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Centers of Biomedical Excellence (COBRE) IDeA Clinical and Translational Research (IDeA CTR) IDeA Networks of Biomedical Research Excellence (INBRE) IDeA Community-Based Research Selected Examples IDeA Co-funding IDeA Net Selected Examples National Association of IDeA Principal Investigators (NAIPI) Selected Science Advances The IDeA Program

J. Donald Capra

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Page 1: J. Donald Capra

• Centers of Biomedical Excellence (COBRE)• IDeA Clinical and Translational Research

(IDeA CTR)• IDeA Networks of Biomedical Research

Excellence (INBRE)• IDeA Community-Based Research

• Selected Examples• IDeA Co-funding• IDeA Net

• Selected Examples• National Association of IDeA Principal

Investigators (NAIPI)• Selected Science Advances

The IDeA Program

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MT

WYID

NV

ND

SD

NE

NM

OK

KS

AR

LA

KY

MS

SC

WV

MEVT

AK

HI PR

DE

RI

NH

INBRE: 24 statewide networksCOBRE: 84 thematic research centers

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'93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 06 07 08 09 10 11$0

$200

$400

$600

$800

$1,000

$1,200

$1,400

$1,600

$1,800

$1 $1 $1 $2 $2 $5 $10 $40 $100

$160 $210 $214 $222 $220 $218 $224 $224 $229 $229

$424

$461

$463

$462 $555

$596 $700

$885 $1,064

$1,305 $1,458

$1,523

$1,631

$1,558

$1,580

$1,585

$1,546

$1,552

$1,550

IDeA Program Appropriations Total NIH Funding to IDeA states

FISCAL YEAR

MIL

LIO

N

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• COBRE center grant program launched in fiscal year 2000

• To expand and develop biomedical faculty research capability

• To enhance research infrastructure including core facilities

• To build multidisciplinary research centers with a thematic scientific focus at doctoral institutions or research institutes

Center Characteristics• Led by an established investigator, funded by NIH, NSF or other

comparable Federal or private sector source• At least 3 research sub-projects, all supervised by junior

investigators• A clear plan for mentoring, career development and graduation

and replacement of junior investigators• Long-term plans for developing and sustaining the center,

investigators, collaborations, and physical infrastructure

Centers of Biomedical Research Excellence (COBRE)Background

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Model of COBRE

Administrative and Research Cores• workshops• training courses

research cores

administrative

bioinformatics

MentoredJunior Investigator

Subprojects

Pilot Projects

Mentors

External Advisory

Board

Page 6: J. Donald Capra

Phase IResearch

Infrastructure

Research Projects (Junior Investigators)

Phase IIResearch

Infrastructure

Research Projects (Junior and Senior

Investigators)

Phase IIIResearch Cores

that are essential for basic and

clinical research

Pilot Project Program

COBRE

Develop advanced research infrastructure and a critical mass of investigators in thematic areas

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The COBRE Program in Oklahoma

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Expected: $14.5MActual: $18M or 125% more than expected by doubling and

increase in faculty number by 33%

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Figure 3. Transition of RR15577 COBRE supported cores from initial funding to current plans. Blue designates RR15577 COBRE support. Purple denotes proposed RR15577 support and white outline only denotes institutional or other forms of independent support from grants, charge backs or other funding sources.

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NIH Fiscal Year98 99 00 01 02 03 04 05 06 07 08 09 10 11

$10,000,000

$20,000,000

$30,000,000

$40,000,000

$50,000,000

$60,000,000

$70,000,000

NIH Funding – OUHSC

Total NIH Budget Allocation 2000-2011 – 67% increase ($18 - $30 billion)

BeginINBRE/COBRE

Total OUHSC NIH Funding 2000-2011 – 152% increase ($21 – $53 million)*

*Comparative increases: Non IDeA State Med Schools 2000-2011 IDeA State Med Schools 2000-2011Virginia Comm Univ – 62% (Ranked 59/57) KUMC – 104% (Ranked 71/59)PSU at Hershey Med Ctr – 50% (Ranked 64/61) Nebraska Med Ctr – 154% (Ranked 74/68)Univ Conn SOM – 26% (Ranked 68/74) Univ Louisville – 154% (Ranked 79/72)

(Blue Ridge Inst. For Med Res: Ranking 2001-2011) OUHSC – 152% (Ranked 78/73)

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“Science in a Culture of Mentoring” Operational from 2000-2014

Awarded $21.7M plus $28.8M in additional grants:

* 14 RO1’s

* 9 R21’s

* 1 RO3

* 18 non-NIH grants

Launched 12 independent research careers

Advances immunology research in Oklahoma through recruiting junior scientists. Their research topics include vaccine immunology, autoimmunity, Alzheimer’s research, and other complex human diseases.

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“Biofilm Formation and Metabolism on Dental Surfaces” Operational from 2000-2010

Awarded $9.7M, with the junior investigators receiving an additional $14M:

* 9 RO1’s

* 24 non-NIH grants Recruits investigators to examine microbial formation on

teeth in order to translate research knowledge into treatment and prevention of oral disease.

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“Functional Genomic/Proteomic Analysis of Bacterial/Host Interactions” Operational from 2000-2010

Awarded $20.9M plus $31M in additional grants:

* 10 RO1’s

* 7 R21’s

* 1 RO3

* 27 non-NIH grants

Supported 8 junior investigators

Used genome-scale and proteomic analysis of bacterial pathogenesis in order to increase the understanding of bacterial and host interactions.

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“Mentoring Vision Research in Oklahoma”

Operational from 2002-2012

Awarded $23.8M plus $33.5M in additional grants:

* 13 RO1’s

* 5 R21’s

* 1 RO3

* 6 non-NIH grants

Improves vision research through the mentoring of early career investigators and develops support for the infrastructure of vision research programs

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“Post-Translational Modification in Host Defense: Interdisciplinary Research in Vascular Biology” Operational from 2003-2015

Awarded $22.2M plus an additional $11M:

* 6 RO1’s

* 25 non-NIH grants Studies the function of diverse protein modifications used in

host defense; builds interdisciplinary program in cardiovascular biology.

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“Molecular Mechanisms and Genetics of Autoimmunity” Operational from 2004-2014

Awarded $24.9M plus $10.7M in additional grants:

* 4 RO1’s

* 2 R21’s

* 1 RO3

* 13 non-NIH grants

Recruited 8 new faculty members

Examines disease processes and potential genetic risk factors in order to understand development and progression of autoimmune disorders

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“Mentoring Diabetes Research in Oklahoma”

Operational from 2007-2012

Supports 5 junior investigators

* 3 RO1’s

* 3 additional NIH grants

*13 non-NIH grants

Mentors junior investigators in diabetes research to facilitate translational research toward the development of new treatments and preventive measures for diabetes.

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Per Capita NIH Dollars(Selected States)

2011 2011 DollarsState NIH dollars Population Per Capita

VT $ 53M 626,431 $ 85

HI $ 61M 1,374,810 $ 44

OK $ 82M 3,791,508 $ 22

MD $1.69B 5,828,289 $290

MA $2.51B 6,587,536 $381

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The IDeA program has transformed biomedical science at

the Oklahoma Medical Research

Foundation and in the state of Oklahoma as a whole.

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IDeA has been the best investment ever made

by Congress or the NIH in the history of biomedical research.

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Thank you