12 BUSINESSWEEKLY June 18-25, 2015

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14MGenomicsThe new genomics powerhouse spun out of the Wellcome Trust Sanger Institute in December, launching with a £12.5 million financing from Syncona Partners. 14MG was founded by the leaders of the Sanger Institute Cancer Genome Project, Professor Michael Stratton, Dr Peter Campbell and Dr Ultan McDermott and serial life science entrepreneur Andy Sandham is executive chairman.

The company is developing cancer genomic diagnostics in partnership with Sanger, which is leveraging the power of its state-of-the-art gene sequencing and cancer genome bioinformatics resources. Based on the Wellcome Trust Genome Campus, 14MG is collaborating with European clinical partners in studies to generate linked clinical genomic datasets using cancer gene panel and other technologies.

14MG has licensed proprietary technology and bioinformatics software from Sanger and will capitalise on the Institute’s research and clinical grade sequencing pipelines. The company’s medical and bioinformatics teams are building a clinical genomic data resource with portal access appropriate for future clinical diagnostic services. www.14mg.co.uk

AbcamCambridge Science Park company, Abcam spun out of Cambridge University and has since become a world leader.

Abcam makes its own antibodies as well as sourcing other top products from various suppliers. It adds 600-800 new products a month to its online catalogue. Abcam’s products cover research areas such as cancer, cardiovascular, chromatin and nuclear signalling, immunology, neuroscience, and stem cells, and includes a growing range of non-primary antibody products including secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits. In June 2015, Abcam launched a range of multiplex miRNA profiling assays for high-throughput validation of miRNA biomarkers, based on its new Firefly™ particle technology.www.abcam.com

AbcodiaAbcodia is developing tests for early detection of cancer and in June 2015 appointed Nadia Altomare as president of its newly established North American operation. She has launched the company’s first early cancer detection product, the ROCA® test in the US; the test has been shown to detect over 86 per cent of ovarian cancers in women with no symptoms. In May 2015, two new investors – Cambridge Innovation Capital and Scottish Equity Partners – contributed to an $8 million funding round for Abcodiato underpin the launch of ROCA on both sides of the Atlantic. Abcodia CEO Dr Julie Barnes says ROCA is the world’s most sensitive and specific ovarian cancer screening test.www.abcodia.com

AbzenaAbzena provides complementary services and technologies to R & D organisations to improve the chances of successful development of therapeutic proteins and antibodies. The group’s technologies and services are provided through wholly-owned subsidiaries, PolyTherics and Antitope. They have been developing and offering their technologies and services for over 10 years and their scientists have provided expertise to a wide range of companies, including most of the top 20 biopharma companies, large and small public and private biotech, and academic groups, across the world. The company raised £22.7m on AIM in July 2014. It has eight antibodies being progressed through clinical development by partners and has opened up a potentially lucrative new market worldwide with antibody drug conjugates.www.abzena.com

AlertMeAlertMe is a leading technology innovator in cloud-based Smart Home Servicesand in February 2015 announced it was being acquired by British Gas for around $100m (£65m). The company helps partners deliver the benefits of the Smart Grid and Smart Home to consumers. The offering combines an award-winning platform, home hub, home area network and innovative hardware and applications, allowing consumers to take control not only of their energy use, but also a myriad of devices and applications in the home.

The company is backed by Index Ventures, Good Energies, CrysalixsetVP and Vantagepoint Capital Partners as well as strategic corporate investor British Gas. It has offices in Cambridge and London (UK),

Oakland CA and Charlotte NC (US) and Amsterdam. AlertMe works with or without a smart meter, so can support not only utility and smart grid partners, but also telecoms operators, software and applications developers, home electronics and appliance OEMs. www.alertme.com

Amino TechnologiesAmino is a world leading IPTV and hybrid/OTT innovator – bringing new entertainment products and solutions to a global market. With over four million devices sold to 850 customers in 85 countries, Amino’s award-winning solutions are deployed by major network operators and service providers worldwide.

Amino is headquartered near Cambridge with offices in the US and China. The company continues to make good progress in its core markets of Western Europe and particularly in North America, where performance has been consistently strong during the last year in which revenues and profits have increased. Momentum in new markets, including the Middle East and Africa region, has also been encouraging with good traction and initial orders achieved. It recently acquired Booxmedia, a Finnish cloud TV platform provider.www.aminocom.com

ARMARM is the world’s leading semiconductor intellectual property (IP) supplier and is at the heart of the development of digital electronic products.

Headquartered in Cambridge, ARM has offices around the world, including design centres in Taiwan, France, India, Sweden, and the US. More than 60 billion ARM-based chips have been shipped to date and ARM revenues typically grow faster than overall semiconductor industry revenues. The company, founded in Cambridge in 1990 is powering 95 per cent of the planet’s smartphones and every major technology innovator in the world is takings its chips to drive a burgeoning suite of products. The company is expanding its Cambridge HQ and is set to increase headcount locally from 1,500 to 3,500 in the next 10 years.www.arm.com

AVEVAQuoted on London’s main market, AVEVA has been the world’s leading engineering software provider to the plant, power and marine industries for almost half a century.

