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(c) AZOTH Analytics January 2016 Global Blood Plasma Market: Trends, Opportunities and Forecasts (2015-2020) By Market Segment (Type of Blood Plasma)- IVIG, Albumin, Factor VIII By Region-North America, Europe, APAC, RoW Market Entry Strategies for Global Players Supply Chain Structure

Global Blood Plasma Market: Trends, Opportunities and Forecasts (2015-2020) - Azoth Analytics

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(c) AZOTH AnalyticsJanuary 2016

Global Blood Plasma Market: Trends, Opportunities and

Forecasts (2015-2020)

• By Market Segment (Type of Blood Plasma)-IVIG, Albumin, Factor VIII

• By Region-North America, Europe, APAC, RoW

• Market Entry Strategies for Global Players• Supply Chain Structure

(c) AZOTH Analytics

S.No Particulars Page No.

1. Research Methodology 12

2. Product Overview 14

3. Executive Summary 20

4. Global Blood Plasma Market Overview

4.1. Market Size & Forecast

4.1.1. By Value & Forecast 22

4.2. Market Shares & Analysis

4.2.1. By Product Type 24

4.2.2. By Company 25

4.3. Global Albumin Type Blood Plasma Market Overview

4.3.1. By Volume 29

4.3.2. By Value 30

4.3.3 By Company 31

4.4. Global IVIG Type Blood Plasma Market Overview

4.4.1. By Value 33

4.4.2 By Volume 34

4.5. Global Factor VIII Type Blood Plasma Market Overview

4.5.1 Overview 36

4.5.2 By Value 37

4.5.3 By Volume 38

2

(c) AZOTH Analytics

S.No Particulars Page No.

4.6. Other Blood Products Market Size

4.6.1. By Value ( Forecast 2020F) 39

5 North America Blood Plasma Market

5.1. Overview 41

5.2. By Value ( Forecast 2015E-2020F) 42

5.3. Factors Affecting Market 43

5.4. Factors Affecting Market 44

6. APAC Blood Plasma Market

6.1. Overview 46

6.2. By Value ( Forecast 2015E-2020F) 47

6.3. Factors Affecting Market 48

7. Europe Blood Plasma Market

7.1. By Value ( Forecast 2015E-2020F) 50

8. RoW Blood Plasma Market

8.1.. By Value ( Forecast 2015E-2020F) 52

8.2. Factors Affecting Market 53

8.3. Factors Affecting Market 54

9 Trends

9.1. Overview 56

3

(c) AZOTH Analytics

S.No Particulars Page No.

9.1.1. Solid and Stable Pricing Power in IG Market 57

9.1.2. Fast Growth of SCIG Market 58

9.1.3. Industrial Fractionators Planning Capacity Expansion 60

9.1.4. Increase in Albumin Market in China 61

9.1.5. Immunoglobulin Segment- High Profitability and Strength 62

10. Market Dynamics

Overview 64

10.1. Drivers

10.1.1 Augmentation in Plasma accumulations in the US 65

10.1.2. Rise in Global Healthcare Expenditure 67

10.1.3. Growth in Ageing Population 68

10.1.4. Growth in Male Population 70

10.1.5. Development Potential from New Indications 71

10.2. Challenges

10.2.1 Rivalry from Recombinant Factor VIII 72

10.2.2. Prospective Threat to Immunoglobulin Market 73

10.2.3. Costing Pressure in Tenders in Plasma-Derived FVIII Market 74

10.2.4. High Manufacturing and Safety Cost 75

11. Policy and Regulatory Landscape

11.1. WHO Blood Safety Regulations 77

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(c) AZOTH Analytics

S.No Particulars Page No.

