Tinnitusbook

G. Attanasio (a,f), P. Ciccarese (b,c), E. Wu (e), T. Clark (b,c,d), E. Pecis (f), R. Filipo(a)

a: Dept. Neurology and Otolaryngology, University La Sapienza, Rome, IT; b: Massachusetts Gen. Hosp., Boston, MA; c: Harvard Med. School, Boston, MA; d: Harvard Initiative in Innovative Computing, Cambridge, MA; e: Alzheimer Res. Forum Found., Boston, MA; f: Acufeni.net Association onlus

3rd Tinnitus Research Initiative Meeting 24-26 June 2009, Stresa, Italy

Tinnitusbook: a proposal for an advanced scientific web community for tinnitus research

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OUR PROJECT

COMMUNITY OF PATIENTS

COMMUNITY OF SCIENTISTS

To create a new interdisciplinary online resource connecting researchers with

researchers, to facilitate rapid progress in Tinnitus research

Tinnitusbook: a proposal for an advanced scientific web community for tinnitus research

Paolo Ciccarese, PhDMass General Hospital / Harvard Medical School

Building Online Communities for Scientists

3rd Tinnitus Research Initiative Meeting

paolo.ciccarese@gmail.com

24-26 June 2009, Stresa, Italy

In collaboration with Alzheimer Research Forum

Alzheimer Research Forum

• Created in 1996 www.alzforum.org• 58,000 Alzheimer Disease (AD) Related

Papers• 1800 AD Related News Articles• Curated 14,700 Antibodies• 5000 Members (AD Scientists)• 6300 Scientists’ Comments• Over 80 live discussions

> The CNN of Alzheimer

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Alzheimer Research Forum

58,000 AD Related Papers

6300 Scientists’ Comments

Over 80 Live Discussions

ARF - People

• Executive Editor (June Kinoshita)• 2 Managing Editors• 3 Science Writers• 3 Consultants (Elizabeth Wu for Knowledge Managment)• 1 Drug Database Curator (Gwen Wong, PhD)• 1 Event Coordinator• 1 Web Developer• 1 Production Assistant• 10 Advisory Board

…and 5000 Scientists!!!

SWAN - Semantic Web Applications in Neuromedicine

• Define Hypotheses, Claims, Research Questions, Comments, Experiments– To relate them in between each others – To relate them to Gene, Protein, Antibodies,

Organisms• Annotate Publications (manual and semi-

automatic)• Efficient browsing of the knowledge base• Knowledge sharing across communities

SWAN Model

SWAN Homepageht

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SWAN Hypotheses

SWAN Hypothesis

SWAN Claim

Qualifiers

SupportiveEvidence

Relationships with other statements in the KB

Lses

SWAN Graph [1]

SWAN Graph [2]

SWAN Graph [3]

Schizophrenia Research Forum

High Number of Resources

• PubMed• Mash Terminology• Entrez Gene• UniProt• Gene Ontology• Alzforum Gene• Alzforum Antibodies• Experimental Data

• Reagents• Experiments• Neuro Imaging• Models• Annotations• Discussions• Commentaries• …

Science Collaboration Framework

• Reusable software that can be used to develop web-based, collaborative, scientific communities

• Support interdisciplinary scientists in publishing, annotating, sharing and discussing content such as articles, perspectives, interviews and news items, as well as assert personal biographies and research interests

stembook.org

stembook.org

• It is an open access collection of invited, original, peer-reviewed chapters (46 a few days ago) covering a range of topics related to stem cell biology written by top researchers in the field at the Harvard Stem Cell Institute and worldwide.

• ISSN 1940-3429

Table of Contents

Example: Link to genes

Other Stem Book features

• eAlert• Commenting and discussion forums• Semiautomatic annotation of Genes in new

articles• Access to the under-development clouds of

resources for life science (genes, proteins, antibodies, organisms…)

PDonline.org

What we can offer

• Experience in creating and maintain online communities

• Reusable software that can speed up the process of creation of a new community

• Access to biomedical knowledge bases• Access to new methods and technologies

as result of our research• Be part of a community of communities

Thank you

• Tim Clark• Gwen Wong• June Kinoshita• Marco Ocana• Elizabeth Wu

• Sudeshna Das• Benjamin Melançon

paolo.ciccarese@gmail.com

Paolo Ciccarese, PhD