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Targeting Endoplasmic Reticulum for Combating Type 1 Diabetes
Fumihiko Urano, MD, PhD April 10, 2012
Understand
Identify
Treat
Three Step Formula
International Registry
UnderstandType 1 diabetes
Root cause ?
Understand T1D at the Molecular Level
Endoplasmic Reticulum Disease
Endoplasmic Reticulum ?
DNA becomes PROTEIN in the ER
Healthy Endoplasmic Reticulum
LIFE
Disruption of Healthy ERcauses beta cell death
How ?
Identify DRUGS that can maintain HEALTHY ER
Induced Pluripotent Stem Cells (iPS cells)
Skin fibroblasts iPS Cells
Beta Cells
Neurons
Understand
Identify
Treat
Three Step Formula
Karen SargentKohsuke Kanekura
Takashi HaraChristine Oslowski
Simin LuBryan O’Sullivan-Murphy
Victor Liu Mai KanekuraMariko Hara
Julie Zhu
URANO LABURANO LAB
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