Its continuing global growth builds on a remarkable success story that started when the company was known as CADCentre and operated within the University of Cambridge in the 1960s. The business hasn’t looked back since CADCentre went private in 1983. It continues to innovate with new generations of software relevant to major global players in its prime markets. www.aveva.com

Axol BioscienceAxol is an exciting biotech company co-founded and co- funded privately by Abcam CEO, Dr Jonathan Milner and Dr Yichen Shi to fulfil the unmet demand for high quality iPS cell-derived, clinically relevant cells for use in biomedical research and discovery.

It is applying cutting-edge stem cell technologies to generate high quality human neural stem cells and neurons. Cerebral cortical neurons are implicated in numerous neurological diseases including Alzheimer’s, autism, epilepsy, traumatic brain injury and stroke.

Axol is providing researchers with an affordable, easily accessible, in vitro human systems to complement their existing studies of cortical development, function and diseases, while helping them to avoid potential ethical challenges faced when considering the use of embryonic stem cells.

Axol’s technology provides a platform for developing or testing novel therapeutic interventions and understanding the disease pathologies more thoroughly. It has substantially increased its product suite and geographical reach in recent times.www.axolbio.com

Azuri TechnologiesEight19 spin-out, Azuri brings power at scale to off-grid customers in rural emerging markets, providing basic needs that are regarded as routine in more developed countries. Azuri has developed the Indigo pay-as-you-go solar power for homes in off-grid markets.

The Indigo technology and business model combines mobile phone and solar technology to deliver affordable pay-as-you-go solar power that replaces kerosene and phone charging services. Azuri

says this is cutting users’ spend by as much as 50 per cent. Since the first Indigo deployments in Kenya in September 2011, the business has been recognised globally for its innovation in solar energy, winning major awards. Not only is the technology improving living conditions but also it is lifting education standards in poorer territories.

Independent research cited by Azuri shows that Indigo lights can extend users’ productive day by as much as 3.2 hours and that children with solar light on average spend an additional 2-2.5 hours per night on homework. www.azuri-technologies.com

BangoBango provides the technology that powers commerce for businesses targeting the growing market of internet enabled mobile phone users.

Bango’s products collect payment from mobile users for online content and services and provide accurate analytics for mobile marketing campaigns and sites. The world’s leading app stores and brands plus thousands of smaller content providers and developers use Bango products to run their mobile businesses. Global leaders plugging into Bango include Amazon, BlackBerry World, Facebook, Firefox Marketplace, Google Play, Microsoft, Mozilla, Samsung, Windows Phone Store and major mobile brands including CNN, Cartoon Network and EA Mobile. More than 140 markets have already been activated by Bango partners.http://bango.com/

Bicycle TherapeuticsBicycle Therapeutics is a biotech company developing a platform technology that enables the creation of a new generation of biotherapeutics which combine the desirable features of small molecules and biopharmaceuticals to create highly specific and highly stable drugs.

It is a spin-out from the Medical Research Council Laboratory of Molecular Biology, Cambridge, based on the pioneering work of the founding scientists Sir Gregory Winter and Dr Christian Heinis.www.bicycletherapeutics.com

BromiumSoftware security startup Bromium, with operations in Cambridge and California, roared out of stealth mid-June 2012 with a $26.5 million Series B round. It went on to raise $76m in less than two years. The Cambridge University Computer Lab spin-out is developing products built on the Bromium Microvisor which makes PCs and mobile devices trustworthy by design – automatically blocking and discarding malware and advanced threats.

It protects data and applications at all times, even on devices that have not been patched, allowing IT to safely embrace mobility and consumer use of enterprise devices, empowering employees and ensuring compliance while simplifying desktop management.

Bromium was founded by Gaurav Banga, ex- CTO of Phoenix Technologies; Simon Crosby, former CTO of the Data Center and Cloud Division of Citrix; and Ian Pratt, chairman of Xen.org and also ex-Citrix. The founders led the development of the Xen hypervisor that today powers the largest clouds and the most secure PCs. www.bromium.com

Cambridge CMOS SensorsCambridge CMOS Sensors is a spin-out from Cambridge University exploiting innovative patented technology, jointly developed in collaboration with the University of Warwick, in the area of CMOS micro-systems. It raised multimillions in a new funding round in July 2014.

The company aims to be a technology provider of CMOS MEMS structures such as basic and smart micro-hotplates, semiconductor sensors (gas sensors, mechanical sensors, temperature sensors, flow sensors etc) and nano-MEMS and nanosensors.

The company has a range of low power consumption, low cost products and is actively involved in leading edge R & D projects for the next generation of micro and nano sensors. Cambridge CMOS was founded in 2008 by Florin Udrea, Julian

Gardner and Bill Milne who have worked together for over 20 years and have a successful record of transferring research to industry. CMOS gas sensors are now being brought to a wider global market following an alliance forged between the company and global big-hitter Future Electronics.

