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StreetRx Price Comparison Non-Bulk vs Bulk

StreetRx Price Comparison

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StreetRx Price Comparison

Non-Bulk

vsBulk

StreetRx.com

THE RADARS® SYSTEMStreetRx has been part of the RADARS System since 2010. The Researched Abuse, Diversion and Addiction-Related Surveillance collects timely product- and geographically-specific data on rates of abuse, misuse, and diversion, contributing to the understanding of trends and aiding the development of effective interventions.

StreetRx (streetrx.com) is a collection of databases, websites, and citizen reports enabling real-time collection, organization, and display of street price data on diverted pharmaceutical controlled substances. Based on principles of crowdsourcing for public health surveillance, the site allows users to anonymously submit prices they paid or heard were paid for diverted prescription drugs.

Unique Visitors per Day

130

250

16412616

MobileAccounts for 80%

of visits

Search86% of visits come from

organic search

Average daily visitors per year identified by Google Analytics

2012

2015

As of April 27, 2015. Not to scale.

Visitor DemographicsBased on 58% of known demographics from Google account users

20%Male

35+ years-old

43%Male

18-34 years-old

15%Female35+ years-old

22%Female

18-34 years-old

As captured by Google Analytics. January 1 through March 31, 2015

42,058 Referrals to Health OrganizationsFrom November 1, 2010 through March 31, 2015

Drug Treatment & Harm

ReductionSubstance abuse treatment locators, overdose prevention

Chronic PainAdvocacy and support organizations

Proper Disposal and

StorageDEA and non-profit

organizations

1,750 1,4381,318

1,420

4,565

1,356

1,4322,062

Percent Discount for ADF VersionsPutative abuse-deterrent formulation versus unprotected formulations with same active ingredient, using statistical comparison that is less influenced by outliers.

4% 36%

45%

54%

7% 22%

25%

42%

55%

Physical Barrier Prodrug(Partial-)Antagonist

Conc

erta

Exal

go

Opa

na E

R

Oxy

Conti

n O

P

Zohy

dro

Vyva

nse

code

ine

Subo

xone

tabl

et

Xart

emis

XR

p<.01

z -38

p<.01

z -38

p<.01

z -3.0

p<.01

z -3.7

p=.78

z 0.3

p<.01

z -8.6

p<.01

z -13

p=.34

z -0.9

p=.24

z -1.2

TBD

?

OROSOROSINTAC INTAC PolyOx

29%

Rita

lin L

A

p<.01

z -3.9

SODAS

24%

Nuc

ynta

ER

p=.10

z -1.6

INTAC

29%

Hys

ingl

a ER

p=0.46

z -0.7

INTAC INTAC

Which drugs have greatest volume discounts?On the black market

STEP 1

STEP 3

STEP 2

STEP 4

USA Data in USDNov 1, 2010 through Mar 31, 2015Solid oral formulations Compare bulk (10+ units) purchases with “retail” purchases, by active ingredient

N = 52,849Price per milligramGeometric means and 95% CINon-parametric Wilcoxan rank-sum (Mann-Whitney) tests

BenzodiazepinesMuscle Relaxers

StimulantsErectile Dysfunction

BenzodiazepinesPercent discount for bulk purchases (10+ at a time)

diazepamn=507

z=3.7 p<0.01

34%

25%

22%

10%

clonazepamn=3,161

z=6.1 p<0.01

alprazolamn=4,583

z=8.7 p<0.01

lorazepamn=1,271

z=1.8 p=0.07

Muscle Relaxers & Neuropathic Pain RelieversPercent discount for bulk purchases (10+ at a time)

pregabalinn=21

z=1.3 p=0.19

48%

46%

22%

0%

gabapentinn=146

z=1.2 p=0.25

carisoprodoln=239

z=3.6 p<0.01

tizanidinen=47

ns

Sleep AidsPercent discount for bulk purchases (10+ at a time)

eszopiclonen=9

z=0.5 p=0.60

59%

30%

24%zolpidem

n=287z=3.3 p<0.01

zaleplonn=8

z=0.5 p=0.61

Erectile DysfunctionPercent discount for bulk purchases (10+ at a time)

tadalafiln=142

z=4.0 p<0.01

73%

61%

0%vardenafil

n=15ns

sildenafiln=251

z=3.8 p<0.01

Percent Discount for Bulk Purchase

Sleep Aids Erectile

Dysfunction

Benzodiazepines Stimulants Opioid AnalgesicsMuscle Relaxants

39% 23% 14% 38% 12% 67%

Thank You

Boston, MA [email protected] @street_rx

@epidemicoepidemico.co

m

OpioidsPercent discount for bulk purchases (10+ at a time)

methadonen=852

z=2.6 p<0.01

oxycodonen=9,910

z=8.6 p<0.01

hydromorpho

nen=1,664

z=2.8 p<0.01

hydrocodonen=6,062

z=7.0 p<0.01

14%

13%

12%

10%

StimulantsPercent discount for bulk purchases (10+ at a time)

modafiniln=87

z=1.5 p=0.13

32%

15%

8%

3%

methylphenid

aten=1,607

z=1.7 p=0.09

amphetamine

sn=13,828

z=9.1 p<0.01

lisdexamphetami

nen=2,038

z=1.8 p=0.07

Descriptive Results Abuse/tamper deterrent formulationOriginal unprotected formulation

95% Confidence interval of the geometric mean