© ANZDATA Registry Prevalence and Incidence 1990-1998 End Stage Renal Failure - Australia ( ) Per Million Functioning Transplant (259) New Pts (82) Deaths

© ANZDATA Registry

Prevalence and Incidence 1990-1998Prevalence and Incidence 1990-1998 End Stage Renal Failure - Australia End Stage Renal Failure - Australia

0

1000

2000

3000

4000

5000

6000

909192939495969798

0

1000

2000

3000

4000

5000

6000

( ) Per Million

FunctioningTransplant

(259)

New Pts (82)

Deaths (55)

TransplantOps (27)

Dialysis (292)

Number of Patients

*(Data to 30 Sept)

PREVA.BRIS98

Extrapolated

© ANZDATA Registry

Prevalence and Incidence 1990-1998Prevalence and Incidence 1990-1998End Stage Renal Failure - New ZealandEnd Stage Renal Failure - New Zealand

0

200

400

600

800

1000

1200

909192939495969798

0

200

400

600

800

1000

1200

( ) Per Million

FunctioningTransplant

(244)

New Pts (93)

Deaths (52)

TransplantOps (27)

Dialysis (295)

Number of Patients

*(Data to 30 Sept)PREVZ.BRIS98

Extrapolated

© ANZDATA Registry

Annual Intake of New Patients 1994-1998Annual Intake of New Patients 1994-1998

Australia 1994 1995 1996 1997 1998

Number 1316 1385 1431 1486 1537

Per Million 74 77 78 80 82

Diabetic 17% 20% 19% 22% 23%

Aboriginal 8% 8% 8% 10% 9%

55-64 yrs 277 314 309 309 311

65-74 yrs 341 334 411 398 391

75-84 yrs 71 102 117 136 175

*

INTAKEA.BRIS98 (Data to 30 Sept)

Extrapolated

© ANZDATA Registry

Annual Intake of New Patients 1994-1998Annual Intake of New Patients 1994-1998

New Zealand 1994 1995 1996 1997 1998

Number 248 287 290 319 351

Per Million 69 78 78 85 93

Diabetic 38% 37% 36% 39% 49%

Maori 33% 32% 33% 34% 36%

Pacific Isl. 13% 13% 11% 8% 14%

55-64 yrs 70 73 72 79 105

65-74 yrs 39 46 55 69 79

75-84 yrs 2 10 6 11 13

INTAKEZ.BRIS98

*

(Data to 30 Sept)

Extrapolated

© ANZDATA Registry

76 79 9066 67

268

84

QLD NSW VIC TAS SA NT WA

New Patients (Per Million) New Patients (Per Million) 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

No.Pats. 264 526 419 31 99 51 154

Australia 82 (n=1544)

New Zealand 89 (n=336)

NEWPTS.BRIS98

© ANZDATA Registry

New Patients - Australia 1993 -1997Mean Patients Per Million Age Group Per Year

148 159188

138 13090

140

222 238 261 239178

307

231

55-64 Yrs 65-74 Yrs

QLD NSW VIC TAS SA NT WA QLD NSW VIC TAS SA NT WA

Aust = 161 Aust = 236

States States

Excluding Aboriginals and Analgesic Nephropathy

© ANZDATA Registry

0

50

100

150

200

250

300

350

909192939495969798

0

50

100

150

200

250

300

350

TOTAL

0 - 19 yrs

20-44 yrs

45-64 yrs

65-74 yrs

75-84 yrs

85-94 yrs

Acceptance of New Patients 1990-1998 *Acceptance of New Patients 1990-1998 *Age Specific Rates - AustraliaAge Specific Rates - Australia

Patients Per Million

(Data to 30 Sept)Extrapolated*

AGESPECA.BRIS98

© ANZDATA Registry

0

50

100

150

200

250

300

350

909192939495969798

0

50

100

150

200

250

300

350

TOTAL

0 - 19 yrs

20-44 yrs

45-64 yrs

65-74 yrs

75-84 yrs

85-94 yrs

Acceptance of New Patients 1990-1998 *Acceptance of New Patients 1990-1998 *Age Specific Rates - New ZealandAge Specific Rates - New Zealand


(Data to 30 Sept)Extrapolated*

AGESPECZ.BRIS98

© ANZDATA Registry

Prevalence and Incidence 1990-1998Prevalence and Incidence 1990-1998Aboriginals - AustraliaAboriginals - Australia

