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Functional analysis of mutation and expression in squamous
cell lung cancer
Lung Cancer, 110, 35-41, 2017
Naomi Kobayashi-Watanabe, Akemi Sato, Tatsuro Watanabe, Tomonori Abe, Chiho Nakashima, Eisaburo Sueoka, Shinya Kimura, Naoko Sueoka-Aragane
Discoidin Domain Receptor2 DDR2
DNADDR2
DDR2
29 DDR2 3.9 (T681I)DDR2 T681I
DDR2 MMP-1 c-Jun
DDR2 c-Jun MMP-1
T681I
DDR2
Differences in the genotype frequency of the variant in familial moyamoya disease patients in Kyushu, Japan.
Neurologia medico-chirurgica, in press
Takamatsu Y, Higashimoto K, Maeda T, Kawashima M, Matsuo M, Abe T, Matsushima T, Soejima H.
MMD
MMD
MMD
MMD 91 70 21 108DNA
27
MMD MMD
MAF minor allele frequency
MMDSNPs
MAF
MMD
Digestion, in press
DPC
2009 2015 78
3445,091 500,000
500,000
Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups
3,505
Digestion, 93, 266-271, 2016
Eri Takeshita, Yasuhisa Sakata, Megumi Hara, Kayo Akutagawa, Natsuko Sakata, Hiroyoshi Endo, Takashi Ohyama, Keiji Matsunaga, Tomomi Yoshioka, Hiroharu Kawakubo, Yuichiro Tanaka, Shimpei Shirai, Yoichiro Ito, Nanae Tsuruoka, Ryuichi Iwakiri, Motoyasu Kusano, Kazuma Fujimoto
F 2 GERD 72 FD 7 F
6F
Work-sharing and male employees’ mental health during economic recession Occupational Medicine, kqx135, 2017 Sep 14.https://doi.org/10.1093/occmed/kqx135
Masumi Nagae, Maiko Sakamoto, Etsuo Horikawa
Job Content Questionnaire JCQSelf-Rating Depression Scale SDS 2008T1 6 T2
336 2 24% T1p < 0.001 SDS
6 2
T2
Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy
Young Japanese Volunteers
Internal Medicine in press
Yuichiro Tanaka, Yasuhisa Sakata, Megumi Hara , Hiroharu Kawakubo, Nanae Tsuruoka, Koji
Yamamoto, Yoichiro Itoh, Hidenori Hidaka, Ryo Shimoda, Ryuichi Iwakiri, Kazuma Fujimoto
2010 20116 550 2230 Frequency Scale for the Symptoms of GERD FSSG
SPSS
45 8.2% 386.9% grade A 37 grade B 1
BMI>25
Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance throughdifferent mechanisms in scirrhous gastric cancer cell lines
Scientific Reports, 7, 11227, 2017
Koichi Baba, Yoshihiko Kitajima, Shuusuke Miyake, Jun Nakamura, Kota Wakiyama,Hirofumi Sato, Keiichiro Okuyama, Hiroshi Kitagawa, Tomokazu Tanaka, Masatsugu Hiraki,Kazuyoshi Yanagihara & Hirokazu Noshiro
/ SGC
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KD SC // /
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HIF -1KD SC c-myc /p27
KD anoikispro-survival signal FAK/Src/PI3K-Akt/ERK signal
KD anoikis recombinant /C ANGPTL4 ANGPTL4 58As9 anoikis
KDANGPTL4 SGC anoikis
Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis Scientific Reports (2017 8 23 accept)
, , , , , , ,
(HIF-1) ,
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Effect of limbering up of the muscles attached to the pelvis on the strength ofupper and lower extremity and trunk muscles through the transitional network
The Journal of Physical Therapy Science 30 11-17 2018
23.6± 3.7 18-33 152
2049
42 61
mobie SAKAI
KS
Impairment of health-related quality of life in patients with chronic hepatitis C is associated with insulin resistance.
Journal of Gastroenterology 49 317-323 2014
Kuwashiro T, Mizuta T, Kawaguchi Y, Iwane S, Takahashi H, Oza N, Oeda S, Isoda H, Eguchi Y, Ozaki I, Anzai K, Fujimoto K.
