INSIGHTEC for STARTUP NATION

INSIGHTEC for STARTUP NATION

Maurice R. Ferré, MD

May 17th, 2016

THE VISION BEHIND THE STARTUP: HISTORY OF SURGERY

10,000 years ago Craniotomies performed surgery and patients survived

1980’s - Introduction of minimally invasive procedures

2000’s - Introduction of non-invasive procedures

THE VISION BEHIND THE STARTUP

• Surgery is an old discipline -> proof of Craniotomies that were done ~10,000 years ago and the patient survived

• If surgery survived for such a long time in a fast-paced environment, it must have positive attributes

INVASIVE SURGERY DRAWBACKS

• Trauma

• Morbidity

• Slow recovery

• Collateral damage (on the way to the target)

• 5% to 10% adverse events on average

• Infection

• Reactions to the anesthesia

• Excessive bleeding

-SURGERY DISADVANTAGES

- -• Focal therapy (vs. systemic therapy)

• Real time feedback on treatment outcome (by surgeon’s vision and palpation)

• Ability to fix functionality

SURGERY BENEFITS

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A non-invasive, outpatient therapy which allows patients to return to routine immediately after treatment

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THE VISION BEHIND THE STARTUP

TRANSLATING THE IDEA INTO A REALITY

WE NEEDED TO

• See inside the body

• Destroy tumors deep inside the body without collateral damage

• Provide real time feedback on tissue viability

• Monitor treatment outcomes in real time

• Develop treatment strategies for a safer treatment (<1% adverse events)

• Demonstrate minimal trauma, morbidity and fast recovery

www.insightec.com

INSIGHTEC’S TECHNOLOGY

Non-invasive therapy platform that combines two proven technologies -High intensity focused ultrasound and Magnetic Resonance Imaging.

The high intensity focused ultrasound (FUS) generates heat at the focal point to ablate the target tissue.

The MRI enables:

1. Identification and targeting

2. Monitoring the treatment progress in real time, using thermometry information

INSIGHTEC IN A SNAP SHOT - VIDEO

COMPANY PROFILE

• Developed Exablate® - the first FDA approved therapeutic device using MR-guided Focused Ultrasound

• INSIGHTEC is a privately held Israeli company founded in 1999

• 172 employees worldwide

• First to develop technology to successfully steer and focus ultrasound through the cranium

• $300K in investments to date

Headquartered in Haifa, Israel. Regional offices in US, China, Japan and Europe

OVER 14,000 EXABLATE

TREATMENTS PERFORMED

Voted one of the top 10 innovative companies to watch for 2016

INSIGHTEC AWARDS

Time magazine voted INSIGHTEC’S technology as one of the best 50 technologies in 2011.

INSIGHTEC was included in the World Medical Innovation Forum’s “Disruptive Dozen” list

The World Economic Forum has selected INSIGHTEC as one of its Technology Pioneers for 2008

REGULATORY STATUS

NEUROSURGERY ONCOLOGYWOMEN'S

HEALTH

• Essential tremor

• Tremor dominant

Parkinson’s

Disease

• Neuropathic pain

• Pain palliation of

bone metastasis

• Primary bone

tumors

• Bone metastasis

• Uterine fibroids (Family

Complete, now removed)

• Uterine fibroids &

Adenomyosis (Future

fertility)

• Commercially approved in

Japan, Australia, China,

Korea and Russia

OUR GLOBAL FOOTPRINT

An install base of ~120 sites around the globe, our customers include well-renowned centers of excellence

Americas17 USA2 Canada1 Mexico2 Brazil

Europe 4 Germany11 Italy3 UK2 Switzerland2 Spain1 Poland3 France1 Czech Republic

Asia 9 Japan4 Korea8 China2 Singapore1 Taiwan1 Malaysia2 Australia4 India1 Vietnam2 GE6 Russia1 Kazakhstan2 Israel1 HK

STATE OF RESEARCH & REGULATORY APPROVAL

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THANK YOU!