatry, Harvard Medical School

Christin Price, MDAssociate Director, BWPOAdministrative Director, Brigham Health Bridge @ChristinPrice

ModeratorMaggie PenmanReporter, WGBH News @maggiepenman

Scott Weiner, MD, MPHDirector, Brigham Comprehensive Opioid Response and Education (B-CORE) Program, Department of Emergency Medicine, Brigham and Women’s Hospital @ScottWeinerMD

EXPERTS WEIGH INPathways to Weight LossZINNER BREAKOUT ROOM

4:20PM - 4:50PM

When daily schedules consist of night-shifts, long hours, and even longer commutes, many may wonder how they can get the proper amount of physical activity, nutritious food, and rest to maintain both a healthy weight and healthy lifestyle as well as prevent ailments such as diabetes and cardiovascular disease. In this session, BWH clinicians and researchers will be engaging the audience in a conversation about evidence-based weight loss strategies, nutrition and the associated clinical and research aspects. A collaboratory will follow in the Shapiro Lounge.

FEATURING

Marie McDonnell, MDChief, Diabetes Section in the Division of Endocrinology at Brigham and Women’s Hospital

Florencia Halperin, MDChief, Division of Endocrinology, Brigham and Women’s Faulkner Hospital; Co-Director, Center for Weight Management and Metabolic Surgery; Division of Endocrinology, Brigham and Women’s Hospital

Ali Tavakkoli, MDCo-Director, Center for Weight Management and Metabolic Surgery, Brigham and Women’s Hospital

AWARDS CEREMONY& RECEPTIONHALE CAFE ATRIUM

5:00PM - 6:00PM

Join us to celebrate the outstanding work of our researchers as we highlight the awards we’ve given throughout the past year as well as reveal the winners of the Connors-Brigham Research Institute Excellence Award in Women’s Health and Gender Biology, Research Excellence Awards, BRI Director’s Transformative Award and the Bright Futures Prize. Refreshments will be served.

BRIGHT FUTURES PRIZE

3 PROJECTS$100,0001 WINNER

The 7th Annual Bright Futures Prize

features three compelling projects

from three researchers. It’s up to

you to decide which project will

be awarded the $100,000 Bright

Futures Prize. We will be announcing

the winner today at the Awards

Ceremony & Reception, but voting

will take place up until 4PM on

November 7, 2018.

To learn more about our finalists and

their projects, please visit

brightfuturesprize.org

POSTER SESSIONACROSS THE HOSPITAL

2:30PM - 3:30PM

CABOT ATRIUM1. LncRNA SNHG12 regulates vascular senescence and atherosclerosis by targeting a DNA-PK-mediated DNA damage response Stefan Haemming, PhD

2. Longer Time in Therapeutic Blood Pressure Range Protects Against Major Adverse Cardiovascular Events and All-Cause Mortality in Patients with Hypertension: A Post-hoc Analysis of SPRINTDNA damage response Nayyra Fatani, PharmD

3. lncRNA Chronos deficiency alleviates induced pathological cardiac hypertrophy and fibrosis Debalina Bagchi, PhD

4. Sacubitril-Valsartan Prevents Cardiac Dysfunction Induced by Oxidative Stress in a Novel Chemogenetic Model of Heart Failure Andrea Sorrentino, PhD

5. ACTRIIA-Fc Rebalances Activin/Growth and Differentiation Factor (GDF) and Bone Morphogenetic protein (BMP)-9 Signaling to Attenuate Experimental Pulmonary arterial Hypertension Lai-Ming Yung, PhD

6. Short-term pre-operative dietary protein and calorie restriction to improve vascular surgery outcomes Jack Ruske, BS

7. Glucose Increases Hexokinase-2 Expression and Glycolytic Capacity in Anaplastic Thyroid Cancer Abha Aggarwal, PhD

8. Bone Mineral Density and Trabecular Bone Score Associations with Diabetes in the VITamin D and OmegA-3 TriaL (VITAL): Effects on Bone Structure and Architecture Study Meryl S. LeBoff, MD

9. Diabetes medication cessation at discharge predicts 1-year diabetes remission following bariatric surgery Keyvan Heshmati, MD

10. Interim Results from a Prospective Human Study of the Immuno-Metabolic Effects of Sleeve Gastrectomy Tammy Lo, MD

11. Yan Li, MD, PhD

12. Integrating an Online Weight Management Program with Population Health Management in the Primary Care Setting: Design and Baseline Characteristics of the PROPS Study (Partnerships for Reducing Overweight and Obesity with Patient-centered Strategies) Barbara De La Cruz, BA

13. Molecular Imaging in Early Detection of Diabetic Retinopathy Yupeng Tu, PhD

DISCOVERPOSTERS

14. Crosstalk between Lipid Metabolism and Mitochondrial Bioenergetics in Tuberous Sclerosis Complex Taylor Kavanagh, BS, MS Candidate

15. Using 3D Models to Optimize the Surgical Approach for Resection of Skull Base Tumors Nir Ben-Shlomo , BA

16. Using Augmented Reality to Visualize Inner Ear Structures for Surgical Planning of Temporal Bone Defects Nir Ben-Shlomo, BA

