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THE NU SKIN OPPORTUNITY
Richard J. DeAgazioRuby Executive
www.stayyoung.nsedreams.com
THE NU SKIN OPPORTUNITY
The world’s leading anti-aging company is addressing the sources of aging, not just the
signs and symptoms.
TRADITION OF INNOVATION
3
• Nu Skin 180• Galvanic Spa• Scanner• Nano• g3• TruFace essence
ultra
SIGNS
Developing products that address the sources of aging, not just the signs and
symptoms.
What is ageLOC?
D. James Morré, PhDDepartment of Medicinal Chemistry and Molecular Pharmacology
andDorothy M. Morré, PhD
Department of Foods and NutritionPurdue University, West Lafayette, Indiana
ARNOX, AN AGING ENZYME: 1ST AGELOC SOURCE OF AGING
Identified a NOX which increases with age Nicotinamide adenine dinucleotide OXidase, a hydroquinone oxidase
NOX
QuinoneReductase
Q10 Q10H2
1/2 O2 H2O
NAD(P)H + H+
NAD(P)+
ProteinSS
ProteinOutside
Inside
Plas
ma
Mem
bran
e
2 O2 SHSH
2 O2-
arNOX Generates Superoxide O2-
A powerful free-radical generator
GENESIS OF AGELOC
Why Some People Look Years Younger
Than They Really Are.
The arNOX discovery helped explain…
HUMAN GENOME
• Our genome encodes for:– our looks– our size– how our bodies work– our health– our behaviors– Our longevity
Genes impact structure and function of the body
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40
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LifespanLifespan
Health or Beauty Index
YEARS
• 2003 discovery after 20 years of research: 25,000 – 30,000 genes form the human genome • Twenty Labs with hundreds
of scientists (United States, the United Kingdom, France, Germany, Japan and China), • $3 billion
After 20 yrs Human Genome Sequenced
The Human Genome consistsof at least 25,000 – 30,000 genes
GATCGACTCCTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCC---TTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTAAAGT
Nu Skin Enterprises Center for Anti-Aging Research (NSE:CAAR)
NSE:CAAR Anti-Aging Genetic Experts
Published over 300 scientific papers, and
their insights have changed the way aging is viewed.
NSE: Center for Anti-Aging Research• Experts in the study of the ultimate
source of aging; our genes. • 30 Years of pioneering anti-aging
research.• Their work both details the genetic basis
of aging, and demonstrates that biological aging is no longer considered an inexorable or inevitable process.
Cellnucleus
DNA (stored on chromosomes)
Genetics 101
ULTIMATE SOURCE OF AGING = GENE EXPRESSION• As you age, your genes don’t change•Which genes are turned on and off does change (e.g. gene
expression).• Expression levels are influenced by your environment (stress,
nutrition, etc…)
IDENTICAL TWINS ARE DIFFERENT
• How is this possible, as their genes are the same?• It turns out that while the genes are identical, the level at which
gene is turned on and off changes based on environmental factors (e.g. gene expression). This causes the differences you can see.
Yellow shows where the twins have similar gene regulation. Red and Green indicate differences (up and down regulation).
To better understand aging, we need to know the expression level for every gene.
arNOX Elastin
…in a single experiment.
Gene Expression Profiling 101
arNOX (0)
Elastin (8)
Collagen (6)
MMP (2)
Microarray (e.g. Gene Chip)Young Skin
Key - High Activity
- Off
- Medium Activity
- Low Activity
Gene 1arNOX
Gene 2Elastin
Gene 3Collagen
Gene 4MMP
Young Skin Fibroblast (Hypothetical)
DNA
mRNA
The expression level for every gene in a single experiment!
arNOX Elastin
Key - High Activity
- Off
- Medium Activity
- Low Activity
DNA Microarray Gene MapOver 25000 Genes
NuSkin ageLOC Approach
• Identify Youth Gene Clusters (YGC’s), and understand their youthful expression patterns
• Target - Investigate the effect different ingredients have on YGC’s.
• Reset - Develop formulae that reset these YGC’s back to their youthful state, thus restoring the youthful biochemistry of a cell.
What is a Youth Gene Cluster (YCG)
• These are groups of genes (e.g. clusters) that work together to exert a specific function in a tissue associated with youthfulness.
• Tissue specific
• Act as master regulators of aging.