Canadian-headquartered Future Electronics is a world-leading innovator in the distribution and marketing of electronic components and has signed a worldwide distribution franchise agreement with the innovator.www.ccmoss.com

Cambridge CognitionAIM-quoted Cambridge Cognition is the leading provider of cognitive assessment software for academic research, healthcare provision and clinical trials. Its cognitive assessment software, powered by Cantab technology, has been highly validated by over 1,200 peer-review publications.

Cantab touchscreen neuropsychological tests are used by academic researchers in studies of cognition; clinical researchers in the pharmaceutical industry, to further knowledge of cognitive function; physicians to improve the monitoring, management and maintenance of cognitive health and wellbeing. The company is in the front line of the fight against dementia and has recently increased traction in the US.www.cambridgecognition.com

Cambridge ConsultantsCambridge Consultants arguably founded the Cambridge technology cluster in 1960 when Tim Eiloart, while studying at Trinity College, amassed £400 to start an enterprise to “put the brains of Cambridge University at the disposal of the problems of British industry.”

The company offers world-class innovative product development and technology consulting from its laboratories in Cambridge UK, and Boston, US. When it launched its latest spin-out – Aveillant – in October 2011, Cambridge Consultants was preserving a lasting and lucrative legacy. The hi- tech radar company, whose technology averts danger to aircraft from wind farm turbines, was the 19th major spin-out from the business since it founded.

Cambridge Consultants’ enterprise has created more than a billion pounds worth of value, over 3,000 jobs – and a lot of millionaires. Spin-offs from the spin-outs reinforce the company’s credentials as a power base for UK growth and GDP through innovation.

The firm is looking to further growth in Asia and other global territories. A Singapore office was opened in 2013 and the company has since substantially upgraded its Cambridge UK and United States facilities and is massively increasing headcount on both sides of the Atlantic.www.cambridgeconsultants.com

Cambridge IntelligenceCambridge Intelligence has created competing technology to Wall Street giant IBM with a new visualisation platform. It moved to a new Cambridge HQ in April.

CEO and Cambridge software specialist Joe Parry spent 12 years at i2 before its acquisition by IBM and has enjoyed brisk progress since founding CI. One of the first customers was a major software corporation and early adoption by US and European clients suggests an increasingly international footprint. The first product, KeyLines, is a flexible network visualisation toolkit designed for law enforcement, fraud detection, counter terrorism, CRM, sales and social network data. Its purpose is to uncover

network structures behind an organisation’s data. It signed a major new deal with a European national police force, bringing client count to double what it was just six months earlier. CI also made its first Latin American sale, meaning the KeyLines visualisation toolkit is now in use by governments, police forces and enterprises across five continents. Parry was recently part of a UK task force specialising in cyber security led by PM David Cameron to US government strongholds, including the White House.cambridge-intelligence.com

13 BUSINESSWEEKLY June 18-25, 2015

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Cambridge Temperature ConceptsCambridge Temperature Concepts (CTC) was founded by a group of scientists from the University of Cambridge in 2006. The team at CTC developed their first product, the DuoFertility fertility monitor, to help couples start families. The DuoFertility technology provides accurate and early detection of exactly when a woman is at the most fertile stage of her cycle. A small sensor patch is worn under the arm which monitors body temperature every second.

The data can then be transferred to a hand- held reader which displays the results in an accessible and easy-to-read manner. CTC recently raised more than $9 million in two tranches to underpin expansion into the US and develop a next generation product under inspirational new CEO Claire Hooper.www.temperatureconcepts.com

CCSCCS, headed by serial entrepreneurs Steve Greaves and John Porter, is a startup backed by business angels – including Robert Sansom and David Cleevely – pioneering a small-cell microwave backhaul system in the mobile industry.

Greaves and Porter were the men behind Adaptive Broadband and Cambridge Broadband Networks. Small-cell networks are accepted as the only realistic solution to the pressing data capacity problem in mobile communications, but as yet no credible solution for backhaul – the transfer of data between these networks and the core infrastructure – has been developed. CCS’s technology is a self-organising, self- optimising multipoint-to-multipoint microwave communications system which operates in cheap and plentiful licensed spectrum.

China Mobile – the world’s largest mobile network operator – has expanded its deployment of the technology with a new installation in its Fujian Mobile branch. Also, earlier this tear, CCS took delivery of the first volume production of its award-winning backhaul solution from market-leading manufacturer MTI (Microelectronic Technology Inc. in China. www.ccsl.com

Consort MedicalConsort Medical is an international medical devices company focused on developing and manufacturing disposable medical devices for drug delivery.

The principal business is the management of Bespak, a global market leader in the manufacture of drug delivery devices for pharmaceutical partner companies, including respiratory, nasal, and injectables products, and the manufacture of devices for the point of care diagnostics market.