17. Chromatin accessibility landscapes of large and small airway cells annotate multiple COPD susceptibility GWAS regions Christopher Benway, PhD

18. IL-6 is Upregulated in TSC2-Deficient Cells and in LAM Patient Serum: Potential Role in LAM Pathogenesis and Therapy Ji Wang, MD

19. The asthma susceptibility gene ORMDL3 regulates autophagy in human bronchial epithelial cells Yuan Hao, PhD

20. Matrix Metalloproteinase-8 (MMP-8) Deficiency Improves Host Responses to Influenza Viral Infections Xiaoyun Wang, PhD

21. Physiologic Basis of Increased Levetiracetam Clearance during Pregnancy as a Tool for Optimizing Seizure Control in Women with Epilepsy Emile Ansari, BS

SCHUSTER LOBBY22. Use of Patient Portal to Recruit Domestic Violence Survivors to Intervention Study Annie Lewis-O’Connor, PhD, NP, MPH

23. Association of Perceived Stress with Evoked Psychological and Hemodynamic Stress Response in Midlife Women Julia Russell, BA

24. Stress Reactivity and Regulation In Pregnant Women With Severe Mental Illness Andrea Yessaillian

25. Association between Postpartum Pain and Risk of Postpartum Depression: A Retrospective Cohort Study Jie Zhou, MD, MS, MBA

26. Preventing Catheter Associated Bloodstream Infection Trough Maria Bentain-Melanson, MSN, BSN

27. Engagement Among Members of the Nursing Committees Maria Bentain-Melanson, MSN, BSN

28. Classification of Injurious Fall Severity in Hospitalized Patients Zoe Burns, MPH

29. Improving Care in the Midst of the Opioid Crisis Hannah Chapman, BSN

30. Patient Activation Related to Fall Prevention: A Multi-Site Study Comparing Patient Activation Before and After Fall TIPS: Tailoring Interventions for Patient Safety Taylor Christiansen, BS

31. Needs assessment and development of CSS ICU mentorship program Mary Lou Cullen, MSN, RN

32. Utilizing Simulation to Promote a Culture of Safe Practice Among Nursing Staff Caring for Patients With Maladaptive Coping: a quality improvement initiative Michael Ferrazzi, MSN

33. Engagement in Family Screening for Hypertrophic Cardiomyopathy Michelle Glowny, BS, MSN

34. The Quadramed Epic Connection Elizabeth Harmon, BSN

35. Comparison of 3 methodologies of blood pressure monitoring for continuous flow LVAD support Karen Morth, MSN

36. Ventricular Assist Device: Patients Perceptions of Hospital Readmissions Deborah Reynolds, DNP

37. CONCERN Factorial Design Survey Methods Test: Using REDCap as a Survey Platform Jose Garcia, Jr., BA

38. Optimization of Audit Data Visualization as a Tool for Sustainability of an Evidence-Based Fall Prevention Program Srijesa Khasnabish, BA

39. Leadership Lead the culture change on Hand Hygiene compliance rate at MICU Hasna Hakim, DNP

40. Sensitivity to reward valuation under stress in major depressive disorder Sarah Boukezzi, PhD

GIFT SHOP - MEZZANINE41. Implementation of a Patient Safety Dashboard Kerrin Bersani, BS

42. visByGene : Shiny Tool For Visualizing Genomic Data Shweta Gopaulakrishnan, MS

43. Systemic Treatment Following Surgical Resection in Patients with a Solitary Breast Cancer Brain Metastasis Logan Cho, BS Candidate

44. Development of a positive psychology intervention in patients post hematopoietic stem cell transplantation - Qualitative Research Phase Hermioni Lokko, MD, MPP

45. Partners HealthCare BioBank Ashley Mici, BS

46. All of Us Research Program Ashley Mici, BS

47. Pain Sensitivity Outcomes Measured in Fibromyalgia Patients and Healthy Controls through Cuff Pressure Algometry Lauren Papianou, BS

48. Identification of novel risk factors for bleeding complications following native kidney biopsy Zoe Kibbelaar, AB

49. The Partners HealthCare Biobank: Returning Unanticipated Genomic Results to Participants Carrie Blout, MS, CGC

50. Low Level Mosaicism in Tuberous Sclerosis Complex (TSC): prevalence, clinical features and transmission risk Krinio Giannikou, PhD

51. A Meta-Analysis Of Steroids In Acute Spinal Cord Injury: Efficacy And Safety Christian Cerecedo Lopez, MD

52. In vivo quantitative analysis of oncolytic virus-tumor kinetics Hirotaka Ito, MD, PhD

53. Adult Spinal Deformity Surgery: A Systematic review of Venous Thromboprophylaxis and Incidence of Venous Thromboembolic Events Nayan Lamba, BA

54. The Effectiveness of Antiepileptic Medications as Prophylaxis of Early Seizure in Traumatic Brain Injury Patients Compared to Placebo: A Systematic Review and Meta-Analysis Marco Mammi, MD

