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It is estimated that 10 million people are infected with Chagas worlwide. Most of them don't receive appropiate medical care. The Barcelona Institute for Global Health works to reduce the impact of this forgotten disease and to secure adequate treatments for those who suffer this scourge.
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Chagas:A neglected disease
And it’s research center
NTDs are:
Neglected Tropical
Chagas is a NTD
Di seases
These diseases, also known as forgotten, affect the most vulnerable populations who have limited public voice
NTDs have an ENORMOUS impact on individuals, families
and communities in low-income countries
One in 6 people on the planet... suffers from some kind of NTD...”
Joaquim Gascon, Director of the Neglected Tropical Diseases Initiatives, ISGlobal
There are
17NTD
1. Dracunculosis
2. Lymphatic filariasis
3. Onchocercosis
4. Schistosomiasis
5. Soil-transmitted helminthes
6. Cysticercosis / Taeniasis
7. Echinococcosis in humans
8. Trachoma causing blindness
9. Fascioliasis
NTDs17 10. Peripheral vascular disease
11. Dengue
12. Rabies13. Cutaneous and mucocutaneous leishmaniasis/ Visceral leishmaniasis
14. Leprosy
15. Buruli ulcer
16. Chagas Disease
17. Human African
Trypanosomiasis
Chagas is caused by a parasite The Trypanosoma cruzi
(T. cruzi)
and transmitted to peoplevia the vector insect: the vinchuca bug or barbeiro, chinche, chipo, pito
Globalization of Chagas
Chagas is endemic in Latin America, BUT due to an increase in people mobility…
...it is now present in:
Canada>5,500
USA>300,000
Europe>80,000
Japan>3,000
Australia>1,500
Chagas causes 10,000 deaths per year ChagasGlobal
An estimated 10 million people are infected Chagas
Global
75-90 millions of people are at risk of infection ChagasGlobal
Chagasis a
globalpublic health
problem
Kinds oftransmission
Vector(insects)
Transfusions/transplants(blood/organs)
Congenital(from infected mother
to newborn) Oral(food or drink
contaminated by a vector insect)
The Chagas Cycle :
TRANSMISSIONACUTE PHASE
CHRONIC PHASE
WITHOUT DIAGNOSIS OR TREATMENT
2 MonthsPeriod of 20-30 years
without symptoms
25-30% of those chronically infected develop
heart complications
10-20% of those chronically infected develop
digestivecomplications
60% of those infected by the T. cruzi parasite are asymptomaticTheir entire lives
Vector
Transfusions/transplants
Congenital
Oral
10,000 deaths from Chagas each year
Economic Impactin Latin America:
The World Bank has classified Chagas disease as one of the main public health problems of the Latin America region, where it is more prevalent than Malaria or Dengue
In Brasil, absence of workers with Chagas has caused losses of 5.6 million USD.
752,000 workdays are lost due to premature deaths
There is a loss of 1,200 million USD in productivity within the 7 countries of the southern cone
Each year:
Howdo we fight
Chagas?
PREVENTION
CONTROL
TREATMENT
R+D
INFORMATION
Prevention
& Control
A vaccine to prevent Chagas doesn’t exist. That’s why it is so important to know the methods of prevention:
Vector Control Fumigation of houses where there are vinchuca bugs;Modification and renovation of the house structure;Conditioning and reordering of the house interior
Transfusion ControlRisk prevention measures for blood banks to eliminatethe transmission of infected blood
Mother-child transmission ControlProtocols for screening pregnant women, diagnosis and treatment for children.
TreatmentACUTE PHASE CHRONIC PHASE
In adults and children over one year, the disease may be curedif treated within the first two months of infection
With specialized attention, patients may maintain a better quality of life
Although less effective, the treatment helps stop the development of the disease’s complications
And in some cases may be able to eliminate the parasite
In children under one year, treatment results in a complete cure
2 MedicinesThere are only
TO TREAT CHAGAS:
But they’re not perfect:
TREATMENT MUST BE DONE UNDER A DOCTOR’S SUPERVISION FOR TWO MONTHS
OF LIMITED ACCESS
NOT VERY EFFECTIVE IN THE CHRONIC PHASE
MAY CAUSE SERIOUS ADVERSE SIDE EFFECTS
R + DWITH MORE RESEARCH AND DEVELOPMENT
WE COULD OFFER BETTER:
MedicalAssistance Pharmaceutical
s
Research & Development
WE NEED MORE
...even though approx. 100 million people are at risk
Out of the total 3.063 million US$ only 20 million are spent on Chagas
Chagas receives less than 1% of the total budget for the research of NTD…
INFORMthe public about the risks and
preventive measures
WE NEED TO
DEVELOP new pharmaceuticals that are more
secure and effective
WE NEED TO
SECURE
the production and distribution of Benznidazol
WE NEED TO
For moreInformation:
www.ISGlobal.org
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