In September 2014 Consort acquired Aesica Holdco for £233.1 million. Since Aesica was established in 2004 it has grown both organically and through acquisitions and has established key strategic relationships with major global blue-chip pharmaceutical companies. The Consort Medical group has facilities in Cambridge, King’s Lynn and Hemel Hempstead in the East of England. Consort recently posted an 85 per cent increase in revenue for the year to April 30 to £184.8 million and pre-tax profit almost 30 per cent higher at £22.7m.http://www.consortmedical.com

CRFSCambridge Radio Frequency Services (CRFS) is a developer and manufacturer of RF spectrum management and surveillance systems. It has developed the RFeye® receiver which sets a new level of cost-effective high-performance signal monitoring and direction finding in-building and outdoors.

Designed to operate autonomously and remotely, the RFeye sweeps the RF spectrum environment at high speeds, monitors spectrum usage, detects interference, classifies signals and geolocates unlicensed, suspicious or rogue transmitters with high degrees of accuracy.

The RFeye is being used in many civilian and non-civilian applications around the world including by spectrum regulators, wireless operators, security agencies and the military.

Headquartered at Cambridge Research Park and with a US subsidiary in California, CRFS has further expanded into the Middle East and North Africa. Its technology was used at the World Cup in Brazil and will be used in the 2016 Olympic Games. www.crfs.com

CSRWireless specialist CSR spun out of Cambridge Consultants in 1999 and floated on the London Stock Exchange in 2004. It is set to become a subsidiary of US giant Qualcomm following a $2.5 billion acquisition set to be signed and sealed by the end of summer 2015.

CSR is headquartered in Cambridge and has more than 3,000 employees working in over 35 offices worldwide. As a global leader in wireless technology, CSR’s Bluetooth, location, FM, Wi-Fi, audio, TV, video, and camera technologies are at the heart of many of the world’s most recognised electronics brands. CSR’s know-how is behind thousands of applications in mobile phones, cars, headsets, laptops, games consoles, portable navigation devices, digital televisions, digital cameras, and a multitude of other consumer electronics products. Qualcomm was attracted by CSR’s leading edge capabilities in wearables and IoT.www.csr.com

DarktraceSpearheaded by former members of the UK and US intelligence community and backed by Mike Lynch (pictured), Darktrace is a world leader in Enterprise Immune System technology, a new category of cyber defence solutions based on pioneering Bayesian mathematics developed at the University of Cambridge.

Darktrace addresses the challenge of insider threat and advanced cyber-attacks through its unique ability to detect previously unidentified threats in real-time, as manifested in the emerging behaviours of the network, devices and individuals.

Some of the world’s largest organisations rely on Darktrace’s probabilistic, self-learning platform to spot anomalous activity within the enterprise, in sectors including energy and utilities, financial services, telecoms, retail and transportation. Darktrace was founded by world-class machine learning specialists and operational government intelligence experts.

The company is headquartered in Cambridge, UK, with offices in London, Milan, New York, Paris, San Francisco and Washington D.C. In March, the company raised $18 million from investors including Invoke Capital, Talis Capital, Hoxton Ventures and private individuals, valuing the company at $80m.www.darktrace.com

DefiniGENDefiniGEN was founded in April 2012 to industrialise the OptiDIFF stem cell production platform developed at the University of Cambridge. US stem cell guru Roger Pedersen is a technology founder.

The company has world-leading expertise in the area of hIPSC-derived human cell production and metabolic disease modelling. The application of these technologies in drug discovery provides pharmaceutical companies with more predictive in vitro cell products enabling the development of safer and more effective treatments. In addition the technology platform utilises fully defined and humanised conditions required for the development of regenerative medicine cellular therapies.

Definigen builds on intellectual property and knowledge resident at the University of Cambridge Regenerative Medicine Department at Addenbrokes Hospital and in addition has in-licensed the Yamanka induced pluripotent stem cell IP portfolio from iPS Academia Japan Inc. the company has been in China to increase awareness about its proposition and seek key alliances to serve Asian markets.www.definigen.com

DisplayLinkReinventing the way computers talk to multiple displays, DisplayLink’s semiconductor and software is used in globally branded PC accessories, like wired and wireless USB graphics adapters, universal docking stations, monitors, and zero clients.

DisplayLink is a privately held company with venture funding from Atlas Venture, Balderton Capital, DAG Ventures and DFJ Esprit Capital and has enjoyed a Lazarus-style transformation.

DisplayLink USB graphics technology allows you to connect almost any kind of display via a standard USB 2.0 or USB 3.0 cable. The technology is designed to be simple and easy to use: just install the DisplayLink software, plug in your DisplayLink device, and within a few seconds you’ve got a new monitor, docking station, or projector connected to your PC or Mac.www.displaylink.com

Domino Printing SciencesFounded in 1978, Domino Printing Sciences plc has just been acquired for more than £1 billion by Japanese company Brother Industries. It will continue to operate under its autonomous brand from Cambridge with the existing management at the helm. Domino has established a global reputation

for the continual development and manufacture of its total coding and printing technologies that meet the needs of manufacturers and sets new industry standards in quality and reliability.