55. Identifying Naturalistic Coaching Behavior among Practicing Surgeons in the Operating Room Jason Pradarelli, MD, MS

56. Impact of personal pain perceptions on pain sensitivity outcomes Abby Warren

57. Combatting burnout by improving sleep health in healthcare workers Natalie Viyaran, BS

58. Prevalence of Burnout Among Physicians: A Systematic Review and Meta-Analysis Lisa Rotenstein, MD, MBA

60. Identify Patients for Early Palliative Care Intervention Using Deep Learning and EHRs Liqin Wang, PhD

MILLER ATRIUM61. Brachial Plexus Block with Liposomal Bupivacaine (EXPAREL) Compared to Placebo Showed Improved Analgesia and Reduced Opioid Consumption after Shoulder Surgery Xiang Bai, MD, PhD

62. The Risk of Complications Associated with Spinal Deformity Surgery in the Elderly Population: A Meta- Analysis Paola Calvachi, MD, MSc

63. The Safety and Efficacy of Tranexamic Acid (TXA) in Adult Spinal Deformity Surgery: A systematic review and meta-analysis Alexander Hulsbergen, BS

64. The importance of chirality for quinazolinone derivatives that increase survival motor neuron protein for spinal muscular atrophy Kevin Hodgetts, PhD

65. The Role of Thyroid Hormone in the Beneficial Effects of Stretching Colleen Carmody, BS

66. The role of selenocysteine lyase in the skeletal muscle Ashley Ogawa-Wong, PhD

67. The impact of Sarcopenia on Mortality in Patients with Necrotizing Soft Tissue Infections Manuel Castillo-Angel, MD

68. Role of BNC1 in keratinocytes proliferation and migration: a critical regulator of wound healing? Rafik Boudra, PhD

69. Exploring the role of IgA on gut microflora Himabindu Kolli, MBBS

70. Human Vagus Produces Specialized Pro-Resolving Mediators of Inflammation with Electrical Stimulation Reducing Pro-Inflammatory Eicosanoids Charlotte Jouvene, PhD

71. Emergency Intraoperative Vascular Surgery Consultations at Brigham and Women’s Hospital James O’Leary, BS

72. A National Assessment of Trauma Systems Using the ACS NBATS Tool: Geographic Distribution of Trauma Center Need Molly Jarman, PhD, MPH

73. Investigating the Inter-Observer Reproducibility of the Urine Sediment Exam Mia Colona

74. The Brain Health Champion Study: Promoting Non-Pharmacological Interventions in Cognitive Disorders Hope Schwartz, BA

75. Capturing Hospitalized Patients’ Safety Concerns: the MySafeCare Application Julie Snyder, BS

HALE CAFE ATRIUM (AWARD WINNERS)76. Identifying Preoperative Predictors of Weight Loss and Weight Regain for Roux-en-Y Gastric Bypass: a Prospective Human Study Hassan Aliakbarian, MD

77. DNA-engineered micromotors powered by metal nanoparticles for motion-based cellphone diagnostics Mohamed Draz, PhD

78. A Novel Icterometer for Hyperbilirubinemia Screening in Low-Resource Settings Lian Folger, BA

79. In vitro validation of novel neuronal target genes implicated in Alzheimer’s disease using a human iPSC-induced neuron system Julie Merchant, BA

80. Psychological Profile Predicting Treatment Non-Adherence to Anti-Estrogen Therapy in Early-Stage Breast Cancer Patients Margo Nathan, MD

81. CRISPR/Cas9 pharmacogenomic screen of small molecule inhibitors of clonal hematopoiesis of indeterminate potential (CHIP) Andrew Nguyen, BS

82. Hypertensive Disorders in First Pregnancy and Maternal Cardiovascular Disease: Mediation by Postpartum Cardiovascular Risk Factors Jennifer Stuart, ScD, MSc, BA

83. BRAINcode: an encyclopedia of human dopamine neuron transcriptomes in health and disease Xianjun Dong, PhD

Staff

Amanda CzechowskiAlexandra GallantClaire O’Brien Alyssa SchifanoJacqueline Slavik, PhDOliva StoddardAnu Swaminathan, PhDTrey Toombs, PhDArianna WilliamsSara Yohannes

Supporters

Thank you to these wonderful companies and organizations who have supported Discover Brigham.

Anna’s TaqueriaAu Bon PainInsomnia CookiesKIND BarsPEAK EventsStacey’s Chips

Get Connected

We’d love it if you’d share your day with us on social media using the hashtag

#DISCOVERBRIGHAM - tag us @BWHResearch and we will be sharing our favorite

posts throughout the day.

Thank You!

We couldn’t host Discover Brigham without the efforts of staff and volunteers or

without our amazing researchers. We also couldn’t do it without you! Thank you for

spending the day with us and we hope you discovered something new at Discover

Brigham.

Documents

#discoverbrighamElzerie de Jager, MBBS(Hons) Research Fellow, Center for Surgery and Public Health – Brigham and Women’s Hospital, Harvard Medical School and the Harvard T. H