C QOL
HCVC
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C 175 (56.4 84 91 ) Quality of Life(QOL)Short Form-36(SF-36) QOL 75g
QOL SF-36 ( )( )
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Perforation and Postoperative Bleeding Associated with Endoscopic Submucosal Dissection
in Colorectal Tumors: An Analysis of 398 Lesions Treated in Saga, Japan
Internal Medicine in press
Koji Yamamoto, Ryo Shimoda, Shinichi Ogata, Megumi Hara, Yoichiro Ito, Naoyuki Tominaga,
Atsushi Nakayama, Yasuhisa Sakata, Nanae Tsuruoka , Ryuichi Iwakiri , Kazuma Fujimoto
(ESD: endoscopi c submucosal di ssecti on) 20124 , .
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) , ,, .
373 68. 7± 9. 9 , 74. 0± 56. 2 (20-427) . 398 19 (4. 8%) , 12 (3. 0%) .
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Outcomes of patients undergoing endoscopic hemostasis for the upper gastrointestinal bleeding
was not influenced by the timing of hospital emergency visit in Japan.
Digestion
Satoko Matsuura, Yasuhisa Sakata, Nanae Tsuruoka, Koichi Miyahara, Megumi Hara, Yoichiro Ito,
Kenichiro Nakayama, Takuya Shimamura, Takahiro Noda, Takahiro Yukimoto, Ryo Shimoda,
Ryuichi Iwakiri, Kazuma Fujimoto
i) ii)
2008 1 2014 12443 2
2
Immunogenicity of Quadrivalent Influenza Vaccine for Patients with InflammatoryBowel Disease Undergoing Immunosuppressive Therapy
Inflammatory Bowel Diseases, in press
Shimpei Shirai, Megumi Hara, Yasuhisa Sakata, Nanae Tsuruoka, Koji Yamamoto, Ryo Shimoda, Yasuhiro Gomi, Hironori Yoshii, Kazuma Fujimoto, Ryuichi Iwakiri
4
4
34 HI
GMT GMTR seroprotection rate (SP%)seroconversion rate (SC%)
132 22
16 TNF- 15 TNF-1
H1N1 : p = 0.81 ; H3N2 p = 0.79 ; B/ Phuket p = 0.82 ; B/Texas : p = 0.84 TNF-
A SP% : OR 0.22 (0.07-0.68), SC% : 0.19 (0.06-0.56)
4 1
The Effect of Pottery Therapy on Heart Rate Variability in College Students with Mental Health Problems
Journal of Mental Disorders and Treatment Volume 3: Issue 1. doi: 10.4172/2471-271X.1000144. 2017
11 20.6 1.46 5
527 9
29 3
11
SD1 SD2 S RMSSD p<0.05 LF/HF(p = 0.374)
Incidence of aspiration pneumonia during hospitalization in Japanese hospitalized cases did not increase whereas concern factors were exacerbated in a time-dependent manner: analysis of DPC data Journal of Clinical Biochemistry and Nutrition, (in press)
Sayuri Nonaka, Susumu Fujii, Megumi Hara, Shigeki Morita, Eisaburo Sueoka, Koichi Node, Kazuma Fujimoto
DPCDPC (2010 15 ) 63,390
(( ) ICU/ECU )
2010 12 2013 15
ICU/ECU
Increased activity in the right prefrontal cortex measured using near-infrared spectroscopy during a flower arrangement task
International Journal of Psychiatry in Clinical Practice In press
Yuka Morita, Fumio Ebara, Yoshimitsu Morita & Etsuo Horikawa
: (FAP) ,. , , ,
. ,FAP NIRS(sAA) .
