View
329
Download
0
Category
Preview:
DESCRIPTION
Presentation of EdgeLeap's CEO Marijana Radonjic at NuGO Week (11 September 2014, Castellammare di Stabia, Italy). This presentation shows how organizing and linking diverse data (food databases, disease associations, genomics, 23andMe genetics profiles) allows us to map a personal food-genomics-health landscape and identify dietary patterns which may affect personal disease risk. For more details see: http://www.edgeleap.com/news/edgeleap-at-nugo-week-2014/
Citation preview
www.edgeleap.com
Marijana Radonjic, PhD
marijana@edgeleap.com
ORGANIZING DATA TO
EMPOWER DECISION MAKING
This presentation remains property of EdgeLeap B.V. and is licensed for reuse under a Creative Commons Attribution 4.0 International License (see http://creativecommons.org/licenses/by/4.0/).
www.edgeleap.com
DATA
DECISION
INFORMATION
KNOWLEDGE
www.edgeleap.com
NuGO week 2014Participant list(hard copy)
www.edgeleap.com
Institute
Person
www.edgeleap.com
In Marijana’s LinkedIn
Not (yet) in Marijana’s LinkedIn
www.edgeleap.com
PERSONALIZED
FOOD-HEALTH LANDSCAPES
marijana@edgeleap.com
www.edgeleap.com
www.edgeleap.com
COMPLEXITY OF HEALTH FACTORS
8
www.edgeleap.com
PEAK INTO THE FUTURE
9
JAN FEB MAR APR MAY JUN
www.edgeleap.com
FOOD - GENOMICS - HEALTH
LANDSCAPE
10
www.edgeleap.com
BRIDGING FOOD AND HEALTH
11
Ingredient GeneFooDB: 9,955 food
ingredients, 858 foods
HMDB: 4,025 associated
enzymes & transporters
Disease
UMLS: 8,521 diseasesDisgeNET: 13,828 associated genes & proteins
GeneticsBiomarkersMechanistic
EnzymesTransporters
www.edgeleap.com
BRIDGING FOOD AND HEALTH
12
Ingredient Gene
Disease
www.edgeleap.com
FOOD - GENOMICS - HEALTH NETWORK
13
Significance filter(Monte Carlo randomization
procedure p < 0.001)
Projection to disease-
ingredient space
Bipartitedisease-gene-ingredient
network
Disease-Ingredientnetwork
www.edgeleap.com 14
Neoplasms
Metabolic syndrome
and complications
Mental disorders817 connected diseases316 connected ingredients1,961 disease-ingredient relations(p < 0.001)Network cluster coefficient = 0.42 (v.s. random graph ~0.006)
FOOD - GENOMICS - HEALTH
LANDSCAPE
www.edgeleap.com 15
NETWORK RECONSTRUCTS DISEASE AND
INGREDIENTS CLASSES
Most or all topology based clusters (47/67 for diseases and 10/10 for ingredients) are significantly enriched with one or more predefined MeSH disease and/or HMDB chemical classes (p < 0.05).
Significant enrichment (p < 0.01)
Clusters enriched with main disease classes
Clusters enriched with main ingredient classes
www.edgeleap.com 16
Raw data
GOING PERSONALIZED
Rs1234(A;A)
Rs1234(G;G)
Increased risk
Decreased risk
Disconnected information
Personal disease-ingredient network
www.edgeleap.com
PERSONAL FOOD - GENOMICS - HEALTH
LANDSCAPE
Disease
Decreased risk
Increased risk
Mixed evidence
Linked to variant
Not linked to variant
Ingredient
AtherosclerosisCoronary diseaseHypertensionObesityDiabetesDementia
Cancers
PsychosisAutismMigrane disordersDepression‘as if’ personalityNicotine dependence
Cluster headacheHypertension
www.edgeleap.com
NUTS – ATHEROSCLEROSIS ASSOCIATION
Disease
Increased risk
Linked to variant
Not linked to variant
Ingredient
Vegetables;Fruits;Herbs and Spices;Nuts;Cereals and cereal products;Pulses;Teas;Gourds;Coffee
CETP
Fats and oils
Herbs and Spices
Cocoa and cocoa products;Fats and oils
Cocoa and cocoa products;Fats and oils
www.edgeleap.com
WHAT ELSE WILL BE AFFECTED?
Disease
Increased risk
Mixed evidence
Linked to variant
Ingredient
www.edgeleap.com
FROM INGREDIENTS TO DIET
23andMe SNP profiles(11 individuals)
Whole foods for which their ingredients enriched in personal networks
www.edgeleap.com
CHALLENGES AHEAD
21
• From ingredients to diets: diets in genetics context
• Beyond genetics: involve broader phenotypic data (dietary
questionnaires, activity measurements, self monitoring devices,
medical history)
• Time resolved data (current status, future risk)
• Standardization of knowledge:
• Ontologies to map between resources
• Publish in structured format
• Add directionality of relations: from associations to causal
www.edgeleap.com
MAKING DECISIONS
22
Understand big picture beyond single SNP-
ingredient associations
Improve advice on dietary lifestyle
Develop healthy food
(Re)position existing product
What to eat to stay healthy?
www.edgeleap.com
THANKS
Georg SummerPhD Student, co-supervised by Maastricht University / TNO / EdgeLeap
Thomas KelderEdgeLeap
www.edgeleap.com
info@edgeleap.com
www.edgeleap.com
edgeleap
@EdgeLeap
Contact us to explore how we can help you in
making most out of your data!
Recommended