Through a global network of 25 subsidiary offices and in excess of 200 distributors, Domino Printing Sciences plc sells to over 120 countries offering extensive customer support. The group employs 2,400 people worldwide with manufacturing facilities situated in UK, China, Germany, India, Sweden and the US. It has significantly expanded its Cambridge HQ and technology suite in recent months and under Brother is committed to roll out new products into fresh markets.www.domino-printing.com

Eagle GenomicsEagle Genomics accelerates the opportunities offered by genomics and new data generation technologies to address some of the world’s key challenges in healthcare, infectious disease, personalised medicine, livestock and crop development, food quality and production, green energy and water recycling.

The Babraham Research Campus company powers new business models and its team of genomic data scientists work side-by-side with customers to create significant and far-reaching advantages – applying solutions to real-world problems.www.eaglegenomics.com

EndomagEndomag, headed by Dr Eric Mayes, has just unveiled a new Cambridge HQ and expansion into the United States via a new office in Austin, Texas. The company is addressing cancer staging and healthcare challenges through the application of advanced magnetic sensing technology and nanotechnology.

The company recently raised an extra £2m to support a pivotal US clinical trial and the launch of a new cancer marker product.

Endomag’s SentiMag instrument and Sienna+ tracer material have been well received by surgeons in Europe and Australasia. The products provide surgeons with a way of locating lymph nodes as part of cancer staging procedures, making them faster, more convenient and cost effective than the traditional radioisotope based techniques. In June 2015, Endomag was shortlisted for its innovative breast cancer staging diagnostic system Sentimag and Sienna+ for the MacRobert Award from the Royal Academy of Engineering. http://endomagnetics.com/

FeaturespacePredictive analytics technology business Featurespace brought off a coup in November 2014 by wooing a top financier as non-executive chairman. The ‘capture’ of Gordon Hurst, who stepped down as group finance director with outsourcing giant Capita, was the latest in a series of transformational advances for the Cambridge University spin-out. Known locally as ‘the new Autonomy,’ and with Mike Lynch on the board, Featurespace was founded in 2005.

Featurespace combines the latest research in statistics and data analysis with a unique method of modelling human behaviour. Its core ARICTM technology is a revolutionary approach to accurately predicting what individuals and dynamic groups of people will do, in real time. Featurespace has deployed a series of award- winning products for fraud and risk management, as well as customer insight and retention. Featurespace has just won E-Gaming Review’s Fraud and Compliance Solution 2015 at the EGR Awards, which recognise excellence and innovation in the gaming industry.www.featurespace.co.uk

FlexEnableFlexEnable is a new Cambridge company forged out of the innovation crucible of Plastic Logic with a suite of killer technologies tipped to disrupt multi-billion-dollar markets such as wearables and the Internet of Things. In what Cambridge entrepreneur Hermann Hauser calls “a spectacular rebirth,” Plastic Logic CEO Indro Mukerjee engineered FlexEnable Ltd – a stand-alone business firmly eyeing truly flexible electronics products and services for wearables and a broad range of industrial markets. The technology suite includes three world-firsts according to Mukerjee. FlexEnable has also cracked the holy grail of OLED technology – organic light-emitting devices.www.flexenable.com

Frontier DevelopmentsFrontier continues to hire big Cambridge. Its founder David Braben’s work in games started way back in 1982 when he co-authored the seminal game

Elite. The company floated on AIM in 2013 with a market cap of around £39.4 million. Fundraising has allowed debt-free Frontier to expand its current profitable business and further extend the features and platforms supported by its proprietary software development platform Cobra.

It also earned a lucrative contract extension from a leading games publisher smitten by the technology. Frontier’s original Elite was written by Braben and Ian Bell while they were still at Cambridge University and first published by Acornsoft on the BBC Micro in September 1984 to huge critical acclaim. Frontier sales have since sold into the high millions across a range of genres. Frontier works with top publishers as well as publishing its own titles. It has just revealed Planet Coaster for PC and opened pre-order sales. Planet Coaster will be the new destination for everyone who cares about creative gaming, coaster parks and involving management sims.www.frontier.co.uk

F-star TechnologyFounded in 2006 and based on discoveries made by Professor Florian Rüker, F-star is a next generation antibody company developing improved therapeutic antibodies and antibody fragments based on its unique Modular Antibody Technology.

This allows the introduction of additional binding sites into antibodies and antibody fragments by engineering the non-CDR loops of constant or variable domains. An oncology- focused biopharma, F-star has launched an independent spin-out business – F-star Beta – which has been granted exclusive licences to a range of oncology assets. F-star Beta is the second asset-centric vehicle created by the Babraham- based innovator.

