ICAWC 2014 - Canine Parvovirus - Cagri Akkin

WHAT IS CPV?

Çağrı AKKIN DVMvet_cagriakkin@hotmail.com +90542 202 37 10

CONTENTSCANINE PARVOVIRAL ENTERITIS

VomitingDiarrheaSevere dehydration Endotoxic or septic shock Multiple organ failureWithout treatment

WHICH BREEDS ARE UNDER RISKETIOLOGY HOW CPV INFECTS A DOGPATHOPHYSIOLOGYCLINICAL FINDINGSDIAGNOSIS TREATMENT Fluid Therapy

Systemic AntibioticsAnti-EmeticsAggressive Adjunctive TreatmentsEradication of Intestinal Parasites

PREVENTION AND CONTROL

WHAT IS CPV?CANINE PARVOVIRAL ENTERITIS

Vomiting

WHAT IS CPV?CANINE PARVOVIRAL ENTERITIS

Diarrhea

WHAT IS CPV?CANINE PARVOVIRAL ENTERITIS

Severe dehydration

WHAT IS CPV?CANINE PARVOVIRAL ENTERITIS

Endotoxic or septic shock

WHAT IS CPV?CANINE PARVOVIRAL ENTERITIS

Multiple organ failure

WHAT IS CPV?CANINE PARVOVIRAL ENTERITIS

Without treatment

Which breeds are under risk

Etiology DNA1970

CPV-2b

HOW CPV INFECTS A DOG

HOW CPV INFECTS A DOG

HOW CPV INFECTS A DOG

Pathophysiology

Pathophysiology

Infection in utero or in pups <8wk old or born to unvaccinated dams

4–5 days later

Clinical Findings

Physical examination findings can include depression, fever, dehydration, and intestinal loops that are dilated

and fluid filled. Abdominal pain warrants further investigation to rule out the potential complication of

intussusception. Severely affected animals may present collapsed with prolonged capillary refill time, poor pulse quality, tachycardia, and hypothermia—signs potentially consistent with septic shock. Although CPV-associated leukoencephalomalacia has been reported, CNS signs

are more commonly attributable to hypoglycemia, sepsis, or acid-base and electrolyte abnormalities. Inapparent or

subclinical infection is common.

Diagnosis

Clinical signs Leukopenia, lymphopenia

ELISA PCR Rapid test kits

Treatment

Fluid Therapy

Treatment

Systemic Antibiotics

Treatment

Anti-Emetics

TreatmentAggressive Adjunctive Treatments

A polyvalent equine origin antiserum against LPS endotoxin

Antiserum

Convalescent serum Recombinant granulocyte colony stimulating factor (rG-

CSF)

Oseltamivir

Treatment

Eradication of Intestinal Parasites

Treatment

Nutrition

 PPN 

A liquid diet 

Prevention and Control

Vaccination for puppies

6–8, 10–12, and 14–16 wk

Prevention and Control

Vaccination for adults

Once a year

Prevention and Control

Isolation housing

Gowning and gloving of personnel

Frequent and thorough cleaning

Prevention and Control

1:30

BIBLIOGRAPHY

Openi.nlm.nih.gov

Histology-world.com

dvm360.com

The Merck Veterinary Manual 8th edition

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