RAD Biomed IncubatorRAD Biomed IncubatorThe Israeli incubator program started in 1991 to provide a sheltered environment for scientists and entrepreneurs from the former USSR

RBM was established in 1992 as general incubator, refocused in 1998 to biotech

Located in Tel-Aviv

Owned by the RAD group of companies

Six active graduate companies

MaimoniDex RAMaimoniDex RA

InnoScent Ltd

9 Incubator companies

The RAD Biomed PortfolioThe RAD Biomed Portfolio

ARIO MEDICA

TouchMed TissueDetectTissueDetect

Drug-delivery pump Gene therapy Peripheral atherectomy

Improved enzymes Molecular diagnostics Cord-blood harvesting

Endoscopy Epidural-space detection

OccuOccuPharmaPharmaOpthalmic drug-delivery

Our PhilosophyOur Philosophy RBM is a biotech incubator that serves as a natural interface

between the world of Israeli academic research and the global biotech industry

Long term vision: to build viable businesses and to create sustainable benefits to the economy and a significant return to investors and to the entrepreneurs

The goal of the incubation period is to prove the technological concept and its  feasibility and to advance it towards commercialization.

To attain our goal we To attain our goal we establish for each project a business establish for each project a business model model && strong IP position, and demonstrate that it  can strong IP position, and demonstrate that it  can

attain profitability in a targeted market segmentattain profitability in a targeted market segment

The Deal FlowThe Deal Flow Projects are admitted to RBM either as a concept or as a small

team with molecule/technology & executive-summary/IP/work-plan etc.

Deal flow is generated in the following mannerDeal flow is generated in the following manner : :

Entrepreneurs approach the incubatorEntrepreneurs approach the incubator

Via our working relationship with TTOs Via our working relationship with TTOs

Proactive search for projects in Israeli academia Proactive search for projects in Israeli academia and and hospitals hospitals

Personal contactsPersonal contacts

Rad BioMed Functions as a mini Pre-Seed VC

Test Criteria

• Clinical Need• Team• Market• IP• Technology• Project status

RAD BioMed’s

Investment

CommitteeProactive

search

for

projects

Approval

ProductPositioning

Incoming deal- flow

Screening the deal-FlowScreening the deal-Flow

Our Nurturing Approach:

Mapping the needs (to reach the long-term goal),

Assessing all the available resources at set-up,

Implementing and supporting

NurturingNurturing The Young Projecthe Young Project

While keeping our focus on the startup’s long term goals, While keeping our focus on the startup’s long term goals,

we build the company’s work-plan we build the company’s work-plan && activities step-by- activities step-by-

step to position it for the next round of financingstep to position it for the next round of financing

RBM provides the incubator projects:

• Management & legal and financial support

• Business development and clinical consulting

• IP strategy and regulatory & reimbursement planning

• Extensive lab space for R&D

Nurturing The PeopleNurturing The People In an ideal world, the “unskilled” entrepreneur would step aside and make room for a “seasoned” business-oriented project-leader

In the “real world” we are limited by budget constraints, so we appoint a project manager and then mentor and coach …

Coaching, coaching, coachingCoaching, coaching, coaching:

Active interaction with project managers

Creating a “business-oriented” thinking process

Adhering to work-plan

FundingFunding

RBM incubator is owned and funded by the

Chairman of the RAD Group of Companies

The projects are funded by the Israeli Government and matching-funds are provided by the owner of RBM

Additional funding may be provided by business angels before or upon entry, and/or during the incubation period

Our companies seek VC or corporate funding upon graduation and at-times also during the incubation period

RBM maintains an active role in the fundraising RBM maintains an active role in the fundraising processprocess

Task Oriented Management Task Oriented Management TeamTeam

Idan Tamir, Ph.D. President & CEOBinah Baum, Ph.D.

MBADirector, Business Dev

Shoshi Keynan, Ph.D.

Project Manager

Drug development specialistsRAD group of

companies

Medical deviceconsultants

project IP experts

Clinical & regulatory experts

Handling The Maturing Handling The Maturing CompanyCompany

Building Value To The Next LevelBuilding Value To The Next Level

√√ Demonstrating proof of concept –critical milestone

√ √ Creating a strong IP position with freedom to operate

√√ Initiating regulatory procedures – what does the FDA look for? Initiating discussion with regulatory consultants

√ √ Preparing succinct business plan for next investment round

√√ Creating a professional advisory board & appointing a medical director

√ √ Initiating alliances with companies e.g. FP7 consortia

√√ Helping to secure follow-up financing / alliances with strategic partners

WeaknessWeaknesseses

Is project funding sufficient for required tasks?

will the tight budget allow us to chose the “perfect” manager?

How well do Government financing programs adapt to changing needs?

Distance from global markets

Support & coaching to company management

Responsibility and accountability

Focus on value creation - always market oriented Work-plan within a limited budget

Achieving technological POC within these constraints

Determination, flexibility & success orientation

StrengthStrengthss

Go Europe:Go Europe:

create alliancescreate alliances

Inclusion of our SMEs in FP7 consortia

Participation of incubator in FP7 consortia

Collaborations betw. our SMEs and clinical-centers

/SMEs in other European bioregions

Incubation of European pre-seed projects in RBMIncubation of European pre-seed projects in RBM

What do we need to do in order “to do betterWhat do we need to do in order “to do better? ”? ”

Janez Potocˇnick,European Commissionerfor science and research