UTI - II

Forthcoming plants

for

UTI treatment

(UTI – II)

Presented by

Dr. Sudhakar Kokate

Director PPRC, India

Plant categories of UTI treatment

Botanical diuretics

Urinary anti-septic and anti-adhesion herbs

Botanicals with anti-nephrotoxic activity

Plants to relieve from benign prostatic hyperplast

(BPH)

Phyto-derivatives against Prostate cancer

PPRC/INDIA 01

My Attitude

Researchers from different labs globally need to

work closely together, discuss problems frequently

and analyze the results instantly.

Herbal medicine research -

1. should be organized

2. consistent team work is absolutely vital.

PPRC/INDIA 02

Data by WHO % Use of herbal medicines

Africa …. 80

China …. 30 – 50

Europe N. America …. > 50

Germany …. 90

India …. 40 – 70

Global market for

herbal medicines …. > $ 60 bn / yr

….. And growing faster

PPRC/INDIA 03

I.

Phyto Diuretics

PPRC/INDIA 04

Solidago virgaurea L. : European goldenrod

Solidago canadensis : Canadian goldenrod

S. gigantea Aiton : Early goldenrod

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These contain saponins and tannins (Weiss 1985)

Multiple compounds contribute to actions

(Okpanyi et. al. 1989)

S. gigantea 60% ethanol extract on animal study

(Leuschher 1995)

S. virgaurea extracts practised to prevent

formation of kidney stones and to help in

removing urinary gravel (Blumenthal et. al. 1998)

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Levisticum officinale

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Levisticum officinale

Also called Lovage root

Family: Apiaceae

Good diuretic (Weiss 1985)

Major active principle: Terpenoids, Iso-valeric acid,

Angelic acid, Coumarins

Approved by the German Commission E for use in

lower UTI and urinary gravel. (Blumenthal et. al. 1998) PPRC/INDIA 08

Petroselinum crispus

PPRC/INDIA 09

Petroselinum crispus

Also called Parsley

The root / fruit is used as a Diuretic

Folk remedy since the ancient times (Yarnell 2002)

Active principles: Terpenoids, Apicol, Flavanoids,

Apigenin

This herb also shows carminative and calcium

channel – blocking activity in vitro (Neuhaus –

Charlisle et. al. 1993)

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Urtica dioica

PPRC/INDIA 11

Urtica dioica

Also called Stinging nettle

Parts – Leaves, Seeds

Used as – Mild diuretic, support for urinary tract

functions, internal anti-inflammatory and roots as

benign prostatic hyperplasia

Aqueous extract have diuretics and natriuretic

effects (Tahri et. al. 2000)

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Ononis spinosa

PPRC/INDIA 13

Ononis spinosa

Also called Spiny restharrow

Chemicals: Phenol, Lectin, Triterpenoid, Volatile

oils – Trans anethole, Camphor, Menthol,

Estragole, Borneol

Family: Fabaceae

Roots: Diuretic (Weiss 1985)

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Equisetum arvense

PPRC/INDIA 15

Equisetum arvense

Also called Horsetail

Active principle: Silicic acid, Silicates

Astringent effect on the genito-urinary system

(Steenkamp 2003)

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Forthcoming

Diuretic plants

PPRC/INDIA 17

Apium graveolens: (celery) fruits

Taraxacum officinale (Dandelion) leaves

Parietaria judaica (Pellitory-of-the-wall)

Galium aparine (Cleavers)

Chimaphila umbellata (Pipsissewa)

Asarum europaeum (Asarabacca)

Carlina vulgaris (Caroline thistle)

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Apium graveolens

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Taraxacum officinale

PPRC/INDIA 20

Parietaria judaica

PPRC/INDIA 21

Galium aparine

PPRC/INDIA 22

Chimaphila umbellata

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Asarum europaeum

PPRC/INDIA 24

Carlina vulgaris

PPRC/INDIA 25

Rosmarinus officinalis (Rosemary)

Centaurium erythraea

Spergularia purpurea

Ananas comosus

Carica papaya

Cyperus rotundus

PPRC/INDIA 26

Rosmarinus officinalis

PPRC/INDIA 27

Centaurium erythraea

PPRC/INDIA 28

Spergularia purpurea

PPRC/INDIA 29

Ananas comosus

PPRC/INDIA 30

Carica papaya

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Cyperus rotundus

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References

Weiss, 1985

Halouri et. al. 2000

Jounad et. al. 2001

Sripanidkulchai et. al. 2001

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Urinary antiseptic

&

anti-adhesion plants

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Arctostaphylos uva-ursi

PPRC/INDIA 35

Arctostaphylos uva-ursi

Also called Uva-ursi

Active principle: Glycoside arbutoside – Arbutin

Used for lower urinary tract infections by

Commission E. 1998 (Blumenthal et. al.)

>7 pH …. Urine environment Arbutin converts

hydroquinone (caution – carcinogenic) which

kills bacteria (Yarnell 2002)

PPRC/INDIA 36

Juniperus spp. fruit

PPRC/INDIA 37

Juniperus spp. fruit

Useful in digestive disorders, kidney and bladder

problems

Volatile oil contains > 100 compounds i.e. alpha

and beta pinene, myrecene, limonene, sabinene

and alcohol, terpinene-4-ol (Clark et. al. 1990)

Animal studies shows that extracts increase

urinary volume PPRC/INDIA 38

Juniperus spp. fruit

Additionally terpinen-4-ol acts as diuretic

Excessive doses of Juniper on animals show

kidney irritation (Schilcher and Leuschner 1997)

PPRC/INDIA 39

Echinacea spp.

PPRC/INDIA 40

Echinacea spp.

E. purpurea – immunostimulating property in

UTI (Kligler 2003)

Three sp. Effective – E. purpurea

E. angustifolia

E. pallida

Purple coneflower is native to North America

PPRC/INDIA 41

Hydrastis canadensis

PPRC/INDIA 42

Hydrastis canadensis

Also known as Goldenseal

Active principle in roots: Hydrastine, Berberine

Berberine: no side effects, compared with

antibiotics, it blocks adhesion of bacteria to

epithelial cells (Subbaiah and Amin 1967, Amin et.

al. 1969)

Anti-microbial activities against bacteria, fungi and

protozoa PPRC/INDIA 43

Hydrastis canadensis

Protective effect against several micro-organisms

including:

E. coli

Streptococcal bacteria

Chlamydia and Proteus sp.

Salmonella typi

Entamoeba histolytica

(Lahiri & Dutta 1967, Mahajan et. al. 1982, Sun et. al. 1988 b)

PPRC/INDIA 44

Agathosma betulina

PPRC/INDIA 45

Agathosma betulina

Also known as Buchu

Used against UTI since the ancient times

Native to South Africa

Effective in treating cases of cystitis, nephritis,

catarrh of the bladder, urethritis

Active principle: Monoterpene disophenol

‘buchu’ PPRC/INDIA 46

Agathosma betulina

In-vitro experiments show that flavonoids exhibit

anti-inflammatory effects

Today, a tincture is used in treatment of genital

and UTI such as kidney stones, prostatitis

PPRC/INDIA 47

Zea mays

PPRC/INDIA 48

Zea mays

Also known as Cornsilk

Chemicals: saponins, tannins, alkaloid, hordenine,

sterols, stigmasterol, allantoin, polyphenols, Vitamin

K, B and C

It soothes and relaxes the lining of ureter, bladder

and urethra

Relieving irritation and improving urine excretion

(Steenkamp 2003) PPRC/INDIA 49

Thank You!!

“BE WITH US”