Diabetic Nephropathy

www.medicinemcq.com 1

DIABETIC NEPHROPATHY

Most common cause of chronic renal failure

www.medicinemcq.com 2

Glomerular lesions• Capillary basement membrane

thickening• Diffuse glomerulosclerosis• Nodular glomeruloscierosis

(Kimmelstiel Wilson syndrome)‑

3

Glomerular capillary basement membranes

• Thickened •May be present without any

associated change in renal function.

www.medicinemcq.com

www.medicinemcq.com 4

Diffuse glomerulosclerosis

• Diffuse increase in mesangial matrix. • Always associated with basement

membrane thickening. • Found in most patients with DM > 10

years. • Presents as nephrotic syndrome.

www.medicinemcq.com 5

Interstitial fibrosis• Tubules - perfused by vessels arising

from efferent arterioles. • Glomerulosclerosis - tubular ischemia

and interstitial fibrosis.

6

Earliest abnormality in diabetic nephropathy

• Thickening of the glomerular basement membrane

• Accumulation of extracellular matrix.

For rest of the slides, visit www.medicinemcq.com > Diabetes Mellitus