+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com www.clireo.com Clear Into the Cloud Pharmaceutical, Biotech, and Medical Device Company Data in the Cloud Leveraging the cloud for regulatory affairs & clinical trial collaboration.

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Dirk K Beth Managing Director Mission3 has been providing cloud software for clinical and regulatory operations since 2007 Pioneered Regulatory Document Management in the cloud #73 fastest growing software company in America 2013 Inc 5000 Offices in Munich, Phoenix, Berlin, Rostock Background

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Webex Right click on the shared screen Click View Change to full screen or other to ensure the best screen sharing Timing The content of the webinar is about hour and we will take a few questions. Please use the chat option to ask questions. Housekeeping

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+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Multi-tenancy | resource pooling Self service Elastic storage Scale up | down Pay per use Ubiquitous network access Cloud software is written specifically for the cloud

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+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Cloud Computing Taxonomy Traditional IT Storage Servers Networking Operation System Security, Clustering Virtualization Data Applications Runtime Youmanage IaaS Storage Servers Networking Operation System Security, Clustering Virtualization Data Applications Runtime Managedbyvendor Youmanage Youmanage PaaS Managedbyvendor Storage Servers Networking Operation System Security, Clustering Virtualization Applications Runtime Data SaaS Managedbyvendor Storage Servers Networking Operation System Security, Clustering Virtualization Applications Runtime Data

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com TIME ITCAPACITY Allocating Resources: The Traditional View Allocated IT resources Oversupply Undersupply Load forecast Initial investment Oversupply Actual load

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+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Security should be implemented in every layer of cloud application architecture. And What About Security? Security Protect Data as it Moves Encrypt data as it moves between the web servers and browsers With a certificate from an external authority, the authentication of both server and browser creates a shared session key used to encrypt the data in both directions Protect Data as it Rests If you are concerned about storing sensitive and confidential data in the cloud, you should encrypt the data before uploading it to the cloud

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com What does this mean to me? Cloud is actually about SERVICE, not technology. Its not our day job to be hung up on technology. Our focus is to ensure the: Global delivery of our applications to our end users. Sharing of data between systems and users. Building of global communities to optimize business processes and capabilities. Meet (and drive) existing and emerging Health Authority guidance and regulations. Internal IT becomes more high value. Moving from IT to CTO. From keeping the systems running to ensuring optimal business value.

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Trends in Our Industry Factors pushing Life Science companies into the Cloud Need to work with more virtual teams Need to be more cost effective Need to work with more global partners Need to better protect IP Consumerization of IT Need to be more agile Need more manageability of data/docs

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Collection and cleaning of clinical data. High volume simulated data generation to validate statistical methods. Gene sequencing processing. Offsite datamarts and data storage. Collaboration with payers / providers. Hosting of business applications. Examples of Cloud Use in Pharma

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Life Sciences Line of Business Applications Looking for A Cloud Home Non-clinical Laboratory Information Management Lab notebook Toxicology Sales and Marketing CRM Digital Asset Management eMPM (Management of Promotional Materials) Sunshine law compliance Clinical CTMS EDC ePRO IVR / IWR eTMF Secure Global Payments Safety Pharmacovigilence Regulatory Submission Management Regulatory Information Management xEVMPD (Europe) Proprietary information Patient Information Time-critical Information Large Volume Data and Documents Collaboration Global Access Ease-of-use Speed / Performance

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Increased ROI Security and Compliance through Specialized Clouds. Established concept matured by a multitude of industries. Cloud customers leverage the knowledge and activities performed by previous tenants to streamline design, deployment, and support. Moving the focus from Technology capability, into Application capabilities. Sharing technology platforms unifies the industry, driving the innovation and evolution of cloud technologies to meet the needs of true, global organizations in the Life Sciences industry. Benefits of Cloud Use in Pharma

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Our Future Global Accessibility Collaborative Environments Global High- Availability

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Our Responsibilities Define clear and achievable short, medium, and long term requirements for the technological infrastructure. All parties involved in providing the infrastructure should be assessed on a regular basis to ensure compliance with regulations and business requirements. Ensure change and configuration control procedures are in place at all levels. Ensure proper risk and impact assessment is undertaken when changing infrastructure. UNDERSTAND OUR USERS. Ensure that systems are implemented to enhance the quality and productivity of user experience; to increase user adoption, build communities, and retain key talent.

+1 602 957 2150 2198 E. Camelback Rd #205 Phoenix, AZ 85016 www.mission3.com Thank You http://www.mission3.com info@mission3.com