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Neuropathology Conference 12/01/05 - Case 2
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Neuropathology Case ConferenceNeuropathology Case Conference
12/02/2005
Case 2:Case 2:
62 y/o Female, Progressive left upper 62 y/o Female, Progressive left upper extremity numbness, extremity numbness, S/P liver transplantS/P liver transplant
Differential DiagnosisDifferential Diagnosis
Malignant MelanomaMalignant Melanoma
Foreign Body Type ReactionForeign Body Type Reaction
Glial NeoplasmGlial Neoplasm
PhaeohyphomycosisPhaeohyphomycosis
Cerebral PhaeohyphomycosisCerebral Phaeohyphomycosis
Dematiaceous fungi (darkly pigmented fungi)
1. Phaeohyphomycosis (CNS cases: Cladophialophora bantiana)
2. Chromoblastomycosis (CNS cases: Fonsecaea pedrosoi)
Dark, thick-walled muriform cells (sclerotic bodies)
• High mortality (70% in C. bantiana) and morbidity
• Fungi identified on frozen section/ touch prep
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