Rank Company¥ name

¥ address

¥ website

Employees¥ L.A. County

¥ total

Revenue1

¥ 2012

¥ 2011

Business Focus Profile¥ parent company

¥ ownership

¥ year founded

Top Local Executive¥ name

¥ title

¥ phone

1Amgen Inc.One Amgen Center DriveThousand Oaks 91320amgen.com

6,00018,000

$17,265$15,582

human therapeutics N/Apublic1980

Robert BradwayChairman, CEO(805) 447-1000

2St. Jude Medical Implantable ElectronicSystems15900 Valley View CourtSylmar 91342sjm.com

1,84015,000

WND3,034

medical device technology St. Jude Medical Inc.public1976

Eric S. FainPresident, ImplantableElectronic Systems(818) 362-6822

3Medtronic Inc.18000 Devonshire St.Northridge 91325medtronic.com

1,50045,000

16,20015,900

diabetes medical technology N/Apublic1949

Katie SzymanPresident, Diabetes(800) 646-4633

4Baxter Healthcare4501 Colorado Blvd.Los Angeles 90039baxter.com

1,20050,800

14,20013,900

diversified health care Baxter International Inc.public1931

Chester ZelayaLos Angeles Plant Manager(818) 240-5600

5Boston Scientific Neuromodulation Corp.25155 Rye Canyon LoopValencia 91355bostonscientific.com

7702

24,0007,2497,622

medical devices Boston Scientific Corp.public1979

Maulik NanavatyPresident(661) 949-4000

6Advanced Bionics LLC28515 Westinghouse PlaceValencia 91355advancedbionics.com

600850

WNDWND

cochlear implants Sonova Holding AGpublic1993

Rainer PlatzPresident(661) 362-1400

7Neutrogena Corp.5760 W. 96th St.Los Angeles 90045neutrogena.com

6002

WNDWNDWND

skin, hair and cosmetics products Johnson & Johnsonpublic1930

Jim ColleranPresident(310) 642-1150

8Grifols Biologicals Inc.2410 Lillyvale Ave.Los Angeles 90032grifolsusa.com

5003

WNDWNDWND

manufacturer of plasma derivatives Grifolspublic1940

Willie ZunigaCEO, President(888) 474-3657

93M Pharmaceuticals Northridge19901 Nordhoff St.Northridge 913243m.com

4003

84,00029,90029,600

pharmaceuticals 3M Co.public1902

Joaquin DelgadoVice President(818) 341-1300

10One Lambda Inc.21001 Kittridge St.Los Angeles 91303onelambda.com

305320

WNDWND

manufacturer of antibody detectionproducts, laboratory instruments andcomputer software

Thermo Fisher Scientificpublic1984

George M. AyoubCEO, President(818) 702-0042

11Gilead Sciences Inc.650 Cliffside DriveSan Dimas 91773gilead.com

2805,195

9,7008,385

manufacturer of AmBisome,packaging and labeling of antiviralproducts

N/Apublic1987

John MartinChairman, CEO(909) 394-4000

12Iris International Inc.9172 Eton Ave.Chatsworth 91311proiris.com

250420

130118

urinalysis and molecular diagnostics Danaher Corp.public1979

Cesar GarciaCEO, President(818) 527-7000

13Agensys Inc.2225 Colorado Ave.Santa Monica 90404agensys.com

250WND

WNDWND

cancer treatments, therapeuticantibodies

Astellas Pharma Inc.public1996

Sef P. KurstjensCEO, President(310) 820-8029

14Implant Direct27030 Malibu Hills RoadCalabasas 91301implantdirect.com

240320

WNDWND

manufacturer of dental implantproducts

Danaher Corp.public2004

Gerald A. NiznickPresident(818) 444-3333

15Physical Optics Corp.20600 Gramercy Place, Building 100Torrance 90501poc.com

235WND

WNDWND

applied technologies, electro-opticsystems, information technology,avionics, wireless communication

N/Aprivate1985

Joanna JannsonChairwoman, CEO, President(310) 320-3088

16Obagi Medical Products Inc.3760 Kilroy Airport Way, Suite 500Long Beach 90806obagi.com

203203

121114

pharmaceutical developer of skincare products

N/Apublic1988

Albert F. HummelCEO, President(562) 628-1007

17Spectrum Chemicals & Laboratory Products14422 South San Pedro StreetGardena 90248spectrumchemical.com

200WND

WNDWND

lab chemicals, equipment andsupplies

Spectrum ChemicalManufacturing Corp.private1971

Mark HurdGeneral Manager(310) 516-8000

1 In millions.2 Estimate from SoCalBio.3 Business Journal estimate.WND - Would Not Disclose Note: Information for this list was provided by the companiesthemselves and Southern California Biomedical Council. Companies are ranked by the totalnumber of employees and the number of L.A. County employees, respectively. To the bestof our knowledge, this information is accurate as of press time. While every effort is made

to ensure the accuracy and thoroughness of the list, omissions and typographical errorssometimes occur. Please send corrections or additions on company letterhead to theResearch Department, Los Angeles Business Journal, 5700 Wilshire Blvd., Suite 170, LosAngeles 90036. ©2013 Los Angeles Business Journal. This list may not be reprinted inwhole or in part without prior written permission from the editor. Reprints are availablefrom the YGS Group, (800) 290-5460 ext. 100.