Bristol-Myers Squibb, the Wall Street-quoted pharmaceutical heavyweight, has an exclusive option to buy F-star Alpha and its novel HER2- targeted therapy being developed to treat breast and gastric cancers in a deal that could stack up to $475 million.www.f-star.com

GeoSpockFounded by CEDAR Enterprise Fellowship winner and 2012 CUE ‘Young Entrepreneur of the Year’, Steve Marsh, GeoSpock – a Cambridge geosearch technology startup – raised over $1.245m new funding in November 2014 and has winged into the TechStars global startup accelerator.

The UK fledgling aims to do for geo-spatial querying what Google did for querying of the worldwide web. Backed by top Cambridge entrepreneurs, the company is set to scale up significantly in the UK but is also targeting operations in Silicon Valley. The current headcount of eight is likely to grow to 20 or so following what is tipped to be a multi-million VC round in mid- 2015.

GeoSpock raised the latest round of cash to commercialise its GeoWarp, Collide and Collide App Designer platforms that enable businesses wishing to take advantage of growing trends in the Internet of Things, big data and multi-dimensional, real-time geospatial experiences. Recent investment was led by notable UK entrepreneurs including Dr Darrin Disley, Dr Jonathan Milner and Peter Keen. www.geospock.com

Horizon DiscoveryHorizon is a leading provider of research tools to support translational genomics research and the development of personalised medicines and is growing like Topsy from its rapidly expanding Cambridge Research Park headquarters where it is set to double its footprint.

Spearheaded by dynamic CEO Dr Darrin Disley, Horizon continues to forge global alliances and enhance its gene editing capability – moves that are in parallel providing researchers with an unprecedented drug discovery toolkit to identify target populations and deliver medicines based on individuals’ genetic make-up.

The company has harvested a stream of multi-million dollar deals since its IPO on AIM at the end of March 2014 with a market cap of £120.5m after raising £68.6m ($113m) from institutional investors against an original target of £25m.

The scale of the IPO mowed down several previous records for a Cambridge biotech float and the business remains committed to creating the largest biotech company in Cambridge’s history. In May 2015, Horizon exceeded market expectations by securing a further $60 million growth capital. It has also expanded, through a transatlantic alliance, into the organ transplant arena.www.horizondiscovery.com

>>> Continued on page 21

21 BUSINESSWEEKLY June 18-25, 2015

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Jagex Jagex Games Studio is a multi-award winning games developer and publisher based in Cambridge. It specialises in the development of high quality browser-based games and is the largest independent games developer and publisher in the UK. The company is recruiting big in Cambridge.Jagex has a long-standing reputation for creating the world’s best online games and for developing hugely popular, high quality, accessible, free-to-play games and for providing an unbeatable community experience for millions of players around the world. Jagex has developed and self-published over 40 online titles including the world’s most popular free online multiplayer game, RuneScape.www.jagex.com

KymabKymab’s technology is based on research from the world-leading Wellcome Trust Sanger Institute and is being commercialised with substantial financial backing from the Wellcome Trust and other global heavyweights.

The company’s broad and flexible technology partnering strategy provides access to KymouseTM – a multi-strain, in vivo human monoclonal antibody discovery platform for the creation of fully human monoclonal antibodies and for testing the resulting mAbs in an in vivo preclinical setting. It is designed to provide the full spectrum of functional human immunoglobin diversity while retaining normal mouse B-cell signalling and maturation.

In May 2015, Kymab, raised an additional $50 million to complete a $90m Series B financing. The new money was invested by Woodford Patient Capital Trust and Malin Corporation. This followede the first $40m Series B investment from the Wellcome Trust and the Bill & Melinda Gates Foundation. The funds will enable Kymab to maximize the potential of its KymouseTM platform and advance its proprietary pipeline of first-in-class therapeutic human monoclonal antibodies in areas of significant unmet medical need.www.kymab.com

MISSION TherapeuticsMISSION Therapeutics Limited, a biotechnology company developing novel inhibitors of

deubiquitylating enzymes (DUBs) involved in the DNA damage response, closed a Series B round of equity financing totalling £20 million ($32 million)in November 2014. New investor Pfizer Venture Investments joined existing investors Sofinnova Partners, Imperial Innovations, S.R. One and Roche Venture Fund, which all participated in the financing.

MISSION was formed to exploit advances in the biology of the DNA damage response for the discovery of new classes of therapeutic agents with novel mechanisms of action. Utilising fundamental research principally generated in the laboratory of Professor Stephen Jackson, MISSION has progressed several small molecule discovery programmes focused on key enzymes in the ubiquitin pathway to selectively target difficult-to- treat cancers.

The financing round enables MISSION to advance its lead programmes, for the treatment of various genetically defined cancers, through preclinical development and to further exploit the potential of its novel DUB technology platform. www.missiontherapeutics.com

OwlstoneUsing leading-edge nanofabrication techniques, Cambridge University spin-out Owlstone has developed a complete chemical detection system on a chip – a ‘dime size’ Field Asymmetric Ion Mobility Spectrometer (FAIMS), with the ability to rapidly monitor a broad range of chemicals at very low quantities with high confidence. It can detect mulitple gases simultaneously in under a second, with detection levels below part per billion (ppb). The sensor can be reprogrammed to detect new gases through software, even after deployment.

