Douglas White Architect AIA 408.730.3333 (office) 408.639.3010 (mobile)

33 architect 1980 - now

3.5 intern architect 1977 - 1980

1.5 Master of Architecture University of Texas Austin, Texas

1975 -1976

4 Bachelor of Arts, Architecture Major College of Environmental Design University of California Berkeley, CA

1971 - 1975

NCARB, Arizona, California, Florida, Illinois, New Jersey, New York

Member of: American Institute of Architects, In-ternational Societyfor Pharmaceutical Engineer-ing,International Conference of Building Officials, Construction Specifications Institute, Institute of Facilities Engineering Mr. White's 37 year career in architectural practice started immediately after receipt of his M. Arch Degree, and has been continuous and without interruption since 1978. During this time—his experience has included designing and managing projects for the phar-maceutical and biotechnology industries, as well as, microelectronics, photovoltaic/solar, aerospace, and other industries.

His experience with biotechnology, biomedi-cal, bioscience and pharmaceutical research and development labs and manufacturing be-gan in 1980 and includes: Standard Research Labs

• Bench/Wet Labs • Fume Hoods/Biosafety Cabinets/LF

Hoods/Walk-in Hoods/Organic • Open Laboratory Design • Modular Laboratory • Hazardous Occcupancies: H-2, H-7, and H

-8 Special Research Labs • BSL-1 to BSL-4, and, BSL-2(+)

[implementing all measures prior to BSL-3 final install of charcoal filtration]

• Tissue Culture Labs/Suites • Animal rooms/Housing/Research Labs • Necropsy Suites/Surgery/Quarantine/

Microisolator • Greenhouses • AIDS Research Labs • Organic Synthesis/Chemistry and Protein

Chemistry • Hazardous Occupancies: H-2, H-4, and H-

8 • Microinjection Process Development/cGMP Manufacturing • Fermentation Areas (Mammalian and Bac-

terial) • Change Rooms/Gown Rooms/Air Locks • Sterile Prep/Sterile Fill/Sterile Processing • Cold Processing Rooms • Clean Rooms ISO 4, ISO 6/5, ISO 7, ISO

8 (aka CL-10, CL-100/1,000, CL-10,000, CL-100,000)

• Biomedical Products Assembly • Biomedical Subassembly

• WFI/Clean Steam Systems Coordination • Blood Fractionation, Purification Areas • Recovery/Purification, Isolation, Extraction • LS BSL 1 - 2 • Chemical Synthesis Research/Manufacturing Support • Environmental - Cold/warm/freezer humidity controlled rooms • Instrument rooms/Equipment Rooms • Centrifugation/Chromatography/Fermentation • Glassware prep/Wash/Dry/Autoclave • Cage wash and animal facility support • Hazardous Materials/Chemical Storage - H-

2, H-4 • HPLC • NMR/Mass Spec. `• Engineering Support • Validation • Media Prep • Dark Rooms • Co2/N2 Source Systems Mr. White has also been responsible for design and planning of office and administrative areas for the same companies for which the above work was accomplished, including: Office and Administrative Areas • Cafeterias/Lunch rooms • Day care facilities • Fitness centers • Libraries • Computer rooms • Security systems • Graphics and signage Mr. White's specific experience in pharmaceutical and biotechnology projects (approximately 500 in number, $500 M in construction cost, and 4 M square feet in area) and includes a wide range of projects with the following clients:

"ONGOING OPERATIONS" Agilent Technologies - Santa Clara, CA

Amgen - Thousand Oaks, CA Brittania Development - Oakland, CA Cholestech, Inc. - Hayward, CA

Ciphergen -Fremont, CA Clinimetrics - San Jose, CA Dewey Land Co. - San Mateo, CA

diaDexus - S. San Francisco, CA Endotex - Cupertino, CA Genelabs, Inc. - Redwood City, CA

Genentech, Inc. - S. San Francisco, CA Geron, Inc. - Menlo Park, CA Iridex - Mountain View, CA

MacFarlane Partners - San Francisco, CA Medimmune - Mountain View & Santa Clara, CA

