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Biotechnology Industry has changed a lot during last decade , which means moving ahead from traditional ways to more advanced technological developments2012 Biotechnology Industry is not the same as it was in 2001
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Biotechnology as Career Option 2012
Choosing a Career path in 21st Century without understanding the Industry would be as good as ship sailing in a sea without a compass
Biotechnology is the research and development of innovative healthcare, agricultural, industrial and environmental products
https://www.facebook.com/pages/Bioinformatics-On-Run
byBioInformaticsOnRun
YOUR APPROACH YOUR DECISION YOUR PASSION
Drug Discovery R&D Organizations SYSTEM Biology Companies Informatics Knowledgebase Development firms Clinical Research Organizations Seed technology and genetically modified food Biofuels Monoclonal Antibodies Environmental and industrial biotechnology Instrumentation and Equipment Out Look How to Approach
Heal the World
Fuel the world
Feed the World
That’s an Impressive introduction and I know the PROBLEMS AND CHALLENGES you
CURRENTLY FACING
PhD Students ,Postdoctoral Researchers
,Professors/Lecturers, Masters Students , Librarians, Commercial
R&D Professionals ,Undergraduates,
Academic Researchers Government /NGO researchers
Biology Informatics and Research and development Challenges
Systems Biology
The Slides will help you to understand the mechanism , workflows , and Process of different segments in life science Industry
This all Started when you try to understand the disease
When you try to understand how the gene are altered
How that affects the proteins they encode
And how these proteins Interact with each other in living cells
How those affected cell change the specific tissue they are in
And finally how the diseases affects the entire patient
Target Identification(Choose a molecule to
target with a drug) Target validation
(Test the Target and Confirm its role in
Diseases)Drug Discovery (Find a promising
Molecule (“ a Lead compound”) that could
become a drug)Early Safety Test
Perform Initial Tests on Promising Compounds
Lead optimization(Alter the Structure of
Lead Candidates to improve Properties)
Drug Discovery Science
Today Scientists are facing More Challenges
Biological network maps
Produce better small molecules
at early drug discovery stages
Complexity of biological system
Visualization
Time and Cost
Storage , retrieval and
analysis of data
Systems Biology as Savior
Systems Biology
Molecular Pathway
Whole Organism
Organs Tissues
Cells
Regulatory Networks
Omics
Modeling
Genomics
Metabolites
Proteomics
OM
ICS
MO
DELI
NG
Organ Complexit
y
Tissue
Cell
Gene translationProtein ExpressionSignaling EventMetabolite Fluxes Identify nodes of signaling networksIdentification of Interaction Partners and Protein Modifications Knockout Knock In Genes
Review of Quantitative models of the System from gene to Physiology Review of approaches for modeling diseases Computationally –based mathematical model of disease predicts patient responses to different therapies
Epigenomics
Methods to Study Proteins
Determining proteins which
are post translationaly
modified
Computational methods in
studying protein biomarkers
Establishing Protein- Protein
interactions
Determining the existence of proteins in complex mixtures
Detecting Proteins
Protein Purification
Protein Structures
Protein-DNA Interactions
Informatics Science
Literature Informatics Publications of databases of biological informationMicroarray datasheetsHigh Throughput Screening datasetsOther Experimental Data
Literature Informatics Imaging Informatics Clinical Informatics Public health Informatics
Establishing Skills in basic
molecular biology and
protein Expression
Well Developed Chemistry Skills
capable of offering end to end complex capabilities
CLINICALLY APPROVED DRUGS
Pre- Clinical Phase
Phase 0
Phase1
Phase 2
Phase 3
Post marketing
surveillance Trial
Translational research
GM CROPS /FOOD/SEEDS
Why are GM food/Crops produced and Developed????
Improve crop Protection Insect resistance Virus resistance Herbicide tolerance
The safety assessment of GM foods Allergenicity Gene Transfer Outcrossing
Examples: Drought tolerant Maize Protecting Plants against Freezing Apple genome sequencing Longer shelf life for tomatoes
Biofuels: Ethanol from Biomass
DIFFERENT ROLES TO PLAY IN BIOTECHNOLOGY INDUSTRY
Monoclonal Antibodies
MarketLarge protein
molecules produced by white blood cells that seek out and destroy harmful
foreign substances Application in many
areas of medicine and biologic science
Are used in the identification of organisms in the
bacteriology laboratory
Also used in the diagnosis of leukemia
Used in the treatment of malignancies
ENVIRONMENTAL/INDUSTRIAL BIOTECHNOLOGY MARKET
Use of microorganis
ms or biological
substances to perform
specific industrial or
manufacturing process
Living cells and Enzymes can be used to produce vitamins,
antibiotics, vaccines and proteins for medicinal purposes
Cells can be modified to
produce enzymes,
which function
biologically as catalysts
to bring about
specific biochemical
reaction
Production of chemicals, pesticides,
biofuels and biodegradabl
e plastics made from renewable
raw materials like starch, vegetable
oils, cellulose and
agricultural waste.
INSTRUMENTATION & EQUIPMENT MARKET
Instrumentation would refer to large-scale equipment such as MRI machines, ultrasound machines, immunoanalyzers and hemoanalyzers.
Devices used for surgery, such as laparascopes, endoscopes and arthoscopes. Durable equipment or DME such as medical beds or chairs, wheelchairs and canes would be part of this category.
DNA sequencers and high throughput screeners. Mass spectrometers are currently used for a variety of clinical applications. Mass spectrometry (MS) is an assessment technology that identifies the mass-to-charge ratio of charged particles
OUTLOOK
Mapping of the human genome Wave of new biologic drug product approvals by the FDA.
Genetic disorders
Metabolic
Infectious disease
Oncology
Opthalmology
Regenerative medicine
0% 10% 20% 30% 40% 50% 60% 70% 80%
Therapeutic areas offer the best in-vestment opportunities
Source::http://thomsonreuters.com/content/science/pdf/white_papers/BIO_ThomsonReuters09_study.pdf
Q. I Know Industry How to approach ?
Proper Education : To excel in biotechnology Industry you need to
have good educational background
Masters of Science ,Masters in technology, PhD is
Preferred
Have focused approach
Know your Interest /Develop Interest
Additional short course Projects and Industry Project is
Preferred
Remember Experience is advantage
Keep track of Industry , follow
trends ,Select Path
CONCLUSION Biotechnology Industry has changed a lot during last decade , which
means moving ahead from traditional ways to more advanced technological developments
2012 Biotechnology Industry is not the same as it was in 2001 Computational, Mathematics and physics knowledge additions to
Biology has opened many new windows for Investors and for Small and Mid-Sized Entrepreneurs which again playing very important role .
Many Students with Diversified Non- life science background are working for this Industry
Companies are investing more and more in Lethal Diseases which is a good sign for the Industry and the society as whole
FDI and Government policies too play a very important role and need to be regularly monitored by anyone who want to have a career in Life science Industry
Thank YOU BioInformaticsOnRun
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