Owlstone has doubled its Cambridge Science Park space and launched a recruitment campaign for a significant number of new UK hires to handle major defence contracts for the US and Taiwan.

The company is also expanding its capability in the medical sensor field and is close to sealing multi-million pound funding from several sources as its technology proves increasingly successful in detecting cancers and other diseases. Owlstone’s new medical division has developed a cancer breathalyser which has progressed through alliances with research and academic partners. Life science researchers are increasingly finding that specific chemical compounds are present in the breath or bodily fluids of people with certain medical conditions, such as TB, cancers or diabetes.

This suggested a new way of diagnosing these diseases early without the need for costly and invasive medical procedures – Owlstone’s sensor can simply test for the presence of these tell-tale chemicals.www.owlstonenanotech.com

QuixantQuixant technology enables manufacturers of gaming machines to design and ship world-beating products in record time. Its range of gaming platforms are high performance, PC compatible systems designed and tuned specifically to meet the complex needs of the gaming industry. The hardware integrates all the features necessary to drive pay to play machines in all major global gaming jurisdictions. Comprehensive software support for Windows and Linux augments the hardware, including device drivers, gaming protocols, example code and even SAS support.

The Quixant gaming platform range represent complete all-in-one logic box solutions for pay to play gaming machines. Users simply add the game software. Late last year Quixant expanded its team and operations in Las Vegas and opened up fresh opportunities in China. www.quixant.com

RealVNCRealVNC was founded in 2002 by the original developers of Virtual Network Computing to promote, enhance and commercialise VNC. RealVNC’s software is now used by hundreds of millions of people worldwide in over one billion devices and in every sector of industry, government and education.

VNC is a de facto standard for remote control and has been used widely in hundreds of different products and applications, from helpdesks to virtualisation. Many millions of licenses to the company’s commercial VNC products have been shipped to customers throughout the world, and across all sectors. Customers range from individuals to the world’s largest organisations. www.realvnc.com

Red Gate SoftwareNinety-one per cent of Fortune 100 companies use Red Gate’s software. The company was founded by Neil Davidson and Simon Galbraith (pictured) in 1999 and makes tools used by over 600,000 .NET, SQL Server, and Oracle professionals worldwide.

Red Gate has three core divisions focusing on developing applications, developing for databases and managing databases for users of Microsoft technologies. The company has a Fledgling Markets team that buys and builds software in markets it believes will form the foundations of Red Gate in the future.

The company opened a sales and support office in Singapore in 2012 to target the Asia Pacific region. It gave the company capability in the world’s three major technology heartlands – the UK where Cambridge remains its global headquarters, the US where Red Gate has operations in Pasadena, California, and now wider Asia. Red Gate recently released a suite of Database Lifecycle Management tools to give developers and DBAs, for the first time, a complete DLM solution.www.red-gate.com

>>> Continued on page 25

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Up until now, there has been a concern over mobile payments,

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DAVID EMSWORTH, HEAD OF RISK AND COMPLIANCE, ZAPP, ON ARICTM FRAUD MANAGER

25 BUSINESSWEEKLY June 18-25 2015

CAMBRIDGE CLUSTERwww.businessweekly.co.uk linkedin.com/company/business-weekly-newspapernews@businessweekly.co.uk

SepuraSepura is a global leader in TETRA digital radio products. It delivers mission-critical communications to customers in the public safety, military, transport, utilities and commercial sectors.

Last November, the company posted record interim revenues that were 18 per cent ahead to €54.5 million with adjusted operating profit up 350 per cent to €2.7m (£2.15m) despite foreign exchange buffeting. Headquartered in Cambridge and now with over 400 staff, Sepura has expanded rapidly across the world and is now a market leader in over 30 countries. It has customers in 68 countries.

It is relocating its headquarters at the end of this year to Cambridge Research Park to cater for major expansion globally. Sepura was founded in 2002 and floated on the London Stock Exchange in 2007, although the organisation has been a major employer in the Cambridge area for many years by virtue of a history which can be traced back through Philips and Pye.www.sepura.com

SimPrintsBacked by funding from ARM and the Bill and Melinda Gates Foundation, SimPrints’ biometric fingerprint scanner is designed to transform access to health records – solving a long-standing problem in the delivery of mobile services in healthcare in developing regions.

Community health workers are often unable to carry out the four antenatal visits recommended by the World Health Organisation due to challenges in patient identification, access to health records and visit verification. SimPrints’ device will accurately connect people to their digital records via a simple fingerprint scan.

The lightweight, durable and cost-effective portable biometric scanner and software integrates with any mobile health application to allow for real-time identification and access to patient records via fingerprint identification.

The scanner will tackle current problems like misidentification caused by common community names or unknown dates-of-birth and the limitations of paper-based health records – prone to loss or damage and often difficult to access. www.simprints.com

SyndicateRoomSyndicateRoom is the UK’s fastest-growing equity crowdfunding platform, having helped companies raise £25 million in its first 21 months. Its unique model drives support through led investment by business angels and venture capitalists.