MJ Research - S. San Francisco, CA Molecular Devices - Sunnyvale, CA NABI (North American Biologicals, Inc.) - Mi-

ami, FL NuGEN - San Carlos, CA Occulex - Sunnyvale, CA

Origin Therapeutics - Burlingame, CA ParAllele - S.San Francisco, CA Plexxikon - Berkeley, CA

Portola Pharmaceuticals - S. San Francisco, CA Receptron, Inc. - Sunnyvale, CA

Renovis - S.San Francisco, CA Rigel, Inc. - S.San Francisco, CA Roche Biosciences - Palo Alto, CA

San Bio - Mountain View, CA Simeon Properties - San Francisco, CA Stanford University - Stanford, CA

SynPep Corporation - Dublin, CA Monogram Biosciences (formely Virologic, Inc.)

- S. San Francisco, CA

"MERGED/ACQUIRED OPERATIONS" Adventis (formerly PRP Gencell, formerly AIS)

- Hayward, CA Becton Dickenson - (formerly CLONTECH Laboratories) - Palo Alto, CA

Sunnyvale, CA Boston Scientific (formerly Target Therapeu-tics) - Fremont, CA

Celera [formerly Axys - (formerly Khepri and

Arris) - S. San Francisco, CA

Cognate Therapeutics (formerly Layton Biosci ence) - Novartris (fomerly Chiron Corporation (formerly

Ciba Corning/Triton Diagnostics) - Alameda, CA Chamberlin Associates (formerly Rouse and

Associates) - S. San Francisco, CA Elan Pharmaceuticals (formerly Athena Neurosciences, Inc.) - S. San Fran-

cisco, CA FemRx (formerly Adeza Biomedical ) - Mountain View, CA

Glycomed, Inc. (a division of Ligand) - Ala-meda, CA

Allergan (formerly Inamed/formerly McGhan Medical) – Santa Barbara, CA Millenium Pharmaceuticals (formerly COR

Thera peutics) - S. San Francisco, CA Bristol Myers Squibb (formerly Medarex, Inc./ formerly GenPharm) - Milpitas, CA

Roche Bioscience (formerly Syntex {U.S.A.}, Inc.) - Palo Alto, CA Syngenta Seeds (formerly Novartis, formerly

Rogers/Sandoz Seeds) - Gilroy, CA Telik (formerly Terrapin Technologies) - S. San Francisco, CA

Invitrogen (acquired Zymed) - S. San Fran-cisco,

CA Amgen – (formerly Tularik, Inc. - S. San Fran cisco, CA,

Tularik, Inc. - New York, NY Tularik, Inc. - Texas Matrix Pharmaceuticals, Inc. (purchased by

Chiron) - Milpitas & San Diego, CA Johnson + Johnson (formerly ALZA Corpora tion - Vacaville, CA & Palo Alto, CA

Gilead (formerly CV Therapeutics) - Palo Alto, CA Fisher Scientific (formerly Microgenics) - Fre

mont, CA

"CEASED OPERATIONS" ArQule - Redwood City, CA;

Biogrowth, Inc. - Richmond, CA DNA Sciences (formerly Kiva) - Fremont, CA Ex-Vivo Therapies - Torrance, CA; S. San

Francisco, CA; and Durham, N. Carolina Immulogic Pharmaceutical Corp. (closed) - Palo Alto, CA

Layton Bioscience - Sunnyvale, CA Origin Medsystems (closed) - Belmont, CA Parnassus Pharmaceuticals (closed) - S. San

Francisco Protogene - Menlo Park, CA Red Cell, Inc. (closed) - San Francisco, CA

Scotgen Biopharmaceuticals (closed) - Menlo Park,CA Solaris - San Ramon, CA

AGY Therapeutics - S. San Francisco, CA Argonaut Technologies - Redwood City, CA Covalent - Burlingame, CA

Zyomix - Hayward, CA Genitope - Redwood City, CA Intuitive Surgical - Mountain View, CA

IriDigm - San Francisco CA

(Please contact WHL for specific information re-garding the projects that were completed for these clients)

