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© 2013 Pearson Education, Inc.
Chapter 22: Microbial Diseases of the Nervous System
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The Nervous System
Bacterial Diseases
Fungal and Protozoan Diseases
Prion Diseases
Viral Diseases
FINAL ROUND
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$100 Question
In the brain, cerebrospinal fluid flows through the
a. subdural space.
b. subarachnoid space.
c. arachnoid mater.
d. pia mater.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$100 Answer
In the brain, cerebrospinal fluid flows through the
a. subdural space.
b. subarachnoid space.
c. arachnoid mater.
d. pia mater.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$200 Question
What is the order of the layer of meninges fromthe innermost to the outermost?
a. arachnoid mater, dura mater, pia mater
b. dura mater, arachnoid mater, pia mater
c. pia mater, dura mater, arachnoid mater
d. pia mater, arachnoid mater, dura mater
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$200 Answer
What is the order of the layer of meninges fromthe innermost to the outermost?
a. arachnoid mater, dura mater, pia mater
b. dura mater, arachnoid mater, pia mater
c. pia mater, dura mater, arachnoid mater
d. pia mater, arachnoid mater, dura mater
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$300 Question
Inflammation of the brain is called
a. meningitis.
b. encephalitis.
c. neuritis.
d. hydrocephalus.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$300 Answer
Inflammation of the brain is called
a. meningitis.
b. encephalitis.
c. neuritis.
d. hydrocephalus.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$400 Question
Drugs can cross the blood–brain barrier ONLY ifthey are
a. large-molecular-weight molecules.
b. small-molecular-weight molecules.
c. water-soluble.
d. lipid-soluble.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$400 Answer
BACK TO GAME
Drugs can cross the blood–brain barrier ONLY ifthey are
a. large-molecular-weight molecules.
b. small-molecular-weight molecules.
c. water-soluble.
d. lipid-soluble.
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$500 Question
Bacteria can grow well in cerebrospinal fluidbecause it has low levels of circulatingantibodies and
a. water.
b. glucose.
c. complement.
d. sodium.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 1: The Nervous System
$500 Answer
BACK TO GAME
Bacteria can grow well in cerebrospinal fluidbecause it has low levels of circulatingantibodies and
a. water.
b. glucose.
c. complement.
d. sodium.
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$100 Question
In adult patients, about 80% of the cases ofbacterial meningitis are now caused byNeisseria meningitidis and
a. Haemophilus influenzae type B.
b. Streptococcus pneumoniae.
c. Listeria monocytogenes.
d. Clostridium tetani.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$100 Answer
In adult patients, about 80% of the cases ofbacterial meningitis are now caused byNeisseria meningitidis and
a. Haemophilus influenzae type B.
b. Streptococcus pneumoniae.
c. Listeria monocytogenes.
d. Clostridium tetani.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$200 Question
The manifestations of tetanus are due to
a. neurotoxin.
b. leukocidins.
c. hemolysins.
d. coagulase.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$200 Answer
The manifestations of tetanus are due to
a. neurotoxin.
b. leukocidins.
c. hemolysins.
d. coagulase.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$300 Question
Which gram-positive rod is known to causestillbirth and neurological disease in animals?
a. Listeria monocytogenes
b. Streptococcus pneumoniae
c. Clostridium botulinum
d. Haemophilus influenzae
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$300 Answer
Which gram-positive rod is known to causestillbirth and neurological disease in animals?
a. Listeria monocytogenes
b. Streptococcus pneumoniae
c. Clostridium botulinum
d. Haemophilus influenzae
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$400 Question
BACK TO GAME
ANSWER
A polysaccharide vaccine that can be muchimproved by conjugation with protein carriersexists against which form of bacterialmeningitis?
a. Haemophilus influenzae
b. pneumococcal
c. meningococcal
d. Listeria monocytogenes
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$400 Answer
BACK TO GAME
A polysaccharide vaccine that can be muchimproved by conjugation with protein carriersexists against which form of bacterialmeningitis?
a. Haemophilus influenzae
b. pneumococcal
c. meningococcal
d. Listeria monocytogenes
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$500 Question
Which of the following statements aboutMycobacterium leprae is FALSE?
a. Patients must be put into isolation.
b. Patients transmit the disease directly.
c. Patients rarely die of the disease.
d. A skin biopsy sample can be used for diagnosis.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 2: Bacterial Diseases
$500 Answer
Which of the following statements aboutMycobacterium leprae is FALSE?
a. Patients must be put into isolation.
b. Patients transmit the disease directly.
c. Patients rarely die of the disease.
d. A skin biopsy sample can be used for diagnosis.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$100 Question
Trypanosoma brucei is transmitted by
a. tsetse flies.
b. body lice.
c. houseflies.
d. head lice.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$100 Answer
Trypanosoma brucei is transmitted by
a. tsetse flies.
b. body lice.
c. houseflies.
d. head lice.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$200 Question
Which etiological agent that causes meningitisproduces an extremely heavy (thick)polysaccharide capsule?
a. Haemophilus influenzae
b. Streptococcus pneumoniae
c. Listeria monocytogenes
d. Cryptococcus neoformans
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$200 Answer
Which etiological agent that causes meningitisproduces an extremely heavy (thick)polysaccharide capsule?
a. Haemophilus influenzae
b. Streptococcus pneumoniae
c. Listeria monocytogenes
d. Cryptococcus neoformans
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$300 Question
Which of the following patients are the mostsusceptible to fungal infections?
a. elderly patients
b. infants
c. immunocompromised patients
d. cardiac patients
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$300 Answer
Which of the following patients are the mostsusceptible to fungal infections?