To date, SyndicateRoom has facilitated fundraising for the first and only crowdfunded IPO as well as the first equity crowdfunded Hollywood film – ‘Salty’ – by Simon West. SyndicateRoom also recently raised its own £1.2m growth funding on the site in just 33 hours. None of its investee companies has failed following fundraising efforts.

SyndicateRoom has helped a range of businesses raise vital cash to commercialise a broad spectrum

of projects through its genuinely novel platform. The company allows its members to co-invest in exciting startups with seasoned investors, democratising the entire process. www.syndicateroom.com

TTPThe Technology Partnership (TTP) is a technology and product development company, working in partnership with clients to bring new products to market and create new business from advances in technology.

The company develops and commercialises technologies and products across a broad range of market sectors. The Technology Partnership is an operating company of TTP Group.

TTP Group, which celebrated its 25th anniversary in 2012, is the holding company which owns Melbourn Science Park, where TTP is based. Other companies in the group are TTP Venture Managers which invests in IT and clean technology companies, TTP Labtech which supplies laboratory- scale instrumentation and develops custom automation for life sciences companies and Tonejet which is a powerful digital printing process targeted at commercial and industrial applications. www.ttp.com

UbisenseUbisense has grown into a leading location solutions company, serving customers such as BMW, Airbus, Aston Martin, Caterpillar, Metro Transit, the US Army, Duke Energy and Deutsche Telekom as well as other FTSE 100 and Fortune 500 companies.

Spun out of Cambridge University’s Computer

Laboratory in 2002, the company is now a leading world player in Real Time Location Systems. It enjoyed a spectacularly successful launch on London Stock Exchange and has gained global traction since in several key territories with its Smart Factory and Myworld solutions for world-leading companies across a range of industry sectors.

Smart Factory is a production-certified system that helps manufacturers sustain continuous flow, optimise efficiency, and reduce errors in manual assembly processes. The Myworld solution contains simple, smart and fast applications that improve operations and maintenance efficiency for utilities and communications enterprises.www.ubisense.net

VecturaVectura focuses on the development of pharmaceutical therapies for the treatment of airways-related diseases.

The company has eight products marketed by its partners and a portfolio of drugs in clinical development; it has disclosed development collaborations and licensed to major pharmaceutical companies including Novartis, Sandoz (the generics arm of Novartis), Baxter, GlaxoSmithKline, UCB, Ablynx, Grifols and Tianjin KingYork Group Company Limited.

Vectura seeks to develop certain programmes itself where this will optimise value. Vectura’s formulation and inhalation technologies are available to other pharmaceutical companies on an out-licensing basis where this complements Vectura’s business strategy.www.vectura.com

VernalisOne of the UK’s leading development stage pharmaceutical companies, Vernalis takes promising product candidates along a commercially-focused path to market. It derives pipeline candidates both from its own research activities and from successful collaboration with a number of global pharmaceutical businesses. Its pipeline focuses on several key areas of disease in CNS and oncology. www.vernalis.com

VocalIQNew software that interprets the spoken word is poised to revolutionise voice recognition systems, proving a more seamless interface between people and their mobile devices, televisions and cars.

The spoken dialogue technology, which is being developed by VocalIQ – a spin-out from the University of Cambridge’s Dialogue Systems Group – was designed to enhance automated voice recognition interfaces, which rely heavily on predefined commands.

VocalIQ’s software, based on more than 10 years of research, offers users the ability to talk more naturally with their smart devices. Instead of merely recognising speech, the technology is able to understand and interpret dialogue. It can also learn on-line so that when it makes mistakes, it learns from them and avoids making the same mistake again.

The more the software is used the smarter it gets. VocalIQ received £750k in seed financing led by technology investor Amadeus Capital Partners. Cambridge Enterprise, the commercialisation arm of the University of Cambridge, is also investing.

VocalIQ’s chairman, Steve Young, is Professor of Information Engineering at the University of Cambridge. He was the original developer of the HTK speech recognition toolkit and co-founder of Entropic, an innovator in speech technologies, which was acquired by Microsoft.www.vocaliq.com

Xaar PrintingXaar, established in 1990, is the world-leading independent supplier of industrial inkjet printheads.

It offers a wide product range to deliver industrial strength inkjet performance, which in turn provides customers with the flexibility and choice required to address the diversity of applications. Its technology is used all over the world in a wide range of manufacturing applications, including graphics, labels, direct-to- shape packaging decoration, ceramic tiles, laminates, and outer case coding – as well as printing with specialist functional fluids for advanced manufacturing techniques.

Xaar designs and manufactures its printheads in the UK – exporting over 90 per cent of production to customers around the world.

The company also develops and sells ink systems, electronics and fluid optimisation services to accelerate inkjet system development and adoption.www.xaar.com

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SimPrints has developed a portable biometric scanner and software that enables real-time identification and access to patient records via fingerprint identification