Solar R + D and Manufacturing: Site Masterplanning and Building Architecture Process flow and facility planning for manufacturing. PV Panel Assembly and Manufacturing, MOCVD Thin film equipment and other tool Fit Ups, Robotics All manufacturiing ISO class 3, 4, 5, 6, 7, and 8. H-2, H-4, H-5, H-8 (Ca) Hazardous Occupancies Life Sciences Manufacturing: WHL experience with manufacturing for biotech and pharmaceuticals/therapeutics companies has in-cluded successful production using fermentation, fractionation, powder blending and pressing, oral osmotics, kilo scale small molecule process develop-ment, cold column chormatography, ex vivo process-ing, fill and finish, packaging, stability, and ware-housing. Also, experience with manufacturing for medical de-vice transdermal device operations has included transdermal devices and patches, cathe-ters, subcutaneous osmotic devices. All manufacturing under cGMP conditions and ISO class 4,5, 6, 7, and 8. H-2, H-4 Hazardous Occupancies Microelectronics and Electronics R + D and Manufacturing: Integrated circuits, hybrid circuits, detectors. PCB and periferal manufacturiing. All manufacturiing ISO class 4, 5, 6, 7, and 8. H-2, H-4, H-5

Ehrlich Rominger Architects

September 1978 – June 1987 (8 years 10 months)

Started at ER as a Draftsperson, total staff was 18. ER formed (1/ 1978), since 1968 it was known as "EHR" (specializing in microelectronics architecture), when CAS was spun out. ER grew larger and moved to Los Altos in 1983 - during that time White was promoted to Job Cap-tain, Project Architect, to Studio Director/Senior Associate. Promoted to Vice President in 1985. During this period worked with and trained by two of the icons of modern Architectural practice in Santa Clara Valley and Northern California: Joe Ehrlich and Jack Rominger http://www.aiascv.org/pages/tracings/09FebTracings.pdf Joe and Jack started their careers working for Birge Clark (http://en.wikipedia.org/wiki/Birge_Clark), which later became Clark Strom-quist Potter and Ehrlich (CSPE). Notable Projects at Ehrlich-Rominger: Project: Genentech, Inc Size: 100,000 sq. ft. of various office, laboratory, manufacturing, and vivarium spaces Objective: Pilot/clinical manufacturing fill and fin-ish for Genentech's Protopin (human growth hor-mone - HGH) including Class 100 fill suite, Class 10,000 cold room chromatograpy. Pharmacology vivarium, with central plant and double dirty/clean corridor. Cafeteria. First modular laboratories. Central Plant to service existing facilities and fu-ture growth.

Project: McDonnell-Douglas Corp. Microelec-tronics Facility Size: 192,000 sq. ft. production facility Objective: IC production facility capable of the manufacturing and design of microelectronics, infrared detectors, and other specialty/military hybrid circuitry. Class 10,000 clean room tech-nology to two (2) class 10 clean rooms. Special floating photo lithography room to be used for microchip imprints. Remodeling of existing pro-duction facility and construction a cafeteria.

The University of Texas at Austin

Master of Architecture, Architecture 1975 – 1976

Studied and learned from faculty that were at the beginnings of the sustainable/green revolu-tion, especially Paco Arumi (http://soa.utexas.edu/news/paco/) in Solar Design and Solar Heat Gain Computer Evaluation. Es-tablished minor coursework in Construction Management: consisting of project scheduling (CPM/PERT), construction administration, esti-mating and bidding strategies

Activities and Societies: Phi Kappa Phi Honors Society, GRID University of California, Berkeley

Bachelor of Arts, Environmental Design - Archi-tecture Major 1971 – 1975

Trained in an interdisciplinary setting through the College of Environmental Design - with coursework in Civil Engineering, Structural En-gineering, Passive Solar Design, Energy Analy-sis and Energy Savings. Worked concurrently with studies at school - AT & T (formerly Pacific Telephone) Payment Processing Oakland, CA.; ASUC Student Store; G.G. Schierle and Asso-ciate Oakland, CA regarding project program-ming and conceptual design for the Intramural Sports Center..