11.2. FDA Blood Safety Regulations 79

11.3. CANADA CAN/CSA-Z902-10 (R2015) - Blood and blood components 81

11.4. PHARMACEUTICAL AND FOOD SAFETY BUREAU (PFSB) JAPAN 84

11.5. UK Blood Safety Regulations 85

11.6. Australia Blood Safety Regulations 92

11.7. India Plasma Product Safety Regulations 95

12. Value Chain Analysis

12.1. Supply Chain Diagram 102

12.2. BLOOD PLASMA SUPPLY CHAIN 103

13. Blood Plasma Trade Data Analysis

13.1. Top 5 Nations with Import By Volume(Million KGS) 106

13.2. Top 5 Nations with Export By Volume(Million KGS) 107

13.3. Top 5 Nations with Import by Value (Billion $) 108

13.4. Top 5 Nations with Export by Value (Billion $) 109

14 Porter Five Force Analysis

14.1. Porter Five Force Model Blood Plasma 110

15 Competitive landscape

15.1. Company Financials 112

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(c) AZOTH Analytics

15.1.1. Top 5 Companies Sales 113

15.1.2. Bottom 5 Companies Sales 114

15.1.3. Top 5 Companies EBITDA 115

15.1.4. Bottom 5 Companies EBITDA 116

15.1.5 Top 5 Companies EBIT 117

15.1.6 Bottom 5 Companies EBIT 118

15.1.7 Top 5 Companies PBT 119

15.1.8 Bottom 5 Companies PBT 120

15.1.9 Top 5 Companies PAT 121

15.1.10 Bottom 5 Companies PAT 122

15.2 Company Ratios

15.2.1 Top 5 Companies Current Ratio 123

15.2.2 Bottom 5 Companies Current Ratio 124

15.2.3 Top 5 Companies Profit Margin 125

15.2.4 Bottom 5 Companies Profit Margin 126

15.2.5 Top 5 Companies Debt Equity Ratio 127

16. Global Blood Plasma Market – Company Profiles

16.1. CSL Ltd. 129

16.2 Baxter International Inc 131

16.3 Grifols S.A 133

16.4 Antares Pharma Inc 135

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(c) AZOTH Analytics

Table of Content

S.No Page No.

16.5 Emergent BioSolutions, Inc. 137

16.6 AMAG Pharmaceuticals, Inc. 139

16.7 Cipla 141

16.8 Octopharma 143

16.9 Biota Pharmaceuticals, Inc. 145

16.10 BioDelivery Sciences International, Inc. 149

17 Strategic Recommendations 151

18 About Us & Disclaimer 156

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Figure No. Figure Title Page No.

Figure 1: Global Blood Plasma Market Size , By Value, 2010-2014 (USD Billion) 22

Figure 2: Growth in Global Ageing Population (2010-2014) in Million 22

Figure 3: 3:Global Blood Plasma Market Size , By Value, 2015E-2020F(USD Billion) 23

Figure 4: India Per Capita Health care Expenditure (USD) 23

Figure 5: Blood plasma Market Share, By Product 2014 24

Figure 6: Blood Plasma Market Share, By Product, By Value,2014(USD Billion) 24

Figure 7: Blood plasma Market , By Company Share 2014 (Percentage) 25

Figure 8: 8:Blood Plasma Market, Company Share, By Value,2014(USD Billion) 25

Figure 9 : Blood plasma Market Immunoglobulin By Company 2014 26

Figure 10: Blood plasma Market Immunoglobulin By Company 2014 27

(c) AZOTH Analytics

List of FiguresFigure

No.Figure Title Page

No.

Figure 11: Global Albumin Market Size , By Volume, 2010-2014 (tons) 29

Figure 12: Global Albumin Market Size , By Volume, 2015E-2020E (tons) 29

Figure 13: Global Albumin Market Size , By Value, 2010-2014 (USD Billion) 30

Figure 14: Global Albumin Market Size , By Value, 2015E-2020E (USD Billion) 30

Figure 15: Blood plasma Market Albumin By Company 2014 31

Figure 16: Global IVIG Market Size , By Volume, 2010-2014 (tons) 33

Figure 17: Global IVIG Market Size , By Volume, 2015E-2020E (tons) 33

Figure 18: Global IVIG Market Size , By Value, 2010-2014 (USD Billion) 34

Figure 19: Global IVIG Market Size , By Value, 2015E-2020E (USD Billion) 34

Figure 20: Global Factor VIII Market Size , By Value, 2010-2014 (USD Billion) 37

Figure 21: Global Factor VIII Market Size , By Value, 2015E-2020E (USD Billion) 37

Figure 22: Global Factor VIII Market Size , By Volume, 2010-2014 (International Units) 38

Figure 23: Global Factor VIII Market Size , By Volume, 2015E-2020E (International Units) 38

Figure 24: Other Blood Products Market Size , By Value, 2010-2014 (USD Billion) 39

Figure 25: Other Blood Products Market Size , By Value, 2015E-2020E (USD Billion) 39

Figure 26: North America Blood Plasma Market Size, By Value, 2010-2014 (USD Billion) 42

Figure 27: North America Blood Plasma Market Size, By Value, 2015E-2020E (USD Billion) 42

Figure 28: North America Aging Population, 2010-2020 (Million) 43

Figure 29: North America Blood Plasma Export to China, By Value, 2010-2014 (USD Billion) 43

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(c) AZOTH Analytics

List of Figures

FigureNo.

Figure Title Page No.

