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1
DEPARTMENT OF PHARMACEUTICSSHRI B. M. SHAH COLLEGE OF PHARMACEUTICAL EDUCATION AND REASERCH,
MODASA-2013
CONTENTS
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IntroductionClassificationAdvantages and DisadvantagesRaw Material SpecificationsDepartmental Layout of Liquid ManufactureQuantitative Layout Of Liquid PreparationImportant QuestionsReferences
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INTRODUCTIONINTRODUCTION
Liquid dosage form are one class of dosage form, which are meant for either internal, external or parenteral use.
Liquid dosage forms are prepared by dissolving active ingredients in an aqueous or non-aqueous solvent, by suspending the drug or by incorporating the drug into one of the two phases of an oil and water systems.
LIQUIDS
MONOPHASIC BIPHASIC
ORAL USE
EXTERNAL USE
PARENTERAL SPECIAL USE
Used in Oral cavity
Used in other than oral cavity
LIQUID IN LIQUID
SOLIDS IN LIQUID
Oral useEMULSION
External useLINIMENTS
Parenteral OralSUSPENSION
ExternalLOTION
SOLUTIONDRAUGHTSDROPSLINCTUSESSYRUPSELIXIRS
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CLASSIFICATIONCLASSIFICATION
1. Immediately available for absorption2. Easy administration 3. They are most suitable dosage forms for infants, children, geriatric and mentally disturbed patients.4. Bitter and obnoxious drugs can be easily given in sweetened, colored and flavored vehicles.5. Doses can easily be varied as per the requirement of the patients.
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ADVANTAGESADVANTAGES
DISADVANTAGESDISADVANTAGES1 . Less stable compare to solid dosage forms.2. Liquid dosage forms are bulky and therefore inconvenient to carry, transport and store.3. Incompatibility is more in liquid dosage forms as compare to solid dosage forms.4. Patients have no accurate measuring device.5. In case of accidental breakage of the container, it may result in loss of the whole dosage forms.
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Raw Material Specifications
Raw Material Specifications
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DEPARTMENTAL LAYOUT OF LIQUID MANUFACTURING
DEPARTMENTAL LAYOUT OF LIQUID MANUFACTURING
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•An area requirement for installation of equipment minimum 30 m2.
Q C
Offices Gowning
Canteen
Incoming goods
Corridor
Corridor
Shipping
Corridor
Packaging
Weighing Processing
Filling
Raw Materials
& Packaging
Storage
Washing
Machine Shop
Finished Products Storage
Corridor Utilities and Services Waste Treatment
Arrival of Entrance for Entrance for Shipment of goods visitors Workers goods
Material flow People flow
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Making Liquid Syrup
Suppose, Plant Capacity:- 1,00,000boottles/day
For preparing:- 1,00,000 bottles (each containing 50ml of liquid syrup)
So, total syrup making:- 5000 L
Raw material Quantity:-
•Drugs:- 10 Kg
•Std granulated sugar:- 2750 Kg
•Other excipients:- 1000 Kg
•Purified water:- q.s
QUANTITATIVE LAYOUT OF LIQUID PREPARATIONQUANTITATIVE LAYOUT OF LIQUID PREPARATION
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OFFICE
C
O
R
R
I
D
O
R
RAW MATERIALAPI & EXCIPIENT
10sq.M
LIQUID & SOLVENT
MEDICINE PREPERATION AREA
30sq.M
SEMI FINISHED STORE
I.P.Q.C.
OFFICE
WASHING EQUIPMENTSTORAGE AREA
WASHING AREA
10sq.MEMPTYBOTTLESTORAGEAREA
LABELING 20sq.M
PACKAGING 20sq.M
FINISHED PRODUCTSTORAGE AREA
30sq.M CHANGE ROOM
GOWNING ROOM
DISTILLATION UNITEXCISE DUTY
syrup
WASHING 10sq.M
FILLING & SEALING 10sq.M
Temp:-25˚CIf hygroscopicTemp:-<25˚CIf sterile areaTemp:-18˚C
Humidity:-40%If hygroscopicHumidity> 40%
Q.C
IMPORTANT QUESTIONS(GTU EXAMS)
IMPORTANT QUESTIONS(GTU EXAMS)
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1. Explain departmental layout with specific requirement of equipments for oral liquid dosage forms. 05
1. Explain departmental layout with specific requirement of equipments for oral liquid dosage forms. 05
2. How will you prepare qualitative and quantitative departmental layout with equipments required for liquid dosage forms? 05
2. How will you prepare qualitative and quantitative departmental layout with equipments required for liquid dosage forms? 05
3. Explain qualitative and quantitative deparmental layout for liquid orals. 05 NOTE:-2 TIMES IN BOARD
3. Explain qualitative and quantitative deparmental layout for liquid orals. 05 NOTE:-2 TIMES IN BOARD
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REFERENCEREFERENCE
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Thank you very much
Success is not a
destination ,
it’s a journey.
A will find a way.
Ph. No. :- +91-8460378336
Address:- 44, Assiyana Society;
Dugarvada Road,
Taluko & City : Modasa
State: Gujarat
Country: India
Email: [email protected]
BEST OF LUCK TO ALL . . . . . . . . . . . . . .
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