22
Functional analysis of mutation and expression in squamous cell lung cancer Lung Cancer, 110, 35-41, 2017 Naomi Kobayashi-Watanabe, Akemi Sato, Tatsuro Watanabe, Tomonori Abe, Chiho Nakashima, Eisaburo Sueoka, Shinya Kimura, Naoko Sueoka-Aragane Discoidin Domain Receptor2 DDR2 DNA DDR2 DDR2 29 DDR2 3.9 (T681I) DDR2 T681I DDR2 MMP-1 c-Jun DDR2 c-Jun MMP-1 T681I DDR2

, 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Embed Size (px)

Citation preview

Page 1: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Functional analysis of mutation and expression in squamous

cell lung cancer

Lung Cancer, 110, 35-41, 2017

Naomi Kobayashi-Watanabe, Akemi Sato, Tatsuro Watanabe, Tomonori Abe, Chiho Nakashima, Eisaburo Sueoka, Shinya Kimura, Naoko Sueoka-Aragane

Discoidin Domain Receptor2 DDR2

DNADDR2

DDR2

29 DDR2 3.9 (T681I)DDR2 T681I

DDR2 MMP-1 c-Jun

DDR2 c-Jun MMP-1

T681I

DDR2

Page 2: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Differences in the genotype frequency of the variant in familial moyamoya disease patients in Kyushu, Japan.

Neurologia medico-chirurgica, in press

Takamatsu Y, Higashimoto K, Maeda T, Kawashima M, Matsuo M, Abe T, Matsushima T, Soejima H.

MMD

MMD

MMD

MMD 91 70 21 108DNA

27

MMD MMD

MAF minor allele frequency

MMDSNPs

MAF

MMD

Page 3: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Digestion, in press

DPC

2009 2015 78

3445,091 500,000

500,000

Page 4: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups

3,505

Digestion, 93, 266-271, 2016

Eri Takeshita, Yasuhisa Sakata, Megumi Hara, Kayo Akutagawa, Natsuko Sakata, Hiroyoshi Endo, Takashi Ohyama, Keiji Matsunaga, Tomomi Yoshioka, Hiroharu Kawakubo, Yuichiro Tanaka, Shimpei Shirai, Yoichiro Ito, Nanae Tsuruoka, Ryuichi Iwakiri, Motoyasu Kusano, Kazuma Fujimoto

F 2 GERD 72 FD 7 F

6F

Page 5: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Work-sharing and male employees’ mental health during economic recession Occupational Medicine, kqx135, 2017 Sep 14.https://doi.org/10.1093/occmed/kqx135

Masumi Nagae, Maiko Sakamoto, Etsuo Horikawa

Job Content Questionnaire JCQSelf-Rating Depression Scale SDS 2008T1 6 T2

336 2 24% T1p < 0.001 SDS

6 2

T2

Page 6: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy

Young Japanese Volunteers

Internal Medicine in press

Yuichiro Tanaka, Yasuhisa Sakata, Megumi Hara , Hiroharu Kawakubo, Nanae Tsuruoka, Koji

Yamamoto, Yoichiro Itoh, Hidenori Hidaka, Ryo Shimoda, Ryuichi Iwakiri, Kazuma Fujimoto

2010 20116 550 2230 Frequency Scale for the Symptoms of GERD FSSG

SPSS

45 8.2% 386.9% grade A 37 grade B 1

BMI>25

Page 7: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance throughdifferent mechanisms in scirrhous gastric cancer cell lines

Scientific Reports, 7, 11227, 2017

Koichi Baba, Yoshihiko Kitajima, Shuusuke Miyake, Jun Nakamura, Kota Wakiyama,Hirofumi Sato, Keiichiro Okuyama, Hiroshi Kitagawa, Tomokazu Tanaka, Masatsugu Hiraki,Kazuyoshi Yanagihara & Hirokazu Noshiro

/ SGC

4 ANGPTL4

controversial SGC ANGPTL4

20%O2 / 1%O2 ANGPTL4ANGPTL4 SGC 58As9 ANGPTL4

KD SC // /

SGC ANGPTL4

HIF -1KD SC c-myc /p27

KD anoikispro-survival signal FAK/Src/PI3K-Akt/ERK signal

KD anoikis recombinant /C ANGPTL4 ANGPTL4 58As9 anoikis

KDANGPTL4 SGC anoikis

Page 8: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis Scientific Reports (2017 8 23 accept)

, , , , , , ,

(HIF-1) ,

, , energy .HIF-1 . , 58As9 HIF-1 knockdown(KD) , Warburg effect(WE)(ROS) apoptosis .

HIF-1 glucose+insulin(GI) apoptosis.