a. elderly patients
b. infants
c. immunocompromised patients
d. cardiac patients
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$400 Question
Which etiological agent has a mortality rate near100%, with death occurring within a few days,after symptoms appear?
a. Cryptococcus neoformans
b. Acanthamoeba
c. Naegleria fowleri
d. Trypanosoma brucei
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$400 Answer
BACK TO GAME
Which etiological agent has a mortality rate near100%, with death occurring within a few days,after symptoms appear?
a. Cryptococcus neoformans
b. Acanthamoeba
c. Naegleria fowleri
d. Trypanosoma brucei
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$500 Question
Granulomatous amebic encephalitis is caused by
a. Balamuthia mandrillaris.
b. Naegleria fowleri.
c. Trypansoma brucei.
d. Cryptococcus neoformans.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 3: Fungal and Protozoan Diseases
$500 Answer
Granulomatous amebic encephalitis is caused by
a. Balamuthia mandrillaris.
b. Naegleria fowleri.
c. Trypansoma brucei.
d. Cryptococcus neoformans.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$100 Question
Which of the following diseases is caused by aprion?
a. rabies
b. Creutzfeldt-Jakob disease
c. polio
d. wound botulism
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$100 Answer
Which of the following diseases is caused by aprion?
a. rabies
b. Creutzfeldt-Jakob disease
c. polio
d. wound botulism
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$200 Question
A prion is a(n)
a. abnormally folded protein.
b. protein subunit.
c. form of a bacterium.
d. viral particle.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$200 Answer
BACK TO GAME
A prion is a(n)
a. abnormally folded protein.
b. protein subunit.
c. form of a bacterium.
d. viral particle.
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$300 Question
Which animal disease is similar to Creutzfeldt-Jacob disease?
a. anthrax
b. sheep scrapie
c. kuru
d. transmissible spongiform encephalopathy
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$300 Answer
Which animal disease is similar to Creutzfeldt-Jacob disease?
a. anthrax
b. sheep scrapie
c. kuru
d. transmissible spongiform encephalopathy
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$400 Question
One hypothesis of the origin of mad cow diseasein cattle is
a. cattle feed contaminated with scrapie.
b. direct contact with animals infected with scrapie.
c. direct contact with other infected species.
d. hormones in cattle feed.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$400 Answer
BACK TO GAME
One hypothesis of the origin of mad cow diseasein cattle is
a. cattle feed contaminated with scrapie.
b. direct contact with animals infected with scrapie.
c. direct contact with other infected species.
d. hormones in cattle feed.
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$500 Question
What conditions does the WHO recommend to sterilizereusable instruments that might have been exposed toprions?
a. strong solution of sulfuric acid with autoclaving at 134°C
b. strong solution of sodium hydroxide with autoclaving at 115°C
c. strong solution of sulfuric acid with extended autoclaving at 115°C
d. strong solution of sodium hydroxide with extended autoclaving at 134°C
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 4: Prion Diseases
$500 Answer
What conditions does the WHO recommend to sterilizereusable instruments that might have been exposed toprions?
a. strong solution of sulfuric acid with autoclaving at 134°C
b. strong solution of sodium hydroxide with autoclaving at 115°C
c. strong solution of sulfuric acid with extended autoclaving at 115°C
d. strong solution of sodium hydroxide with extended autoclaving at 134°C
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$100 Question
Which disease has an incubation period that isusually long enough to allow immunity todevelop from postexposure vaccination?
a. polio
b. rabies
c. Hansen’s disease
d. arboviral encephalitis
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$100 Answer
Which disease has an incubation period that isusually long enough to allow immunity todevelop from postexposure vaccination?
a. polio
b. rabies
c. Hansen’s disease
d. arboviral encephalitis
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$200 Question
A vaccine against which disease occasionallyreverts to a virulent form and causes disease?
a. rabies
b. Japanese encephalitis
c. West Nile encephalitis
d. polio
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$200 Answer
A vaccine against which disease occasionallyreverts to a virulent form and causes disease?
a. rabies
b. Japanese encephalitis
c. West Nile encephalitis
d. polio
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$300 Question
A misdiagnosis of Guillain-Barré syndrome isoften given to patients with
a. arboviral encephalitis.
b. furious rabies.
c. polio.
d. paralytic rabies.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$300 Answer
BACK TO GAME
A misdiagnosis of Guillain-Barré syndrome isoften given to patients with
a. arboviral encephalitis.
b. furious rabies.
c. polio.
d. paralytic rabies.
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$400 Question
Eastern equine encephalitis has a mortality rateof _____ or more.
a. 20%
b. 50%
c. 30%
d. 70%
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$400 Answer
Eastern equine encephalitis has a mortality rateof _____ or more.
a. 20%
b. 50%
c. 30%
d. 70%
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$500 Question
Arboviral encephalitis is usually diagnosed by
a. agglutination tests.
b. ELISA tests.
c. Gram stain.
d. titer.
BACK TO GAME
ANSWER
© 2013 Pearson Education, Inc.
Topic 5: Viral Diseases
$500 Answer
Arboviral encephalitis is usually diagnosed by
a. agglutination tests.
b. ELISA tests.
c. Gram stain.
d. titer.
BACK TO GAME
© 2013 Pearson Education, Inc.
FINAL ROUND Question
The tetanus vaccine is a(n)
a. conjugated vaccine.
b. toxoid.
c. attenuated whole-agent vaccine.
d. inactivated whole-agent vaccine.
BACK TO GAME
ANSWER