: NIRS WOT-220(HITACHI) , . sAA, .FAP
(BTT) : FAP BTT sAA
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sAA FAP BTTFAP
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The Palliative Effect of Endoscopic Uncovered Self-expandable Metallic Stent
Placement Versus Gastrojejunostomy on Malignant Gastric Outlet Obstruction: A Pilot
Study with a Retrospective Chart Review in Saga, Japan
Internal medicine, in press
Takahiro Yukimoto, Tomohito Morisak, Sho Komukai, Hisako Yoshida, Daisuke Yamaguchi,
Nanae Tsuruoka, Koichi Miyahara, Yasuhisa Sakata, Shinichi Shibasaki, Seiji Tsunada,
Takahiro Noda, Seiji Yunotani, Kazuma Fujimoto
2010 1 2016 12 65
S 38 B
27 S B
B
(51.4% vs. 26.3% ; P = 0.042) S
(4.5 vs. 3.0 days ; P = 0.013) S
(OR: 0.60, 95%CI: 0.36– 1.01, P = 0.053) S
Recommendations from primary care physicians, family, friends, and work colleagues influence patients’ decisions related to hepatitis screening, medical examinations, and antiviral treatment
Experimental and Therapeutic Medicine, in press
Michiaki Okada, Satoshi Oeda, Naoko E Katsuki, Shinji Iwane, Yasunori Kawaguchi, Saori
Kawamoto, Yoshimi Tomine, Jun Fukuyoshi, Keishiro Maeyama, Hideo Tanaka, Keizo Anzai, and
Yuichiro Eguchi
(1) (2) (3)
3
182 18
( 64.3% , 77.5%, 75.8%)
(3.3-19.8%)(76.9%, 73.0%, 77.5%) (50.0%, 26.3%,
64.3%) (58.3%, 38.9%, 58.3%) (33.3%, 33.3%, 42.9%)TVCM
Occult hepatitis B virus infection and surgical outcomes in non-B,non-C patients with curative resection for hepatocellular carcinoma World journal of hepatology, 9 35 ,1286-1295 ,2017
Hiroki Koga, Keita Kai, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro
NBNC risk factor NASH metabolic factorHBV NBNC
HBV
1984 2012 477 HBs HCVNBNC 83 DNA 78
DNA RT-PCR 2 DNAHBV
66.3± 11.9 19 (24.4%) 27 (34.6%) 24
(30.8%) NASH 8 (10.3%) 27 34.6 HBVHBV
OS Vp p 0.0378 DFS Vpp 0.0217
NCNB 30 HBV 80% HBV
HBVHBV
NBNC-HCC 34.6% HBVHBV
Plasma adsorption membranes are able to efficiently remove High Mobility Group Box-1 (HMGB-1)
Journal of Nippon Medical School, in press
Takayuki Onohara, Yuichiro Sakamoto, Satoshi Inoue
HMGB-1HMGB-1
HMGB-1
3 IM-TR IM-PH BRS 1/350HMGB-1
25 50 75 HMGB-1
IM-TR HMGB-1 25 90BRS 50 IM-PH 10
3
HMGB-1 30kDaIM-TR IM-PH
BRSHMGB-1
HMGB-1
Possible involvement of pericytes in intraplaque hemorrhage of carotid stenosis
Journal of Neurosurgery,in press
IPHIPH
2008 8 2016 3 53 56glycophorin A IPH
high IPH > 10 low IPH <10 2CD34
NG2 CD146 IPH
56 37 high-grade IPH 19 low-grade IPHCD34 2 NG2
CD146 high IPH low IPH 5.7± 0.517.1± 2.4 p <0.0001 6.6± 0.8 18.4± 2.5 p < 0.0001
high-grade IPH
A study on work engagement among nurses in Japan: the relationship to job-demands, job-resources, and nursing competence Journal of Nursing Education and Practice Vol 6(5),111-117,2016 Toshihiro Hontake, Hiromi Ariyoshi
< > (Work Engagement: WE)(Job-Demands: JD) (Job Resource: JR)
JR (Nursing Competence: NC)WE < > 917 Utrecht Work engagement Scale Brief Scales for Job Stress-Nurse Clinical Nursing Competence Self-Assessment Scale< >JD WE JR WE JR
WE JR NC
< >WE
WE JR
JR WD JD WEJR NC WE