15 HIF-1 apoptosis. ,58As9 YC-1(10 M) , apoptosis

. HIF-1 ROS.NAC ROS apoptosis ,

YC-1 HIF-1 ROS apoptosis .,CoCl2 OCR/ECAR YC-1 WE

. YC-1 GI 58As9 ROSapoptosis . GI 58As9 GLUT1 glucose

uptake . ,YC-1 acetyl-CoA ,WE ROS . Nude mouse model

YC-1(1mg/kg) PBS , HIF-1 apoptosis. YC-1+GI apoptosis

. ,YC-1+GI , HIF-1 pimonidazole

. , 8-OHdG apoptosis marker level .YC-1+GI ,OXPHOS ROS

+ .

Page 9: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Effect of limbering up of the muscles attached to the pelvis on the strength ofupper and lower extremity and trunk muscles through the transitional network

The Journal of Physical Therapy Science 30 11-17 2018

23.6± 3.7 18-33 152

2049

42 61

mobie SAKAI

KS

Page 10: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Impairment of health-related quality of life in patients with chronic hepatitis C is associated with insulin resistance.

Journal of Gastroenterology 49 317-323 2014

Kuwashiro T, Mizuta T, Kawaguchi Y, Iwane S, Takahashi H, Oza N, Oeda S, Isoda H, Eguchi Y, Ozaki I, Anzai K, Fujimoto K.

C QOL

HCVC

QOL C

C 175 (56.4 84 91 ) Quality of Life(QOL)Short Form-36(SF-36) QOL 75g

QOL SF-36 ( )( )

8(PCS) (MCS) HOMA-IR

MCS PCS 2

QOL 1544 GH

HOMA-IR PCS MCSHOMA-IR 2 PCS

C QOL

Page 11: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Perforation and Postoperative Bleeding Associated with Endoscopic Submucosal Dissection

in Colorectal Tumors: An Analysis of 398 Lesions Treated in Saga, Japan

Internal Medicine in press

Koji Yamamoto, Ryo Shimoda, Shinichi Ogata, Megumi Hara, Yoichiro Ito, Naoyuki Tominaga,

Atsushi Nakayama, Yasuhisa Sakata, Nanae Tsuruoka , Ryuichi Iwakiri , Kazuma Fujimoto

(ESD: endoscopi c submucosal di ssecti on) 20124 , .

ESD , ESD.

2012 4 2016 5 20 - 50 mmESD 373 (398 ) (

) , ,, .

373 68. 7± 9. 9 , 74. 0± 56. 2 (20-427) . 398 19 (4. 8%) , 12 (3. 0%) .

, . , .

. ESD ,

.

Page 12: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Outcomes of patients undergoing endoscopic hemostasis for the upper gastrointestinal bleeding

was not influenced by the timing of hospital emergency visit in Japan.

Digestion

Satoko Matsuura, Yasuhisa Sakata, Nanae Tsuruoka, Koichi Miyahara, Megumi Hara, Yoichiro Ito,

Kenichiro Nakayama, Takuya Shimamura, Takahiro Noda, Takahiro Yukimoto, Ryo Shimoda,

Ryuichi Iwakiri, Kazuma Fujimoto

i) ii)

2008 1 2014 12443 2

2

Page 13: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Immunogenicity of Quadrivalent Influenza Vaccine for Patients with InflammatoryBowel Disease Undergoing Immunosuppressive Therapy

Inflammatory Bowel Diseases, in press

Shimpei Shirai, Megumi Hara, Yasuhisa Sakata, Nanae Tsuruoka, Koji Yamamoto, Ryo Shimoda, Yasuhiro Gomi, Hironori Yoshii, Kazuma Fujimoto, Ryuichi Iwakiri

4

4

34 HI

GMT GMTR seroprotection rate (SP%)seroconversion rate (SC%)

132 22

16 TNF- 15 TNF-1

H1N1 : p = 0.81 ; H3N2 p = 0.79 ; B/ Phuket p = 0.82 ; B/Texas : p = 0.84 TNF-

A SP% : OR 0.22 (0.07-0.68), SC% : 0.19 (0.06-0.56)

4 1

Page 14: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

The Effect of Pottery Therapy on Heart Rate Variability in College Students with Mental Health Problems

Journal of Mental Disorders and Treatment Volume 3: Issue 1. doi: 10.4172/2471-271X.1000144. 2017

11 20.6 1.46 5

527 9

29 3

11

SD1 SD2 S RMSSD p<0.05 LF/HF(p = 0.374)

Page 15: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Incidence of aspiration pneumonia during hospitalization in Japanese hospitalized cases did not increase whereas concern factors were exacerbated in a time-dependent manner: analysis of DPC data Journal of Clinical Biochemistry and Nutrition, (in press)

Sayuri Nonaka, Susumu Fujii, Megumi Hara, Shigeki Morita, Eisaburo Sueoka, Koichi Node, Kazuma Fujimoto

DPCDPC (2010 15 ) 63,390

(( ) ICU/ECU )

2010 12 2013 15

ICU/ECU

Page 16: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Increased activity in the right prefrontal cortex measured using near-infrared spectroscopy during a flower arrangement task

International Journal of Psychiatry in Clinical Practice In press

Yuka Morita, Fumio Ebara, Yoshimitsu Morita & Etsuo Horikawa

: (FAP) ,. , , ,

. ,FAP NIRS(sAA) .