Figure 30: Plasma Collection In America, By Volume, 2010-2014 (Million Litres) 44

Figure 31: APAC Blood Plasma Market Size, By Value, 2010-2014 (USD Billion) 47

Figure 32: APAC Blood Plasma Market Size, By Value, 2015E-2020E (USD Billion) 47

Figure 33: China Blood Plasma Import from North America, By Value, 2010-2014 (USD Million) 48

Figure 34: Europe Blood Plasma Market Size, By Value, 2010-2014 (USD Billion) 50

Figure 35: Europe Blood Plasma Market Size, By Value, 2015E-2020E (USD Billion) 50

Figure 36: ROW Blood Plasma Market Size, By Value, 2010-2014 (USD Billion) 52

Figure 37: ROW Blood Plasma Market Size, By Value, 2015E-2020E (USD Billion) 52

Figure 38: IVIG (KG/M) Usage Comparison 62

Figure 39: US Plasma Accumulations (2010-2014) 66

Figure 40: Rise in Global Healthcare Expenditure, 2010-2014 USD 67

Figure 41: Growth in Global Ageing Population (2010-2014) Million 69

Figure 42: Growth in Male Population, 2010-2014 (Million) 70

Figure 43: Blood Plasma Imports, By Top Countries, 2010-2014 (Million KGS) 106

Figure 44: Blood Plasma Exports, By Top Countries, 2010-2014 (Million KGS) 107

Figure 45: Blood Plasma Imports, By Top Countries, 2010-2014 (Billion $) 108

Figure 46: Blood Plasma Exports, By Top Countries, 2010-2014 (Billion $) 109

Figure 47: Top 5 Companies Sales in USD Billion 113

Figure 48: Bottom 5 Companies Sales in USD Million 114

Figure 49: Top 5 Companies EBITDA in USD Billion 115

Figure 50: Bottom 5 Companies EBITDA in USD Billion 116

9

(c) AZOTH Analytics

List of Figures

FigureNo.

Figure Title Page No.

Figure 51: Top 5 Companies EBIT in USD Billion 117

Figure 52: Bottom 5 Companies EBIT in USD Billion 118

Figure 53: Top 5 Companies PBT in USD Billion 119

Figure 54: Bottom 5 Companies PBT in USD Billion 120

Figure 55: Top 5 Companies PAT in USD Billion 121

Figure 56: Bottom 5 Companies PAT in USD Billion 122

Figure 57: Top 5 Companies Current Ratio 123

Figure 58: Bottom 5 Companies Current Ratio 124

Figure 59: Top 5 Companies Profit Margin 125

Figure 60: Bottom 5 Companies Profit Margin 126

Figure 61: Top 5 Companies Debt Equity Ratio 127

Figure 62: CSL Ltd. Percentage Revenue, By Product Segment (2014-2015) 129

Figure 63: CSL Ltd. Percentage Revenue, By Geography (2014-2015) 129

Figure 64: CSL Ltd. Sales (USD Billion) 2010-2014 130

Figure 65: Baxter International Inc. Percentage Revenue, By Product Segment (2014) 130

Figure 66: Baxter International Inc. Percentage Revenue, By Geography (2014) 131

Figure 67: Baxter International Inc. Sales (USD Billion) 2010-2014 132

Figure 68: Grifols S.A Percentage Revenue, By Product Segment (2014) 134

Figure 69: Grifols S.A Percentage Revenue, By Geography (2014) 134

Figure 70: Grifols SA Sales (USD Billion) 2010-2014 135

10

(c) AZOTH Analytics

List of Figures

FigureNo.

Figure Title Page No.

Figure 71: Antares Pharma Inc. Revenue (USD Billion) 2010-2014 137

Figure 72: Emergent BioSolutions, Inc. Revenue (USD Billion) 2010-2014 139

Figure 73: AMAG Pharmaceuticals, Inc. Revenue (USD Billion) 2010-2014 141

Figure 74: Octopharma Revenue (USD Billion) 2010-2014 143

Figure 75: Biota Pharmaceuticals, Inc. Revenue (USD Billion) 2010-2014 145

Figure 76: BioDelivery Sciences International, Inc. Revenue (USD Billion) 2010-2014 147

Figure 77: Flamel Technologies SA. Revenue (USD Billion) 2010-2014 149

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(c) AZOTH Analytics

Global Blood Plasma Market Size

• .

12

xx

xx

xx

xx

xx

2010 2011 2012 2013 2014

Figure 1: Global Blood Plasma Market Size , By Value,

2010-2014 (USD Billion)

xx

xx

xx

xx

xx Immunoglobuli

nAlbumin

Factor VIII

A1PI

xxxx

xx

xx

xxImmunoglobulin

Albumin

Factor VIII

A1PI

Others

xxxx

xxxx

xxxx

2015E 2016F 2017F 2018F 2019F 2020F

Figure 3:Global Blood Plasma Market Size , By Value, 2015E-

2020F(USD Billion)

Figure 5: Global Blood plasma Market Share, By Product

2014

Figure 6: Global Blood Plasma Market Share, By

Product, By Value,2014(USD Billion)

CAGR: xx%CAGR: xx%

(c) AZOTH Analytics

Global Blood Plasma Market Size

• .

