Chaperone Proteins

By Robin Hrynyszyn and Rachel Johnson

Proteins = Tiny Machines

Amino Acid Chain

Goo

3D Protein Shapes

There are 2 types of chaperones

•During folding

•After folding

Heat Shock Proteins

Questions?

Sources

• 1. http://people.cryst.bbk.ac.uk/~ubcg16z/hsplec.html

• 2. http://en.wikipedia.org/wiki/Protein_folding

• 3. http://www.maroonbiotech.com/research/sct.html

• 4. https://www.research.gov/research-portal/appmanager/base/desktop;jsessionid=GjR7SG6DGsPgRHpvR2Q3TRpRV82HTDR8179X3m1yGzh1Ys3xGd0R!-1826466010!941996275?_nfpb=true&_windowLabel=awards_1&_urlType=action&wlpawards_1_id=%2FresearchGov%2FAwardHighlight%2FPublicAffairs%2F23777_ModelingtheTriggerFactorMolecule.html&wlpawards_1_action=selectAwardDetail

• 5. http://www.shmoop.com/biomolecules/theme-b.html

• 6. http://www.trhvidsten.com/Research.html

• 7. http://ehis.ebscohost.com/ehost/pdfviewer/pdfviewer?sid=f3b80c2b-290e-424c-b1f8-3c00cbf192dd%40sessionmgr12&vid=4&hid=7

http://people.cryst.bbk.ac.uk/~ubcg16z/hsplec.html

http://en.wikipedia.org/wiki/Protein_folding

http://www.maroonbiotech.com/research/sct.html

https://www.research.gov/research-portal/appmanager/base/desktop;jsessionid=GjR7SG6DGsPgRHpvR2Q3TRpRV82HTDR8179X3m1yGzh1Ys3xGd0R!-1826466010!941996275?_nfpb=true&_windowLabel=awards_1&_urlType=action&wlpawards_1_id=%2FresearchGov%2FAwardHighlight%2FPublicAffairs%2F23777_ModelingtheTriggerFactorMolecule.html&wlpawards_1_action=selectAwardDetail

http://www.shmoop.com/biomolecules/theme-b.html

http://www.trhvidsten.com/Research.html

Chaperone Proteins

Technology

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Drowsy Chaperone (B'Way)

Drowsy Chaperone b Way

For Peer Review · For Peer Review 4 113 Correct folding of a therapeutic protein is essential for activity and complex proteins can require 114 specific chaperone proteins to facilitate

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UreG, a chaperone in the urease assembly process, is an … · 4 and CO2, the participation of four accessory proteins is required (8-12).These proteins (UreD, UreF, UreG, UreE) are

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ReviewArticle Heat Shock Proteins in Cancer Immunotherapy · 7.HSP90 HSP90 is a molecular chaperone that facilitates the matu-rationofsubstrates.Severalkinases,transcriptionfactors,E3