: NIRS WOT-220(HITACHI) , . sAA, .FAP

(BTT) : FAP BTT sAA

FAP FAP BTT : NIRS FAP

BTTFAP

sAA FAP BTTFAP

: FAP . ,FAP, .

Page 17: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

The Palliative Effect of Endoscopic Uncovered Self-expandable Metallic Stent

Placement Versus Gastrojejunostomy on Malignant Gastric Outlet Obstruction: A Pilot

Study with a Retrospective Chart Review in Saga, Japan

Internal medicine, in press

Takahiro Yukimoto, Tomohito Morisak, Sho Komukai, Hisako Yoshida, Daisuke Yamaguchi,

Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada,

Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto

2010 1 2016 12 65

S 38 B

27 S B

B

(51.4% vs. 26.3% ; P = 0.042) S

(4.5 vs. 3.0 days ; P = 0.013) S

(OR: 0.60, 95%CI: 0.36– 1.01, P = 0.053) S

Page 18: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Recommendations from primary care physicians, family, friends, and work colleagues influence patients’ decisions related to hepatitis screening, medical examinations, and antiviral treatment

Experimental and Therapeutic Medicine, in press

Michiaki Okada, Satoshi Oeda, Naoko E Katsuki, Shinji Iwane, Yasunori Kawaguchi, Saori

Kawamoto, Yoshimi Tomine, Jun Fukuyoshi, Keishiro Maeyama, Hideo Tanaka, Keizo Anzai, and

Yuichiro Eguchi

(1) (2) (3)

3

182 18

( 64.3% , 77.5%, 75.8%)

(3.3-19.8%)(76.9%, 73.0%, 77.5%) (50.0%, 26.3%,

64.3%) (58.3%, 38.9%, 58.3%) (33.3%, 33.3%, 42.9%)TVCM

Page 19: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Occult hepatitis B virus infection and surgical outcomes in non-B,non-C patients with curative resection for hepatocellular carcinoma World journal of hepatology, 9 35 ,1286-1295 ,2017

Hiroki Koga, Keita Kai, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

NBNC risk factor NASH metabolic factorHBV NBNC

HBV

1984 2012 477 HBs HCVNBNC 83 DNA 78

DNA RT-PCR 2 DNAHBV

66.3± 11.9 19 (24.4%) 27 (34.6%) 24

(30.8%) NASH 8 (10.3%) 27 34.6 HBVHBV

OS Vp p 0.0378 DFS Vpp 0.0217

NCNB 30 HBV 80% HBV

HBVHBV

NBNC-HCC 34.6% HBVHBV

Page 20: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Plasma adsorption membranes are able to efficiently remove High Mobility Group Box-1 (HMGB-1)

Journal of Nippon Medical School, in press

Takayuki Onohara, Yuichiro Sakamoto, Satoshi Inoue

HMGB-1HMGB-1

HMGB-1

3 IM-TR IM-PH BRS 1/350HMGB-1

25 50 75 HMGB-1

IM-TR HMGB-1 25 90BRS 50 IM-PH 10

3

HMGB-1 30kDaIM-TR IM-PH

BRSHMGB-1

HMGB-1

Page 21: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

Possible involvement of pericytes in intraplaque hemorrhage of carotid stenosis

Journal of Neurosurgery,in press

IPHIPH

2008 8 2016 3 53 56glycophorin A IPH

high IPH > 10 low IPH <10 2CD34

NG2 CD146 IPH

56 37 high-grade IPH 19 low-grade IPHCD34 2 NG2

CD146 high IPH low IPH 5.7± 0.517.1± 2.4 p <0.0001 6.6± 0.8 18.4± 2.5 p < 0.0001

high-grade IPH

Page 22: , 110, 35-41, 2017 - gab.med.saga-u.ac.jp · Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada, Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto 2010

A study on work engagement among nurses in Japan: the relationship to job-demands, job-resources, and nursing competence Journal of Nursing Education and Practice Vol 6(5),111-117,2016 Toshihiro Hontake, Hiromi Ariyoshi

< > (Work Engagement: WE)(Job-Demands: JD) (Job Resource: JR)

JR (Nursing Competence: NC)WE < > 917 Utrecht Work engagement Scale Brief Scales for Job Stress-Nurse Clinical Nursing Competence Self-Assessment Scale< >JD WE JR WE JR

WE JR NC

< >WE

WE JR

JR WD JD WEJR NC WE