13

xx

xx

xx

xx

xx

xx

xx

CSL

Baxter

Grifols

Octapharma

Biotest

Kedrion

Others

xx 2.00

xx

xx

xx

xx

xxCSL

Baxter

Grifols

Octapharma

Biotest

Kedrion

Others

Figure 8: Global Blood Plasma Market, Company

Share, By Value,2014(USD Billion)

Figure 5: Global Blood plasma Market Share, By

Product 2014

xx

xx

xxxx

xx

xxCSL

Grifols

Baxter

Octapharma

Biotest

Others

Figure 9: Blood plasma Market Immunoglobulin By Company

2014

(c) AZOTH Analytics

Global Blood Plasma Market Size

• .

14

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Figure 11: Global Albumin Market Size , By

Volume, 2010-2014 (tons)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Figure 12: Global Albumin Market Size , By

Volume, 2015E-2020E (tons)

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Figure 13: Global Albumin Market Size , By

Value, 2010-2014 (USD Billion)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Source: Azoth Analytics

Figure 14: Global Albumin Market Size , By

Value, 2015E-2020E (USD Billion)

CAGR: xx%CAGR: xx%

CAGR: xx%CAGR: xx%

(c) AZOTH Analytics

Global Blood Plasma Market Size

• .

15

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Figure 16: Global IVIG Market Size , By

Volume, 2010-2014 (tons)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Figure 17: Global IVIG Market Size , By

Volume, 2015E-2020E (tons)

xxxx

xxxx

xx

2010 2011 2012 2013 2014

CAGR: xx%

Figure 18: Global IVIG Market Size , By Value,

2010-2014 (USD Billion)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

CAGR: xx%

Figure 19: Global IVIG Market Size , By Value,

2015E-2020E (USD Billion)

CAGR: xx% CAGR: xx%

(c) AZOTH Analytics

Global Factor VIII Market Size

• .

16

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Figure 20: Global Factor VIII Market Size ,

By Value, 2010-2014 (USD Billion)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Figure 21: Global Factor VIII Market Size ,

By Value, 2015E-2020E (USD Billion)

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Figure 24: Other Blood Products Market

Size , By Value, 2010-2014 (USD Billion)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Figure 25: Other Blood Products Market

Size , By Value, 2015E-2020E (USD Billion)

CAGR: xx%

CAGR: xx%CAGR: xx%

CAGR: xx%

(c) AZOTH Analytics

North America Blood Plasma Market Size, By Value

• .

17

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Figure 26:North America Blood Plasma Market

Size, By Value, 2010-2014 (USD Billion)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Figure 27:North America Blood Plasma

Market Size, By Value, 2015E-2020E (USD

Billion)

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Figure 31:APAC Blood Plasma Market Size,

By Value, 2010-2014 (USD Billion)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Figure32: APAC Blood Plasma Market Size, By

Value, 2015E-2020E (USD Billion)

Source: Azoth Analytics

CAGR: xx%

Figure 34:Europe Blood Plasma Market

Size, By Value, 2010-2014 (USD Billion)

CAGR: xx% CAGR: xx%

CAGR: xx%

(c) AZOTH Analytics

Europe Blood Plasma Market Size, By Value

• .

18

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Source: Azoth Analytics Estimates

Figure 35: Europe Blood Plasma Market

Size, By Value, 2015E-2020E (USD Billion)

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Figure 36:ROW Blood Plasma Market Size,

By Value, 2010-2014 (USD Bn)

xxxx

xxxx

xxxx

2015 2016 2017 2018 2019 2020

Figure 37: ROW Blood Plasma Market Size,

By Value, 2015E-2020E (USD Bn)

CAGR: xx%

xxxx

xxxx

xx

2010 2011 2012 2013 2014

Source: Azoth Analytics

CAGR: xx%

Figure 34:Europe Blood Plasma Market

Size, By Value, 2010-2014 (USD Billion)

CAGR: xx% CAGR: xx%

(c) AZOTH Analytics

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19

Global Blood Plasma Market: Trends, Opportunities and Forecasts (2015-2020) -(Blood Plasma -IVIG, Albumin, Factor VIII, By Region-North America, Europe, APAC, Market Entry Strategies for Global Players))

Date of Publication: January 2016Number of Pages: 155Price: US$ 2200 (Single-User License)

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