Younger Than Chronological Age
In additional to understanding the genetic basis of aging in Humans, mice, fruit flies, yeast and roundworms are also fruitful models for the
genetic/aging scientist
Gene Expression Profiling 101Gene 1arNOX
Gene 2Elastin
Gene 3Collagen
Gene 4MMP
Young Skin Fibroblast (Hypothetical)
DNA
mRNA
Gene 1arNOX
Gene 2Elastin
Gene 3Collagen
Gene 4MMP
Old Skin Fibroblast (Hypothetical)
DNA
mRNA
Gene Expression Profiling 101Young Skin Old Skin
arNOX (0)
Elastin (8)
Collagen (6)
MMP (2)
arNOX (8)
Elastin (0)
Collagen (2)
MMP (4)
Key - High Activity
- Off
- Medium Activity
- Low Activity
Down regulation Up regulationNo Change
arNOX (+8)
Elastin (-8)
Collagen (-4)
MMP(+2)
Changes with Aging
By comparing the two, you can understand the genetic changes associated with aging
INTELLIGENTBIOINFORMATICS
DATABASE
YOUTH GENE CLUSTERS
Map of Aging Genetics (Whole Genome)
• Huge Proprietary Database• Over 25 Million aging related genetic
changes and growing.• Bio-Informatics on this database yields
the genetic map of the aging process• Shows us the path we need to take
ageLOC Process
• Identifying Youth Gene Clusters (YGC’s), and understanding their youthful expression level
• Targeting - Cataloging the effect different ingredients have on YGC’s.
• Resetting - Developing formulas that reset these YGC’s back to their youthful state, thus restoring the youthful biochemistry of a cell.
How Do We Target and Reset YGC’s - Remember the Gene Chip?
Key - High Activity
- Off
- Medium Activity
- Low Activity
DNA Microarray Gene MapOver 20000 Genes
Identifying Changes (Old vs. Young YGC Profile)
Young Skin Old Skin
A B
C D
A B
C D
Key - High Activity
- Off
- Medium Activity
- Low Activity
By comparing the two, you can understand the genetic changes associated with aging
Targeting & Resetting YGC
Young Skin
Old SkinA B
C DA B
C D
Key - High Activity
- Off
- Medium Activity
- Low Activity
Once you map the changes, you can screen for ingredients and formulas that reverse these changes
Post Application
A B
C D
AGING
ageLOC
ageLOC Process
• Identifying Youth Gene Clusters (YGC’s), and understanding their youthful expression level
• Targeting - Cataloging the effect different ingredients have on YGC’s.
• Resetting - Developing formulas that reset these YGC’s back to their youthful state, thus restoring the youthful biochemistry of a cell.
SECOND GENERATION AGELOC PRODUCTS
Gene Activity in Skin Cells
DNA Microarray Gene Map
Over 25000 Genes
Skin
StructureTIMP1
COL7A1AQP3
IL1B
PPARG
TNFA
POMC
IL1B
IL6
SOD2
MT2A
TXNRD1
60+ GENES
For Human Skin: 4 YGCs identified
Pigment
20+ GENES
Cell Turnover
35+ GENES
Hydration
20+ GENES
Texture, Smoothness
Radiance
Pore Size
Hydration
Discoloration
Skin Tone
Signs of Aging
Fine Lines & Wrinkles
Youthful Skin
Structure
Four YGCs Identified
Youth Gene Clusters
Pigment
Hydration
Cellular Turnover
ageLOC Science
Skin Structure
Changes in gene activity patterns yield tissue changes as we age
“Interventions can impact gene activity patterns even late in life and may reverse skin aging”*
*Adler, Chang et al. Cell Cycle 2008;7(5):556-559
“THE PROOF IS IN THE PUDDING”Meaning: The true value or quality of something can only be judged when it's put to use.
“Nu Skin has never developed a product that delivers these kindof results before (both in clinical results and user perception”
Dr. Helen Knaggs, PhD VP of NuSkin R&D
1. Nu Skin Enterprises Center for Anti-Aging Research (NSE:CAAR) brings together experts in the field of anti-aging genetics
2. Only we can Identify Youth Gene Clusters (YGC) 3. AgeLOC Science Targets the Ultimate Sources of Aging4. Only Nu Skin understand how to Reset Youth Gene
Clusters to their youthful state5. Over the next 10 years as the ageLOC approach
matures, its full impact will be realized on many more products - enabling Nu Skin to stay years ahead of our competition
ageLOC Summary
Nutritional Intervention affects age related gene expression and can Reverse Aging
Lee et al, Science 1999;285(5432):1390-3; Colman et al, Science 2009;325:201-204
AGELOC OBJECTIVE: LIFESPAN VS. HEALTH or BEAUTY SPAN
20 40 60 80 100 1200
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40
60
80
100
120
HealthspanLifespan
Health or Beauty Index
YEARS
THANK YOU
Richard J. DeAgazio
www.stayyoung.nsedreams.com
rdeagazio@rcn.com
617-413-9777
THANK YOU
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