Researched by David Nusbaum

THE PACESETTER: With 6,000 employees in Los Angeles County, Amgen Inc. is the largest local biotech/biomed employer. The Thousand Oaks company has 18,000 employees worldwide and reported $17.3 billion in revenue last year, an increase from $15.6 billion in 2011. The company spent approximately $3.4 billion on research and development last year. Amgen had two products each exceed $4 billion in revenue last year. Its best-selling drugs, Neulasta and Neupogen, are used to reduce infections in patients on chemotherapy generated $5.3 billion.

1

THE LIST Ranked by number of L.A. County Employees

BIoTech/BIomed comPANIeS

PURCHASED: One Lambda Inc. was acquired by Thermo Fisher Scientific Inc. in September in a deal valued at $925 million.

NexT weekThe Largest Residential Developers in L.A. County

10

•

•

Please see page 18

APRIL 22, 2013 LOS ANGELES BUSINESS JOURNAL 17

ACQUISITION: Iris International Inc. was acquired by Danaher Corp. in October in a transaction valued at $338 million.

SANTA MONICA: Agensys Inc., an affiliate of Tokyo-based Astellas Phama Inc., opened a new, 160,000 square-foot research and development facility in Santa Monica in January.

Source: Bloomberg News

Source: Ernst & Young Global Biotechnology Report

Source: California Association of Realtors

4

5

6

7

8

9

10

11

12

‘08 ‘09 ‘10 ‘11 ’12

50

54

58

62

66

70

0

200

400

600

800

1000The MixWorldwide M&A transactions by industry.

Space FillersThird quarter vacancy rates for office propertied by market segment.

in billions

’07 ’08 ’09 ’10 ’11

$600

480

360

240

120

0

Consumer 26%Financial 18Energy 15Communications 12Industrial 11Misc. 18

Biotech Charts/jd1st

Recent GrowthAmgen’s net income. (in billions)$2.26 2.36 3.67 2.95 3.17 4.2 4.61 4.63 3.68 4.352003 2004 2005 2006 2007 2008 2009 2010 2011 2012Source: Amgen Inc.

Biotech DollarsU.S. biotechnology industry revenue. (in billions)$39 45 51 59 62 68 70 56 62 592002 2003 2004 2005 2006 2007 2008 2009 2010 2011Source: Ernst & Young Global Biotechnology Report

Insurance Charts

Climbing Up Nationwide premiums earned by the property/casualty insurance sector. (in billions) $348 388 413 418 436 439 438 422 420 433 335* 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

Property Income Property/casualty insurance industry net income after taxes. (in billions) $3 29.9 36 43 63.7 61.9 3 28.7 34.7 -19.2 27* 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Results for the first three quarters through Sept. 30, 2012. Source: Insurance Information Institute

Biotech DollarsU.S. biotechnology industryrevenue. (in billions)

’07 ’08 ’09 ’10 ’11

$70

66

62

58

54

50

Source: Amgen Inc.

Recent GrowthAmgen’s net income. (in billions)

’08 ’09 ’10 ’11 ’12

$5.0

4.6

4.2

3.8

3.4

3.0

•

•

12

13 FACTORY: Implant Direct opened a second factory in the area last year, an 18,000-square-foot factory in Westlake Village. It also has a 40,000-square-foot factory in Calabasas.

•

Rank Company¥ name

¥ address

¥ website

Employees¥ L.A. County

¥ total

Revenue1

¥ 2012

¥ 2011

Business Focus Profile¥ parent company

¥ ownership

¥ year founded

Top Local Executive¥ name

¥ title

¥ phone

18Sakura Finetek USA Inc.1750 W. 214th St.Torrance 90501sakuraus.com

1602

2502

WNDWND

pathology laboratory instrumentsand disposables

Sakura Global Holding Co.private1986

Takashi TzuzukiChairman, CEO(310) 972-7800

19Posey Co.5635 Peck RoadArcadia 91006posey.com

1432

WNDWNDWND

manufacturer of health care products N/Aprivate1937

Ernest PoseyCEO(800) 767-3933

20Staar Surgical Co.1911 Walker Ave.Monrovia 91016staar.com

136301

6463

eye care products N/Apublic1982

Barry G. CaldwellCEO, President(626) 303-7902

21Biosense Webster Inc.3333 Diamond Canyon RoadDiamond Bar 91765biosensewebster.com