0

100

200

300

400

500

909192939495969798

0

100

200

300

400

500

( ) Per Million

FunctioningTransplant (305)

New Pts (392)

Deaths (218) Transplant

Ops (84)

Dialysis (1346)

Number of Patients

*(Data to 30 Sept)

ABORIG.BRIS98

Extrapolated

© ANZDATA Registry

New Acceptances New Acceptances by Raceby Race

Australia 1990-Australia 1990-19981998

90 91 92 93 94 95 96 97 98

177 180 196

289348 375

298

438

392

52 57 60 64 70 67 70 73 76

Caucasoid

Aboriginal


RACEA.BRIS98*

*

(Data to 30 Sept) Extrapolated

© ANZDATA Registry

New Acceptances New Acceptances by Raceby Race

New Zealand New Zealand 1990-19981990-1998 * *

150102 103

166 165195

153 148

241

111159 142 145 159 174 177 194 223

39 47 58 46 48 57 56 63 58

90 91 92 93 94 95 96 97 98

CaucasoidMaoriPacific Islander


*RACEZ.BRIS98 (Data to 30 Sept)

Extrapolated

© ANZDATA Registry

Prevalence and Incidence 1990-1998Prevalence and Incidence 1990-1998Maoris - New ZealandMaoris - New Zealand

0

100

200

300

400

909192939495969798

0

100

200

300

400

( ) Per Million


New Pts (223)

Deaths (118)

TransplantOps (26)

Dialysis (670)

Number of Patients

*(Data to 30 Sept)MAORI.BRIS98

Extrapolated

© ANZDATA Registry

Prevalence and Incidence 1990-1998Prevalence and Incidence 1990-1998Pacific Islanders - New ZealandPacific Islanders - New Zealand

0

50

100

150

200

909192939495969798

0

50

100

150

200

( ) Per Million


New Pts (241)

Deaths (111) Transplant

Ops (32)

Dialysis (866)

Number of Patients

*(Data to 30 Sept)

PACISLAND.BRIS98

Extrapolated

© ANZDATA Registry

Patient Flow Diagram - AustraliaPatient Flow Diagram - Australia 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 1510

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 883

5405

5067

121

4585

4820150

479

34

© ANZDATA Registry

Patient Flow Diagram - New ZealandPatient Flow Diagram - New Zealand 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 326

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 174

1095

993

24

851

900 34

100

10

© ANZDATA Registry

Patient Flow Diagram - QueenslandPatient Flow Diagram - Queensland 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 261

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 165

831

791

24

917

974 23

96

3

© ANZDATA Registry

Patient Flow Diagram - New South Wales Patient Flow Diagram - New South Wales 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 518

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 337

2051

1959

44

1563

1624 47

148

8

© ANZDATA Registry

Patient Flow Diagram - VictoriaPatient Flow Diagram - Victoria 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 399

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 209

1410

1278

21

1096

1157 35

98

20

© ANZDATA Registry

Patient Flow Diagram - TasmaniaPatient Flow Diagram - Tasmania 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 31

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 24

106

107

1

97

106 2

14

0

© ANZDATA Registry

Patient Flow Diagram - South AustraliaPatient Flow Diagram - South Australia 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 96

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 53

315

312

20

486

506 25

64

3

© ANZDATA Registry

Patient Flow Diagram - Northern Territory Patient Flow Diagram - Northern Territory 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 51

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 18

161

142

1

42

51 2

15

0

© ANZDATA Registry

Patient Flow Diagram - Western Australia Patient Flow Diagram - Western Australia 1-Oct-97 to 30-Sep-981-Oct-97 to 30-Sep-98

New Patients 154

TRANSPLANTDIALYSIS

1-Oct-97

30-Sep-98

Deaths 77

531

478

10

384

402 16

44

0

© ANZDATA Registry

New Patients Creatinine at EntryNew Patients Creatinine at EntryApril - Sept 1998April - Sept 1998

Australia New Zealand

HD(583)

PD (198)

HD(100)

PD (70)

Median 821 731 825 671

25-75% 637-1919 600-940 660-1135 538-794

Mean SD 868 (378) 767 (256) 918 (368) 697 (200)

© ANZDATA Registry

Median Creatinine Clearance mls/minMedian Creatinine Clearance mls/minApril - Sept 1998April - Sept 1998

