Seminario: Biologia molecular

“THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT

MARCH” AND “PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”

 Manuela Rendón DíezMedicine Student

III Semester

Molecular Biology

FOLDING

FOLDING

Introduction

DNADNA

RNARNA

ProteinsProteins

actions

enzyme structural

inmunological

contractil

homeostatic

“THWARTING PROTEIN

PRODUCTION SLOWS CANCER

CELL´S MALIGNANT MARCH”

Science Daily(July 18, 2013)

“THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH”

(July 18, 2013)

Protein synthesis and cell proliferation is closely associated with the stress response.

Inhibiting translation

retards tumor growth

“THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH”

(July 18, 2013)

Heat shock factor

protein 1 (HSF1)

Increases survival despite the efforts of natural defenses

and therapeutic

help them survive and

thrive

increases protein

translation

malignancy increases

hyperactive response of cancer cells

“THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH”

(July 18, 2013)

Rohinitib (RHT)

Inhibits tumor growth

Interrupts the translation and activity

of HSF1

Suppresses glucose uptake

Personal Observation

I think that the discovery of new compounds that suppress the translational and proliferative activity of

the cells has great importance for the treatment of different cancers, or as a therapeutic alternative to reduce the

maximum pathogenesis.

“PROTEINS KEY IN STEM CELL

PRODUCTION IDENTIFIED”

Science Daily(July 5, 2013)

“PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”(July 5, 2013)

Pluripotent stem cells (iPSCs)

are transformed into many cell types

Useful in therapeutics

“PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”(July 5, 2013)

Proteins play a critical role in pluripotency

“PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”(July 5, 2013)

Proteins identified by the splicing code

Act as a switch

Activate and deactivate the pluripotency of stem cells

Personal Observation

I think that the development of stem cells is of great 

importance to medical and scientific research, its use in regenerative medicine, 

immunotherapy, gene therapy, pain relief treatments, cancer, 

diabetes, cloning, set the standard in scientific 

development, but, for me, it leaves much to be desired in 

ethical issues.

Medical Utility

The medical importance of      protein synthesis is mainly      based on the 

large number of functions that these play a biological level, from hormones, neurotransmitters, antibodies, enzymes, transporters, etc..

Medical Utility

Medical Utility

The development of new       methods for the treatment 

of      diseases that are related to     protein 

synthesis and cell                 proliferation will be the 

solution to future pathologies that were considered incurable.

Medical Utility

The      production of stem cells will then be an 

alternative for                   survival.

BIBLIOGRAPHY 

*Martínez Sánchez, Lina María. Biología Molecular. 7 Ed. Medellín. UPB. Facultad  de Medicina 2012. 102-106 pp.

*Proteins Key in Stem Cell Production Identified. Science Daily (online magazine). 2013 (July 5).

Avaliable at: http://www.sciencedaily.com/releases/2013/07/130705113622.htm 

*Thwarting Protein Production Slows Cancer Cell´s Malignant March. Science Daily (online magazine). 2013 (July 18).

Avaliable at:  http://www.sciencedaily.com/releases/2013/07/130718142420.htm