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The Role of Regenera-ve Medicine in the 100YSS
Contribu-on 128, ID 1172 100YSS Conference, Houston TX
2012 Sept 15 Mar-ne RothblaF, mar@Unither.com United Therapeu-cs Corpora-on
100YSS Regenera-ve Medicine mar@Unither.com 2
Supernovas (eg Crab Nebula) èGalac-c Cosmic Rays, With The Ejected Protons Ricoche-ng Like Billiard Balls Against Galaxy’s Magne-c Field
100YSS Regenera-ve Medicine mar@Unither.com 4
Gamma Rays Produced when Ubiquitous Galac-c Cosmic Rays Interact with Interstellar Medium Reveals
100YSS Regenera-ve Medicine mar@Unither.com 5
100YSS Regenera-ve Medicine mar@Unither.com 7
In Vivo Organ Regenera-on Via Stem Cell Transplanta-on
1st Genera-on iPS Technology
100YSS Regenera-ve Medicine mar@Unither.com 8
In Vivo Organ Regenera-on Via Stem Cell Transplanta-on
2nd Genera-on iPS Technology
Rat Lungs Can Be Kept Breathing in a Fluid-‐Air System for a Week
100YSS Regenera-ve Medicine mar@Unither.com 12
Ex Vivo Organ Regenera-on for Transplanta-on (Pig Lungs)
100YSS Regenera-ve Medicine mar@Unither.com 14
Human Peripheral Endothelial Progenitor Cells Can Be Cultured, Manipulated & SEEDED
Human Umbilical Vascular Endothelial Cells Used To Date 100YSS Regenera-ve Medicine
mar@Unither.com 15
Timeframe Considera-on
• Human Lung Has About 109 Endothelial Cells • Within a Month, Endothelial Progenitor Cells Found in Peripheral Circula-on Can be Cultured to Around 106
• Doubling Time of Around 30 Days • May Require About a Year to Grow Lungs for Transplant Once Decide to Proceed
100YSS Regenera-ve Medicine mar@Unither.com 16
hEPCR hVWF hCD73
pVWFKO hTFPI hTBM
hCD39
19
Coagulate
GP1b GP2b3q
GTKO hMCP HLA-‐E
hDAF hMIRL
Immune
SIRP/CD47 Lec-ns Sialyda-on Selec-ns
100YSS Regenera-ve Medicine mar@Unither.com
Da Vinci Robots Have Now Explanted Livers for Transplanta-on
100YSS Regenera-ve Medicine mar@Unither.com 21
Robo-c Transplanta-on on 100YSS of Xenograis or Regen Organs Will Be Prac-cal
100YSS Regenera-ve Medicine mar@Unither.com 22
Just Like Shepard’s May 1961 Flight Was <.1% to the Moon
23 100YSS Regenera-ve Medicine mar@Unither.com
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