Australia HD PD HD PD

All 7 7

Male 8 8Female 6 6 QLD 7 7

NSW 8 8Diabetic 9 9 VIC 7 7Non Diabetic 7 7 TAS 7 7

SA 7 6Age 25-54 8 9 NT 8 5 55-64 7 7 WA 9 7 65-74 6 7 75-84 6 6

© ANZDATA Registry

Median Creatinine Clearance at EntryMedian Creatinine Clearance at EntryApril - Sept 1998April - Sept 1998

New Zealand HD PD HD PD

All 7 8

Male 9 10 Diabetic 6 9Female 5 7 Non Diabetic 10 7

Age 25-54 8 9 Caucasoid 9 7 55-64 7 8 Maori 7 9 65-74 7 8 Pacific Isl 6 10

© ANZDATA Registry

26

64

9 1

24

66

9 19

63

207 11

55

28

4

<5 5-9 10-14 15-19 <5 5-9 10-14 15-19

Creatinine Clearance mls/min

% HD

New Patients Creatinine Clearance at EntryNew Patients Creatinine Clearance at EntryApril - Sept 1998 AustraliaApril - Sept 1998 Australia

AllPts % 15 63 16 5 17 59 20 3

Female (n=198)Male (n=337)

Female (n=71)Male (n=97)

% PD

© ANZDATA Registry

9

64

196 9

4933

524

61

132

14

72

140

<5 5-9 10-14 15-19 <5 5-9 10-14 15-19



25-54 Yrs (n=228)65-74 Yrs (n=129)

25-54 Yrs (n=57)65-74 Yrs (n=44)

% HD % PD

© ANZDATA Registry

9

55

257 6

60

23815

67

13 519

61

181

<5 5-9 10-14 15-19 <5 5-9 10-14 15-19



Diabetic (n=127)Other-No AN (n=382)

Diabetic (n=48)Other-No AN (n=106)

% HD % PD

© ANZDATA Registry

15

63

165

17

59

20

3

<5 5-9 10-14 15-19



% HD (n=535) % PD (n=168)

© ANZDATA Registry

36

8

18 18

28

10

27

1523

18

34

10

22 20

34

10

42

14

26

8

Diab AN HT Other Male Female 25-54yrs

65-74yrs

NotLate

Late

Early Start Treatment April - Sept 1998Early Start Treatment April - Sept 1998Proportion of New Patients with Proportion of New Patients with

Creatinine Clearance Creatinine Clearance 10 mls/min 10 mls/min

% HD % PD

HD 127 26 63 319 337 198 228 130 390 145 PD 48 10 18 88 97 71 55 44 145 23

Total

Australia

© ANZDATA Registry

23 2125

1622 25

911

30 28

12

34

0

16


Early Start Treatment April - Sept 1998Early Start Treatment April - Sept 1998Proportion of New Patients with Proportion of New Patients with

Creatinine Clearance Creatinine Clearance 10 mls/min10 mls/min

HD 78 176 164 6 39 19 56 PD 36 60 39 8 9 2 12

Total

% HD Australia 22 New Zealand 29 % PD 24 24

© ANZDATA Registry

Blood Pressure Sept 1998 Australia

• No gender difference

• Haemodialysis pts slightly higher

• Vascular diseases higher

• Mean arterial pressure decreases with age

• Higher pressure with “colour”

© ANZDATA Registry

0%

20%

40%

60%

80%

100%

50607080901001101201301401501601701801902002100%

20%

40%

60%

80%

100%

Cumulative Distribution of Blood PressureCumulative Distribution of Blood PressureSept 1998 AustraliaSept 1998 Australia

Dias Sys

14080

© ANZDATA Registry

50

100

150

Mean Arterial Blood Pressure DialysisMean Arterial Blood Pressure Dialysis Sept 1998 Australia Sept 1998 Australia

103

103

All PD HD

100

© ANZDATA Registry

0

50

100

150

200

145

80

80

150

80

140

All PD HD

Sys

Dia

Median Systolic / Diastolic Blood Pressure DialysisMedian Systolic / Diastolic Blood Pressure Dialysis Sept 1998 AustraliaSept 1998 Australia

© ANZDATA Registry

7

23

31

19 20 17

915

39

23

6 4

HD PD HD PD HD PD

25-44 Yrs

65-74 Yrs

Age, Blood Pressure and Dialysis MethodAge, Blood Pressure and Dialysis Method Sept 1998 Australia Sept 1998 Australia

