The evolution of medicine: DNA

THE EVOLUTION OF MEDICINE: DNA

Daniela Márquez ObandoUniversidad Pontificia

Bolivariana

FOLDING

FOLDING

INTRODUCTIONDNA

Double strand macromolecule(D Watson y F Crick)

Components:Phosphates + Sugar +

nitrogenous bases

Medical importance: Genetic theraty

SWEET GENES: NEW WAY FOUND BY WICH

METABOLISM IS LINKED TO THE REGULATION OF

DNAScience Daily (July 4, 2014)

SWEET GENES: NEW WAY FOUND BY WICH METABOLISM IS LINKED TO THE REGULATION OF DNA

“Epigenetic regulation of DNA” is an important mechanism by which the PDC enzyme transfers an acetyl group from acetyl Co-A molecule to a histone.It has importance in the normal functions of cells like growth

SWEET GENES: NEW WAY FOUND BY WICH METABOLISM IS LINKED TO THE REGULATION OF DNA

Despite the great importance of histone acetylation in the struggle to develop medical treatments, before this discovery the source of the acetyl group was unknown in the nucleus.

SWEET GENES: NEW WAY FOUND BY WICH METABOLISM IS LINKED TO THE REGULATION OF DNA

With new knowledge about the work that the PDC enzyme in the nucleus, scientists and people with great knowledge of the subject, will be able to conduct research on potential treatments against diseases such as the fast growth of cancer cells.

OBSERVATIONThis discovery has much importance in medicine because, as is known beforehand, the cancer a disease that is more prevalent in the world and this finding may have a clear choice of therapy and healing.

DNA 'REPLICATION FORK' RECONSTITUTED

FOR THE FIRST TIME

Science Daily (July 9, 2014)

DNA 'REPLICATION FORK' RECONSTITUTED FOR THE FIRST TIME

The replication fork has much similarity to a zipper opening system. The CMG has an important role in the course of the rack and as a result of this system, are obtain two separate strands of DNA that become templates for daughters copies.

DNA 'REPLICATION FORK' RECONSTITUTED FOR THE FIRST TIME

O'Donnell and a group of investigators purified and formed for the first time, the central components involved in the eukaryotic replication fork, allowing detailed study of this process and who is the regulation by the cell.

DNA 'REPLICATION FORK' RECONSTITUTED FOR THE FIRST TIME

Repeatedly cancer is caused by a malfunction at the cellular level and much of this responsibility may be due to damage in the processes of replication, transcription and translation. With this invention, researchers will be able to more easily study the replication process and generate alternative treatment of some diseases.

OBSERVATION

Rebuilding the biochemical events at the molecular level what happens in the replication of DNA is very important not only to learn more about this process, also in diseases such as cancer, which often arise from damage to DNA inheritance.

MEDICAL UTILITY

MEDICAL UTILITY

Today procedures such as gene therapy so it is very useful to know and study the processes involved are made, such as the replication of DNA

MEDICAL UTILITY

Understand the causes of disorders today have no clear explanation.

MEDICAL UTILITY

With new knowledge, try to develop treatments for multiple diseases.

BIBLIOGRAPHY

MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p.

“Sweet genes: New way found by which metabolism is linked to the regulation of DNA” Science Daily. Science

Daily, 4 July 2014. “DNA 'replication fork'

reconstituted for the first time” Science Daily. Science Daily, 9 July 2014

THANKS