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بنام خداي زيبائيها. Major Histocompatibility complex OR. MHC. MHC. The principal function of T cells are : Defense against intracellular microbes Activation of other cells(B cells ,Macrophages ) peptide recognition by T and B cells is different. - PowerPoint PPT Presentation
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Major Histocompatibility Major Histocompatibility complexcomplex
OROR
MHCMHC
MHCMHC
The principal function of T cells are :The principal function of T cells are :Defense against intracellular microbesDefense against intracellular microbesActivation of other cells(B cells ,Macrophages )Activation of other cells(B cells ,Macrophages )
peptide recognition by T and B cells peptide recognition by T and B cells is different.is different.
B cells recognize soluble as well as cell associated AgsB cells recognize soluble as well as cell associated AgsIn contrast ,T cells recognize peptide which is displaying only In contrast ,T cells recognize peptide which is displaying only
by APC in associated with MHC proteins.by APC in associated with MHC proteins.
MHCMHC MHC genes are the most polymorphic genesMHC genes are the most polymorphic genes MHC genes are codominantly expressed in MHC genes are codominantly expressed in
each individualeach individual There are two main type of MHC:class I & IIThere are two main type of MHC:class I & II The physiologic function of MHC molecules The physiologic function of MHC molecules
is presentation of peptides to T cells ,control is presentation of peptides to T cells ,control of immune responsiveness to all proteins of immune responsiveness to all proteins and graft rejectionand graft rejection
MHC-I present cytosolic peptides to T MHC-I present cytosolic peptides to T cytotoxic cells and MHC-II present cytotoxic cells and MHC-II present endocytosed peptides to Thendocytosed peptides to Th cellscells
MHC genesMHC genes
MHC –I structureMHC –I structure
MHC-II structureMHC-II structure
T cell receptor and MHC T cell receptor and MHC interactioninteraction
Polymorphism of class IIPolymorphism of class II
HLA-DPA 12HLA-DPA 12 HLA-DPB 88HLA-DPB 88 HLA-DQA 17HLA-DQA 17 HLA-DQB 42HLA-DQB 42 HLA-DR >400HLA-DR >400
Polymorphism of class IPolymorphism of class I
HLA-A >280HLA-A >280 HLA-B >500HLA-B >500 HLA-C >130HLA-C >130
MHC genes and graft rejectionMHC genes and graft rejection
HLA expressionHLA expression
Peptide presentation by MHC-IIPeptide presentation by MHC-II
Peptide presentation by MHC-IPeptide presentation by MHC-I