Fig. 1: Before NET treatment — This heart rate scan shows a dramatic increase in reactivity as the subject is given verbal cues relating to a distressing situation. 3 4 5 6 7 3 4 5 6 7 Fig. 2: After NET treatment — Now a normal level of reactivity is seen as the same verbal cues are given relating to the subject’s distressing situation. For more information on this and other NET studies visit ONEfoundation.org Abstract PURPOSE: A growing number of research studies have implicated the cerebellum in emotional processing and regulation, especially with regard to negative emotional memories. However, there currently are no studies showing functional changes in the cerebellum as a result of treatment for traumatic stress symptoms. The Neuro Emotional Technique (NET) is an intervention designed to help improve symptoms related to traumatic stress using an integrative approach that combines emotional, cognitive, and motor processing, with a partic- ular focus on autonomic nervous system regulation.... METHODS: We enrolled patients with a prior cancer diagnosis who experienced distressing cancer-related memories associated with traumatic stress symptoms of at least 6 months in duration. Participants were ran- domized to either the NET intervention or a waitlist control. To evaluate the primary outcome of neurophysio- logical effects, all participants received resting-state functional blood oxygen level-dependent (BOLD) magnetic resonance imaging (rs-fMRI) before and after the NET intervention. In addition, autonomic reactivity was measured using heart rate response to the traumatic stimulus. Pre/post comparisons were performed between the NET and control groups.. RESULTS: The results demonstrated significant changes in the NET group, as compared to the control group, in the functional connectivity between the cerebellum (including the vermis) and the amygdala, parahippocampus, and brain stem. Likewise, participants receiving the NET intervention had significant re- ductions in autonomic reactivity based on heart rate response to the traumatic stimulus compared to the control group. CONCLUSIONS: This study is an initial step towards establishing a neurological signature of treatment effect for the NET intervention. Specifically, functional connectivity between the cerebellum and the amygdala and prefrontal cortex appear to be associated with a reduction in autonomic reactivity in response to distressing cancer-related memories. J Cancer Surviv. 2017 Oct 19. doi: 10.1007/s11764-017-0653-9. Changes in cerebellar functional connectivity and autonomic regulation in cancer patients treated with the Neuro Emotional Technique for traumatic stress symptoms Monti DA 1 , Tobia A 1 , Stoner M 1 , Wintering N 1 , Matthews M 1 , Conklin CJ 2 , Mohamed FB 2 , Chervoneva I 3 , Newberg AB 4,5 Fig. 1 Fig. 2 https://www.ncbi.nlm.nih.gov/pubmed/29052102

1 . 2 - NETmindbody...for the NET intervention. Specifically, functional connectivity between the cerebellum and the amygdala and prefrontal cortex appear to be associated with a

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Fig. 1: Before NET treatment — This heart rate scanshows a dramatic increase in reactivity as the subjectis given verbal cues relating to a distressing situation.

3 4 5 6 7 3 4 5 6 7

Fig. 2: After NET treatment — Now a normal levelof reactivity is seen as the same verbal cues are givenrelating to the subject’s distressing situation.

For more information on this and other NET studies visit ONEfoundation.org

Abstract

PURPOSE: A growing number of research studies have implicated the cerebellum in emotional processingand regulation, especially with regard to negative emotional memories. However, there currently are no stud-ies showing functional changes in the cerebellum as a result of treatment for traumatic stress symptoms. TheNeuro Emotional Technique (NET) is an intervention designed to help improve symptoms related to traumaticstress using an integrative approach that combines emotional, cognitive, and motor processing, with a partic-ular focus on autonomic nervous system regulation....

METHODS: We enrolled patients with a prior cancer diagnosis who experienced distressing cancer-relatedmemories associated with traumatic stress symptoms of at least 6 months in duration. Participants were ran-domized to either the NET intervention or a waitlist control. To evaluate the primary outcome of neurophysio-logical effects, all participants received resting-state functional blood oxygen level-dependent (BOLD)magnetic resonance imaging (rs-fMRI) before and after the NET intervention. In addition, autonomic reactiv-ity was measured using heart rate response to the traumatic stimulus. Pre/post comparisons were performedbetween the NET and control groups..

RESULTS: The results demonstrated significant changes in the NET group, as compared to the controlgroup, in the functional connectivity between the cerebellum (including the vermis) and the amygdala,parahippocampus, and brain stem. Likewise, participants receiving the NET intervention had significant re-ductions in autonomic reactivity based on heart rate response to the traumatic stimulus compared to the con-trol group.

CONCLUSIONS: This study is an initial step towards establishing a neurological signature of treatment effectfor the NET intervention. Specifically, functional connectivity between the cerebellum and the amygdala andprefrontal cortex appear to be associated with a reduction in autonomic reactivity in response to distressingcancer-related memories.

J Cancer Surviv. 2017 Oct 19. doi: 10.1007/s11764-017-0653-9.

Changes in cerebellar functional connectivity and autonomic regulation in cancer patients

treated with the Neuro Emotional Technique for traumatic stress symptomsMonti DA1, Tobia A1, Stoner M1, Wintering N1, Matthews M1, Conklin CJ2, Mohamed FB2, Chervoneva I3, Newberg AB4,5

Fig. 1 Fig. 2

https://www.ncbi.nlm.nih.gov/pubmed/29052102