<120 Syst >160 Syst >100 Diast

% Pts

© ANZDATA Registry

Erythropoietin: Target HaemoglobinErythropoietin: Target Haemoglobin

Australia

Median 25% 75% Range

Angina 11.75 11.0 12.0 10.0-12.5

No Angina 11.0 10.75 11.5 9.75-12.5

New Zealand

Median 25% 75% Range

Angina 11.5 10.0-12.0

No Angina 11.0 10.0-11.5

© ANZDATA Registry

Erythropoietin Usage AustraliaErythropoietin Usage Australia Sept Sept 19981998

HD (3583) PD (1420)

Pts Treated 83% 68%

Median Hb 11.0 11.1

Dose / Kg / Wk 102 85

IV Dose * 8.5% 0%

Iron No 30% 46% Oral 32% 45% IV 30% 5% Both 8% 4%* Tas 62%

© ANZDATA Registry

Erythropoietin Usage New ZealandErythropoietin Usage New Zealand

Sept 1998Sept 1998

HD PDPts Treated 44% 23%Median Hb 10.0 9.9Dose / Kg / Wk 96 76IV Dose 2.4% 0.7%

Iron No 30% 46% Oral 32% 44% IV 30% 5% Both 9% 4%

© ANZDATA Registry

HD PD

QLD * (716) 87% 74%NSW ** (1767) 80% 65%VIC (1148) 84% 72%TAS (90) 93% 69%SA (287) 88% 92%NT (154) 95% 95%WA (337) 69% 54%

Erythropoietin Usage Australia Erythropoietin Usage Australia Sept 1998Sept 1998

* 115 )** 284 )

not included due to lack of data return

© ANZDATA Registry

47 42 41 3856

30 29

75 7184

93 88 96

69


Proportion Patients Receiving Erythropoietin Proportion Patients Receiving Erythropoietin Sept 1998 Sept 1998

1993 Aust 43% New Zealand 27% 1998 Aust 78% New Zealand 44%

% Pts

HDHD

© ANZDATA Registry

2920 20

32 30

7

6353

72 69

92 95

54


Proportion Patients Receiving Erythropoietin Proportion Patients Receiving Erythropoietin Sept 1998 Sept 1998

1993 Aust 21% New Zealand 9% 1998 Aust 61% New Zealand 23%

% Pts

PDPD

© ANZDATA Registry

100

8479 76

72 7581 8382 83

70

60 59 58 5862 65

0-4 5-14 15-24 25-34 35-44 45-54 55-64 65-74 75-84

Age Group

HD PD

Erythropoietin Usage Erythropoietin Usage Sept 1998 AustraliaSept 1998 Australia

% Pts

© ANZDATA Registry

100

5360

39 3844 49

39

100

64

4233

27 2417 18

24

0-4 5-14 15-24 25-34 35-44 45-54 55-64 65-74 75-84

Age Group

HD PD

Erythropoietin Usage Erythropoietin Usage Sept 1998 New ZealandSept 1998 New Zealand

% Pts

© ANZDATA Registry

Median Haemoglobin Level g/dlSept 1998 Australia

HD PD

QLD 10.7 11.0NSW 11.0 11.0VIC 11.1 11.3TAS 11.1 12.0SA 10.9 11.6NT 11.1 11.1WA 10.7 11.0

© ANZDATA Registry

Erythropoietin Median Dose U/Kg Per WeekSept 1998 Australia

HD PD

QLD 92 82NSW 98 93VIC 105 71TAS 103 69SA 100 91NT 145 123WA 110 89

© ANZDATA Registry

I.V. Iron FrequencyI.V. Iron Frequency

Wk 2 wks 4 wks PRN

Australia 33% 10% 22% 35%

New Zealand 50% 20% 30%

© ANZDATA Registry

Proportion of Pts NOT Receiving IronSept 1998 Australia

HD PD

QLD 14% 38%

NSW 39% 56%

VIC 23% 32%

TAS 34% 60%

SA 52% 66%

NT 9% 70%

WA 35% 42%

Documents

© ANZDATA Registry Prevalence and Incidence 1990-1998 End Stage Renal Failure - Australia ( ) Per Million Functioning Transplant (259) New Pts (82) Deaths