1282

WNDWNDWND

cardiac care products Johnson & Johnsonpublic1998

Shlomi NachmanPresident(909) 839-8500

22Numotech Inc.9420 Reseda Blvd., Suite 504Northridge 91324numobag.com

1002

WNDWNDWND

wound care management andtreatment

N/Aprivate1990

Dr. Robert FeltonCEO, President(877) 686-6832

23HemaCare Corp.15350 Sherman Way, Suite 350Van Nuys 91406hemacare.com

952

1201816

blood services N/Apublic1978

Pete van der WalCEO, President(818) 226-1968

24PolyPeptide Laboratories Inc.365 Maple Ave.Torrance 90503polypeptide.com

852

4502

WNDWND

GMP peptide manufacturer forpharmaceutical industry

PolyPeptide Groupprivate1996

Jane SalikCEO(310) 782-3569

25Response Genetics Inc.1640 Marengo St., Sixth FloorLos Angeles 90033responsegenetics.com

7090

1923

research and development of clinicaldiagnostic tests for cancer

N/Apublic1999

Thomas A. BolognaChairman, CEO(323) 224-3900

1 In millions.2 Business Journal estimate.WND - Would Not Disclose Note: Information for this list was provided by the companiesthemselves and Southern California Biomedical Council. Companies are ranked by the totalnumber of employees and the number of L.A. County employees, respectively. To the bestof our knowledge, this information is accurate as of press time. While every effort is made

to ensure the accuracy and thoroughness of the list, omissions and typographical errorssometimes occur. Please send corrections or additions on company letterhead to theResearch Department, Los Angeles Business Journal, 5700 Wilshire Blvd., Suite 170, LosAngeles 90036. ©2013 Los Angeles Business Journal. This list may not be reprinted inwhole or in part without prior written permission from the editor. Reprints are availablefrom the YGS Group, (800) 290-5460 ext. 100.

Researched by David Nusbaum

Continued from page 17

Source: Bloomberg News

Source: Ernst & Young Global Biotechnology Report

Source: California Association of Realtors

4

5

6

7

8

9

10

11

12

‘08 ‘09 ‘10 ‘11 ’12

50

54

58

62

66

70

0

200

400

600

800

1000The MixWorldwide M&A transactions by industry.

Space FillersThird quarter vacancy rates for office propertied by market segment.

in billions

’07 ’08 ’09 ’10 ’11

$600

480

360

240

120

0

Consumer 26%Financial 18Energy 15Communications 12Industrial 11Misc. 18

Biotech Charts/jd1st

Recent GrowthAmgen’s net income. (in billions)$2.26 2.36 3.67 2.95 3.17 4.2 4.61 4.63 3.68 4.352003 2004 2005 2006 2007 2008 2009 2010 2011 2012Source: Amgen Inc.

Biotech DollarsU.S. biotechnology industry revenue. (in billions)$39 45 51 59 62 68 70 56 62 592002 2003 2004 2005 2006 2007 2008 2009 2010 2011Source: Ernst & Young Global Biotechnology Report

Insurance Charts

Climbing Up Nationwide premiums earned by the property/casualty insurance sector. (in billions) $348 388 413 418 436 439 438 422 420 433 335* 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

Property Income Property/casualty insurance industry net income after taxes. (in billions) $3 29.9 36 43 63.7 61.9 3 28.7 34.7 -19.2 27* 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Results for the first three quarters through Sept. 30, 2012. Source: Insurance Information Institute

Biotech DollarsU.S. biotechnology industryrevenue. (in billions)

’07 ’08 ’09 ’10 ’11

$70

66

62

58

54

50

Source: Amgen Inc.

Recent GrowthAmgen’s net income. (in billions)

’08 ’09 ’10 ’11 ’12

$5.0

4.6

4.2

3.8

3.4

3.0

18 LOS ANGELES BUSINESS JOURNAL THE LIST APRIL 22, 2013

<< CALL FOR NOMINATIONS >>

The CIO/CTO Awards will honor Chief Information Offi cers, or more broadly, those in the top information tech-nology positions within their organizations (VP, Director, etc). These important individuals and teams play vital roles in making Los Angeles businesses, institutions and nonprofi t groups successful. Together with their CEOs, their decisions impact all aspects of the businesses including their company’s growth, probability, functionality and competiveness in the marketplace.

Awards will be presented in the following categories:

• Emerging Business

• Corporate

• Enterprise

• Nonprofi t/Government/Institution/ Public

• IT Team (internal)

• IT Service Partner (external)

• Lifetime Achievement

Nomination Deadline: Tuesday, April 30, 2013To nominate or for more information please visit www.labusinessjournal.com/bizevents or contact Jessica Ramey at 323.549.5225 ext. 213 or jramey@socalbusinessjournals.com

PRESENTING SPONSORS:

The Los Angeles Business Journal is proud to announce the 2013 CIO/CTO Awards.

PLATINUM SPONSOR:

MANUFACTURING: Staar Surgical Co., a developer and manufacturer of minimally invasive ophthalmic products, is moving parts of its manufacturing operations from Japan and Switzerland to Los Angeles this year.

20